INTRODUCTION Aminoglycosides are a class of antibiotics used mainly in the treatment of aerobic gram-negative bacilli infections, although they are also effective against other bacteria including Staphylococci and Mycobacterium tuberculosis. They are often used in combination with other antibiotics. Streptomycin – 1944 Actinomycetes – Streptomyces griseus Bactericidal antibiotics which is interfere with protein synthesis Used to treat aerobic Gram –ve bacteria Exhibit ototoxicity and nephrotoxicity MECHANISM OF ACTION These drugs inhibit protein synthesis in the bacteria, there permeability is increased and cell contents leak out and death of cell occurs. These drugs leave bactericidal action. CLINICAL USES Gram –ve bacillary infection – Septicaemia, pelvic & abdominal sepsis Bacterial endocarditis – enterococcal, streptococcal or staphylococcal infection of heart valves Pneumonias, Tuberculosis Tularemia Plague, Brucellosis Topical – Neomycin, Framycetin:- Infections of conjunctiva or external ear and also used it before surgery. COMMON INDICATIONS OF AMINOGLYCOSIDES Gram negative bacillary infections particularly septicemia, meningitis, UTI’s renal, pelvic and abdominal sepsis. Bacterial endocarditis: usually gentamicin is preferred as a part of regimen. Other infections such as tuberculosis, plague, brucellosis etc. Topical uses: neomycin, framycetin and sisomicin are used for various topical infections. NURSING IMPLICATIONS The renal function should be regularly monitored. Patients should be regularly enquired about any side effects. Patients should be warned for not driving or operating the machinery. Patient should be advised to take plenty of water during the course. Monitor the sign and symptoms of hearing loss.

1. AMINOGLYCOSIDES
NEHA BHARTI
M.Sc. N(MEDICAL SURGICAL NURSING)
NURSING TUTOR, SMVDCoN

2. INTRODUCTION
• Aminoglycosides are a class of antibiotics
used mainly in the treatment of aerobic gram-
negative bacilli infections, although they are
also effective against other bacteria including
Staphylococci and Mycobacterium
tuberculosis.
• They are often used in combination with other
antibiotics.

3. • Streptomycin – 1944
• Actinomycetes – Streptomyces griseus
• Bactericidal antibiotics which is interfere with
protein synthesis
• Used to treat aerobic Gram –ve bacteria
• Exhibit ototoxicity and nephrotoxicity

4. MECHANISM OF ACTION
• These drugs inhibit protein synthesis in the
bacteria, there permeability is increased and
cell contents leak out and death of cell occurs.
These drugs leave bactericidal action.

7. CLINICAL USES
• Gram –ve bacillary infection – Septicaemia, pelvic &
abdominal sepsis
• Bacterial endocarditis – enterococcal, streptococcal or
staphylococcal infection of heart valves
• Pneumonias, Tuberculosis
• Tularemia
• Plague, Brucellosis
Topical – Neomycin, Framycetin:- Infections of
conjunctiva or external ear and also used it before
surgery.

18. DRUG DOSE
Gentamicin 3-5 mg/Kg/day in 1-3 doses
Streptomycin 0.75 mg-1 gm IM OD/BD for 7-10 days
Amikacin 15 mg/Kg/day in 1-3 doses
Tobramycin 3-5 mg/Kg/day in 1-3 doses
Netilmicin 4-6 mg/Kg/day in 1-3 doses
Sisomicin 0.3% e drops/ 0.1% cream
Kanamycin 15 mg/kg/day in 1-3 doses
Neomycin 0.25-1gm QID oral, 0.3-0.5% eye drops and ointment
Framycetin 1% skin cream, eye drops and ointment and 0.5%

24. COMMON INDICATIONS OF
AMINOGLYCOSIDES
• Gram negative bacillary infections particularly
septicemia, meningitis, UTI’s renal, pelvic and
abdominal sepsis.
• Bacterial endocarditis: usually gentamicin is
preferred as a part of regimen.
• Other infections such as tuberculosis, plague,
brucellosis etc.
• Topical uses: neomycin, framycetin and sisomicin
are used for various topical infections.

25. NURSING IMPLICATIONS
The renal function should be regularly monitored.
Patients should be regularly enquired about any side
effects.
Patients should be warned for not driving or
operating the machinery.
Patient should be advised to take plenty of water
during the course.
Monitor the sign and symptoms of hearing loss.