The document discusses post-treatment bias in social science research. It begins by listing several big social science questions that are difficult to answer, such as whether democratization reduces conflict or ethnic diversity causes civil war. It then explains that while experiments are useful, most research is observational. It discusses how causal inference works by comparing equivalent treatment and control groups, but that omitted variable bias is a major challenge if confounding factors differ between the groups. Post-treatment bias occurs when researchers control for consequences of the treatment or have the wrong causal ordering of predictors.