Article about body-on-a-chip technology as an alternative to animal studies for pharmacological research.

1. New body-on-a-chip technology to
advance pharmacological research
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2. Researchers from MIT have developed
"physiome on chip" technology that could be
used to evaluate new drugs and detect side
effects before the drugs are tested in human
clinical trials. This could be used an
alternative to animal testing for
pharmacological testing before human
clinical trials.
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3. They used a microfluidic platform that connects
engineered tissues from ted different organs,. By
doing so, the researchers were able to accurately
replicate human organ interactions considerable
periods at a time, allowing them to measure the
effects of medication on different organs.
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4. This system is also well designed to test
immunotherapy as the antibodies are unique to
humans and could not be reliably tested in animals.
This research is published in the journal Scientific
Reports.
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5. Citation: Edington, Collin D., Wen Li Kelly Chen, Emily Geishecker, Timothy
Kassis, Luis R. Soenksen, Brij M. Bhushan, Duncan Freake, Jared Kirschner,
Christian Maass, Nikolaos Tsamandouras, Jorge Valdez, Christi D. Cook, Tom
Parent, Stephen Snyder, Jiajie Yu, Emily Suter, Michael Shockley, Jason
Velazquez, Jeremy J. Velazquez, Linda Stockdale, Julia P. Papps, Iris Lee,
Nicholas Vann, Mario Gamboa, Matthew E. Labarge, Zhe Zhong, Xin Wang, Laurie
A. Boyer, Douglas A. Lauffenburger, Rebecca L. Carrier, Catherine Communal,
Steven R. Tannenbaum, Cynthia L. Stokes, David J. Hughes, Gaurav Rohatgi,
David L. Trumper, Murat Cirit, and Linda G. Griffith. "Interconnected
Microphysiological Systems for Quantitative Biology and Pharmacology Studies."
Scientific Reports 8, no. 1 (2018). doi:10.1038/s41598-018-22749-0.
For full article visit please visit “New body-on-a-chip
technology to advance pharmacological research”
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