Innate Imm Trapping

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Innate Imm Trapping

  1. 1. INNATE IMMUNITY: NEUTROPHILS AND THEIR PRODUCTS
  2. 3. Greek Myelos = bone marrow Bursa Bone marrow
  3. 4. Act rapidily Incapable of sustained effort Act more slowly
  4. 7. NEUTROPHIL 8 x 10 6 /min Life span: 2-4 days Cannot divide Fine granular cytoplasm Segmented nucleus Two pools: circulating and sequestered in microvasculature
  5. 8. Direct movement of cells (leucocytes) under the influence of an external chemical gradient.
  6. 11. CHEMOTAXIS Bacteria products Integrins/selectins (gradient) 1 2 3 4 5 6
  7. 12. Rolling Adherence Emigration Selectin- mediated Integrin- mediated Inflammatory stimuli Chemotaxis Blood flow The stages of neutrophil adhesion and emigration from blood vessels. PMN
  8. 13. The proteins and their ligands engaged in neutrophil-vascular endothelial cell binding
  9. 15. Phagocytosis
  10. 16. ADHERENCE AND OPSONIZATION Opsonin (Greek > sauce). A molecule that facilitates phagocytosis by coating foreign particles (neutralizes –ve charges) Zeta potential - + C +++
  11. 17. Receptor for C Receptor for Ab ADHERENCE AND OPSONIZATION
  12. 18. Streptococcus agalactie Neutrophil
  13. 19. ADHERENCE AND OPSONIZATION
  14. 20. INGESTION AND PHAGOSOME FORMATION
  15. 21. PHAGOLYSOSOME
  16. 22. Neutrophil Activation
  17. 23. DESTRUCTION The Respiratory Burst O 2 Superoxide anion Hydrogen peroxide 1 3 4 5 2
  18. 24. LYTIC ENZYMES
  19. 25. SURFACE RECEPTORS
  20. 26. The Removal of Apoptotic Neutrophils

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