4. Western blot of spinal cords from 15 day old mice shows that there is ~35% less neurofascin 155 (Nfasc155, oligodendrocyte-specific) in the cerebroside sulfotransferase knockout (KO) mice. Neurofascin 186 (Nfasc186, neuron-specific) and extracellular-regulated kinase 2 (ERK2, loading control) do not vary. n≥3, p=0.001 Adapted from Pomicter et al ., Brain 2010:133;389-405.
5. A developing (left) and mature (right) node:paranode (blue:orange) region is shown with voltage-gated sodium channels in blue, contactin-associated protein in red, and neurofascin proteins (186 at the neuronal node and 155 at the myelin paranode) in green. Bar = 5 μ m. Adapted from Pomicter et al ., Brain 2010:133;389-405.
