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The Numb Hand
______
JAMES T MAZZARA, MD
ORTHOPEDIC ASSOCIATES OF HARTFORD, PC
MANCHESTER / ROCKY HILL
HARTFORD HOSPITAL GLASTONBURY SURGERY CENTER
CONNECTICUT JOINT REPLACEMENT INSTITUTE @ ST FRANCIS HOSPITAL
ECHN
Contact Information
James T Mazzara, MD
Orthopedic Associates of Hartford, PC
29 Haynes Street
Manchester, CT 06040
_________________
150 Enterprise Drive
Rocky Hill, CT 06067
860-649-2267
www.HartfordSportsOrthopedics.com
The Nerve
 3 Types of nerves
 Motor
 Muscle control
 Go from brain to muscles
 Sensory
 Sensation
 Go from body to brain
 Autonomic
 Involuntary
 Heart rate, blood pressure,
digestion, sweating
Idiopathic Nerve Damage
 Unknown cause
 Older than 60
 Numbness, tingling and pain
 Unsteady gait
 Weakness or cramps
Toxic Nerve Damage
 Lead, mercury, arsenic, thallium
 Anticonvulsants
 Cancer medications
 Heart or blood pressure medications
 Infection fighting drugs
 Skin condition treatment drugs
Alcohol-Related Nerve Damage
 Abnormal sensations
 Pain
Feels like "pins and needles"
 Numbness
 Muscle weakness, cramps, or aches
 Muscle spasms / contractions
 Tingling
 Constipation / Diarrhea
 Incontinence (leaking urine) or difficulty with urination
 Impotence in men
 Nausea / vomiting
Inflammatory Nerve Damage
Infectious (with a specific casual agent identified)
 Lyme disease
 HIV / AIDS
 Herpes Zoster (Shingles)
 Hepatitis B and C
Autoimmune or possibly infectious
 Sarcoidosis
 Polyarteritis Nodosa (PAN)
 Rheumatoid Arthritis
 Systemic Lupus Erythematosus (Lupus)
 Sjögren's Syndrome
Anatomy
Anatomy
Nerves of the Skin
Compressive Neuropathy
 Neuropraxia
Slow nerve conduction with and intact nerve
Damage is reversible
Compressive Neuropathy
 Axonotmesis
Severe injury with
nerve degeneration
Intact nerve fibers
Recovery is possible
and depends on the
distance of nerve
lesion to the site of
innervation
Compressive Neuropathy
 Neurotmesis
 Complete disruption of
the nerve
 Full recovery is unlikely
Our Focus
 Nerve compression conditions of the arm and
hand
Carpal Tunnel Syndrome
Anterior interosseus nerve syndrome
Pronator Syndrome
Cubital Tunnel Syndrome
Radial Tunnel Syndrome
Posterior interosseus nerve syndrome
Wartenberg’s syndrome
Nerve Injuries of the Arm
 More common in younger industrial workers
1994: 93,000 cases of repetitive use disorders
41% of these were carpal tunnel syndrome
 Overall 1 million adults/year require treatment
for CTS
Epidemiology
CTS Mean age @
diagnosis
Distribution
Males 50 years 22%
Females 51 years 78%
Compressive Neuropathy
 Associated symptoms
Poorly characterized &
difficult to label tendon
and muscle symptoms
Contributing Factors
 Work place
Repetitiveness
Force
Mechanical stress
Posture
Vibration
Temperature
Contributing Factors
 Carpal tunnel epidemiology
studies
Higher correlation with health
habits & lifestyle
Obesity
Tobacco use
Caffeine
Contributing Factors
 Definitive risk factors
Female
Pregnancy
Diabetes
Hypothyroidism
Rheumatoid arthritis
Contributing Factors
 Study of idiopathic carpal tunnel
syndrome
Analyzed the synovium of patients
with CTS
 Findings suggested that repeated
episodes of ischemia and reperfusion
may lead to the development of CTS
Contributing Factors
 Occupational risk factors alone do not explain the
occurrence of CTS in the workforce
 CTS due to multiple overlapping factors
 There are non work-related factors that cause carpal tunnel
syndrome.
 Work related activities may aggravate or be associated with
increased rates of carpal tunnel syndrome.
Contributing Factors
 Traction injuries
Compression at one site may tether the nerve
Leads to restricted nerve mobility with traction
and stretching of the nerve
Contributing Factors
 Nerve compression impairs
microcirculation
Systemic Factors
 Lower threshold for
compressive neuropathy
 Bilateral
Diabetes
Alcoholism
Hypothyroidism
Industrial solvent
exposure
Aging
Phases of Compressive Neuropathy
 Early
 Intermediate
 Late / Advanced
Early Phase
 Low grade compression
 Symptoms come and go
 Conservative treatment is
effective
NSAIDS
Steroid injections
Splints
Intermediate Phase
 Intraneural circulation is
persistently compromised
 Constant paresthesia and
numbness
 Respond best to nerve
decompression
Advanced Phase
 Continuous edema and
compression induce
intraneural fibrosis
 Irreversible damage with
some permanent loss of
sensation and motor
function
 Surgery stops the
progression of the
functional loss
Wasting of muscle in the thumb muscles is typical for
advance irreversible nerve damage from carpal
tunnel syndrome.
Double Crush Phenomenon
 2 separate points of nerve
compression
Compression proximally lowers
the threshold for compression
neuropathy at a distal point
Interrupted transport of
enzymes and
neurotransmitters along the
axon
Double Crush Phenomenon
 Surgical decompression may
lead to incomplete symptom
relief
Cervical radiculopathy &
CTS
Still consider CT release
Advise the patient
Clinical Presentation
 Dynamic
Symptoms are activity
specific
Exertional
 Insidious
Gradual onset
Unrelated to activity
Worse at night
Carpal Tunnel Syndrome
 Anatomic predisposing
factors
Decreased size of
carpal tunnel
Bony abnormalities
Thickened
transverse carpal
ligament
Carpal Tunnel Syndrome
 Anatomic predisposing factors
Increased contents of carpal
tunnel
Ganglion cysts
Neuroma, lipoma,
myeloma, hypertrophic
synovium, fracture callus,
osteophytes, hematoma
Carpal Tunnel Syndrome
 Neuropathic conditions
Diabetes
Alcoholism
Double crush
phenomenon
Proximal
compression of
median nerve
History of cervical nerve root
injury
Carpal Tunnel Syndrome
 Inflammatory
predisposing
conditions
Tenosynovitis
Rheumatoid
arthritis
Infection
Gout
Carpal Tunnel Syndrome
 Alterations in fluid
balance
Pregnancy
Long-term
hemodialysis
Raynaud’s
disease
Obesity
Carpal Tunnel Syndrome
 Position and use of wrist
Repetitive flexion /
extension
Repetitive forceful
squeezing and releasing
or torsion of a tool
Finger motion with wrist
extension
Typists, musicians
Vibration exposure
Carpal Tunnel Syndrome
 Weightbearing with wrist
extension
Paraplegia
Use of a can or walker
Long-distance cycling
Carpal Tunnel Syndrome
 Immobilization with the
wrist flexed
Wrist fractures can cause
scarring, swelling and
crowding of the carpal
tunnel
Awkward sleep position
Carpal Tunnel Syndrome Symptoms
 Pain & paresthesia palmar radial
hand
 Symptoms worse at night
 Symptoms worse with repetitive
forceful use of hands
 In more advanced cases of CTS,
aching and pain may also travel
up the arm to the shoulder or
neck along the course of the
median nerve
Carpal Tunnel Syndrome Diagnostic Tests
 Phalen’s test (Wrist flexion test)
Numbness / tingling < 60
seconds
Sensitivity 0.75
Specificity 0.47
Carpal Tunnel Syndrome Diagnostic Tests
 Percussion test (Tinel’s
sign)
Tingling at site of nerve
tapping
Sensitivity 0.60
Specificity 0.67
Carpal Tunnel Syndrome Diagnostic Tests
 Compression test
Paresthesia < 30 seconds
Sensitivity 0.87
Specificity 0.90
Carpal Tunnel Syndrome Diagnostic Tests
 Hand diagram
Appropriate
markings on radial
digits not on palm
Sensitivity 0.96
Specificity 0.73
Value of a negative
test 0.91
Carpal Tunnel Syndrome Diagnostic Tests
 2-point discrimination
Unable to discriminate
6mm
Advanced nerve
dysfunction
Carpal Tunnel Syndrome Diagnostic Tests
 Vibrometry
Note asymmetry with
contralateral hand or
radial versus ulnar
Sensitivity 0.87
Carpal Tunnel Syndrome Diagnostic Tests
 Semmes-Weinstein
monofilaments
Positive if unable to feel
filaments less than 2.83
Sensitivity 0.83
Carpal Tunnel Syndrome Diagnostic Tests
 X-rays
Trauma
Rheumatoid disease
Basal joint arthritis
Carpal Tunnel Syndrome Diagnostic Tests
 Nerve conduction
testing
 Sensory testing
Positive if latency
>3.5mm/sec or if
0.5mm/sec > other
hand
Carpal Tunnel Syndrome Diagnostic Tests
 EMG
 Tests the motor part of the
nerve
Positive if latency >4.5
mm/sec or if 1.0 mm/sec
> other hand
Carpal Tunnel Syndrome Diagnostic Tests
 EMG
Tests for denervation of
thenar muscles
Very advanced nerve
damage
Objective confirmation
Carpal Tunnel Syndrome Diagnostic Tests
 Chest x-ray
Smokers
Ulnar nerve symptoms
Shoulder pain
 MRI
Evaluate nerve
compression in forearm
Ganglion cyst
compressing carpal
tunnel
Carpal Tunnel Syndrome Diagnostic Tests
 Most sensitive
Semmes-Weinstein filament
Vibrometry
Threshold tests
Carpal Tunnel Syndrome
 Consider overall health
 If both hands are involved
Consider systemic or metabolic causes
 Consider proximal compression
Cervical radiculopathy
Pronator syndrome
Carpal Tunnel Syndrome
 Nonoperative treatment
Nighttime splinting in neutral
No splints worn during the day.
Circulation to the nerve is
helped by wrist motion from
daily activities
NSAIDs to reduce synovitis
Manage contributing systemic
causes
Carpal Tunnel Syndrome
 Corticosteroid injections
Transient relief in 80%
22% symptom free at 1 year
Valuable to diagnose CTS
and differentiate from other
causes of nerve compression
Carpal Tunnel Syndrome
 Injections are an excellent predictor of a
patient's response to surgery
 Excellent prognostic tool
87% with a positive response to injection had
successful surgery
54% with a negative response to injection had
successful surgery
Carpal Tunnel Syndrome
 Corticosteroid injections
Most effective if
symptomatic for < 1
year
Diffuse and
intermittent numbness
Normal 2-point
discrimination
No weakness or thenar
atrophy
EMG reveals no
denervation
1-2 millisecond
prolongation on NCS
40% of this group symptom
free at 1 year
Carpal Tunnel Syndrome
 Alternative treatments
Vitamin B6 (Pyridoxine)
Cold Laser
Acupuncture
TENS
Chiropractic manipulations
 No scientific evidence of efficacy
Carpal Tunnel Release
 Indicated for failed conservative treatment
 Earlier surgery yields better results
CTR within 3 years of symptom onset yields
better results
Carpal Tunnel Release
 Advanced cases
 Surgery to release the carpal
tunnel may only prevent
progression of the nerve
damage
 Permanent nerve damage
may not recover or improve
after surgery.
 Weakness and numbness may
be permanent but the pain,
aching, tingling and nighttime
symptoms often improve
Carpal Tunnel Release
 Patients with intermittent
pre-op symptoms obtain
better sensory recovery
than patients with
constant symptoms
Carpal Tunnel Release
 Mini-open
Good visualization of
nerve & ligament
Fewer complications
Grip strength recovery in
3 months
Pinch strength 6w
Transverse
Carpal
Ligament
Median Nerve
Carpal Tunnel Release Complications
 Transient
 Infection
 Sensitivity
 Pillar pain
 Permanent
 Nerve injury
 Anatomic variations
involving motor
branches
Carpal Tunnel Syndrome
 May be associated with
ulnar neuropathy @
Guyon’s canal
 Responds to CTR alone
Carpal Tunnel Release
 Post-op
Bulky dressing for 48 hours
Remove dressing and use
hand as tolerated
Keep wound clean, dry
and covered with a
Band-aid
Carpal Tunnel Release
 Post op course
Progressive activities
Return to work 21 days
without restrictions
Carpal Tunnel Release
 @ 3 weeks
Pronator Syndrome
 Median nerve entrapment
at the elbow
 Symptoms can be similar to
those of carpal tunnel
syndrome
Pronator Syndrome
 Symptoms
Weakness and aching of
the thumb muscles
Numbness in the thumb,
index & middle finger
Numbness in the area of the
palmar cutaneous nerve
 mid palm and thenar
eminence
Pronator Syndrome
 Diagnostic findings
Pain in upper forearm
Positive Tinel’s sign in
forearm
No finger numbness with
wrist flexion
No symptoms at night
Unlike CTS
Pronator Syndrome: Compression Sites
 Compression @ bicipital
aponeurosis
Resisted elbow flexion with
forearm supination
Pronator Syndrome: Compression Sites
 Compression @ pronator muscle
Resisted forearm pronation
with elbow extended
Pronator Syndrome: Compression Sites
 Compression @ origin of
FDS
 Resisted isolated flexion of
the PIP of middle finger
Pronator Syndrome
 Nerve conduction tests
Not helpful
20-30% of patients with CTS may have
conduction delays in forearm
Anterior Interosseous Nerve Syndrome
 Median nerve compression in
the forearm
 Motor deficit
 Weakness of the long flexors of the
thumb and index finger
 No sensory deficit
Anterior Interosseous Nerve Syndrome
 Examination
Precision tip to tip pinch
“A OK sign”
Pinch (thumb and index
finger) weakness
Motor weakness of the long flexor tendons of
the thumb and index fingers of the right hand
Anterior Interosseous Nerve Syndrome
 Spontaneous onset
 EMG-NCS is helpful in
confirming the diagnosis
Anterior Interosseous Nerve Syndrome
 Nonoperative Treatment
Observation
Splinting in elbow
flexion
Surgery if not improved
in 8-12 weeks
Anterior Interosseous Nerve Syndrome
 Surgical decompression of all potential sites of
compression
 May take up to 6 months to improve
Cubital Tunnel Syndrome
 Ulnar nerve compression at the
elbow
 “The Funny Bone”
 Osborne’s Ligament over the nerve
becomes thick and hypertrophic
causing nerve compression
Cubital Tunnel Syndrome
 Sources of
compression
fascial bands
exuberant
synovium
tumors
ganglions
anconeus
epitrochlearis
bone spurs
Cubital Tunnel Syndrome
 Symptoms
Numbness along the little
finger and ulnar ½ of ring
finger
Weakness of grip & torque
Cubital Tunnel Syndrome
 Pain medial elbow
 Tinel’s sign @ cubital tunnel
 Symptoms worse with elbow
flexion
Cubital Tunnel Syndrome
 Pain and numbness on dorsal
and volar ulnar hand
 Weakness ring
& little finger flexors
Cubital Tunnel Syndrome
 Froment’s sign
Weak intrinsic muscles
controlling finger motion of
the little and ring finger
The long flexor of the thumb
(FPL) compensates for
paralyzed thumb adductor
Cubital Tunnel Syndrome
 Intrinsic muscle weakness
Unable to adduct little
and ring fingers
Cubital Tunnel Syndrome
 Jeanne’s sign
Compensatory
hyperextension of the
thumb MP joint
Cubital Tunnel Syndrome
 Thumb adductor weakness
 Severe atrophy
Muscle wasting
Cubital Tunnel Syndrome
 Pollock’s test
Weakness of the flexor strength
of the ring and little fingers
Cubital Tunnel Syndrome
 Examine cervical spine
 Consider thoracic outlet syndrome
 Assess elbow for arthritis
 Check for ulnar nerve subluxation (snapping)
Cubital Tunnel Syndrome
 Tinel’s sign @ cubital tunnel
 Elbow flexion test (<60 sec)
Cubital Tunnel Syndrome
 Ulnar nerve pressure test
Direct pressure
Elbow 20o
Forearm supinated
Positive if < 60 seconds
Cubital Tunnel Syndrome
 Sensory exam
Numbness on all surfaces of
little finger and the ulnar
half of the ring finger
S-W monofilament test
Cubital Tunnel Syndrome
 Nonoperative treatment
Activity modification
Don’t lean on the elbow
NSAIDs
Night-time extension splints
Elbow splints while sleeping may be helpful. This
is a child sized knee pad from a sporting goods
store used as a splint. The padded side of the
splint is on the volar side of the elbow to block
elbow flexion.
Cubital Tunnel Syndrome
 Surgical options
Simple decompression
Medial epicondylectomy
Submuscular transposition
Subcutaneous transposition
Cubital Tunnel Syndrome
 Medial Epicondylectomy
Ulnar nerve
compression
after release
of Osborne’s
ligament
Hand
Medial
epicondyle
Cubital Tunnel Syndrome
 Medial Epicondylectomy
Medial
epicondyle
removed
Flexor-
pronator
attachment
releasedRelaxed
ulnar
nerve
Elbow @ 90 degrees flexion
Cubital Tunnel Syndrome
 Medial Epicondylectomy
Flexor-
pronator
mass
reattached
to medial
epicondyle
Elbow flexed 90 degrees
Cubital Tunnel Syndrome
 Submuscular Transposition
Cubital Tunnel Syndrome
 88% Good-excellent results
 8% failure or recurrence
 Compared to 25 – 40% other techniques
JBJS July, 2003
Cubital Tunnel Syndrome
 Submuscular Transposition with Flexor Origin Slide
Preserved
sensory
nerves
Decompressed
ulnar nerve
Hand
Cubital Tunnel Syndrome
 Submuscular Transposition
Preserved
sensory
nerves
Decompressed
ulnar nerve
A
B
Cubital Tunnel Syndrome
 Submuscular Transposition: Nerve moved anteriorly and positioned beneath the flexor
muscle and fascia.
Transposed ulnar
nerve
A
B
Hand
Cubital Tunnel Syndrome
 Subcutaneous Transposition: Nerve released and moved anteriorly but is kept above the
muscle and secured by a slip of extensor fascia sutured to the skin serving as a sleeve to
stabilize the nerve
Cubital Tunnel Syndrome
 Surgical results
 80-90% good results
 Functional recovery 6 months
 Moderate – severe compression
 Recurrence rates or poor results in 25-30%
 Patients with a normal EMG with clear symptoms of cubital
tunnel syndrome can do well with an in situ decompression
 Athletes and younger patients with mild cubital tunnel
typically get a subcutaneous transposition
 More severe cases of cubital tunnel syndrome appear to do
better with a lower rate of recurrence with a submuscular
transposition with flexor origin slide
Ulnar Tunnel Syndrome
 Ulnar nerve compression in
Guyon’s canal
 Symptoms depend on site of
compression
 Motor
 Sensory
 Mixed
Ulnar Tunnel Syndrome
 Causes of compression
 Ganglion cysts
 Synovial inflammation
 Fractures of hook of hamate
 Ulnar artery thrombosis
 Anomalous muscle
 Palmaris brevis hypertrophy
Ulnar Tunnel Syndrome
 Evaluation
CT scan for hook of hamate
fracture
MRI for ganglion cyst
Doppler ultrasound for ulnar
artery thrombosis
Ulnar Tunnel Syndrome
 Treatment
Nonoperative
Splints
NSAIDs
Operative
Treat underlying cause
(cyst, fracture)
Nerve decompression
Radial Nerve
 Compression above the elbow
 Posterior interosseous nerve syndrome
 Radial tunnel syndrome
 Wartenberg’s syndrome
Radial Nerve
 Compression above the elbow
Rare
Fibrous arch of lateral head of
triceps
Weakness of wrist extensors
Sensory changes on top forearm up
to the thumb
Radial Nerve
 May be related to humeral
fracture callus
 EMG-NCS confirms the
diagnosis
 Surgical decompression if not
improved in 3 months
Posterior Interosseous Nerve (PIN) Syndrome
 Motor portion of radial nerve
compressed in proximal forearm
 Motor only, no sensory function
 Innervates wrist and finger extensors
Posterior Interosseous Nerve (PIN) Syndrome
 Gradual onset
 Subtle loss of strength with radial
deviation in wrist extension
ECRL (the long wrist extensor
muscle) still functional
Posterior Interosseous Nerve (PIN) Syndrome
 EMG: diagnostic
 X-rays: evaluate for radial head
 Fractures
 Arthritis
 Dislocations
 MRI: ganglions cysts, lipomas
Posterior Interosseous Nerve (PIN) Syndrome
 Compression sites
Thick fascia @ the front of
the elbow joint
(radiocapitellar joint)
Recurrent radial artery
branches
Posterior Interosseous Nerve (PIN) Syndrome
 Compression sites
Fibrous edge of ECRB
(wrist extensor) muscle
Arcade of Frohse at the
proximal edge of
supinator muscle
Posterior Interosseous Nerve (PIN) Syndrome
 Treatment
Avoid aggravating activities
NSAIDs
Surgical release if not improved in 4-12 weeks
Strength recovery may take 18 months
85% good – excellent results
Radial Tunnel Syndrome
 Pain
 No motor or sensory deficits
 Same nerve and compression sites as PIN syndrome
 Work-related
Associated with forceful elbow extension or forearm
rotation
Radial Tunnel Syndrome
 Symptoms
Deep ache on lateral elbow &
forearm
Night pain
Confused with lateral epicondylitis
5% of lateral epicondylitis
patients have concurrent radial
tunnel syndrome
Radial Tunnel Syndrome
 Examination
Provocative tests
Resisted supination test
with wrist extension
Passive pronation with
wrist flexion
Radial Tunnel Syndrome
 Examination
Tender over radial tunnel
in the upper forearm
May also be tender over
the lateral epicondyle
Middle finger test elicits
pain on resistance
tending
Radial Tunnel Syndrome
 EMG-NCS not helpful
 Diagnostic injection into radial tunnel
Causes PIN palsy
Relieves symptoms
Radial Tunnel Syndrome
 Nonoperative Treatment
Activity modification
Wrist splinting
NSAIDs
Therapy with modalities
Radial Tunnel Syndrome
 Surgical release
51% good results (Mayo)
Maximal recovery @ 9-18 months
Workers’ comp do not do as well
Worst results
Work-related injuries
Chronic pain
Poorly localized symptoms on exam
Radial Tunnel Syndrome Decompression
Radial
Nerve
Sensory branch
Posterior Interosseus
nerve motor branch
Supinator m.
Arcade of Frohse
Left
Hand
Wartenberg’s Syndrome
 Sensory branch of radial nerve
Compressed between brachioradialis &
extensor carpi radialis longus tendons with
forearm pronation
May be due to local trauma or constricting
jewelry
Area of compression as the
radial nerve exits this interval
between the two tendons, BR
and ECRL, causing local
tenderness and numbness
and tingling over the first
webspace, thumb and index
finger
Wartenberg’s Syndrome
 Symptoms
Pain, numbness,
paresthesia over dorsal-
radial hand
Worse with wrist
movement & tight pinch
with thumb-index finger
Wartenberg’s Syndrome
 Examination
Pain with forced forearm pronation
Tinel’s sign over nerve
Injection test into junction of BR confirms
diagnosis
Differentiate from deQuervain’s tenosynovitis
Wartenberg’s Syndrome
 Nonoperative Treatment
Rest
NSAIDs
Avoid aggravating activities
Wrist splints
Wartenberg’s Syndrome
 Surgical
decompression after 6
months of
nonoperative
treatment
 75% good results
Tendon of
Brachioradialis
Radial Nerve
Sensory Branch
Hand
Thank You

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The Numb Hand | Nerve Injuries in the Hand | South Windsor, Rocky Hill, Glastonbury CT

  • 1. The Numb Hand ______ JAMES T MAZZARA, MD ORTHOPEDIC ASSOCIATES OF HARTFORD, PC MANCHESTER / ROCKY HILL HARTFORD HOSPITAL GLASTONBURY SURGERY CENTER CONNECTICUT JOINT REPLACEMENT INSTITUTE @ ST FRANCIS HOSPITAL ECHN
  • 2. Contact Information James T Mazzara, MD Orthopedic Associates of Hartford, PC 29 Haynes Street Manchester, CT 06040 _________________ 150 Enterprise Drive Rocky Hill, CT 06067 860-649-2267 www.HartfordSportsOrthopedics.com
  • 3. The Nerve  3 Types of nerves  Motor  Muscle control  Go from brain to muscles  Sensory  Sensation  Go from body to brain  Autonomic  Involuntary  Heart rate, blood pressure, digestion, sweating
  • 4. Idiopathic Nerve Damage  Unknown cause  Older than 60  Numbness, tingling and pain  Unsteady gait  Weakness or cramps
  • 5. Toxic Nerve Damage  Lead, mercury, arsenic, thallium  Anticonvulsants  Cancer medications  Heart or blood pressure medications  Infection fighting drugs  Skin condition treatment drugs
  • 6. Alcohol-Related Nerve Damage  Abnormal sensations  Pain Feels like "pins and needles"  Numbness  Muscle weakness, cramps, or aches  Muscle spasms / contractions  Tingling  Constipation / Diarrhea  Incontinence (leaking urine) or difficulty with urination  Impotence in men  Nausea / vomiting
  • 7. Inflammatory Nerve Damage Infectious (with a specific casual agent identified)  Lyme disease  HIV / AIDS  Herpes Zoster (Shingles)  Hepatitis B and C Autoimmune or possibly infectious  Sarcoidosis  Polyarteritis Nodosa (PAN)  Rheumatoid Arthritis  Systemic Lupus Erythematosus (Lupus)  Sjögren's Syndrome
  • 11. Compressive Neuropathy  Neuropraxia Slow nerve conduction with and intact nerve Damage is reversible
  • 12. Compressive Neuropathy  Axonotmesis Severe injury with nerve degeneration Intact nerve fibers Recovery is possible and depends on the distance of nerve lesion to the site of innervation
  • 13. Compressive Neuropathy  Neurotmesis  Complete disruption of the nerve  Full recovery is unlikely
  • 14. Our Focus  Nerve compression conditions of the arm and hand Carpal Tunnel Syndrome Anterior interosseus nerve syndrome Pronator Syndrome Cubital Tunnel Syndrome Radial Tunnel Syndrome Posterior interosseus nerve syndrome Wartenberg’s syndrome
  • 15. Nerve Injuries of the Arm  More common in younger industrial workers 1994: 93,000 cases of repetitive use disorders 41% of these were carpal tunnel syndrome  Overall 1 million adults/year require treatment for CTS
  • 16. Epidemiology CTS Mean age @ diagnosis Distribution Males 50 years 22% Females 51 years 78%
  • 17. Compressive Neuropathy  Associated symptoms Poorly characterized & difficult to label tendon and muscle symptoms
  • 18. Contributing Factors  Work place Repetitiveness Force Mechanical stress Posture Vibration Temperature
  • 19. Contributing Factors  Carpal tunnel epidemiology studies Higher correlation with health habits & lifestyle Obesity Tobacco use Caffeine
  • 20. Contributing Factors  Definitive risk factors Female Pregnancy Diabetes Hypothyroidism Rheumatoid arthritis
  • 21. Contributing Factors  Study of idiopathic carpal tunnel syndrome Analyzed the synovium of patients with CTS  Findings suggested that repeated episodes of ischemia and reperfusion may lead to the development of CTS
  • 22. Contributing Factors  Occupational risk factors alone do not explain the occurrence of CTS in the workforce  CTS due to multiple overlapping factors  There are non work-related factors that cause carpal tunnel syndrome.  Work related activities may aggravate or be associated with increased rates of carpal tunnel syndrome.
  • 23. Contributing Factors  Traction injuries Compression at one site may tether the nerve Leads to restricted nerve mobility with traction and stretching of the nerve
  • 24. Contributing Factors  Nerve compression impairs microcirculation
  • 25. Systemic Factors  Lower threshold for compressive neuropathy  Bilateral Diabetes Alcoholism Hypothyroidism Industrial solvent exposure Aging
  • 26. Phases of Compressive Neuropathy  Early  Intermediate  Late / Advanced
  • 27. Early Phase  Low grade compression  Symptoms come and go  Conservative treatment is effective NSAIDS Steroid injections Splints
  • 28. Intermediate Phase  Intraneural circulation is persistently compromised  Constant paresthesia and numbness  Respond best to nerve decompression
  • 29. Advanced Phase  Continuous edema and compression induce intraneural fibrosis  Irreversible damage with some permanent loss of sensation and motor function  Surgery stops the progression of the functional loss Wasting of muscle in the thumb muscles is typical for advance irreversible nerve damage from carpal tunnel syndrome.
  • 30. Double Crush Phenomenon  2 separate points of nerve compression Compression proximally lowers the threshold for compression neuropathy at a distal point Interrupted transport of enzymes and neurotransmitters along the axon
  • 31. Double Crush Phenomenon  Surgical decompression may lead to incomplete symptom relief Cervical radiculopathy & CTS Still consider CT release Advise the patient
  • 32. Clinical Presentation  Dynamic Symptoms are activity specific Exertional  Insidious Gradual onset Unrelated to activity Worse at night
  • 33. Carpal Tunnel Syndrome  Anatomic predisposing factors Decreased size of carpal tunnel Bony abnormalities Thickened transverse carpal ligament
  • 34. Carpal Tunnel Syndrome  Anatomic predisposing factors Increased contents of carpal tunnel Ganglion cysts Neuroma, lipoma, myeloma, hypertrophic synovium, fracture callus, osteophytes, hematoma
  • 35. Carpal Tunnel Syndrome  Neuropathic conditions Diabetes Alcoholism Double crush phenomenon Proximal compression of median nerve History of cervical nerve root injury
  • 36. Carpal Tunnel Syndrome  Inflammatory predisposing conditions Tenosynovitis Rheumatoid arthritis Infection Gout
  • 37. Carpal Tunnel Syndrome  Alterations in fluid balance Pregnancy Long-term hemodialysis Raynaud’s disease Obesity
  • 38. Carpal Tunnel Syndrome  Position and use of wrist Repetitive flexion / extension Repetitive forceful squeezing and releasing or torsion of a tool Finger motion with wrist extension Typists, musicians Vibration exposure
  • 39. Carpal Tunnel Syndrome  Weightbearing with wrist extension Paraplegia Use of a can or walker Long-distance cycling
  • 40. Carpal Tunnel Syndrome  Immobilization with the wrist flexed Wrist fractures can cause scarring, swelling and crowding of the carpal tunnel Awkward sleep position
  • 41. Carpal Tunnel Syndrome Symptoms  Pain & paresthesia palmar radial hand  Symptoms worse at night  Symptoms worse with repetitive forceful use of hands  In more advanced cases of CTS, aching and pain may also travel up the arm to the shoulder or neck along the course of the median nerve
  • 42. Carpal Tunnel Syndrome Diagnostic Tests  Phalen’s test (Wrist flexion test) Numbness / tingling < 60 seconds Sensitivity 0.75 Specificity 0.47
  • 43. Carpal Tunnel Syndrome Diagnostic Tests  Percussion test (Tinel’s sign) Tingling at site of nerve tapping Sensitivity 0.60 Specificity 0.67
  • 44. Carpal Tunnel Syndrome Diagnostic Tests  Compression test Paresthesia < 30 seconds Sensitivity 0.87 Specificity 0.90
  • 45. Carpal Tunnel Syndrome Diagnostic Tests  Hand diagram Appropriate markings on radial digits not on palm Sensitivity 0.96 Specificity 0.73 Value of a negative test 0.91
  • 46. Carpal Tunnel Syndrome Diagnostic Tests  2-point discrimination Unable to discriminate 6mm Advanced nerve dysfunction
  • 47. Carpal Tunnel Syndrome Diagnostic Tests  Vibrometry Note asymmetry with contralateral hand or radial versus ulnar Sensitivity 0.87
  • 48. Carpal Tunnel Syndrome Diagnostic Tests  Semmes-Weinstein monofilaments Positive if unable to feel filaments less than 2.83 Sensitivity 0.83
  • 49. Carpal Tunnel Syndrome Diagnostic Tests  X-rays Trauma Rheumatoid disease Basal joint arthritis
  • 50. Carpal Tunnel Syndrome Diagnostic Tests  Nerve conduction testing  Sensory testing Positive if latency >3.5mm/sec or if 0.5mm/sec > other hand
  • 51. Carpal Tunnel Syndrome Diagnostic Tests  EMG  Tests the motor part of the nerve Positive if latency >4.5 mm/sec or if 1.0 mm/sec > other hand
  • 52. Carpal Tunnel Syndrome Diagnostic Tests  EMG Tests for denervation of thenar muscles Very advanced nerve damage Objective confirmation
  • 53. Carpal Tunnel Syndrome Diagnostic Tests  Chest x-ray Smokers Ulnar nerve symptoms Shoulder pain  MRI Evaluate nerve compression in forearm Ganglion cyst compressing carpal tunnel
  • 54. Carpal Tunnel Syndrome Diagnostic Tests  Most sensitive Semmes-Weinstein filament Vibrometry Threshold tests
  • 55. Carpal Tunnel Syndrome  Consider overall health  If both hands are involved Consider systemic or metabolic causes  Consider proximal compression Cervical radiculopathy Pronator syndrome
  • 56. Carpal Tunnel Syndrome  Nonoperative treatment Nighttime splinting in neutral No splints worn during the day. Circulation to the nerve is helped by wrist motion from daily activities NSAIDs to reduce synovitis Manage contributing systemic causes
  • 57. Carpal Tunnel Syndrome  Corticosteroid injections Transient relief in 80% 22% symptom free at 1 year Valuable to diagnose CTS and differentiate from other causes of nerve compression
  • 58. Carpal Tunnel Syndrome  Injections are an excellent predictor of a patient's response to surgery  Excellent prognostic tool 87% with a positive response to injection had successful surgery 54% with a negative response to injection had successful surgery
  • 59. Carpal Tunnel Syndrome  Corticosteroid injections Most effective if symptomatic for < 1 year Diffuse and intermittent numbness Normal 2-point discrimination No weakness or thenar atrophy EMG reveals no denervation 1-2 millisecond prolongation on NCS 40% of this group symptom free at 1 year
  • 60. Carpal Tunnel Syndrome  Alternative treatments Vitamin B6 (Pyridoxine) Cold Laser Acupuncture TENS Chiropractic manipulations  No scientific evidence of efficacy
  • 61. Carpal Tunnel Release  Indicated for failed conservative treatment  Earlier surgery yields better results CTR within 3 years of symptom onset yields better results
  • 62. Carpal Tunnel Release  Advanced cases  Surgery to release the carpal tunnel may only prevent progression of the nerve damage  Permanent nerve damage may not recover or improve after surgery.  Weakness and numbness may be permanent but the pain, aching, tingling and nighttime symptoms often improve
  • 63. Carpal Tunnel Release  Patients with intermittent pre-op symptoms obtain better sensory recovery than patients with constant symptoms
  • 64. Carpal Tunnel Release  Mini-open Good visualization of nerve & ligament Fewer complications Grip strength recovery in 3 months Pinch strength 6w Transverse Carpal Ligament Median Nerve
  • 65. Carpal Tunnel Release Complications  Transient  Infection  Sensitivity  Pillar pain  Permanent  Nerve injury  Anatomic variations involving motor branches
  • 66. Carpal Tunnel Syndrome  May be associated with ulnar neuropathy @ Guyon’s canal  Responds to CTR alone
  • 67. Carpal Tunnel Release  Post-op Bulky dressing for 48 hours Remove dressing and use hand as tolerated Keep wound clean, dry and covered with a Band-aid
  • 68. Carpal Tunnel Release  Post op course Progressive activities Return to work 21 days without restrictions
  • 70. Pronator Syndrome  Median nerve entrapment at the elbow  Symptoms can be similar to those of carpal tunnel syndrome
  • 71. Pronator Syndrome  Symptoms Weakness and aching of the thumb muscles Numbness in the thumb, index & middle finger Numbness in the area of the palmar cutaneous nerve  mid palm and thenar eminence
  • 72. Pronator Syndrome  Diagnostic findings Pain in upper forearm Positive Tinel’s sign in forearm No finger numbness with wrist flexion No symptoms at night Unlike CTS
  • 73. Pronator Syndrome: Compression Sites  Compression @ bicipital aponeurosis Resisted elbow flexion with forearm supination
  • 74. Pronator Syndrome: Compression Sites  Compression @ pronator muscle Resisted forearm pronation with elbow extended
  • 75. Pronator Syndrome: Compression Sites  Compression @ origin of FDS  Resisted isolated flexion of the PIP of middle finger
  • 76. Pronator Syndrome  Nerve conduction tests Not helpful 20-30% of patients with CTS may have conduction delays in forearm
  • 77. Anterior Interosseous Nerve Syndrome  Median nerve compression in the forearm  Motor deficit  Weakness of the long flexors of the thumb and index finger  No sensory deficit
  • 78. Anterior Interosseous Nerve Syndrome  Examination Precision tip to tip pinch “A OK sign” Pinch (thumb and index finger) weakness Motor weakness of the long flexor tendons of the thumb and index fingers of the right hand
  • 79. Anterior Interosseous Nerve Syndrome  Spontaneous onset  EMG-NCS is helpful in confirming the diagnosis
  • 80. Anterior Interosseous Nerve Syndrome  Nonoperative Treatment Observation Splinting in elbow flexion Surgery if not improved in 8-12 weeks
  • 81. Anterior Interosseous Nerve Syndrome  Surgical decompression of all potential sites of compression  May take up to 6 months to improve
  • 82. Cubital Tunnel Syndrome  Ulnar nerve compression at the elbow  “The Funny Bone”  Osborne’s Ligament over the nerve becomes thick and hypertrophic causing nerve compression
  • 83. Cubital Tunnel Syndrome  Sources of compression fascial bands exuberant synovium tumors ganglions anconeus epitrochlearis bone spurs
  • 84. Cubital Tunnel Syndrome  Symptoms Numbness along the little finger and ulnar ½ of ring finger Weakness of grip & torque
  • 85. Cubital Tunnel Syndrome  Pain medial elbow  Tinel’s sign @ cubital tunnel  Symptoms worse with elbow flexion
  • 86. Cubital Tunnel Syndrome  Pain and numbness on dorsal and volar ulnar hand  Weakness ring & little finger flexors
  • 87. Cubital Tunnel Syndrome  Froment’s sign Weak intrinsic muscles controlling finger motion of the little and ring finger The long flexor of the thumb (FPL) compensates for paralyzed thumb adductor
  • 88. Cubital Tunnel Syndrome  Intrinsic muscle weakness Unable to adduct little and ring fingers
  • 89. Cubital Tunnel Syndrome  Jeanne’s sign Compensatory hyperextension of the thumb MP joint
  • 90. Cubital Tunnel Syndrome  Thumb adductor weakness  Severe atrophy Muscle wasting
  • 91. Cubital Tunnel Syndrome  Pollock’s test Weakness of the flexor strength of the ring and little fingers
  • 92. Cubital Tunnel Syndrome  Examine cervical spine  Consider thoracic outlet syndrome  Assess elbow for arthritis  Check for ulnar nerve subluxation (snapping)
  • 93. Cubital Tunnel Syndrome  Tinel’s sign @ cubital tunnel  Elbow flexion test (<60 sec)
  • 94. Cubital Tunnel Syndrome  Ulnar nerve pressure test Direct pressure Elbow 20o Forearm supinated Positive if < 60 seconds
  • 95. Cubital Tunnel Syndrome  Sensory exam Numbness on all surfaces of little finger and the ulnar half of the ring finger S-W monofilament test
  • 96. Cubital Tunnel Syndrome  Nonoperative treatment Activity modification Don’t lean on the elbow NSAIDs Night-time extension splints Elbow splints while sleeping may be helpful. This is a child sized knee pad from a sporting goods store used as a splint. The padded side of the splint is on the volar side of the elbow to block elbow flexion.
  • 97. Cubital Tunnel Syndrome  Surgical options Simple decompression Medial epicondylectomy Submuscular transposition Subcutaneous transposition
  • 98. Cubital Tunnel Syndrome  Medial Epicondylectomy Ulnar nerve compression after release of Osborne’s ligament Hand Medial epicondyle
  • 99. Cubital Tunnel Syndrome  Medial Epicondylectomy Medial epicondyle removed Flexor- pronator attachment releasedRelaxed ulnar nerve Elbow @ 90 degrees flexion
  • 100. Cubital Tunnel Syndrome  Medial Epicondylectomy Flexor- pronator mass reattached to medial epicondyle Elbow flexed 90 degrees
  • 101. Cubital Tunnel Syndrome  Submuscular Transposition
  • 102. Cubital Tunnel Syndrome  88% Good-excellent results  8% failure or recurrence  Compared to 25 – 40% other techniques JBJS July, 2003
  • 103. Cubital Tunnel Syndrome  Submuscular Transposition with Flexor Origin Slide Preserved sensory nerves Decompressed ulnar nerve Hand
  • 104. Cubital Tunnel Syndrome  Submuscular Transposition Preserved sensory nerves Decompressed ulnar nerve A B
  • 105. Cubital Tunnel Syndrome  Submuscular Transposition: Nerve moved anteriorly and positioned beneath the flexor muscle and fascia. Transposed ulnar nerve A B Hand
  • 106. Cubital Tunnel Syndrome  Subcutaneous Transposition: Nerve released and moved anteriorly but is kept above the muscle and secured by a slip of extensor fascia sutured to the skin serving as a sleeve to stabilize the nerve
  • 107. Cubital Tunnel Syndrome  Surgical results  80-90% good results  Functional recovery 6 months  Moderate – severe compression  Recurrence rates or poor results in 25-30%  Patients with a normal EMG with clear symptoms of cubital tunnel syndrome can do well with an in situ decompression  Athletes and younger patients with mild cubital tunnel typically get a subcutaneous transposition  More severe cases of cubital tunnel syndrome appear to do better with a lower rate of recurrence with a submuscular transposition with flexor origin slide
  • 108. Ulnar Tunnel Syndrome  Ulnar nerve compression in Guyon’s canal  Symptoms depend on site of compression  Motor  Sensory  Mixed
  • 109. Ulnar Tunnel Syndrome  Causes of compression  Ganglion cysts  Synovial inflammation  Fractures of hook of hamate  Ulnar artery thrombosis  Anomalous muscle  Palmaris brevis hypertrophy
  • 110. Ulnar Tunnel Syndrome  Evaluation CT scan for hook of hamate fracture MRI for ganglion cyst Doppler ultrasound for ulnar artery thrombosis
  • 111. Ulnar Tunnel Syndrome  Treatment Nonoperative Splints NSAIDs Operative Treat underlying cause (cyst, fracture) Nerve decompression
  • 112. Radial Nerve  Compression above the elbow  Posterior interosseous nerve syndrome  Radial tunnel syndrome  Wartenberg’s syndrome
  • 113. Radial Nerve  Compression above the elbow Rare Fibrous arch of lateral head of triceps Weakness of wrist extensors Sensory changes on top forearm up to the thumb
  • 114. Radial Nerve  May be related to humeral fracture callus  EMG-NCS confirms the diagnosis  Surgical decompression if not improved in 3 months
  • 115. Posterior Interosseous Nerve (PIN) Syndrome  Motor portion of radial nerve compressed in proximal forearm  Motor only, no sensory function  Innervates wrist and finger extensors
  • 116. Posterior Interosseous Nerve (PIN) Syndrome  Gradual onset  Subtle loss of strength with radial deviation in wrist extension ECRL (the long wrist extensor muscle) still functional
  • 117. Posterior Interosseous Nerve (PIN) Syndrome  EMG: diagnostic  X-rays: evaluate for radial head  Fractures  Arthritis  Dislocations  MRI: ganglions cysts, lipomas
  • 118. Posterior Interosseous Nerve (PIN) Syndrome  Compression sites Thick fascia @ the front of the elbow joint (radiocapitellar joint) Recurrent radial artery branches
  • 119. Posterior Interosseous Nerve (PIN) Syndrome  Compression sites Fibrous edge of ECRB (wrist extensor) muscle Arcade of Frohse at the proximal edge of supinator muscle
  • 120. Posterior Interosseous Nerve (PIN) Syndrome  Treatment Avoid aggravating activities NSAIDs Surgical release if not improved in 4-12 weeks Strength recovery may take 18 months 85% good – excellent results
  • 121. Radial Tunnel Syndrome  Pain  No motor or sensory deficits  Same nerve and compression sites as PIN syndrome  Work-related Associated with forceful elbow extension or forearm rotation
  • 122. Radial Tunnel Syndrome  Symptoms Deep ache on lateral elbow & forearm Night pain Confused with lateral epicondylitis 5% of lateral epicondylitis patients have concurrent radial tunnel syndrome
  • 123. Radial Tunnel Syndrome  Examination Provocative tests Resisted supination test with wrist extension Passive pronation with wrist flexion
  • 124. Radial Tunnel Syndrome  Examination Tender over radial tunnel in the upper forearm May also be tender over the lateral epicondyle Middle finger test elicits pain on resistance tending
  • 125. Radial Tunnel Syndrome  EMG-NCS not helpful  Diagnostic injection into radial tunnel Causes PIN palsy Relieves symptoms
  • 126. Radial Tunnel Syndrome  Nonoperative Treatment Activity modification Wrist splinting NSAIDs Therapy with modalities
  • 127. Radial Tunnel Syndrome  Surgical release 51% good results (Mayo) Maximal recovery @ 9-18 months Workers’ comp do not do as well Worst results Work-related injuries Chronic pain Poorly localized symptoms on exam
  • 128. Radial Tunnel Syndrome Decompression Radial Nerve Sensory branch Posterior Interosseus nerve motor branch Supinator m. Arcade of Frohse Left Hand
  • 129. Wartenberg’s Syndrome  Sensory branch of radial nerve Compressed between brachioradialis & extensor carpi radialis longus tendons with forearm pronation May be due to local trauma or constricting jewelry Area of compression as the radial nerve exits this interval between the two tendons, BR and ECRL, causing local tenderness and numbness and tingling over the first webspace, thumb and index finger
  • 130. Wartenberg’s Syndrome  Symptoms Pain, numbness, paresthesia over dorsal- radial hand Worse with wrist movement & tight pinch with thumb-index finger
  • 131. Wartenberg’s Syndrome  Examination Pain with forced forearm pronation Tinel’s sign over nerve Injection test into junction of BR confirms diagnosis Differentiate from deQuervain’s tenosynovitis
  • 132. Wartenberg’s Syndrome  Nonoperative Treatment Rest NSAIDs Avoid aggravating activities Wrist splints
  • 133. Wartenberg’s Syndrome  Surgical decompression after 6 months of nonoperative treatment  75% good results Tendon of Brachioradialis Radial Nerve Sensory Branch Hand