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Review: 
Question Domain & Evidence Pyramid 
Remember, certain study designs offer stronger evidence for 
different types of research questions (and guide you toward 
the best questions for appraisal.) The most common question 
domains are therapy, diagnosis, prognosis, & etiology. 
Levels of 
Evidence 
A meta-analysis, systematic review, or practice guideline that 
synthesizes multiple studies of the most appropriate study design 
can be even stronger evidence when relevant to your question, 
patient, outcomes, and inclusion/exclusion criteria.
Evidence Pyramid 
Article 
Types
Review: Question Domain & Evidence Pyramid

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Review: Question Domain & Evidence Pyramid

  • 1. Review: Question Domain & Evidence Pyramid Remember, certain study designs offer stronger evidence for different types of research questions (and guide you toward the best questions for appraisal.) The most common question domains are therapy, diagnosis, prognosis, & etiology. Levels of Evidence A meta-analysis, systematic review, or practice guideline that synthesizes multiple studies of the most appropriate study design can be even stronger evidence when relevant to your question, patient, outcomes, and inclusion/exclusion criteria.