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How to Prepare Fortified Eye
Drops for Infective Keratitis
Cases?
Dr. Vidushi Sharma
MBBS (AIIMS), MD (Ophthalmology,
AIIMS)
FRCS (UK)
Dr. Suresh K Pandey
MS (Ophthalmology, PGIMER)
Anterior Segment Fellowship (USA)
SuVi Eye Institute & Research Centre
C-13, TALWANDI, KOTA, RAJASTHAN, INDIA
Email- suvieye@gmail.com
www.suvieye.com
Phone +91 9351412449
USE OF FORTIFIED EYE
DROPS
 INFECTIVE KERATITTIS
(BACTERIAL/FUNGAL)
 At present, 4th generation
fluoroquinolones (Moxifloxacin and
Gatifloxacin) are commonly used
HOW TO PREPARE FORTIFIED
CEFAZOLINE (50 mg/ml) EYE DROP?
 Get a vial of 250 mg of cefazolin
available(REFLIN 250 MG) & mix 5ml
of artificial tears in giving a
concentration of 50mg/ml.
 Get a vial of 500 mg of cefazolin
available(REFLIN 500 mg) & mix 10
ml of artificial tears in giving a
concentration of 50mg/ml.
HOW TO PREPARE FORTIFIED
TOBRAMYCIN (13.6%) EYE DROP?
 Inject 2ml of tobramycin (40mg/ml)
injection in a 5 ml bottle of
commercially available 0.3%
tobramycin drops
 fortified tobramycin (13.6%) can be
helpful for bacterial ulcer caused by
gram negative organisms.
HOW TO PREPARE FORTIFIED
AMPHOTERICIN B (0.15%) EYE DROP?

Step 1: - Mix 10 ml of sterile water in 50 mg of
Amphotericin-B powder. This will give you 5mg/ml
solution.
Step 2: - Take 3 ml (15mg) from above solution and
mix 7 ml of sterile water. This will give you 15mg/10ml
i.e. 1.5mg/ml i.e. 0.15%
 Keep this solution on a refrigerator door. Drops are
clear yellow in colour if they turn milky then discard
them.
How to Prepare Fortified Eye
Drops for Infective Keratitis
Cases?
Dr. Vidushi Sharma
MBBS (AIIMS), MD (Ophthalmology,
AIIMS)
FRCS (UK)
Dr. Suresh K Pandey
MS (Ophthalmology, PGIMER)
Anterior Segment Fellowship (USA)
SuVi Eye Institute & Research Centre
C-13, TALWANDI, KOTA, RAJASTHAN, INDIA
Email- suvieye@gmail.com
www.suvieye.com
Phone +91 9351412449

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How to prepare fortified eye drops for management of infective keratitis dr suresh k pandey and dr vidushi sharma pandey suvi eye institute kota india

  • 1. How to Prepare Fortified Eye Drops for Infective Keratitis Cases? Dr. Vidushi Sharma MBBS (AIIMS), MD (Ophthalmology, AIIMS) FRCS (UK) Dr. Suresh K Pandey MS (Ophthalmology, PGIMER) Anterior Segment Fellowship (USA) SuVi Eye Institute & Research Centre C-13, TALWANDI, KOTA, RAJASTHAN, INDIA Email- suvieye@gmail.com www.suvieye.com Phone +91 9351412449
  • 2. USE OF FORTIFIED EYE DROPS  INFECTIVE KERATITTIS (BACTERIAL/FUNGAL)  At present, 4th generation fluoroquinolones (Moxifloxacin and Gatifloxacin) are commonly used
  • 3. HOW TO PREPARE FORTIFIED CEFAZOLINE (50 mg/ml) EYE DROP?  Get a vial of 250 mg of cefazolin available(REFLIN 250 MG) & mix 5ml of artificial tears in giving a concentration of 50mg/ml.  Get a vial of 500 mg of cefazolin available(REFLIN 500 mg) & mix 10 ml of artificial tears in giving a concentration of 50mg/ml.
  • 4. HOW TO PREPARE FORTIFIED TOBRAMYCIN (13.6%) EYE DROP?  Inject 2ml of tobramycin (40mg/ml) injection in a 5 ml bottle of commercially available 0.3% tobramycin drops  fortified tobramycin (13.6%) can be helpful for bacterial ulcer caused by gram negative organisms.
  • 5. HOW TO PREPARE FORTIFIED AMPHOTERICIN B (0.15%) EYE DROP?  Step 1: - Mix 10 ml of sterile water in 50 mg of Amphotericin-B powder. This will give you 5mg/ml solution. Step 2: - Take 3 ml (15mg) from above solution and mix 7 ml of sterile water. This will give you 15mg/10ml i.e. 1.5mg/ml i.e. 0.15%  Keep this solution on a refrigerator door. Drops are clear yellow in colour if they turn milky then discard them.
  • 6. How to Prepare Fortified Eye Drops for Infective Keratitis Cases? Dr. Vidushi Sharma MBBS (AIIMS), MD (Ophthalmology, AIIMS) FRCS (UK) Dr. Suresh K Pandey MS (Ophthalmology, PGIMER) Anterior Segment Fellowship (USA) SuVi Eye Institute & Research Centre C-13, TALWANDI, KOTA, RAJASTHAN, INDIA Email- suvieye@gmail.com www.suvieye.com Phone +91 9351412449