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K. Bhuvaneshwari
 It is a rare, degenerative, superficial ulcer,
starting at the corneal margin and
spreading circumferentially and axiall...
BENIGN /TYPICAL
 Unilateral
 Reponds well to treatment
 Elderly people
MALIGNANT
 Bilateral
 Very poorly responds to
...
 It is an auto immune disorder.
 Associated with infections- helminthiasis,
hepatitisC, herpes simplex and zoster.
Vario...
 Molecular mimicry may be involved,
stimulating an auto immune response.
 Deposition of immune complex over
peripheral c...
 Auto immune lysis of the epithelium with
release of collagenolytic enzymes.
 Grey infiltrates , which break down, formi...
 severe and persistent neuralgic pain.
 Redness
 Photophobia
 Lacrimation
 Decrease in visual acuity due to associate...
 CBC with differentials
 ESR
 RF
 Complement fixation
 ANA,ANCA & circulating immune complexes
 VDRL, FTA-ABS
 Urin...
 Topical steroids and antibiotics
 Excision of a 4-7 mm strip of adjacent
conjunctiva may prove successful by
eliminatin...
Mooren’s ulcer
Mooren’s ulcer
Mooren’s ulcer
Mooren’s ulcer
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mooren's ulcer a degenerative superficial ulcer of the cornea.

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Mooren’s ulcer

  1. 1. K. Bhuvaneshwari
  2. 2.  It is a rare, degenerative, superficial ulcer, starting at the corneal margin and spreading circumferentially and axially over the whole of this tissue.  It is a rapidly progressive, painful, ulcerative keratitis  It can be only be diagnosed in the absence of systemic cause and must be differentiated from other corneal abnormlities such as,Terriens degeneration.
  3. 3. BENIGN /TYPICAL  Unilateral  Reponds well to treatment  Elderly people MALIGNANT  Bilateral  Very poorly responds to treatment  Younger people  progressive
  4. 4.  It is an auto immune disorder.  Associated with infections- helminthiasis, hepatitisC, herpes simplex and zoster. Various theories  The antigen antibody reaction to infectious toxin deposited in the peripheral cornea causes inflammation and ulceration.
  5. 5.  Molecular mimicry may be involved, stimulating an auto immune response.  Deposition of immune complex over peripheral cornea Other causes:  Physical trauma, foreign bodies, chemical burns, surgeries such as cataract extraction and keratoplasty.
  6. 6.  Auto immune lysis of the epithelium with release of collagenolytic enzymes.  Grey infiltrates , which break down, forming small ulcers that spread and coalesce.  It destroys the epithelium and superficial stromal lamellae, forming a whitish overhanging edge, while the base quickly becomes vascularised.
  7. 7.  severe and persistent neuralgic pain.  Redness  Photophobia  Lacrimation  Decrease in visual acuity due to associated iritis, central corneal involvement and irregular astigmatism.
  8. 8.  CBC with differentials  ESR  RF  Complement fixation  ANA,ANCA & circulating immune complexes  VDRL, FTA-ABS  Urine analysis
  9. 9.  Topical steroids and antibiotics  Excision of a 4-7 mm strip of adjacent conjunctiva may prove successful by eliminating conjunctival sources of collagenase , proteoglycanase and other inflammatory mediators.  Perforation: ulcer debridement cyanoacrylate adhesive soft contact lenses.  Lamellar keratoplasty with i.v methotrexate – halt the process
  • RishabhVageriya

    Aug. 28, 2021
  • VernanDsouza

    Jan. 13, 2021
  • RaagaveeK

    Nov. 23, 2020
  • MahmoudGabr23

    Feb. 1, 2020
  • GinniKhosa

    Sep. 16, 2019
  • TulsiPanchal1

    Sep. 27, 2018

mooren's ulcer a degenerative superficial ulcer of the cornea.

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