It is a rare, degenerative, superficial ulcer,
starting at the corneal margin and
spreading circumferentially and axially
over the whole of this tissue.
It is a rapidly progressive, painful,
It can be only be diagnosed in the
absence of systemic cause and must be
differentiated from other corneal
abnormlities such as,Terriens
Reponds well to treatment
Very poorly responds to
It is an auto immune disorder.
Associated with infections- helminthiasis,
hepatitisC, herpes simplex and zoster.
The antigen antibody reaction to infectious
toxin deposited in the peripheral cornea
causes inflammation and ulceration.
Molecular mimicry may be involved,
stimulating an auto immune response.
Deposition of immune complex over
Physical trauma, foreign bodies, chemical
burns, surgeries such as cataract extraction
Auto immune lysis of the epithelium with
release of collagenolytic enzymes.
Grey infiltrates , which break down, forming
small ulcers that spread and coalesce.
It destroys the epithelium and superficial
stromal lamellae, forming a whitish
overhanging edge, while the base quickly
severe and persistent neuralgic pain.
Decrease in visual acuity due to associated
iritis, central corneal involvement and
Topical steroids and antibiotics
Excision of a 4-7 mm strip of adjacent
conjunctiva may prove successful by
eliminating conjunctival sources of
collagenase , proteoglycanase and other
soft contact lenses.
Lamellar keratoplasty with i.v methotrexate
– halt the process
Aug. 28, 2021
Jan. 13, 2021
Nov. 23, 2020
Feb. 1, 2020
Sep. 16, 2019
Sep. 27, 2018
mooren's ulcer a degenerative superficial ulcer of the cornea.