The document provides tips for making wholesome food alternatives, noting that coconut and olives are high in saturated and monounsaturated fats so should be used sparingly. It also warns that vegetable grains are sometimes cooked with added saturated fat or cholesterol and canned or preserved vegetables may contain added sodium. Nuts and seeds are high in calories and fat though some varieties like macadamia nuts are also high in saturated fat. Foods high in soluble fiber like oats, beans, and apples are recommended choices. The document concludes by advising readers to read nutrition labels to understand foods and make wise choices that will support lifelong health.
Vancouver Spine Care Centre is based in Canada and offers quality treatment to all the issue related to spine malfunctioning. The physicians are specialized in the field of spine care. The founders of the clinic Dr. Dean Greenwood and Dr. Richard Hunter have got more than 29 years of full time experience in the field of spine care.
You will discover food quantities and weight loss, a balanced diet in weight loss, the blood type principle of weight loss, the science of weight loss, the magic bullet of protein and benefits of right food to health.
What is ketogenic diet keto diet weight loss - low carb foodsSOAIBSAYYED
There are tons of reasons why obese or overweight people try to lose weight. Some want to be healthier, to feel and look better while others want to have more energy to accomplish their daily tasks.No matter what the reason is, healthy weight management and successful weight loss depend on sensible goals as well as expectations. If you set goals for yourself, it is not impossible to meet them and have the chance to maintain your weight.Anyone can lose weight effectively. Get to know all your needed information her
There are tons of reasons why obese or overweight people try to lose weight. Some want to be healthier, to feel and look better while others want to have more energy to accomplish their daily tasks.
No matter what the reason is, healthy weight management and successful weight loss depend on sensible goals as well as expectations. If you set goals for yourself, it is not impossible to meet them and have the chance to maintain your weight.
Anyone can lose weight effectively. Get to know all your needed information here.
The ketogenic diet or as like some people prefer to call it; the
Keto diet or low carb diet is about consuming a lot of protein
and fats but fewer carbs. This diet makes the body send the
fats that we consume to the liver, which the latter transform it
into energy to keep the body strong and active for a long time
without feeling tired quickly.
Vancouver Spine Care Centre is based in Canada and offers quality treatment to all the issue related to spine malfunctioning. The physicians are specialized in the field of spine care. The founders of the clinic Dr. Dean Greenwood and Dr. Richard Hunter have got more than 29 years of full time experience in the field of spine care.
You will discover food quantities and weight loss, a balanced diet in weight loss, the blood type principle of weight loss, the science of weight loss, the magic bullet of protein and benefits of right food to health.
What is ketogenic diet keto diet weight loss - low carb foodsSOAIBSAYYED
There are tons of reasons why obese or overweight people try to lose weight. Some want to be healthier, to feel and look better while others want to have more energy to accomplish their daily tasks.No matter what the reason is, healthy weight management and successful weight loss depend on sensible goals as well as expectations. If you set goals for yourself, it is not impossible to meet them and have the chance to maintain your weight.Anyone can lose weight effectively. Get to know all your needed information her
There are tons of reasons why obese or overweight people try to lose weight. Some want to be healthier, to feel and look better while others want to have more energy to accomplish their daily tasks.
No matter what the reason is, healthy weight management and successful weight loss depend on sensible goals as well as expectations. If you set goals for yourself, it is not impossible to meet them and have the chance to maintain your weight.
Anyone can lose weight effectively. Get to know all your needed information here.
The ketogenic diet or as like some people prefer to call it; the
Keto diet or low carb diet is about consuming a lot of protein
and fats but fewer carbs. This diet makes the body send the
fats that we consume to the liver, which the latter transform it
into energy to keep the body strong and active for a long time
without feeling tired quickly.
Helpful Guidelines for Successful Weight Loss 2021ADELBENCHIKH1
Weight loss should occur when you eat fewer calories than you use. Increasing physical activity while limiting your calories will help with weight loss and weight maintenance. Talk to your dietitian about your calorie needs to achieve your weight loss goals
Being overweight or obese can lead to a range of health problems. Although many different “fad” diets are available, a balanced lifestyle and nutritious diet are the key to healthful living and better weight control.
If you suffer from excess weight, especially in the areas of the abdomen and buttocks, and want to know the ideal way to burn fat that prevents you from gaining weight quickly, this article is directed to you, read it carefully. Many people suffer from rapid weight gain even just to get out of the diet for one day, and although there are many factors for this, there are a number of tips that can be followed by increasing metabolic rates and burning the accumulated fat in the body firsthand, even if it is very slow.
How to Lose Weight Fast: 3 Simple Steps, Based on Sciencekheris asma
If your doctor recommends it, there are ways to lose weight safely. A steady weight loss of 1 to 2 pounds per week is recommended for the most effective long-term weight management.
That said, many eating plans leave you feeling hungry or unsatisfied. These are major reasons why you might find it hard to stick to a healthier eating plan.
However, not all diets have this effect. Low carb diets and whole food, lower calorie diets are effective for weight loss and may be easier to stick to than other diets.
Best weight loss method with 100 % best natural Wright loss product ... Check inside the book thera are healthy tips for loss your heavy weight and burn your fat try that product ...
There are tons of reasons why obese or overweight people try to lose
weight. Some want to be healthier, to feel and look better while others
want to have more energy to accomplish their daily tasks.
No matter what the reason is, healthy weight management and
successful weight loss depend on sensible goals as well as
expectations. If you set goals for yourself, it is not impossible to meet
them and have the chance to maintain your weight.
Anyone can lose weight effectively. Get to know all your needed
information here.
Simple Weight Loss Tips - Secrets and Strategies of Losing and Maintaining We...Tanveer Padder
• This presentation will give you some of the best-known weight loss tips, which really work.
• I have made this presentation for my patients and has been very helpful.
• Not only will you lose weight but also you will be able to maintain the lost weight.
• These are simple day-to-day choices which will work with everybody.
• The presentation focuses on balance between healthy diet, regular exercise, watching calories and above all life style changes.
• I am also providing a list of lowest calorie foods, vegetables and fruits that should be part of your balanced diet.
Want to lose weight in 21-Days with Smoothie Only Diet?miloud karrab
I must say, smoothies are perfect for healthy lifestyle. I consider smoothie as lifestyle rather than calling it as a smoothie diet.
Does it make you feel better? Yes, whenever we get into discussion about any kind of diet, it alerts our inner thoughts like restriction and disciplines about what you eat or drink.
But, Smoothie diet is not as tough as you think, just look at it as your daily lifestyle and you will be able to achieve your goal easily even if you are living very busy routine life.
Do not mistake phrase – Smoothie only diet with strict liquid diet! There are many ways to lose weight by following smoothie diet. I recommend you to check health coach Drew’s 21-Day Smoothie Diet program, if you are looking for a weight loss program based on green smoothies!
Introducing Wonderful Weigth - How to Maintian
the Weight Loss From Your New Year's Resolution. Inside this
eBooks, you will discover the topics about weight loss resolution
basics, use walks, user fruits rich in vitamin c, swich our trans fatsfor healthier fats,
If your doctor recommends it, there are ways to lose weight safely. A steady weight loss of 1 to 2
pounds per week is recommended for the most effective long-term weight management.
That said, many eating plans leave you feeling hungry or unsatisfied. These are major reasons
why you might find it hard to stick to a healthier eating plan.
This may sound so good you want to pinch yourself, but it is indeed true. No other affiliate program can match the level of crazy payouts like this one! We’re talking about converting a $1 sale and racking in $45 AOV.
Yes- there are other offers that payout more than $45. But it takes much more persuasion, effort, and shady marketing tactics to make 1, 3, or 6 bottle supplement sales instead of a $1 sale for our meal plans.
Vegetables, fruits, and grains are normally low in fat and have no cholesterol. Most are great sources of dietary fiber, complex carbs, and vitamins.
The American Heart Association recommends that you eat foods that are high in complex carbs and fiber. Below are some tips for making healthy food choices: click the link to learn more
https://bit.ly/reshealt
Global Medical Cures™ | Womens Health-NUTRITION
DISCLAIMER-
Global Medical Cures™ does not offer any medical advice, diagnosis, treatment or recommendations. Only your healthcare provider/physician can offer you information and recommendations for you to decide about your healthcare choices.
17 Signs You Work With Healthy Body Healthy Mindewennaaxl7
Consuming snacks, beverages, and foods, and obtaining regular physical exercise might assist you to get to and keep a healthful weightreduction. Making life style choices that are proper can help women and men prevent a few health problems.
Helpful Guidelines for Successful Weight Loss 2021ADELBENCHIKH1
Weight loss should occur when you eat fewer calories than you use. Increasing physical activity while limiting your calories will help with weight loss and weight maintenance. Talk to your dietitian about your calorie needs to achieve your weight loss goals
Being overweight or obese can lead to a range of health problems. Although many different “fad” diets are available, a balanced lifestyle and nutritious diet are the key to healthful living and better weight control.
If you suffer from excess weight, especially in the areas of the abdomen and buttocks, and want to know the ideal way to burn fat that prevents you from gaining weight quickly, this article is directed to you, read it carefully. Many people suffer from rapid weight gain even just to get out of the diet for one day, and although there are many factors for this, there are a number of tips that can be followed by increasing metabolic rates and burning the accumulated fat in the body firsthand, even if it is very slow.
How to Lose Weight Fast: 3 Simple Steps, Based on Sciencekheris asma
If your doctor recommends it, there are ways to lose weight safely. A steady weight loss of 1 to 2 pounds per week is recommended for the most effective long-term weight management.
That said, many eating plans leave you feeling hungry or unsatisfied. These are major reasons why you might find it hard to stick to a healthier eating plan.
However, not all diets have this effect. Low carb diets and whole food, lower calorie diets are effective for weight loss and may be easier to stick to than other diets.
Best weight loss method with 100 % best natural Wright loss product ... Check inside the book thera are healthy tips for loss your heavy weight and burn your fat try that product ...
There are tons of reasons why obese or overweight people try to lose
weight. Some want to be healthier, to feel and look better while others
want to have more energy to accomplish their daily tasks.
No matter what the reason is, healthy weight management and
successful weight loss depend on sensible goals as well as
expectations. If you set goals for yourself, it is not impossible to meet
them and have the chance to maintain your weight.
Anyone can lose weight effectively. Get to know all your needed
information here.
Simple Weight Loss Tips - Secrets and Strategies of Losing and Maintaining We...Tanveer Padder
• This presentation will give you some of the best-known weight loss tips, which really work.
• I have made this presentation for my patients and has been very helpful.
• Not only will you lose weight but also you will be able to maintain the lost weight.
• These are simple day-to-day choices which will work with everybody.
• The presentation focuses on balance between healthy diet, regular exercise, watching calories and above all life style changes.
• I am also providing a list of lowest calorie foods, vegetables and fruits that should be part of your balanced diet.
Want to lose weight in 21-Days with Smoothie Only Diet?miloud karrab
I must say, smoothies are perfect for healthy lifestyle. I consider smoothie as lifestyle rather than calling it as a smoothie diet.
Does it make you feel better? Yes, whenever we get into discussion about any kind of diet, it alerts our inner thoughts like restriction and disciplines about what you eat or drink.
But, Smoothie diet is not as tough as you think, just look at it as your daily lifestyle and you will be able to achieve your goal easily even if you are living very busy routine life.
Do not mistake phrase – Smoothie only diet with strict liquid diet! There are many ways to lose weight by following smoothie diet. I recommend you to check health coach Drew’s 21-Day Smoothie Diet program, if you are looking for a weight loss program based on green smoothies!
Introducing Wonderful Weigth - How to Maintian
the Weight Loss From Your New Year's Resolution. Inside this
eBooks, you will discover the topics about weight loss resolution
basics, use walks, user fruits rich in vitamin c, swich our trans fatsfor healthier fats,
If your doctor recommends it, there are ways to lose weight safely. A steady weight loss of 1 to 2
pounds per week is recommended for the most effective long-term weight management.
That said, many eating plans leave you feeling hungry or unsatisfied. These are major reasons
why you might find it hard to stick to a healthier eating plan.
This may sound so good you want to pinch yourself, but it is indeed true. No other affiliate program can match the level of crazy payouts like this one! We’re talking about converting a $1 sale and racking in $45 AOV.
Yes- there are other offers that payout more than $45. But it takes much more persuasion, effort, and shady marketing tactics to make 1, 3, or 6 bottle supplement sales instead of a $1 sale for our meal plans.
Vegetables, fruits, and grains are normally low in fat and have no cholesterol. Most are great sources of dietary fiber, complex carbs, and vitamins.
The American Heart Association recommends that you eat foods that are high in complex carbs and fiber. Below are some tips for making healthy food choices: click the link to learn more
https://bit.ly/reshealt
Global Medical Cures™ | Womens Health-NUTRITION
DISCLAIMER-
Global Medical Cures™ does not offer any medical advice, diagnosis, treatment or recommendations. Only your healthcare provider/physician can offer you information and recommendations for you to decide about your healthcare choices.
17 Signs You Work With Healthy Body Healthy Mindewennaaxl7
Consuming snacks, beverages, and foods, and obtaining regular physical exercise might assist you to get to and keep a healthful weightreduction. Making life style choices that are proper can help women and men prevent a few health problems.
Global Medical Cures™ | Pocket Guide to Maintaining Healthy Weight
DISCLAIMER-
Global Medical Cures™ does not offer any medical advice, diagnosis, treatment or recommendations. Only your healthcare provider/physician can offer you information and recommendations for you to decide about your healthcare choices.
8 tips for healthy eating eat well
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
1. Creating Wholesome Food Alternatives
Vegetables, fruits, and grains are typically low in
fat and have no cholesterol. Most are wonderful sources
of dietary fiber, complicated carbs, and vitamins.
The American Heart Association recommends that you
eat foods that are high in complex carbs and fiber.
Below are some ideas for making wholesome food options:
- Coconut is high in saturated fat, whilst olives
are high in monounsaturated fats and calories. You
ought to use these items sparingly to avoid acquiring
also many calories from fat.
- When vegetable grains are cooked, saturated fat
or cholesterol is frequently added. For instance, egg
yolks might be added to bread or even pasta.
- Processed, canned, or preserved vegetables might
also include added sodium. With some folks, too
much sodium (salt) might lead to high blood pressure.
There are some food organizations that are really
canning vegetables with much less salt. You can appear
for these in the industry region or decide on fresh and
even frozen vegetables.
- Nuts and seeds tend to be high in calories and
fat, even though a majority of the fat is polyunsaturated
or monounsaturated. There are some varieties,
macadamie nuts for example, that are also high in
saturated fat.
Foods that are high in soluble fiber are a great
choice as well. Examples consist of oat bran,
oatmeal, beans, peas, rice bran, barley, and
even apple pulp.
Whenever you are searching for healthy weight loss food choices,
always make positive you read the nutrition label
or data about the food. You can then
2. figure out what the food consists of and how wholesome
it truly is for your body. By taking your time
and making your healthy food alternatives wisely,
you will have a lifetime to enjoy the foods that
will take care of you. David Soskin wellness coach can aid.
healthy weight loss