What is the difference in secretory and co translational pathway in yeast versus to human cells?Does secretory and co transnlational pathway take place in Er or cytoplasm in yeast?Please explain in details. Solution The difference in the secretory and co translational pathway in yeast versus humans is that cotranslational translocation occurs in the yeast in the Endoplasmic Reticulum ..It takes place when the signal sequence is sufficiently hydrophobic otherwise it does not take place.Moreover when we fuse the OST 1 signal to msGFP, then Ost1 signal sequence usually yields an efficient translocation as well as efficient secretion at the same time On the other hand in humans the Cotranslational translocation takes place when the membrane- bound ribosomes are inserted.This helpsin growing the various nascent polypeptide chains directly into an ER translocation pore. The secretory and co translational pathway takes place in endoplasmic reticulum(ER) of the yeast as it helps the signal to fuse in a hydphobic environment unlike the ribosomes in humans..

1. What is the difference in secretory and co translational pathway in yeast versus to human
cells?Does secretory and co transnlational pathway take place in Er or cytoplasm in yeast?Please
explain in details.
Solution
The difference in the secretory and co translational pathway in yeast versus humans is that
cotranslational translocation occurs in the yeast in the Endoplasmic Reticulum ..It takes place
when the signal sequence is sufficiently hydrophobic otherwise it does not take place.Moreover
when we fuse the OST 1 signal to msGFP, then Ost1 signal sequence usually yields an efficient
translocation as well as efficient secretion at the same time
On the other hand in humans the Cotranslational translocation takes place when the membrane-
bound ribosomes are inserted.This helpsin growing the various nascent polypeptide chains
directly into an ER translocation pore.
The secretory and co translational pathway takes place in endoplasmic reticulum(ER) of the
yeast as it helps the signal to fuse in a hydphobic environment unlike the ribosomes in humans.