When chromosomal fragments enter a cell , they must do what in order to replicate When chromosomal fragments enter a cell , they must do what in order to replicate Solution Chromosomes are compact structurs and highly condensed with histone proteins. In order to under go replication, these cromosomal fragments must undergo decondensation and form chromatin, which is loosly attached with histones. When it dissociates from histones, the DNA is readily available to the Replication machinary and under go replication.