Concisely, how may HDL metabolism and the onset of type-II diabetes be correlated? What\'s the evidence? Solution Chylomicros are the major lipoprotein components of dietary lipids, which primarily enable synthesis of triacylglycerol components of low-density lipoproteins, high-density lipoproteins, very low-density lipoproteins finally followed by synthesis of cholesterol esters and cholesterol by Mevalonate pathway. The individuals who have been suffering from type 2 diabetes are associated with high lipid profiles of High-density lipoproteins (HDL) and these can be examined by higher HDL clearance. These aspects can be evidenced by the calculating “apoA-1” and “apoA-2” kinetics. It has clearly illustrated that these is significant correlations between the HDL clearance & plasma levels of glucose in type 2 diabetes patients.