Resveratrol, natural anti cancer supplement from Richard Clement Nutrition.

1. Resveratrol
Richard Clement Nutrition
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12/10/2012 1

2. Cancer need to be prevented
Richard Clement Nutrition
www.web-outpatients.com
Taking Resveratrol daily may be as smart as stopping
smoking
It could be considered malpractice not to discuss the
Company
benefit of Resveratrol with patients, the low cost, the
LOGO
absence of side-effects, the growing scientific evidence
makes it one of my favorite recommendation.
12/10/2012 2

3. RESVERATROL: Antioxidant
Polygonum extract clearly has
antioxidant effects.
Antioxidant activity of extract from
Polygonum cuspidatum
Hsu CY, Chan YP, Chang JBiol Res.
2007;40(1):13-21. Epub 2007 Jul 19
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4. RESVERATROL: Breast Cancer
 Oncogene. 2012 Dec 3. doi:
 Elevated lipogenesis in epithelial stem-like cell confers survival
 advantage in ductal carcinoma in situ of breast cancer.
 Pandey PR, Xing F, Sharma S, Watabe M, Pai SK, Iiizumi-Gairani M, Fukuda K,
Hirota S, Mo YY, Watabe K.
 Source
 Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois
University School of Medicine, Springfield, IL, USA.
 Abstract
 Upregulation of lipogenesis is a hallmark of cancer and blocking the lipogenic
pathway is known to cause tumor cell death by apoptosis. We have also shown that
resveratrol was capable of blocking the lipogenic gene expression in CSCs and
significantly suppressed their ability to generate DCIS in animals, which provides us
with a strong rationale to use this agent for chemoprevention DCIS.Oncogene
advance online publication, 3 December 2012; doi:10.1038/onc.2012.519.
12/10/2012 4

5. RESVERATROL: Anticancer
 Polygonum cuspidatum, contains piceatannol
a superior anticancer agent.
An effective sample preparation approach for
screening the anticancer compound piceatannol
using HPLC coupled with UV and fluorescence detection
Lin LL, Lien CY, Cheng YC, Ku KLChromatogr B Analyt
Technol Biomed Life Sci. 2007 Jun 15;853(1-2):175-82.
Epub 2007 Mar
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6. RESVERATROL:
Better Source Polyganum
Resveratrol is a new anticancer
composition which is less toxicity
and higher efficiency in Polygonum
cuspidatum.
 Studies on active substance of anticancer effect
in Polygonum cuspidatum
Feng L, Zhang LF, Yan T, Jin J, Tao WY.The
Biopharmaceutical Laboratory, School of
Biotechnology, Yangtze University, Wuxi, China
12/10/2012 6

7. RESVERATROL; Cardioprotection
Trans-resveratrol supplementation
may be a potential alternative to conventional
HRT for cardioprotection
and osteoporosis prevention and may
confer other potential health benefits in women
Benefits of resveratrol in women's health Bagchi
D, Das DK, Tosaki A, Bagchi M, Kothari SC
Drugs Exp Clin Res. 2001;27(5-6):233-48
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8. RESVERATROL:Anti-osteosarcoma
 Oncol Lett. 2012 Oct;4(4):837-839.
Epub 2012 Jul 25.
 Effects of resveratrol on vascular endothelial
growth factor expression in osteosarcoma cells and
cell proliferation.
 Liu Z, Li Y, Yang R.
 Source
 Department of Orthopedics, First Affiliated Hospital of
Xinxiang Medical University, Weihui, Henan 453100;
 Abstract
 resveratrol (Res) may exert an anti-osteosarcoma effect
by inhibiting VEGF expression in tumor cells.
12/10/2012 8

9. RESVERATROL:Anti-mesothelioma
 Food Chem Toxicol. 2012 Nov 9;52C:61-68. doi: 10.1016/j.fct.2012.10.060. [Epub ahead of print]
 Synergistic anti-cancer effects of resveratrol and chemotherapeutic agent clofarabine against human
malignant mesothelioma MSTO-211H cells.
 Lee YJ, Lee YJ, Im JH, Won SY, Kim YB, Cho MK, Nam HS, Choi YJ, Lee SH.
 Source
 Division of Molecular Cancer Research, Soonchunhyang Medical Research Institute,
Soonchunhyang University, Cheonan 330-090, Republic of Korea; Soonchunhyang
Environmental Health Center for Asbestos, Cheonan Hospital, College of Medicine,
Soonchunhyang University, Cheonan 330-090, Republic of Korea.
 Abstract
 Dietary phytochemicals as adjuvants have been suggested to play important roles in
enhancing chemotherapeutic potential owing to multitargeted chemopreventive
properties and lack of substantial toxicity.. The combined treatment of resveratrol and
clofarabine produced a synergistic antiproliferative effect. Taken together, the data
provide evidence that the synergistic antiproliferative effect of resveratrol and
clofarabine is linked to the inhibition of Akt and Sp1 activities, and suggest that this
combination may have therapeutic value in treatment of malignant mesothelioma.
12/10/2012 9

10. RESVERATROL:Protect Arteries
 Acta Clin Croat. 2012 Jun;51(2):227-35.
 The protective effects of resveratrol on human coronary artery endothelial cell damage induced by
hydrogen peroxide in vitro.
 Sayin O, Arslan N, Guner G.
 Source
 Research Laboratory, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
 Abstract
 Oxidative stress is defined as imbalance between the production and destruction of
reactive oxygen species. The aim of this study was to investigate whether resveratrol
could protect human endothelial cells against hydrogen peroxide damage in vitro. In
this in vitro study on human coronary endothelial cells, the effects of resveratrol on
the glutathione content in human coronary endothelial cells in vitro were evaluated
with high performance liquid chromatography. The effects of resveratrol on protein
expression of the glutamate cysteine ligase, glutathione peroxidase and glutathione
reductase enzymes were evaluated with the Western blot method. Resveratrol
increased the reduced glutathione contents significantly (p < 0.05). Resveratrol
increased protein expression of the glutamate cysteine ligase, glutathione
peroxidase-1 and glutathione reductase enzymes (p < 0.05). All data supported each
other and suggested that resveratrol had a protective effect against human coronary
artery endothelial cell damage. It is thought that these results could pave the way to
the new therapeutic approaches to protect against oxidative stress that develops in
cardiovascular diseases.
12/10/2012 10

11. RESVERATROL:
Atherosclerosis Prevention
 Int J Cardiol. 2012 Oct 22. pii: S0167-5273(12)01133-3. doi:
10.1016/j.ijcard.2012.09.027. [Epub ahead of print]
 Resveratrol for primary prevention of atherosclerosis: Clinical
trial evidence for improved gene expression in vascular
endothelium.
 Agarwal B, Campen MJ, Channell MM, Wherry SJ, Varamini B,
Davis JG, Baur JA, Smoliga JM.
 Source
 Institute for Diabetes, Obesity, and Metabolism, Perelman School of
Medicine, University of Pennsylvania, Philadelphia, PA, United
States.
.
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12. RESVERATROL:
Atherosclerosis Prevention
 Int J Cardiol. 2012 Oct 22. pii: S0167-5273(12)01133-3. doi:
10.1016/j.ijcard.2012.09.027. [Epub ahead of print]
 Resveratrol for primary prevention of atherosclerosis: Clinical
trial evidence for improved gene expression in vascular
endothelium.
 Agarwal B, Campen MJ, Channell MM, Wherry SJ, Varamini B,
Davis JG, Baur JA, Smoliga JM.
 Source
 Institute for Diabetes, Obesity, and Metabolism, Perelman School of
Medicine, University of Pennsylvania, Philadelphia, PA, United
States.
.
12/10/2012 12

13. RESVERATROL:
DNA repair
 J Oncol. 2012;2012:370481. Epub 2012 Sep 10.
 DNA Repair and Cancer Therapy: Targeting APE1/Ref-1 Using Dietary Agents.
 Raffoul JJ, Heydari AR, Hillman GG.
 Source
 Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
 Abstract
 Epidemiological studies have demonstrated the cancer protective effects of dietary agents and
other natural compounds isolated from fruits, soybeans, and vegetables on neoplasia. Studies
have also revealed the potential for these natural products to be combined with chemotherapy or
radiotherapy for the more effective treatment of cancer. In this paper we discuss the potential for
targeting the DNA base excision repair enzyme APE1/Ref-1 using dietary agents such as soy
isoflavones, resveratrol, curcumin, and the vitamins ascorbate and α-tocopherol. We also discuss
the potential role of soy isoflavones in sensitizing cancer cells to the effects of radiotherapy. A
comprehensive review of the dual nature of APE1/Ref-1 in DNA repair and redox activation of
cellular transcription factors, NF-κB and HIF-1α, is also discussed. Further research efforts
dedicated to delineating the role of APE1/Ref-1 DNA repair versus redox activity in sensitizing
cancer cells to conventional treatment are warranted.
12/10/2012 13

14. RESVERATROL:
May prevent hepatic steatosis
 Biotechnol Lett. 2012 Dec;34(12):2205-12. doi: 10.1007/s10529-012-1034-0. Epub 2012 Sep 1.
 Resveratrol prevents hepatic steatosis induced by hepatitis C virus core protein.
 Jiang L, Gu Y, Ye J, Liu F, Zhao Y, Wang C, Xu Y, Cao X, Zhang L, Dong W, Li F, Wang J, Wang
H, Li Q.
 Source
 State Key Laboratory of Cancer Biology and Department of Pathology, Xijing Hospital, Fourth
Military Medical University, No.17, Changle West Road, Xi'an, 710032, Shaanxi, China.
 Abstract
 Hepatitis C virus (HCV) core protein plays an important role in the development of hepatic
steatosis in patients with chronic HCV infection. Treatment of C57BL/6 mice infected with HCV
core recombinant adenoviruses with resveratrol significantly decreased hepatic triacylglycerols
(TAG) while the serum TAG level was unaffected. RT-PCR and Western blotting showed that
HCV core protein attenuated the expression of Sirt1 and PPAR-α, which would be reversed by
resveratrol. This was also confirmed in primary mouse hepatic cells infected with HCV core
protein expressing adenovirus. Thus, resveratrol may prevent against hepatic steatosis by
blocking the inhibited expression of Sirt1 and PPAR-α induced by HCV core protein.
12/10/2012 14

15. Richard Clement Nutrition
www.web-outpatients.com
1-877-438-3042
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Fax 305-594-2174
Richard Clement Nutrition
Since 12 years
Created by Richard Clement MD
No reported adverse events or side –effects
FDA regulated facility
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Resveratrol From
20 cents to 60
cents a day
depending of
intake.
12/10/2012 15