The story follows four characters - two mice named Sniff and Scurry, and two little people named Hem and Haw - who search for cheese in a maze. One day they discover their usual cheese station is empty. While the mice quickly set off to find new cheese, Hem refuses to accept the change and wants the old cheese back. Haw decides to venture into the maze to search for new cheese. After overcoming his fears, Haw finds new cheese and learns to accept and even enjoy change.