This company presentation provides an overview of a company that has over 40 years of experience in fluorination chemistry. They have manufacturing capabilities across various scales and expertise in selective fluorination techniques. They employ over 580 staff globally, including 185 scientists. They offer custom synthesis of over 3,000 compounds and have an online catalogue of over 25,000 building blocks. Their facilities include laboratories in India and the UK, as well as a cGMP pilot plant in India. They have the capability to perform a wide range of chemical processes.

1. Company Presentation 2014

2. • Over 40 years of experience in Fluorination
• Public traded company
• Manufacturing capabilities of developing fluorinating reagents at all scales
• Expertise in site selective fluorination & perfluorination techniques
• Innovator of novel fluorinated building blocks
• Portfolio of over 25,000 compounds
About Us – NFIL & MOL

3. Global Presence

4. Global Presence
Over 580 professionally qualified employees across the globe...
• 185 scientists in India and UK - Most at PhD or BSc (or equivalent)
• 70 commercial staff - with strong scientific background
throughout the organisation
• 285 production engineers and technicians
• 35 support staff
• 5 full time HSE personnel

5. Importance of Fluorine

6. Fluorination Strategy

7. O CF 3 O CHF 2 O CF 2
ClS CF 3 S CHF 2 S CF 2
Cl
O
Br
CF 3
Novelty increases
• Known compounds
• Inexpensive
• Commercially available
S
Br
CF 3
S
Br
CHF 2
S
Br
CF 2
Cl
O
Br
CF 2
Cl
O
Br
CHF 2
• Not commercially available
• Unknown or few lit reports
• Novel
Novel functional groups

8. O CF 3
O
Br
CF 3
• Known compound
• Inexpensive
• Commercially available
• Not commercially available
• No literature reports
• Novel
N Br
O
CF 3
N
N Br
O
CF 3
• Known compound
• Expensive
• Only recently available
Novelty increases
Novel molecules

9. Custom Synthesis
• Over 3000 IP protected compounds produced over past ten years
• Complex multi-stage chemistry undertaken by team of experienced PhD chemists
• Strong track record of on-time delivery to agreed specifications with accurate updates
as per client requirements
• Fast turn-around time, typically less than six weeks for most projects
• All IP related to custom projects stored on secure, limited access, database
• Rapid access to cost-effective raw material sources from our own catalogue of over
25,000 building blocks
• Route development and optimisation if required, including further scale up

10. Custom Synthesis - Examples
C
CH
H22
OO
OO
–
–
NN
+
+
H
H
OO
OO
RR
OO
RR
250g prepared, 4 stages
ClClHH
O
O
N
N
RR
OO
N
N
NN OO
OO R
R
1g prepared, 7 stages
R
R
O
O
NN
NN
OO
RR
OO
R
R
NNHH
RR
NN
OO RR
5 g prepared, 7 stages
OO
R
R
NN
OO
OO
OOHH
RR
100g prepared, 3 stages
R
R
O
O
OO
R
R
SS NN
OO
100g prepared, 8 stages
ClClHH
NN
NN
HH
NN
OO
RR
RR
15g prepared, 14 stages

11. Chemistry Processes
• Acylation
• Alkylation-liquid & vapor phase
• Bromination & chlorination
• Side chain chlorination
• Fluorination - both liquid & vapour phase
• Nitration
• Reduction
• Catalytic Hydrogenation
• Hydro-dehalogenation
• Fries Rearrangement
• Esterification
• Claisen’s Condensation
• Diazotization
• Hydrolysis
• Oxidation
• Ammonolysis
• Deamination
• Grignard’s Reactions
• Cyanation
• Halex Reactions

12. Online catalogue
• Extensive range of over 25,000 novel
organic building blocks and intermediates
• Secure on-line ordering & account setup
• Structure searchable
• Credit cards accepted
• New products added weekly
• Large stock for prompt despatch
• MSDS’s downloaded from site

13. UK Operations, Runcorn
• 55 fume hoods across 6 laboratories
• High pressure chemistry facilities including:
- Fluorination
- Carbonylation
- Hydrogenation
• Radley’s Carousel’s & Biotage Isolera automated
chromatography systems for rapid screening
• Vessel sizes up to 20 L (Glass & stainless steel)
• MLS microwave reactor

14. R&D Operations, India
• 27,000 ft2 of laboratories
• Two Aliphatic & Aromatic Synthetic Labs
• Special laboratories include:
- Continuous Vapor Phase Fluorination Lab
- High Pressure Lab
- Inorganic Synthetic Lab
• Operational temperature ranges from -78 C to 400 C
• Online literature search facilities including Reaxsys, STN & Sci-Finder

15. cGMP pilot plant: Dewas, India
• Flexible reactors systems: 50L to 1500L
• GL, SS, Alloy 20, Hastelloy, Nickel & Inconel
reactors
• Multiple solids isolation and drying capabilities
• 2-stage cGMP distillation column and a
separate liquids packaging
• cGMP hydrogenation unit for corrosive reaction
conditions - pressures up to 40 psi
• cGMP fluorination suite opened July 2012
• Full on-site analytical support and equipment

16. • Approval for significant expansion of current cGMP
facility in Dewas given September 2013
• Multi-ton, multi-purpose plant scheduled for completion
Q1-2015
• Expansion of R&D and analytical laboratories at Dewas
site also approved
• Expansion required due to number of projects moving
into Phase III and commercial
Dewas Site - Expansion Plans

17. Dewas Site - Expansion Plans
• New cGMP plant will have Intermediate, High pressure
Hydrogenation & Distillation area
• Mfg. plant will have working capaciy of 28KL
• Various type of MOC such as SS316L,Glass Lined,Halar
lined & Inconel.
• Min reactor capacity 500Ltr & max capacity of 3000Ltr
• Max operating pressure will be 100 Bar

18. • GMP Plant will have 10 reactors in Intermediate Area and 6
reactors in High Pressure Area.
• Additional space for minimum of 4 reactors in Intermediate area
and 2 reactors in High Pressure area shall be provided
• Two Distillation systems will be provided in GMP plant.
• New Kilo Lab, process development labs and analytical and in-
process labs to be added
• New Admin building (only ground floor) with Area of 310 Sq Mts
will be provided.
• A NMR and Reaction calorimeter apart from including additional
GCs and HPLCs in QC has also been considered
Dewas Site - Expansion Plans

19. Quality Control
• NMR (300MHz)
• GC; HPLC; GC-MS; LC-MS
• Titration including KF
• UV spectrophotometer
• Stability chambers inc. photo-stability
• Polarimetry & variety of chiral LC columns
for enantio-pure compounds
• Melting-point apparatus with AVI files
• X-ray Fluorimeter
• Flame Photometers

20. Health, Safety & Environment
• Site specific safety protocols
• On-site fire station, medical centre & 24 hour security
• Comprehensive staff training programs
• Process safety (project specific)
- HAZOP
- COSHH
- Risk Analysis
• ISO 9001/14001/18001 accredited firm
• Regular external assessments
• Client audits are both welcome & encouraged

21. Why?
• Reliable
• Project management
• High quality
• On-time deliverables
• Core expertise in fluorination – from R&D to commercial
• Highly experienced team – diverse range of chemistries offered
• Flexibility
• Strong track-record on health & safety and the environment

22. Company Presentation 2013