This document contains 20 multiple choice questions from a medical quiz covering various topics in physiology and medicine. Some of the questions require identifying structures, diseases, drugs and their mechanisms of action. Other questions involve clinical vignettes and require diagnosis or selecting the appropriate investigation or treatment.

1. WISSEN 2018 MEDIQUIZ
PRELIMS

2. Q1) IDENTIFY THE MARKED STRUCTURE

3. CAVUM SEPTUM PELLUCIDUM or THE 5TH
VENTRICLE

4. Q2) IDENTIFY
• Discovered by Indian physiologist A.S. Paintal
• Afferents are unmyelinated vagal C fibres
• Activated by : 1) Hyperinflation of lung
2) IV injection of capsaicin
3) Pulmonary congestion
• Response consists of rapid breathing , bradycardia and hypotension

5. J receptor reflex

6. • A 6-day-old male baby was brought to emergency with swelling over right
half of face since birth and jaundice and lethargy for 2 days. Parents also
noticed progressively increasing yellowish discoloration of skin and sclera
for 2 days and lethargy and decreased oral acceptance for one day. There
was no history of fever, trauma, bleeding from any site, seizures, ear or
eye discharge.
• On examination, Large, indurated, erythematous, non-pulsatile swelling
was present over whole of right half of the face, which was firm in
consistency . P/E and other investigations confirmed no external or
internal bleeding .
• blood investigations revealed Hb 5.4 gm/dl. Peripheral smear revealed
features of hemolysis with severe thrombocytopenia , agulation profile
was deranged with INR 2.4 and increased aPTT and elevated D-dimer
levels .Fibrinogen level was. LDH was also increased. MRI findings
revealed a hemangioma.

7. Q3) DIAGNOSIS?

8. KASABACH-MERRITT PHENOMENON.

9. Q4(a) ID A&B.
Q4(b) Name the group
of drugs acting on A?

10. ans
• A- CPT 1
• B – CPT 2
• Sulfonyl ureas

11. Q5) MATCH THE FOLLOWING
1
2
3
4
Y
Z

12. ANS
• 1-z
• 2-y
• 3-z
• 4-y

13. Q6(a) The following drug
blocks which isoform of
Na+ channel?
Q6(b) What syndrome
results from the congenital
absence of this channel?

14. • A . Na1.8
• B . CIPS ( congenital insensitivity pain syndrome)

15. Q7) A guy reports with possible
acetaminophen poisoning which was
consumed 8 hrs ago. You calculate the
serum concentration to be 200mg/dl.

16. • A) administer NAC
• B) matthew rumack normogram

18. Bacillus anthracis
• Malignant pustule
• String of pearls appearance colonies in solid media with penicillin
• Bamboo stick appearance in gram staining
• Medussa head appearance colony in solid agar media.

19. • MAY-HEGGLIN anomaly
• SEBASTIAN syndrome
• EPSTEIN’S syndrome
• FLETCHER’S syndrome

20. ANS : GIANT PLATELETS

21. Q10(a) For which disease this drug is used?
(b) Explain the MOA?

22. belimumab
• Only approved biological agent for SLE
• Belimumab is a fully human IgG1λ recombinant monoclonal antibody
directed against BLyS. Specific binding of belimumab with the soluble
BLyS prevents the interaction of BLys with its three receptors and
indirectly decreases the B-cell survival and production of
autoantibodies.

23. Q11) MATCH THE FOLLOWING WITH
APPROPRIATE ANSWERS.
A
1. AQUAPORIN
2. K+ CHANNEL
3. ACh CHANNEL

24. ANS
• A-2
• B-3
• C-1

25. Q12) WHAT IS THIS EFFECT KNOWN AS?
• MALE TISSUE TRANSPLANTED TO FEMALES – REJECTED
• FEMALE TISSUE TRANSPLANTED TO MALES - ACCEPTED

26. ans
• EICHWALD SILMSER EFFECT/SEX LINKED GRAFT REJECTION

27. Q13) DIAGNOSE

28. TIN MAN SYNDROME

29. Q14) How Hypercortisolism causes
myopathy?

30. Selective atrophy of fast twitch (type 2)
myofibres

32. Holoprosencephaly

33. • A 25-year-old man was admitted to AIIMS due to the acute appearance of
seizures and cardiac arrest.
• During his 1-month hospitalization in the ICU he acquired nosocomial
infections which were treated with various antibiotics.
• During his recovery period in the internal medicine department, he developed
intense pruritus and an erythematous-fine maculopapular rash covering the
neck and upper torso 30 min after intravenous drug X infusion without any
local infusion site erythema.
• The patient's reaction was completely relieved by intravenous antihistamine
administration (dimetindene; 0.1 mg/kg).

34. C. Jeikium , VANCOMYCIN

35. Q17) FOLLOWING ARE THE OTHER NAMES
FOR?
• Eosinophillic pseudo-leukemia
• Frimodt-moller and barton’s syndrome

36. TPE/OCCULT FILARIASIS

37. • A 21 year old man was admitted to hospital with painful chest, thighs, and
generalised abdominal pain. The haemoglobin (Hb) was 7.5 g/dl, white cell
count 22.5 × 109, and the electrolytes were normal apart from a slightly raised
C-reactive protein (CRP) level of 30 mg/l.
• Radiographs of his abdomen and thighs were normal, but his chest radiograph
showed a small degree of basal atelectasis bilaterally. His oxygen saturation
was 96% on air.
• On the third day, however, he became more drowsy with arterial blood gases
of pH 7.35, PaO2 13.5 kPa, and PaCO2 7.5 kPa on 40% oxygen. A repeat chest
radiograph showed new infiltrates in both lower zones and a diagnosis is
made.
• PBS revealed Drepanocytes.

38. ACUTE CHEST SYNDROME In SICKLE CELL
ANEMIA.

39. Q19) What could be the possible explanation
that links A & B?

40. PSEUDOTHROMBOCYTOPENIA
http://www.bloodjournal.org/content/117/16/416
8?sso-checked=true

41. *Q20) ID THE TRANSPORTER
• A baby boy is brought to the hospital because of convulsions. In the
course of a workup, his body temperature and plasma glucose are
found to be normal, but his cerebrospinal fluid glucose is 12 mg/dL
(normal, 65 mg/dL).
• Extensive epileptiform discharges observed in the fasting state were
improved markedly by food intake, as documented in EEG recordings
1 and 2 h after a meal.
• FURTHER investigations revealed a transporter deficiency

42. GLUT 1 55K deficiency