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Rencontres Interventionnelles - Transradial Approach RITA
                    Prague, Czech Republic,
          Thursday 29th & Friday 30th September 2011




Puncture, radial spasm and
     wire progression:
  remaining problems in TRA?


                              Jacques Monségu, MD

         Val-de-Grâce Military Hospital, Paris


                                                             1	
  
Puncture, radial spasm and wire progression

       Radial failure predictors
A multivariate analysis of a large serie: 6,962 TRA (94-98)


Causes of the 475 TRA failures (7%):
- unsuccessful puncture (69%)
-  difficult anatomy (16%),
-  brachial artery spasm (8%),
-  unsuccessful canulation (5%)
-  miscellaneous (2%)
     G.Barbeau AHA 1999
Puncture, radial spasm and wire progression
Premedication with
    hydroxyzine               The puncture
    dichlorhydrate

Patient information

Good installation
   of the arm

A dedicated sheath

Quiet atmosphere

Local anesthesia:
    EMLA® and
    xylocaïne


                                                         3	
  
Puncture, radial spasm and wire progression

EMLA® vs Local Infiltration Anesthesia
   for Radial Artery Cannulation

                                 EMLA       Lidocaïne       p
n                                 269           269
Pain during Puncture             2 (1-3)      7 (6-8)     0.0001
Additional Lidocaïne (%)           7            34        <0.0001
Failure of Cannulation (%)         4             10        0.006
Radial Spasm (%)                    1             4        0.002
Time to Sheath Insertion (min)    4 (3-5)      6 (2-12)   0.0002


       Joly Anesth Analg 1998; 87:403-06

                                                                    4	
  
Puncture, radial spasm and wire progression

    Subcutaneous 500 μg Nitroglycerin
      for Radial Artery Cannulation

                                 NTG +            NTG -           p
Number of patients              33 / 42          30 / 42
Number of puncture            1.27 / 1.16      1.43 / 1.5      0.29 / < 0.05
Radial Spasm (%)                   1               4             0.002
Time to Cannulation (sec)       75 / 146       132 / 213    < 0.001 / < 0.05
Pulse improvement                79%              10%            0.005


    Candemir J Vasc Interv Radiol 2009; 20:1151-6
    Ouadhour Cath Cardiov Interv 2008; 72:343-6

                                                                               5	
  
Puncture, radial spasm and wire progression

Sometimes falsy missing «Atrophic» Radial Artery
                 Dorsal Carpal Branch




                                                   6	
  
Puncture, radial spasm and wire progression

   How to recover a radial ?

Ø Subcutaneous nitrates
Ø High blood pressure level
Ø Hyperemia by brachial compression:
       NO release
Ø Avoid pain
Ø And espacially be quiet and patient…


                                                      7	
  
Puncture, radial spasm and wire progression

 A good flow, but the wire
      don’t advance!

         Reasons ?
         Radial posterior wall ?
         Small branch ?
         Loops ?

                                              8
Puncture, radial spasm and wire progression
          A good flow, but the wire
               don’t advance!
Solutions
Ø  Never force
Ø  Flow verification
Ø  Needle rotation
Ø  Perform a «J » to the wire or use
a J specific wire
Ø  Cannulation with venous needle
and inject contrast to understand
Ø  New puncture higher, with bare
needle possibly

                                                      9	
  
Puncture, radial spasm and wire progression

                       Radial spasm
                        Multivariate Analysis
                  127 pts with spasm /637 pts without

                                      OR                 95% CI

Anatomical anomalies                  5.1                2.1 - 11.4
Use of > 3 catheters                  3.0                1.9 – 4.7
Moderate-to-severe pain during        2.6                1.4 – 4.9
radial artery cannulation
The use of phentolamine as            1.8                1.1 – 2.9
spasmolytic
Post vasodilation radial diameter    0.98               0.98 – 0.99

     R.J Ruiz-Salmeron
     Rev Esp Cardiol 2005;85(5):504-11
                                                                      10	
  
Puncture, radial spasm and wire progression

         How to treat spasm ?
PREVENTION:
Ø A good « cocktail »: Verapamil
    +/- nitrates and Heparin
Ø No pain: Emla®, Xylocaine…
Ø A quick puncture
Ø The least catheters
Ø Long hydrophilic sheath?
Ø Anesthesiologist??

TREATMENT:
Ø Vasodilators…
Ø Sedation…
                                                  11	
  
Puncture, radial spasm and wire progression

ANesthesia In Trans-radial Approach
        RESULTS: Spasm
        P < 0.0001




                                    visual analogic
                                         scale




  Benamer H, ANITA Study TCT 2006
                                                      12	
  
Puncture, radial spasm and wire progression

            0.035’’ wire don’t advance!
  1533        Normal           High         Radial        Radial        Other
 patients     anatomy      bifurcations     loops      tortuosities   anomalies

  No. of      1321 (86%)     108 (7%)      35 (2.3%)     30 (2%)      39 (2.5%)
 patients
Female %         28            29             49           50            33

   Age        63.0±11.0     65.5±10.8     69.8±10.4     72.2±7.7      65.1±11.8

Procedure     41.3±21.5     45.2±23.2     49.4±17.1     41.0±12.7     42.1±19.2
time (min)
X-ray time     9.7±8.0       9.3±6.5       10.0±6.6     10.7±6.5       9.6±7.1
  (min)
Failure %        0.9           4.6           37.1         23.3         12.9%




    Lo, Heart 2009; 95: 410-5
                                                                                  13	
  
Puncture, radial spasm and wire progression


         0.035’’ wire don’t advance!
ACTIONS:                           To avoid…
Ø  Never force +++

Ø  Contrast injection

Ø  Take an hydrophilic wire

Ø External side-compression


                                                     14
Puncture, radial spasm and wire progression

       Hydrophilic wire use




                                              15	
  
Puncture, radial spasm and wire progression

        With a 0.014’’ !
Puncture, radial spasm and wire progression

             But, be careful …




                                              17	
  

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Monsegu J

  • 1. Rencontres Interventionnelles - Transradial Approach RITA Prague, Czech Republic, Thursday 29th & Friday 30th September 2011 Puncture, radial spasm and wire progression: remaining problems in TRA? Jacques Monségu, MD Val-de-Grâce Military Hospital, Paris 1  
  • 2. Puncture, radial spasm and wire progression Radial failure predictors A multivariate analysis of a large serie: 6,962 TRA (94-98) Causes of the 475 TRA failures (7%): - unsuccessful puncture (69%) -  difficult anatomy (16%), -  brachial artery spasm (8%), -  unsuccessful canulation (5%) -  miscellaneous (2%) G.Barbeau AHA 1999
  • 3. Puncture, radial spasm and wire progression Premedication with hydroxyzine The puncture dichlorhydrate Patient information Good installation of the arm A dedicated sheath Quiet atmosphere Local anesthesia: EMLA® and xylocaïne 3  
  • 4. Puncture, radial spasm and wire progression EMLA® vs Local Infiltration Anesthesia for Radial Artery Cannulation EMLA Lidocaïne p n 269 269 Pain during Puncture 2 (1-3) 7 (6-8) 0.0001 Additional Lidocaïne (%) 7 34 <0.0001 Failure of Cannulation (%) 4 10 0.006 Radial Spasm (%) 1 4 0.002 Time to Sheath Insertion (min) 4 (3-5) 6 (2-12) 0.0002 Joly Anesth Analg 1998; 87:403-06 4  
  • 5. Puncture, radial spasm and wire progression Subcutaneous 500 μg Nitroglycerin for Radial Artery Cannulation NTG + NTG - p Number of patients 33 / 42 30 / 42 Number of puncture 1.27 / 1.16 1.43 / 1.5 0.29 / < 0.05 Radial Spasm (%) 1 4 0.002 Time to Cannulation (sec) 75 / 146 132 / 213 < 0.001 / < 0.05 Pulse improvement 79% 10% 0.005 Candemir J Vasc Interv Radiol 2009; 20:1151-6 Ouadhour Cath Cardiov Interv 2008; 72:343-6 5  
  • 6. Puncture, radial spasm and wire progression Sometimes falsy missing «Atrophic» Radial Artery Dorsal Carpal Branch 6  
  • 7. Puncture, radial spasm and wire progression How to recover a radial ? Ø Subcutaneous nitrates Ø High blood pressure level Ø Hyperemia by brachial compression: NO release Ø Avoid pain Ø And espacially be quiet and patient… 7  
  • 8. Puncture, radial spasm and wire progression A good flow, but the wire don’t advance! Reasons ? Radial posterior wall ? Small branch ? Loops ? 8
  • 9. Puncture, radial spasm and wire progression A good flow, but the wire don’t advance! Solutions Ø  Never force Ø  Flow verification Ø  Needle rotation Ø  Perform a «J » to the wire or use a J specific wire Ø  Cannulation with venous needle and inject contrast to understand Ø  New puncture higher, with bare needle possibly 9  
  • 10. Puncture, radial spasm and wire progression Radial spasm Multivariate Analysis 127 pts with spasm /637 pts without OR 95% CI Anatomical anomalies 5.1 2.1 - 11.4 Use of > 3 catheters 3.0 1.9 – 4.7 Moderate-to-severe pain during 2.6 1.4 – 4.9 radial artery cannulation The use of phentolamine as 1.8 1.1 – 2.9 spasmolytic Post vasodilation radial diameter 0.98 0.98 – 0.99 R.J Ruiz-Salmeron Rev Esp Cardiol 2005;85(5):504-11 10  
  • 11. Puncture, radial spasm and wire progression How to treat spasm ? PREVENTION: Ø A good « cocktail »: Verapamil +/- nitrates and Heparin Ø No pain: Emla®, Xylocaine… Ø A quick puncture Ø The least catheters Ø Long hydrophilic sheath? Ø Anesthesiologist?? TREATMENT: Ø Vasodilators… Ø Sedation… 11  
  • 12. Puncture, radial spasm and wire progression ANesthesia In Trans-radial Approach RESULTS: Spasm P < 0.0001 visual analogic scale Benamer H, ANITA Study TCT 2006 12  
  • 13. Puncture, radial spasm and wire progression 0.035’’ wire don’t advance! 1533 Normal High Radial Radial Other patients anatomy bifurcations loops tortuosities anomalies No. of 1321 (86%) 108 (7%) 35 (2.3%) 30 (2%) 39 (2.5%) patients Female % 28 29 49 50 33 Age 63.0±11.0 65.5±10.8 69.8±10.4 72.2±7.7 65.1±11.8 Procedure 41.3±21.5 45.2±23.2 49.4±17.1 41.0±12.7 42.1±19.2 time (min) X-ray time 9.7±8.0 9.3±6.5 10.0±6.6 10.7±6.5 9.6±7.1 (min) Failure % 0.9 4.6 37.1 23.3 12.9% Lo, Heart 2009; 95: 410-5 13  
  • 14. Puncture, radial spasm and wire progression 0.035’’ wire don’t advance! ACTIONS: To avoid… Ø  Never force +++ Ø  Contrast injection Ø  Take an hydrophilic wire Ø External side-compression 14
  • 15. Puncture, radial spasm and wire progression Hydrophilic wire use 15  
  • 16. Puncture, radial spasm and wire progression With a 0.014’’ !
  • 17. Puncture, radial spasm and wire progression But, be careful … 17