1. A comparison of outcomes from in vitro fertilization cycles stimulated
with either recombinant luteinizing hormone (LH) or human
chorionic gonadotropin acting as an LH analogue delivered as
human menopausal gonadotropins, in subjects with good or poor
ovarian reserve: A retrospective analysis
Michael H. Dahan *, Mohammed Agdi, Fady Shehata, WeonYoung Son, Seang Lin Tan
McGill Reproductive Center, McGill University, Royal Victoria Hospital, Montreal, Canada
European Journal of Obstetrics & Gynecology and Reproductive Biology 172 (2014) 70–73
Anna Hnug
Product Manager
Feb 17th, 2014
2. Background information
- Addition of LH may benefit certain patients
有些特性的病人加入LH後可以
促進濾泡發育(folliculargenesis)
及增加懷孕率
• 年齡較大(>35 yr)
• Poor responder
• Very low serum LH level
在幾個meta-analysis中可看到,
LH+FSH的protocol比FSH
alone的protocol
• 懷孕率較高
• 臨床懷孕率較高
• 活產率較高
• 著床率較高(r-hLH)
• 使用FSH的劑量較少(agonist
long protocol)
• 取得較多的卵(antagonist
protocol)
12. Recombinant human LH supplementation versus
supplementation with urinary hCG-based LH activity during
controlled ovarian stimulation in the long GnRH-agonist protocol: a
matched case–control study
Klaus F. Bühler1 & Robert Fischer2
1Kinderwunschzentrum Hanover-Langenhagen & Wolfsburg, GMP Müseler-Albers/Arendt/Bühler/Schill,
Langenhagen, Germany and
2Fertility Center Hamburg, Hamburg, Germany
European Journal of Obstetrics & Gynecology and Reproductive Biology 172 (2014) 70–73
16. Results (Table 3)
r-hLH+r-hFSH , ≦35 yr sub gr. 的implantation
rate per ET 顯著較高(24.8% vs. 17.2% & 17.5%)
17. Discussion
The pts population analysed can be regarded as representative for
routine ART treatment in Germany
r-hLH (in combination with r-hFSH) 比u-hMG 的懷孕率顯著較高(per
cycle and per ET); 著床率顯著較高(per ET)
Age subgroup analysis: r-hLH 對於小於35歲的pts, 有較明顯的效益
19. TNUH current standard luteal phase support
• For fresh IVF cycle, Estrade (2 mg) 3 bid and Crinone 1 bid
for follicle number > 10 or for all cases
• For fresh IVF cycle, Utrogestan (100 mg) 1 tid or Crinone 1 qd,
plus Pregnyl (hCG 1500 IU) q3d, 3 doses, for follicle number < 10
• For frozen ET with natural cycle, Crinone 1 qd
• For frozen ET with HRT* cycle, Crinone 1 bid
* HRT: Hormone Replacement Treatment
20. Starting time and duration of the luteal phase
support
• For the fresh IVF cycle, start since 2 days after OPU (2-4 cell stage)
- After pregnancy test, if the corpus lutein is rescued, stop the LPS gradually.
- If the corpus lutein is not rescued, continue to GA 12 weeks.
• For frozen ET with natural cycle, start since 2 days after ovulation (2-4 cell stage).
- Stop LPS after pregnancy test or continue to GA 7-9 weeks.
• For HRT cycle, the day of LPS is defined as ovulation day,
- continue to GA 12 weeks.
21. Early pregnancy / Extend the luteal support
• For the fresh IVF cycle,
- If the corpus lutein is rescued, taper and then stop the LPS at GA 5 weeks.
-If the corpus lutein is not rescued, continue to GA 12 weeks.
• For frozen ET with natural cycle,
- stop LPS after pregnancy test or continue to GA 7-9 weeks.
• For HRT cycle, continue to GA 12 weeks.
22. Feedback on Crinone
• Good results
• No pain, No dizziness
• Reduce OHSS
• Some with itching, not common