Usually the K+ ions will be more inside the cell during nerve impulse. When anesthesia is given, the K+ leak channels open and the K+ ions move out of thr cell. Hyperpolarization is a change in a cell membranes potential that make the cell more negative and inhibits action potentials. This happens when an anesthetic is injected. This cause the cell to rest i.e, less likely to fire. Solution Usually the K+ ions will be more inside the cell during nerve impulse. When anesthesia is given, the K+ leak channels open and the K+ ions move out of thr cell. Hyperpolarization is a change in a cell membranes potential that make the cell more negative and inhibits action potentials. This happens when an anesthetic is injected. This cause the cell to rest i.e, less likely to fire..