This document discusses piperazine derivatives, which are a class of chemical compounds containing a piperazine functional group. It provides information on the general properties and structure of piperazine, as well as its industrial production. Several common piperazine derivatives are mentioned, including those used as anthelmintics to treat parasitic worm infections and others used to manufacture plastics, pesticides, and brake fluid. The document concludes by noting that Shree Ganesh Chemicals is a leading manufacturer and exporter of piperazine derivatives, producing fine quality piperazine hydrochloride and derivatives for use as drug intermediates and supplying many countries.

1. PIPERAZINE
DERIVATIVES ?
WHAT IS
GUIDE AND ITS'VARIOUS USES
2021

2. ABOUT US
GANESH CHEMICALS IS PHARMACEUTICALS
INTERMEDIATES AND CHEMICALS MANUFACTURERES
,ANKLESHWAR - INDIA
Shree Ganesh Chemicals One Of The Leading Pharmaceuticals
Intermediates And Specialized Chemicals, Ankleshwar Working
Since 1999. We use state of an art manufacturing facilities to
produce top-quality pharmaceuticals intermediates (APIs) and
specialized pharma chemicals. Our Experts team uses
innovative methods to produce pure chemicals for clients. SGCs
have the right experience to offer effective custom chemistry
services. Our products comply with all the necessary standards
and our frequent quality testing ensures that we deliver only
flawless products to our customers.

3. PIPERAZINE
DERIVATIVES
GeneralInformation,propertiesAndUses

4. P
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GENERAL INFORMATION
Piperazine is an organic compound that consists of a six-membered ring
containing two nitrogen atoms at opposite positions in the ring. Piperazine exists
as small alkaline deliquescent crystals with a saline taste.
The piperazines are a broad class of chemical compounds, many with important
pharmacological properties, which contain a core piperazine functional group.
Piperazine is freely soluble in water and ethylene glycol, but insoluble in diethyl
ether. It is a weak base with two pKb of 5.35 and 9.73 at 25 °C. the pH of a 10%
aqueous solution of piperazine is 10.8–11.8. Piperazine readily absorbs water and
carbon dioxide from the air. Although many piperazine derivatives occur naturally,
piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-
dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine
hydrochloride, or by reduction of pyrazine with sodium in ethanol.
A form in which piperazine is commonly available industrially is as the
hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C.
Industrial production:
Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or
ethanolamine. These are the only routes to the chemical used commercially. The
piperazine is separated from the product stream, which contains ethylenediamine,
diethylenetriamine, and other related linear and cyclic chemicals of this type.

5. CAS NUMBER: 110-85-0
CHEMICAL FORMULA: C4H10N2
MOLAR MASS: 86. 138 G· MOL−1
APPEARANCE: WHITE CRYSTALLINE SOLID
MELTING POINT: 106 °C (223 °F; 379 K)
BOILING POINT: 46 °C (295 °F; 419 K) SUBLIMATES
SOLUBILITY IN WATER: FREELY SOLUBLE[2]
ACIDITY (PKA): 9. 8
BASICITY (PKB): 4. 19
MAGNETIC SUSCEPTIBILITY (Χ): -56. 8· 106CM3/MOL
PROPERTIES

6. PIPERAZINE HYDRATE, PIPERAZINE ADIPATE AND PIPERAZINE CITRATE (USED
TO TREAT ASCARIASIS AND ENTEROBIASIS[7]) ARE THE MOST COMMON
ANTHELMINTIC PIPERAZINE COMPOUNDS. THESE DRUGS ARE OFTEN REFERRED
TO SIMPLY AS "PIPERAZINE" WHICH MAY CAUSE CONFUSION BETWEEN THE
SPECIFIC ANTHELMINTIC DRUGS, THE ENTIRE CLASS OF PIPERAZINE-
CONTAINING COMPOUNDS, AND THE COMPOUND ITSELF.
DIETHYLCARBAMAZINE, A DERIVATIVE OF PIPERAZINE, IS USED TO TREAT
SOME TYPES OF FILARIASIS.
OTHER USES:
PIPERAZINES ARE ALSO USED IN THE MANUFACTURE OF PLASTICS, RESINS,
PESTICIDES, BRAKE FLUID AND OTHER INDUSTRIAL MATERIALS. PIPERAZINES,
ESPECIALLY BZP AND TFMPP WERE EXTREMELY COMMON ADULTERANTS IN THE
CLUB AND RAVE SCENE, OFTEN BEING PASSED OFF AS MDMA, ALTHOUGH THEY
DO NOT SHARE MANY SIMILARITIES IN THEIR EFFECTS.
PIPERAZINE IS ALSO A FLUID USED FOR CO2 AND H2S SCRUBBING IN
ASSOCIATION WITH METHYL DIETHANOLAMINE (MDEA).
USES

7. Shree Ganesh Chemicals Is A Leading Piperazine Derivatives
manufacturers are considered as Top Piperazine Derivatives
manufacturer and Exporter.
Piperazine Derivatives are our Top most products as drug
intermediates. SGCs are counted among the leading
manufacturers and exporters of piperazine derivatives
worldwide.
SGC is one of the most renowned piperazine manufacturers
and piperazine exporters in India And Worldwide. We make
fine quality piperazine hydrochloride for several clients.
Piperazine Derivatives are our top products as drug
intermediates. We manufacture chemicals, including
piperazine derivatives and supply them to many other
countries as well.
Piperazine Derivatives Manufacturers

8. 1 - ( 3 -
C H L O R O P H E N Y L )
P I P E R I Z A N E
H Y D R O C H L O R I D E
Case No: 870-24-6
API/Enduse: Tramadol
1 - ( 3 -
C H L O R O P H E N Y L ) - 4 - ( 3 -
C H L O R O P R O P Y L )
P I P E R A Z I N E
H Y D R O C H L O R I D E
Case No: 1942-52-5
API/Enduse: Trazadone
1 - A C E T Y L - ( 4 -
H Y D R O X Y P H E N Y L )
P I P E R A Z I N E
Case No: 13242-
API/Enduse: Ketcanazole
PIPERAZINE DERIVATIVES HAVE MANY APPLICATIONS. OUR
MANUFACTURE AND EXPORT BY US AS MENTIONED BELOW:

9. CONTACT INFO
MAILING ADDRESS
Plot No. 6708-6711,GIDC
Estate, Ankleshwar-393002,Gujarat, India
PHONE NUMBER
+91 9638786186
EMAIL ADDRESS
info@shreeganeshchemical.com

10. THANK YOU...