This document provides an overview of systemic risks and how they could interplay in the coming decade. It discusses how growing complexities and interdependencies between global systems like finance, supply chains, health, and the environment are increasing systemic risk. It then explores three potential threats: emerging market uncertainties as countries face economic and political challenges; the proliferation of interstate conflicts and frictions as countries prioritize domestic concerns; and slow progress on global challenges due to a lack of international cooperation. It concludes by discussing implications for systemically important sectors like energy, financial services, and healthcare.