Many follicles, high AMH levels, and many eggs retrieved yet no pregnancy. The quality and maturation of eggs is important for IVF success. Inadequate or improper dosage and timing of stimulation and trigger medicines can lead to eggs not maturing optimally. Conditions like PCOS can have many follicles that do not reach maturation. Treatments aim to support egg maturation through the use of specific hormones and monitoring follicle development and ovarian reserve through tests like AMH, FSH, and ultrasound. While low ovarian reserve can be treated, earlier diagnosis and treatment is key along with considering the age of the patient.

1. Part II
MANY FOLLICLES, GOOD
NUMBER OF EGGS
RETRIEVED, HIGH AMH
LEVEL, YET NO
PREGNANCY!

2. 020 71966712
How does an embryologist know
which eggs are mature?
• An egg has an outer shell called the zona
pellucida, which protects the internal structures
and helps in fertilization
• Eggs are classified as mature when a small cell
(called the polar body) can be seen within the
shell of the egg

3. 020 71966712
Response to IVF medications: quality matters
The very important aspect of IVF treatments are
medications, timing & quality of medications
 In IVF stimulation, there are many medications
given to optimize the conditions of growth,
implantation etc
 Many times, this medicine induces the response
but not to the extent it is expected
 Very often, the retrieved eggs may not be
matured & degenerate fast
IVF treatments: for egg maturation, response to
medication is the key

4. 020 71966712
• Inadequate Dosage And Timings Of Stimulant Or
Trigger Medicines
• When follicles have reached a certain size, the fertility
team will take a call for the trigger medicines
• These medicines help in ovulation and maturation of
eggs without much degeneration. Then the eggs are
released from the follicular wall
• If the timings and dosage of the medicines are
inadequate, there are possibility eggs will not mature
optimally
IVF treatments for egg maturation :Time and
Dosage matter

5. Conditions like PCOS or diminished Ovarian Reserve:
• it is often noted that, in the case of PCOS, there are
many follicles which may not reach up to the
maturation phase. Effects of PCOS on egg quality
depend on the women’s age
• As age increases, the quality of eggs may decrease.
PCOS patients often have increased androgen levels
020 71966712
IVF treatments for egg maturation in case of
PCOS

6. • Yes. There are specific hormones which are
responsible for the production and maturation of
follicles
• Your doctor will confirm egg maturity by testing
your follicle-stimulating hormone (FSH) level and
anti-mullerian hormone (AMH), which confirm the
ovarian reserve, correlating these values with an
ultrasound to check your antral follicle count
Is there a treatment for immature
eggs?
020 71966712

7. 020 71966712
• Research shows that the number of active antral
follicles is a good indicator of ovarian reserve
• A normal number is between 6 and 10; less than 6
antral follicles indicate low ovarian reserve. There are
many treatments available to conceive even with a low
egg count
• Nevertheless, getting the diagnosis and treatment well
in advance is the key and the age of the couple is still
the important factor
Is there a treatment for immature eggs?

8. Address
Renaissance, J.M. Road, Pune,
Maharashtra, India- 411004.
www.yashivf.com
020 71966712
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