This document discusses several key areas related to women and epilepsy, including the effects of antiepileptic drugs (AEDs) on appearance, the relationship between female hormones and seizure control, fertility, contraception, and pregnancy considerations. Specifically, it notes that certain AEDs can cause hirsutism, weight changes, and menstrual irregularities. It also discusses how estrogen and progesterone levels impact seizure frequency and the risk of birth defects associated with taking AEDs during pregnancy. The document recommends consultation with a neurologist or obstetrics specialist before and during pregnancy.
Gauging market potential of ulipristal acetate : A Perception Study of New Fe...Dhwni Sheth
A study to support "Strategy & Decision Making" of a top Indian pharmaceutical company wherein management wanted to launch innovative molecule - Ulipristal Acetate in India ( Based on the market potential of Ella-One _ successfully running female contraceptive in UK market )
Medication in pregnancy by dr alka mukherjee nagpur m.s. indiaalka mukherjee
Pregnancy is a unique period in a woman’s life. Many changes are happening to her body that may affect the pharmacology of medications. During pregnancy, a woman’s gastric pH is increased and gastric motility is reduced which may interfere with the rate and extent of medication absorption. Maternal plasma volume is increased leading to changes in the volume of distribution. In addition, increases in progesterone and estradiol levels may affect the hepatic metabolism of some medications. Glomerular filtration rate is increased due to increase renal blood flow which may affect renally cleared medications. Despite the changes, the pharmacology of most medications is not altered enough to require dosing changes.1 The placenta is an organ of exchange allowing the mother to pass nutrients and medications to the fetus; therefore, medications administered to pregnant women have the potential to affect the growing fetus. The fetus is generally at the greatest risk of developing teratogenic effects from medications during the first trimester, but it is drug specific. The use of medications in pregnancy should be evaluated for the benefits and risks to both the mother and fetus. Upon evaluation, some medications may be used sparingly during some trimesters and contraindicated in others. 2 All efforts should be made to optimize the risk benefit ratio. Drugs with low molecular weight, low maternal protein binding, low ionization, and high lipophilicity are more likely to cross the placenta and cause pharmacologic affects.1 The developing fetus’s body systems are not mature; therefore, the fetus may lack the ability to metabolize medications causing teratogenic effects. 2 The FDA has categorized the potential teratogenic risk of medications by an A, B, C, D, X system.
Gauging market potential of ulipristal acetate : A Perception Study of New Fe...Dhwni Sheth
A study to support "Strategy & Decision Making" of a top Indian pharmaceutical company wherein management wanted to launch innovative molecule - Ulipristal Acetate in India ( Based on the market potential of Ella-One _ successfully running female contraceptive in UK market )
Medication in pregnancy by dr alka mukherjee nagpur m.s. indiaalka mukherjee
Pregnancy is a unique period in a woman’s life. Many changes are happening to her body that may affect the pharmacology of medications. During pregnancy, a woman’s gastric pH is increased and gastric motility is reduced which may interfere with the rate and extent of medication absorption. Maternal plasma volume is increased leading to changes in the volume of distribution. In addition, increases in progesterone and estradiol levels may affect the hepatic metabolism of some medications. Glomerular filtration rate is increased due to increase renal blood flow which may affect renally cleared medications. Despite the changes, the pharmacology of most medications is not altered enough to require dosing changes.1 The placenta is an organ of exchange allowing the mother to pass nutrients and medications to the fetus; therefore, medications administered to pregnant women have the potential to affect the growing fetus. The fetus is generally at the greatest risk of developing teratogenic effects from medications during the first trimester, but it is drug specific. The use of medications in pregnancy should be evaluated for the benefits and risks to both the mother and fetus. Upon evaluation, some medications may be used sparingly during some trimesters and contraindicated in others. 2 All efforts should be made to optimize the risk benefit ratio. Drugs with low molecular weight, low maternal protein binding, low ionization, and high lipophilicity are more likely to cross the placenta and cause pharmacologic affects.1 The developing fetus’s body systems are not mature; therefore, the fetus may lack the ability to metabolize medications causing teratogenic effects. 2 The FDA has categorized the potential teratogenic risk of medications by an A, B, C, D, X system.
For medical students in Obstetrics . Safe prescribing during pregnancy and breastfeeding. safe drugs and methods to reduce passage to baby in chronic conditions with polytherapy
Prescribing safely in pregnancy and lactationMini Sood
Slides for medical students dealing with pregnant and postpartum women. Safe drugs for common conditions. Presentation with interactive quiz. 48 slides
New generation Antibiotics /certified fixed orthodontic courses by Indian den...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Therapeutic startegies for human papillomavirus infection and associated cancersAdeniyiAkiseku
Human papillomavirus (HPV) infection is linked to development of cancer of cervix, vagina, vulva, penis, ano-genital and non-genital oro-pharyngeal sites. HPV being a sexually transmitted virus infects both genders equally but with higher chances of pathological outcome in women. In the absence of organized screening programs, women report HPV-infected lesions at relatively advanced stages where they are subjected to standard treatments that are not HPV-specific. HPV infection-driven lesions usually take 10–20 years for malignant progression and are preceded by well-characterized pre-cancer stages. Despite availability of window for pharmacological intervention, therapeutic that could eradicate HPV from infected lesions is currently lacking. A variety of experimental approaches have been made to address this lacuna and there has been significant progress in a number of lead molecules which are in different stages of clinical and pre-clinical development. Present review provides a brief overview of the magnitude of the problem and current status of research on promising lead molecules, formulations and therapeutic strategies that showed potential to translate to clinically-viable HPV therapeutics to counteract this reproductive health challenge
Manipal is the best multispeciality hospital in Jaipur providing affordable and comprehensive medical & health care services which provide advanced medical treatment. Visit us at: https://www.manipalhospitals.com/jaipur/
Manipal Hospital Vijayawada is the best multispecialty hospital in with the latest technology and top surgeons offering world-class services.Visit us at: https://www.manipalhospitals.com/vijayawada/
For medical students in Obstetrics . Safe prescribing during pregnancy and breastfeeding. safe drugs and methods to reduce passage to baby in chronic conditions with polytherapy
Prescribing safely in pregnancy and lactationMini Sood
Slides for medical students dealing with pregnant and postpartum women. Safe drugs for common conditions. Presentation with interactive quiz. 48 slides
New generation Antibiotics /certified fixed orthodontic courses by Indian den...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Therapeutic startegies for human papillomavirus infection and associated cancersAdeniyiAkiseku
Human papillomavirus (HPV) infection is linked to development of cancer of cervix, vagina, vulva, penis, ano-genital and non-genital oro-pharyngeal sites. HPV being a sexually transmitted virus infects both genders equally but with higher chances of pathological outcome in women. In the absence of organized screening programs, women report HPV-infected lesions at relatively advanced stages where they are subjected to standard treatments that are not HPV-specific. HPV infection-driven lesions usually take 10–20 years for malignant progression and are preceded by well-characterized pre-cancer stages. Despite availability of window for pharmacological intervention, therapeutic that could eradicate HPV from infected lesions is currently lacking. A variety of experimental approaches have been made to address this lacuna and there has been significant progress in a number of lead molecules which are in different stages of clinical and pre-clinical development. Present review provides a brief overview of the magnitude of the problem and current status of research on promising lead molecules, formulations and therapeutic strategies that showed potential to translate to clinically-viable HPV therapeutics to counteract this reproductive health challenge
Manipal is the best multispeciality hospital in Jaipur providing affordable and comprehensive medical & health care services which provide advanced medical treatment. Visit us at: https://www.manipalhospitals.com/jaipur/
Manipal Hospital Vijayawada is the best multispecialty hospital in with the latest technology and top surgeons offering world-class services.Visit us at: https://www.manipalhospitals.com/vijayawada/
Manipal Hospital Vijayawada is the best multispecialty hospital in with the latest technology and top surgeons offering world-class services.Visit us at: https://www.manipalhospitals.com/vijayawada/
Manipal is the best multispeciality hospital in Jaipur providing affordable and comprehensive medical & health care services which provide advanced medical treatment. Visit us at: https://www.manipalhospitals.com/jaipur/
Manipal Hospital is the best multispeciality hospital in Jayanagar Bangalore near JP Nagar, Banashankari which provides top-notch medical & healthcare services.Visit us at: https://www.manipalhospitals.com/jayanagar/
Manipal Hospital is the best multispeciality hospital in Jayanagar Bangalore near JP Nagar, Banashankari which provides top-notch medical & healthcare services.Visit us at: https://www.manipalhospitals.com/jayanagar/
CORONARY CT ANGIOGRAM: CURRENT APPLICATIONS & FUTURE PROSPECTSKatySam
Manipal is the best multispeciality hospital in Jaipur providing affordable and comprehensive medical & health care services which provide advanced medical treatment. Visit us at: https://www.manipalhospitals.com/jaipur/
Manipal Hospital is the best multispeciality hospital in Jayanagar Bangalore near JP Nagar, Banashankari which provides top-notch medical & healthcare services.Visit us at: https://www.manipalhospitals.com/jayanagar/
DIAGNOSIS AND MANAGEMENT OF TUBERCULOSIS IN INDIA - CURRENT SCENARIOKatySam
Manipal Hospital is the best multispecialty hospital in Malleshwaram near Rajajinagar, Yeshwanthpur with the latest technology and top surgeons offering world-class services.Visit us at: https://www.manipalhospitals.com/malleshwaram/
Manipal Hospital is the best multispecialty hospital in Malleshwaram near Rajajinagar, Yeshwanthpur with the latest technology and top surgeons offering world-class services.Visit us at: https://www.manipalhospitals.com/malleshwaram/
Manipal Hospitals Brookefield clinic is the best multi-specialty clinic in Brookfield Bangalore near Whitefield, providing world-class healthcare services with top doctors.Visit us at: https://www.manipalhospitals.com/clinics-brookefield/
INDIGENOUS AYURVEDIC HERBALS AND SUPPLEMENTS – ARE THEY REALLY SAFE?KatySam
Manipal Hospitals Brookefield clinic is the best multi-specialty clinic in Brookfield Bangalore near Whitefield, providing world-class healthcare services with top doctors.Visit us at: https://www.manipalhospitals.com/clinics-brookefield/
How many patients does case series should have In comparison to case reports.pdfpubrica101
Pubrica’s team of researchers and writers create scientific and medical research articles, which may be important resources for authors and practitioners. Pubrica medical writers assist you in creating and revising the introduction by alerting the reader to gaps in the chosen study subject. Our professionals understand the order in which the hypothesis topic is followed by the broad subject, the issue, and the backdrop.
https://pubrica.com/academy/case-study-or-series/how-many-patients-does-case-series-should-have-in-comparison-to-case-reports/
Navigating Challenges: Mental Health, Legislation, and the Prison System in B...Guillermo Rivera
This conference will delve into the intricate intersections between mental health, legal frameworks, and the prison system in Bolivia. It aims to provide a comprehensive overview of the current challenges faced by mental health professionals working within the legislative and correctional landscapes. Topics of discussion will include the prevalence and impact of mental health issues among the incarcerated population, the effectiveness of existing mental health policies and legislation, and potential reforms to enhance the mental health support system within prisons.
Telehealth Psychology Building Trust with Clients.pptxThe Harvest Clinic
Telehealth psychology is a digital approach that offers psychological services and mental health care to clients remotely, using technologies like video conferencing, phone calls, text messaging, and mobile apps for communication.
Navigating the Health Insurance Market_ Understanding Trends and Options.pdfEnterprise Wired
From navigating policy options to staying informed about industry trends, this comprehensive guide explores everything you need to know about the health insurance market.
Welcome to Secret Tantric, London’s finest VIP Massage agency. Since we first opened our doors, we have provided the ultimate erotic massage experience to innumerable clients, each one searching for the very best sensual massage in London. We come by this reputation honestly with a dynamic team of the city’s most beautiful masseuses.
Leading the Way in Nephrology: Dr. David Greene's Work with Stem Cells for Ki...Dr. David Greene Arizona
As we watch Dr. Greene's continued efforts and research in Arizona, it's clear that stem cell therapy holds a promising key to unlocking new doors in the treatment of kidney disease. With each study and trial, we step closer to a world where kidney disease is no longer a life sentence but a treatable condition, thanks to pioneers like Dr. David Greene.
CHAPTER 1 SEMESTER V - ROLE OF PEADIATRIC NURSE.pdfSachin Sharma
Pediatric nurses play a vital role in the health and well-being of children. Their responsibilities are wide-ranging, and their objectives can be categorized into several key areas:
1. Direct Patient Care:
Objective: Provide comprehensive and compassionate care to infants, children, and adolescents in various healthcare settings (hospitals, clinics, etc.).
This includes tasks like:
Monitoring vital signs and physical condition.
Administering medications and treatments.
Performing procedures as directed by doctors.
Assisting with daily living activities (bathing, feeding).
Providing emotional support and pain management.
2. Health Promotion and Education:
Objective: Promote healthy behaviors and educate children, families, and communities about preventive healthcare.
This includes tasks like:
Administering vaccinations.
Providing education on nutrition, hygiene, and development.
Offering breastfeeding and childbirth support.
Counseling families on safety and injury prevention.
3. Collaboration and Advocacy:
Objective: Collaborate effectively with doctors, social workers, therapists, and other healthcare professionals to ensure coordinated care for children.
Objective: Advocate for the rights and best interests of their patients, especially when children cannot speak for themselves.
This includes tasks like:
Communicating effectively with healthcare teams.
Identifying and addressing potential risks to child welfare.
Educating families about their child's condition and treatment options.
4. Professional Development and Research:
Objective: Stay up-to-date on the latest advancements in pediatric healthcare through continuing education and research.
Objective: Contribute to improving the quality of care for children by participating in research initiatives.
This includes tasks like:
Attending workshops and conferences on pediatric nursing.
Participating in clinical trials related to child health.
Implementing evidence-based practices into their daily routines.
By fulfilling these objectives, pediatric nurses play a crucial role in ensuring the optimal health and well-being of children throughout all stages of their development.
We understand the unique challenges pickleball players face and are committed to helping you stay healthy and active. In this presentation, we’ll explore the three most common pickleball injuries and provide strategies for prevention and treatment.
CRISPR-Cas9, a revolutionary gene-editing tool, holds immense potential to reshape medicine, agriculture, and our understanding of life. But like any powerful tool, it comes with ethical considerations.
Unveiling CRISPR: This naturally occurring bacterial defense system (crRNA & Cas9 protein) fights viruses. Scientists repurposed it for precise gene editing (correction, deletion, insertion) by targeting specific DNA sequences.
The Promise: CRISPR offers exciting possibilities:
Gene Therapy: Correcting genetic diseases like cystic fibrosis.
Agriculture: Engineering crops resistant to pests and harsh environments.
Research: Studying gene function to unlock new knowledge.
The Peril: Ethical concerns demand attention:
Off-target Effects: Unintended DNA edits can have unforeseen consequences.
Eugenics: Misusing CRISPR for designer babies raises social and ethical questions.
Equity: High costs could limit access to this potentially life-saving technology.
The Path Forward: Responsible development is crucial:
International Collaboration: Clear guidelines are needed for research and human trials.
Public Education: Open discussions ensure informed decisions about CRISPR.
Prioritize Safety and Ethics: Safety and ethical principles must be paramount.
CRISPR offers a powerful tool for a better future, but responsible development and addressing ethical concerns are essential. By prioritizing safety, fostering open dialogue, and ensuring equitable access, we can harness CRISPR's power for the benefit of all. (2998 characters)
Medical Technology Tackles New Health Care Demand - Research Report - March 2...pchutichetpong
M Capital Group (“MCG”) predicts that with, against, despite, and even without the global pandemic, the medical technology (MedTech) industry shows signs of continuous healthy growth, driven by smaller, faster, and cheaper devices, growing demand for home-based applications, technological innovation, strategic acquisitions, investments, and SPAC listings. MCG predicts that this should reflects itself in annual growth of over 6%, well beyond 2028.
According to Chris Mouchabhani, Managing Partner at M Capital Group, “Despite all economic scenarios that one may consider, beyond overall economic shocks, medical technology should remain one of the most promising and robust sectors over the short to medium term and well beyond 2028.”
There is a movement towards home-based care for the elderly, next generation scanning and MRI devices, wearable technology, artificial intelligence incorporation, and online connectivity. Experts also see a focus on predictive, preventive, personalized, participatory, and precision medicine, with rising levels of integration of home care and technological innovation.
The average cost of treatment has been rising across the board, creating additional financial burdens to governments, healthcare providers and insurance companies. According to MCG, cost-per-inpatient-stay in the United States alone rose on average annually by over 13% between 2014 to 2021, leading MedTech to focus research efforts on optimized medical equipment at lower price points, whilst emphasizing portability and ease of use. Namely, 46% of the 1,008 medical technology companies in the 2021 MedTech Innovator (“MTI”) database are focusing on prevention, wellness, detection, or diagnosis, signaling a clear push for preventive care to also tackle costs.
In addition, there has also been a lasting impact on consumer and medical demand for home care, supported by the pandemic. Lockdowns, closure of care facilities, and healthcare systems subjected to capacity pressure, accelerated demand away from traditional inpatient care. Now, outpatient care solutions are driving industry production, with nearly 70% of recent diagnostics start-up companies producing products in areas such as ambulatory clinics, at-home care, and self-administered diagnostics.
Medical Technology Tackles New Health Care Demand - Research Report - March 2...
Women and Epilepsy
1. Women and Epilepsy
The main areas to consider are:
AEDs and appearance
Female hormones and seizure control
Fertility
Contraception
Pregnancy
Phenytoin therapy in childhood can cause hirsutism, gingival hyperplasia and coarsen of facial features. Sodium
valproate can cause hair loss, acne and hirsutism. Sodium valproate can also stimulate appetite leading to
obesity, as can vigabatrin, gabapentin and pregabalin.
Conversely, topiramate can cause significant weight loss
Experimental evidence from animal studies suggests that the change in seizure frequency during the menstrual
cycle may be related to the relative oestrogen and progesterone concentrations, with oestrogens being
considered to have pro-convulsant and progestogens anticonvulsant properties, respectively.
A reasonable treatment option in women who develop PCOS and/or ovulatory dysfunction while taking valproate
is to consider discontinuation of the drug and treatment with an alternative AED, if possible.
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2. The AEDs phenobarbital, primidone, phenytoin, carbamazepine, topiramate and eslicarbazepine acetate are
inducers of the hepatic P450 microsomal isoenzyme CYP3A4 which is responsible for the metabolism of
oestrogens and progestogens. This results in increased metabolism of the combined oral contraceptive pill and
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Obstetric/neurology pre-conceptual counselling service should be available to allow rapid assessment of women
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must be discussed.
The prescription of folic acid before conception and at least until the end of the first trimester is recommended in
patients taking antiepileptic medication, as it is for all women. It causes an increased risk of neural tube defect in
children born to mothers taking AEDs, in particular, sodium valproate and carbamazepine.
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