A contingency table, also known as cross tabulation, is a matrix format table that presents the frequency distribution of multiple variables, as introduced by Karl Pearson in 1904. It is significant in multivariate statistics for uncovering the dependence structure of variables, utilizing concepts from information theory. An example involves a scenario with two variables, sex and handedness, where a contingency table can display the distribution of males and females with different handedness among a sampled population.