The purpose of the study was to model the clustering of COVID-19 in Bulawayo, Zimbabwe. A cross-sectional study design was used to provide a snapshot of the occurrence of COVID-19 in Bulawayo at a particular time. About 246 COVID-19 cases were randomly selected from the list of cases that occurred in Bulawayo as of 1 August 2020. The data was analyzed in ArcGIS using spatial autocorrelation and hotspot analysis. From the observed pattern, the results demonstrated a significant overall spatial autocorrelation and clustering of COVID-19 cases in Bulawayo. The hotspot analysis showed hotspot localities around the Western Suburbs such as Nkulumane, Cowdry Park, and Luveve. These are high-density suburbs, endorsing that pattern of COVID-19 infections is related to the population density pattern in Bulawayo. In conclusion, hotspot areas detected in this study can help identify future infectious disease surveillance.
Modeling and Forecasting the COVID-19 Temporal Spread in Greece: An Explorato...Konstantinos Demertzis
Within the complex framework of anti-COVID-19 health management, where the criteria of diagnostic testing, the availability of public-health resources and services, and the applied anti-COVID-19 policies vary between countries, the reliability and accuracy in the modeling of temporal spread can prove to be effective in the worldwide fight against the disease. This paper applies an exploratory time-series analysis to the evolution of the disease in Greece, which currently suggests a success story of COVID-19 management. The proposed method builds on a recent conceptualization of detecting connective communities in a time-series and develops a novel spline regression model where the knot vector is determined by the community detection in the complex network. Overall, the study contributes to the COVID-19 research by proposing a free of disconnected past-data and reliable framework of forecasting, which can facilitate decision-making and management
of the available health resources.
Remote sensing in the analysis between forest cover and COVID-19 cases in Col...IJECEIAES
This article explores the relationship between forest cover and coronavirus disease 2019 (COVID-19) cases in Colombia using remote sensing techniques and data analysis. The study focuses on the CORINE land cover methodology's five main land cover categories: artificial territory, agricultural territories, forests and semi-natural areas, humid areas, and water surfaces. The research methodology involves several phases of the unified method of analytical solutions for data mining (ASUM-DM). Data on COVID-19 cases and forest cover are collected from the Colombian National Institute of Health and Advanced Land Observation Satellite (ALOS PALSAR), respectively. Land cover data is processed using QGIS software. The results indicate an inverse relationship between forest cover and COVID-19 cases, as evidenced by Pearson's index ρ of -0.439 (p-value <0.012). In addition, a negative correlation is observed between case density and forests and semi-natural areas, one of the land cover categories. The findings of this study suggest that higher forest cover is associated with lower numbers of COVID-19 cases in Colombia. The results could potentially inform government organizations and policymakers in implementing strategies and policies for forest conservation and the inclusion of green areas in densely populated urban areas.
Assessment of the Spatial and Temporal Trend of the COVID-19 Pandemic in SenegalAI Publications
Following the declaration of COVID-19 as a global pandemic and the reporting of one case in Senegal, the number of regions with confirmed cases of infection increased considerably, with the disease now being reported throughout the country after 3 months of evolution. It is therefore necessary to assess the evolution of the disease in the country as the situation evolves in order to rapidly identify best practices for adoption. The objective of this paper is to make a preliminary spatial and temporal assessment and comparison of the results of the COVID-19 pandemic in the regions of Senegal. Data on the evolution of COVID-19 (confirmed cases of infection, deaths, recoveries), population, density and area of each region were analysed using a set of statistical tools. The results show that the COVID-19 pandemic has spread stubbornly in Senegal. In the space of 112 days (from March 2 to June 21), Senegal reached a number of 5888 infected cases for 3919 cured, 1885 active and 84 deaths for a total of 67855 tests performed. About 40 people out of 10,000 have been tested so far and 4 out of 10,000 have tested positive. The Mann-Kendall test indicates that the number of confirmed daily cases is slowly increasing, with the slope of Sen estimated at about 1.2 person/day across the country. In addition, the Pettitt test indicates a sharp change in the upward trend across the country on April 26, 2020. Among the main affected regions, Dakar, Thies and Touba are noted with an extremely high rate of increase. Principal component analysis and hierarchical ascending classification have made it possible to divide Senegal's 14 regions into 3 groups in terms of the number of confirmed cases, active cases, recovered cases and reported deaths, and the population, area and density of the region. The 1st group concerns the Dakar region, the 2nd Diourbel and Thies and the 3rd the other regions. Furthermore, statistics related to COVID-19 in the regions of Senegal are highly correlated with population size and density. This study revealed convincing spatial differences in the evolution of the pandemic between the regions of Senegal. The study recommends that the approaches adopted by regions that have achieved very low levels of COVID-19 be incorporated into health care management plans for the pandemic throughout the country, even as the situation evolves.
An open toolbox for generating map of actively confirmed SARS-CoV-2 or COVID-...journalBEEI
The recent outbreak of novel coronavirus, SARS-CoV-2 or COVID-19, discovered in late 2019, being continued to spread across regions worldwide, has resulted in 1,914,916 “confirmed” cases with up to 123,010 deaths, as in situation report –85 by World Health Organization (WHO). Most of the developed disease monitoring and tracking tools currently available only present the reported cases up to country-level and not detail down to provincial- or state-, city- level within the countries. This is insignificant for supporting activities in quickly reducing and preventing the spread of the disease within a certain country because further detail potential infectious locations are not provided for people to avoid traveling or passing by there. Thus, this work presents an open toolbox for generating map of actively “Confirmed” cases in a country, i.e., Vietnam, given a dataset containing their statuses and current locations, detail down to provincial-or state-, city-level. The newly released algorithm reduced approximately 24.41% of processing time of the preceding one. In addition, the algorithm can be easily extended for supporting other countries given suitable datasets.
Modeling and Forecasting the COVID-19 Temporal Spread in Greece: An Explorato...Konstantinos Demertzis
Within the complex framework of anti-COVID-19 health management, where the criteria of diagnostic testing, the availability of public-health resources and services, and the applied anti-COVID-19 policies vary between countries, the reliability and accuracy in the modeling of temporal spread can prove to be effective in the worldwide fight against the disease. This paper applies an exploratory time-series analysis to the evolution of the disease in Greece, which currently suggests a success story of COVID-19 management. The proposed method builds on a recent conceptualization of detecting connective communities in a time-series and develops a novel spline regression model where the knot vector is determined by the community detection in the complex network. Overall, the study contributes to the COVID-19 research by proposing a free of disconnected past-data and reliable framework of forecasting, which can facilitate decision-making and management
of the available health resources.
Remote sensing in the analysis between forest cover and COVID-19 cases in Col...IJECEIAES
This article explores the relationship between forest cover and coronavirus disease 2019 (COVID-19) cases in Colombia using remote sensing techniques and data analysis. The study focuses on the CORINE land cover methodology's five main land cover categories: artificial territory, agricultural territories, forests and semi-natural areas, humid areas, and water surfaces. The research methodology involves several phases of the unified method of analytical solutions for data mining (ASUM-DM). Data on COVID-19 cases and forest cover are collected from the Colombian National Institute of Health and Advanced Land Observation Satellite (ALOS PALSAR), respectively. Land cover data is processed using QGIS software. The results indicate an inverse relationship between forest cover and COVID-19 cases, as evidenced by Pearson's index ρ of -0.439 (p-value <0.012). In addition, a negative correlation is observed between case density and forests and semi-natural areas, one of the land cover categories. The findings of this study suggest that higher forest cover is associated with lower numbers of COVID-19 cases in Colombia. The results could potentially inform government organizations and policymakers in implementing strategies and policies for forest conservation and the inclusion of green areas in densely populated urban areas.
Assessment of the Spatial and Temporal Trend of the COVID-19 Pandemic in SenegalAI Publications
Following the declaration of COVID-19 as a global pandemic and the reporting of one case in Senegal, the number of regions with confirmed cases of infection increased considerably, with the disease now being reported throughout the country after 3 months of evolution. It is therefore necessary to assess the evolution of the disease in the country as the situation evolves in order to rapidly identify best practices for adoption. The objective of this paper is to make a preliminary spatial and temporal assessment and comparison of the results of the COVID-19 pandemic in the regions of Senegal. Data on the evolution of COVID-19 (confirmed cases of infection, deaths, recoveries), population, density and area of each region were analysed using a set of statistical tools. The results show that the COVID-19 pandemic has spread stubbornly in Senegal. In the space of 112 days (from March 2 to June 21), Senegal reached a number of 5888 infected cases for 3919 cured, 1885 active and 84 deaths for a total of 67855 tests performed. About 40 people out of 10,000 have been tested so far and 4 out of 10,000 have tested positive. The Mann-Kendall test indicates that the number of confirmed daily cases is slowly increasing, with the slope of Sen estimated at about 1.2 person/day across the country. In addition, the Pettitt test indicates a sharp change in the upward trend across the country on April 26, 2020. Among the main affected regions, Dakar, Thies and Touba are noted with an extremely high rate of increase. Principal component analysis and hierarchical ascending classification have made it possible to divide Senegal's 14 regions into 3 groups in terms of the number of confirmed cases, active cases, recovered cases and reported deaths, and the population, area and density of the region. The 1st group concerns the Dakar region, the 2nd Diourbel and Thies and the 3rd the other regions. Furthermore, statistics related to COVID-19 in the regions of Senegal are highly correlated with population size and density. This study revealed convincing spatial differences in the evolution of the pandemic between the regions of Senegal. The study recommends that the approaches adopted by regions that have achieved very low levels of COVID-19 be incorporated into health care management plans for the pandemic throughout the country, even as the situation evolves.
An open toolbox for generating map of actively confirmed SARS-CoV-2 or COVID-...journalBEEI
The recent outbreak of novel coronavirus, SARS-CoV-2 or COVID-19, discovered in late 2019, being continued to spread across regions worldwide, has resulted in 1,914,916 “confirmed” cases with up to 123,010 deaths, as in situation report –85 by World Health Organization (WHO). Most of the developed disease monitoring and tracking tools currently available only present the reported cases up to country-level and not detail down to provincial- or state-, city- level within the countries. This is insignificant for supporting activities in quickly reducing and preventing the spread of the disease within a certain country because further detail potential infectious locations are not provided for people to avoid traveling or passing by there. Thus, this work presents an open toolbox for generating map of actively “Confirmed” cases in a country, i.e., Vietnam, given a dataset containing their statuses and current locations, detail down to provincial-or state-, city-level. The newly released algorithm reduced approximately 24.41% of processing time of the preceding one. In addition, the algorithm can be easily extended for supporting other countries given suitable datasets.
Use of Digital Technologies in Public Health Responses to Tackle Covid-19: th...hiij
This paper aims to study the fight against COVID-19 in Bangladesh and digital intervention initiatives. To achieve the purpose of our research, we conducted a methodical review of online content. We have reviewed the first digital intervention that COVID-19 has been used to fight against worldwide. Then we reviewed the initiatives that have been taken in Bangladesh. Our paper has shown that while Bangladesh can take advantage of the digital intervention approach, it will require rigorous collaboration between government organizations and universities to get the most out of it. Public health can become increasingly digital in the future, and we are reviewing international alignment requirements. This exploration also focused on the strategies for controlling, evaluating, and using digital technology to strengthen epidemic management and future preparations for COVID-19.
USE OF DIGITAL TECHNOLOGIES IN PUBLIC HEALTH RESPONSES TO TACKLE COVID-19: TH...hiij
This paper aims to study the fight against COVID-19 in Bangladesh and digital intervention initiatives. To
achieve the purpose of our research, we conducted a methodical review of online content. We have
reviewed the first digital intervention that COVID-19 has been used to fight against worldwide. Then we
reviewed the initiatives that have been taken in Bangladesh. Our paper has shown that while Bangladesh
can take advantage of the digital intervention approach, it will require rigorous collaboration between
government organizations and universities to get the most out of it. Public health can become increasingly
digital in the future, and we are reviewing international alignment requirements. This exploration also
focused on the strategies for controlling, evaluating, and using digital technology to strengthen epidemic
management and future preparations for COVID-19.
Health Informatics - An International Journal (HIIJ)hiij
Health Informatics - An International Journal (HIIJ)
USE OF DIGITAL TECHNOLOGIES IN PUBLIC
HEALTH RESPONSES TO TACKLE COVID-19: THE
BANGLADESH PERSPECTIVE
https://aircconline.com/hiij/V11N1/11122hiij01.pdf
Vol.11, No.1, February 2022
DOI : 10.5121/hiij.2022.11101
Modified SEIR and machine learning prediction of the trend of the epidemic o...IJECEIAES
Susceptible exposed infectious recovered (SEIR) is a fitting model for coronavirus disease (COVID-19) spread prediction. Hence, to examine the effect of different levels of social distancing on the spreading of the disease, a variable was introduced in the SEIR equations system used in this work. We also used an artificial intelligence approach using a machine learning (ML) method known as deep neural network. This modified SEIR model was applied on the available initial spread data until June 25th, 2021 for the Hashemite Kingdom of Jordan. Without lockdown in Jordan, the analysis demonstrates potential infection to roughly 3.1 million people during the peak of spread approximately 3 months, starting from the date of lockdown (March 21st). Conversely, the present partial lockdowns strategy by the Kingdom was expected to reduce the predicted number of infections to 0.5 million in 9 months period. The analysis also demonstrates the ability of stricter lockdowns to effectively flatten the graph curve of COVID-19 in Jordan. Our modified SEIR and deep neural network (DNN) model were efficient in the prediction of COVID-19 epidemic sizes and peaks. The measures taken to control the epidemic by the government decreased the size of the COVID-19 epidemic.
Thai COVID-19 patient clustering for monitoring and prevention: data mining t...IAESIJAI
This research aims to optimize emerging infectious disease monitoring techniques in Thailand, which will be extremely valuable to the government, doctors, police, and others involved in understanding the seriousness of the spread of novel coronavirus to improve government policies, decisions, medical facilities, treatment. The data mining techniques included cluster analysis using K-means clustering. The infection data were obtained from the open data of the digital government development agency, Thailand. The dataset consisted of 1,893,941 cumulative cases from January 2020 to October 2021 of the outbreak. The results from clustering consisted of 8 groups. Clustering results determined the three largest, three medium-sized, and the two most minor numbers of infected people, respectively. These clusters represent their activities, namely touching an infected person and checking themselves. The components of emerging diseases in Thailand are closely related to waves, gender, age, nationality, career, behavioral risk, and region. The province of onset was mainly in Bangkok and its vicinity or central Thailand, as well as industrial areas. Adult workers aged 19 to 27 years and 43 to 54 years or over were seeds of new infection sources.
Dermatological health in the COVID-19 erakomalicarol
COVID-19 and its impact on dermatological health was reviewed
from theoretical and statistical frameworks in the present study. A
cross-sectional and retrospective work was documented with a selection of sources indexed to Scopus, considering the period from
2019 to 2022, as well as the search by keywords. Approaches were
discussed in order to outline a comprehensive model that considered the differences between the parties involved, as well as their
relationships in a risk context. The proposal contributes to the state
of the question in terms of the prediction of contingencies derived
from the probability and affectation of dermatological health
The International Journal of Computational Science, Information Technology an...rinzindorjej
The International Journal of Computational Science, Information Technology and Control Engineering (IJCSITCE) is an open access peer-reviewed journal that publishes quality articles which make innovative contributions in all areas of Computational Science, Mathematical Modeling, Information Technology, Networks, Computer Science, Control and Automation Engineering. IJCSITCE is an abstracted and indexed journal that focuses on all technical and practical aspects of Scientific Computing, Modeling and Simulation, Information Technology, Computer Science, Networks and Communication Engineering, Control Theory and Automation. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on advanced techniques in computational science, information technology, computer science, chaos, control theory and automation, and establishing new collaborations in these areas.
PANDEMIC INFORMATION DISSEMINATION WEB APPLICATION: A MANUAL DESIGN FOR EVERYONEijcsitcejournal
The aim of this research is to generate a web application from an inedited methodology with a series of
instructions indicating the coding in a flow diagram. The primary purpose of this methodology is to aid
non-profits in disseminating information regarding the COVID-19 pandemic, so that users can share vital
and up-to-date information. This is a functional design, and a series of screenshots demonstrating its
behaviour is presented below. This unique design arose from the necessity to create a web application for
an information dissemination platform; it also addresses an audience that does not have programming
knowledge. This document uses the scientific method in its writing. The authors understand that there is a
similar design in the bibliography; therefore, the differences between the designs are described herein; it
is very important to point out that this proposal can be taken as an alternative to the design of any web
application.
The susceptible-infected-recovered-dead model for long-term identification o...IJECEIAES
The coronavirus (COVID-19) epidemic has spread massively to almost all countries including Indonesia, in just a few months. An important step to overcoming the spread of the COVID-19 is understanding its epidemiology through mathematical modeling intervention. Knowledge of epidemic dynamics patterns is an important part of making timely decisions and preparing hospitals for the outbreak peak. In this study, we developed the susceptible-infected-recovered-dead (SIRD) model, which incorporates the key epidemiological parameters to model and estimate the long-term spread of the COVID-19. The proposed model formulation is data-based analysis using public COVID-19 data from March 2, 2020 to May 15, 2021. Based on numerical analysis, the spread of the pandemic will begin to fade out after November 5, 2021. As a consequence of this virus attack, the cumulative number of infected, recovered, and dead people were estimated at ≈ 3,200,000, ≈ 3,437,000 and ≈ 63,000 people, respectively. Besides, the key epidemiological parameter indicates that the average reproduction number value of COVID-19 in Indonesia is 7.32. The long-term prediction of COVID-19 in Indonesia and its epidemiology can be well described using the SIRD model. The model can be applied in specific regions or cities in understanding the epidemic pattern of COVID-19.
The study aimed to investigate into the impact of a National COVID-19 Health contact tracing and monitoring system for Namibia. The study used qualitative methods as a research strategy. Qualitative data was collected
through zoom meeting and a Google form link was distributed to the participants. The findings of the study revealed
that a total of 18 participants responded to the semi-structured questions of which 38.9% represents male while
female 61.1%. The age group between 18–25 response rate were 22.2%, age group between 26–35 response rate were
55.6%, age group between 36–45 response rate were 16.7% and the age group between 46 and above response rate
was 10% represented in green colour to represent participants who fall in the age group between 46 and above
This paper presents a time series analysis of a novel coronavirus, COVID-19, discovered in China in December 2019 using intuitionistic fuzzy logic system with neural network learning capability. Fuzzy logic systems are known to be universal approximation tools that can estimate a nonlinear function as closely as possible to the actual values. The main idea in this study is to use intuitionistic fuzzy logic system that enables hesitation and has membership and non-membership functions that are optimized to predict COVID-19 outbreak cases. Intuitionistic fuzzy logic systems are known to provide good results with improved prediction accuracy and are excellent tools for uncertainty modelling. The hesitation-enabled fuzzy logic system is evaluated using COVID-19 pandemic cases for Nigeria, being part of the COVID-19 data for African countries obtained from Kaggle data repository. The hesitation-enabled fuzzy logic model is compared with the classical fuzzy logic system and artificial neural network and shown to offer improved performance in terms of root mean squared error, mean absolute error and mean absolute percentage error. Intuitionistic fuzzy logic system however incurs a setback in terms of the high computing time compared to the classical fuzzy logic system.
Predicting the status of COVID-19 active cases using a neural network time s...IJECEIAES
The design of intelligent systems for analyzing information and predicting the epidemiological trends of the disease is rapidly expanding because of the coronavirus disease (COVID-19) pandemic. The COVID-19 datasets provided by Johns Hopkins University were included in the analysis. This dataset contains some missing data that is imputed using the multi-objective particle swarm optimization method. A time series model based on nonlinear autoregressive exogenou (NARX) neural network is proposed to predict the recovered and death COVID-19 cases. This model is trained and evaluated for two modes: predicting the situation of the affected areas for the next day and the next month. After training the model based on the data from January 22 to February 27, 2020, the performance of the proposed model was evaluated in predicting the situation of the areas in the coming two weeks. The error rate was less than 5%. The prediction of the proposed model for April 9, 2020, was compared with the actual data for that day. The absolute percentage error (AE) worldwide was 12%. The lowest mean absolute error (MAE) of the model was for South America and Australia with 3 and 3.3, respectively. In this paper, we have shown that geographical areas with mortality and recovery of COVID-19 cases can be predicted using a neural network-based model.
Digital technology and COVID-19
The past decade has allowed the development of a multitude of digital tools. Now they can be used to remediate the COVID-19 outbreak.
Daniel Shu Wei Ting, Lawrence Carin, Victor Dzau and Tien Y. Wong, publicado en Nature Medicine.
Population Mapping Approach, Health Interoperability, and Informatics to Mana...Abdul Joseph Fofanah
The emergence of recent outbreaks and the current pandemic have had increasing demands for past and present patient medical information, as preparedness and response strategies, create new data sharing and exchange demands on health information systems (HIS). A review of interoperability technique and human mobility mapping was critically examined and key design requirements during HIS implementations as parameters to improve the current health systems across mobility corridors. This paper also presents a mobility mapping network methodology and to support health authorities for preparedness and response especially areas in the health sectors that require improvement for any infectious diseases and future outbreaks or pandemic transmission. To realize the universal health coverage (UHC), we present some key parameters matrix; level of care, national standards and guidelines, health promotion, health education, safe blood transfusion, mobile clinics and field hospitals, infection control in healthcare settings, and patient safety, and healthcare waste management. The proposed human population mobility mapping (HPMM) methodology is presented with mathematical theories to better understand how human mobility contributes to the spread of infectious diseases within and out of any country’s corridor. The aim of the proposed algorithm is to determine the best practices that would be used to address health challenges in the health sectors during or post outbreaks of infectious diseases as a result of human mobility. In the adapted algorithm designed we were able to map out some localities (in) (Sierra Leone and Nepal) using GIS techniques to determine places of high vulnerability. The data was analyzed, and the result obtained shows that the higher the population at a specific locality the greater the chances of contracting the diseases.
In 2020, tourists were the main vectors for the rapid geographical spread of SARS-CoV-2, which in its first sixmonths caused more than half a million fatalities worldwide. In this context, we investigated when, and if,
tourism should be interrupted to delay pandemics. We did this by considering the temporal and geographical
spread of COVID-19 and related fatalities, the World Health Organization’s official guidelines and travel
advices, the perspectives of tourists and tourism workers regarding the economic and social impacts caused by
tourism interruption
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
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achieve the purpose of our research, we conducted a methodical review of online content. We have
reviewed the first digital intervention that COVID-19 has been used to fight against worldwide. Then we
reviewed the initiatives that have been taken in Bangladesh. Our paper has shown that while Bangladesh
can take advantage of the digital intervention approach, it will require rigorous collaboration between
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focused on the strategies for controlling, evaluating, and using digital technology to strengthen epidemic
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Health Informatics - An International Journal (HIIJ)hiij
Health Informatics - An International Journal (HIIJ)
USE OF DIGITAL TECHNOLOGIES IN PUBLIC
HEALTH RESPONSES TO TACKLE COVID-19: THE
BANGLADESH PERSPECTIVE
https://aircconline.com/hiij/V11N1/11122hiij01.pdf
Vol.11, No.1, February 2022
DOI : 10.5121/hiij.2022.11101
Modified SEIR and machine learning prediction of the trend of the epidemic o...IJECEIAES
Susceptible exposed infectious recovered (SEIR) is a fitting model for coronavirus disease (COVID-19) spread prediction. Hence, to examine the effect of different levels of social distancing on the spreading of the disease, a variable was introduced in the SEIR equations system used in this work. We also used an artificial intelligence approach using a machine learning (ML) method known as deep neural network. This modified SEIR model was applied on the available initial spread data until June 25th, 2021 for the Hashemite Kingdom of Jordan. Without lockdown in Jordan, the analysis demonstrates potential infection to roughly 3.1 million people during the peak of spread approximately 3 months, starting from the date of lockdown (March 21st). Conversely, the present partial lockdowns strategy by the Kingdom was expected to reduce the predicted number of infections to 0.5 million in 9 months period. The analysis also demonstrates the ability of stricter lockdowns to effectively flatten the graph curve of COVID-19 in Jordan. Our modified SEIR and deep neural network (DNN) model were efficient in the prediction of COVID-19 epidemic sizes and peaks. The measures taken to control the epidemic by the government decreased the size of the COVID-19 epidemic.
Thai COVID-19 patient clustering for monitoring and prevention: data mining t...IAESIJAI
This research aims to optimize emerging infectious disease monitoring techniques in Thailand, which will be extremely valuable to the government, doctors, police, and others involved in understanding the seriousness of the spread of novel coronavirus to improve government policies, decisions, medical facilities, treatment. The data mining techniques included cluster analysis using K-means clustering. The infection data were obtained from the open data of the digital government development agency, Thailand. The dataset consisted of 1,893,941 cumulative cases from January 2020 to October 2021 of the outbreak. The results from clustering consisted of 8 groups. Clustering results determined the three largest, three medium-sized, and the two most minor numbers of infected people, respectively. These clusters represent their activities, namely touching an infected person and checking themselves. The components of emerging diseases in Thailand are closely related to waves, gender, age, nationality, career, behavioral risk, and region. The province of onset was mainly in Bangkok and its vicinity or central Thailand, as well as industrial areas. Adult workers aged 19 to 27 years and 43 to 54 years or over were seeds of new infection sources.
Dermatological health in the COVID-19 erakomalicarol
COVID-19 and its impact on dermatological health was reviewed
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cross-sectional and retrospective work was documented with a selection of sources indexed to Scopus, considering the period from
2019 to 2022, as well as the search by keywords. Approaches were
discussed in order to outline a comprehensive model that considered the differences between the parties involved, as well as their
relationships in a risk context. The proposal contributes to the state
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The International Journal of Computational Science, Information Technology an...rinzindorjej
The International Journal of Computational Science, Information Technology and Control Engineering (IJCSITCE) is an open access peer-reviewed journal that publishes quality articles which make innovative contributions in all areas of Computational Science, Mathematical Modeling, Information Technology, Networks, Computer Science, Control and Automation Engineering. IJCSITCE is an abstracted and indexed journal that focuses on all technical and practical aspects of Scientific Computing, Modeling and Simulation, Information Technology, Computer Science, Networks and Communication Engineering, Control Theory and Automation. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on advanced techniques in computational science, information technology, computer science, chaos, control theory and automation, and establishing new collaborations in these areas.
PANDEMIC INFORMATION DISSEMINATION WEB APPLICATION: A MANUAL DESIGN FOR EVERYONEijcsitcejournal
The aim of this research is to generate a web application from an inedited methodology with a series of
instructions indicating the coding in a flow diagram. The primary purpose of this methodology is to aid
non-profits in disseminating information regarding the COVID-19 pandemic, so that users can share vital
and up-to-date information. This is a functional design, and a series of screenshots demonstrating its
behaviour is presented below. This unique design arose from the necessity to create a web application for
an information dissemination platform; it also addresses an audience that does not have programming
knowledge. This document uses the scientific method in its writing. The authors understand that there is a
similar design in the bibliography; therefore, the differences between the designs are described herein; it
is very important to point out that this proposal can be taken as an alternative to the design of any web
application.
The susceptible-infected-recovered-dead model for long-term identification o...IJECEIAES
The coronavirus (COVID-19) epidemic has spread massively to almost all countries including Indonesia, in just a few months. An important step to overcoming the spread of the COVID-19 is understanding its epidemiology through mathematical modeling intervention. Knowledge of epidemic dynamics patterns is an important part of making timely decisions and preparing hospitals for the outbreak peak. In this study, we developed the susceptible-infected-recovered-dead (SIRD) model, which incorporates the key epidemiological parameters to model and estimate the long-term spread of the COVID-19. The proposed model formulation is data-based analysis using public COVID-19 data from March 2, 2020 to May 15, 2021. Based on numerical analysis, the spread of the pandemic will begin to fade out after November 5, 2021. As a consequence of this virus attack, the cumulative number of infected, recovered, and dead people were estimated at ≈ 3,200,000, ≈ 3,437,000 and ≈ 63,000 people, respectively. Besides, the key epidemiological parameter indicates that the average reproduction number value of COVID-19 in Indonesia is 7.32. The long-term prediction of COVID-19 in Indonesia and its epidemiology can be well described using the SIRD model. The model can be applied in specific regions or cities in understanding the epidemic pattern of COVID-19.
The study aimed to investigate into the impact of a National COVID-19 Health contact tracing and monitoring system for Namibia. The study used qualitative methods as a research strategy. Qualitative data was collected
through zoom meeting and a Google form link was distributed to the participants. The findings of the study revealed
that a total of 18 participants responded to the semi-structured questions of which 38.9% represents male while
female 61.1%. The age group between 18–25 response rate were 22.2%, age group between 26–35 response rate were
55.6%, age group between 36–45 response rate were 16.7% and the age group between 46 and above response rate
was 10% represented in green colour to represent participants who fall in the age group between 46 and above
This paper presents a time series analysis of a novel coronavirus, COVID-19, discovered in China in December 2019 using intuitionistic fuzzy logic system with neural network learning capability. Fuzzy logic systems are known to be universal approximation tools that can estimate a nonlinear function as closely as possible to the actual values. The main idea in this study is to use intuitionistic fuzzy logic system that enables hesitation and has membership and non-membership functions that are optimized to predict COVID-19 outbreak cases. Intuitionistic fuzzy logic systems are known to provide good results with improved prediction accuracy and are excellent tools for uncertainty modelling. The hesitation-enabled fuzzy logic system is evaluated using COVID-19 pandemic cases for Nigeria, being part of the COVID-19 data for African countries obtained from Kaggle data repository. The hesitation-enabled fuzzy logic model is compared with the classical fuzzy logic system and artificial neural network and shown to offer improved performance in terms of root mean squared error, mean absolute error and mean absolute percentage error. Intuitionistic fuzzy logic system however incurs a setback in terms of the high computing time compared to the classical fuzzy logic system.
Predicting the status of COVID-19 active cases using a neural network time s...IJECEIAES
The design of intelligent systems for analyzing information and predicting the epidemiological trends of the disease is rapidly expanding because of the coronavirus disease (COVID-19) pandemic. The COVID-19 datasets provided by Johns Hopkins University were included in the analysis. This dataset contains some missing data that is imputed using the multi-objective particle swarm optimization method. A time series model based on nonlinear autoregressive exogenou (NARX) neural network is proposed to predict the recovered and death COVID-19 cases. This model is trained and evaluated for two modes: predicting the situation of the affected areas for the next day and the next month. After training the model based on the data from January 22 to February 27, 2020, the performance of the proposed model was evaluated in predicting the situation of the areas in the coming two weeks. The error rate was less than 5%. The prediction of the proposed model for April 9, 2020, was compared with the actual data for that day. The absolute percentage error (AE) worldwide was 12%. The lowest mean absolute error (MAE) of the model was for South America and Australia with 3 and 3.3, respectively. In this paper, we have shown that geographical areas with mortality and recovery of COVID-19 cases can be predicted using a neural network-based model.
Digital technology and COVID-19
The past decade has allowed the development of a multitude of digital tools. Now they can be used to remediate the COVID-19 outbreak.
Daniel Shu Wei Ting, Lawrence Carin, Victor Dzau and Tien Y. Wong, publicado en Nature Medicine.
Population Mapping Approach, Health Interoperability, and Informatics to Mana...Abdul Joseph Fofanah
The emergence of recent outbreaks and the current pandemic have had increasing demands for past and present patient medical information, as preparedness and response strategies, create new data sharing and exchange demands on health information systems (HIS). A review of interoperability technique and human mobility mapping was critically examined and key design requirements during HIS implementations as parameters to improve the current health systems across mobility corridors. This paper also presents a mobility mapping network methodology and to support health authorities for preparedness and response especially areas in the health sectors that require improvement for any infectious diseases and future outbreaks or pandemic transmission. To realize the universal health coverage (UHC), we present some key parameters matrix; level of care, national standards and guidelines, health promotion, health education, safe blood transfusion, mobile clinics and field hospitals, infection control in healthcare settings, and patient safety, and healthcare waste management. The proposed human population mobility mapping (HPMM) methodology is presented with mathematical theories to better understand how human mobility contributes to the spread of infectious diseases within and out of any country’s corridor. The aim of the proposed algorithm is to determine the best practices that would be used to address health challenges in the health sectors during or post outbreaks of infectious diseases as a result of human mobility. In the adapted algorithm designed we were able to map out some localities (in) (Sierra Leone and Nepal) using GIS techniques to determine places of high vulnerability. The data was analyzed, and the result obtained shows that the higher the population at a specific locality the greater the chances of contracting the diseases.
In 2020, tourists were the main vectors for the rapid geographical spread of SARS-CoV-2, which in its first sixmonths caused more than half a million fatalities worldwide. In this context, we investigated when, and if,
tourism should be interrupted to delay pandemics. We did this by considering the temporal and geographical
spread of COVID-19 and related fatalities, the World Health Organization’s official guidelines and travel
advices, the perspectives of tourists and tourism workers regarding the economic and social impacts caused by
tourism interruption
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Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
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Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
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Richard's aventures in two entangled wonderlandsRichard Gill
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Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
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2. Norman Karimazondo et al. International Journal of Engineering and Applied Computer Science (IJEACS)
Volume: 04, Issue: 03, ISBN: 9780995707544, April 2022
DOI: 10.24032/IJEACS/0403/001 www.ijeacs.com 10
Using Geographic Information Systems (GIS) to
Model the Clustering Effect of COVID-19 in South-
Western Zimbabwe
Abstract—The purpose of the study was to model the clustering of
COVID-19 in Bulawayo, Zimbabwe. A cross-sectional study
design was used to provide a snapshot of the occurrence of
COVID-19 in Bulawayo at a particular time. About 246 COVID-
19 cases were randomly selected from the list of cases that
occurred in Bulawayo as of 1 August 2020. The data was
analyzed in ArcGIS using spatial autocorrelation and hotspot
analysis. From the observed pattern, the results demonstrated a
significant overall spatial autocorrelation and clustering of
COVID-19 cases in Bulawayo. The hotspot analysis showed
hotspot localities around the Western Suburbs such as
Nkulumane, Cowdry Park, and Luveve. These are high-density
suburbs, endorsing that pattern of COVID-19 infections is
related to the population density pattern in Bulawayo. In
conclusion, hotspot areas detected in this study can help identify
future infectious disease surveillance.
Keywords- COVID-19, GIS, Hotspot Analysis, Spatial
Autocorrelation.
I. INTRODUCTION
The “Novel Coronavirus 2019-nCov” (COVID-19), which
began from Wuhan, Hubei Province of China in December
2019, resulted in severe acute respiratory syndrome (SARS)
has rapidly spread to other countries around the globe,
including Zimbabwe [2]. Despite substantial efforts to contain
the disease within China, particularly in Hubei, a large number
of countries are battling to slow down the spread of the “Novel
Coronavirus 2019-nCov” through testing, rapid screening,
isolation, contact tracing, case management as well as applying
social distancing and lockdowns [21]. The study proposed
additional ways to fight against COVID-19 using GIS in
supporting early and easy detection of emerging hotspots to
contain the disease. Therefore, this study specifically modeled
the clustering of COVID-19 in Bulawayo using the Getis-Ord
Gi* statistical method based on hotspot analysis. Global
Moran's I statistic, is used to test the null hypothesis, “Covid-19
is randomly distributed in Bulawayo”. This section has laid the
introductory background to the study. The next section gives
the related literature in detail. This is followed by the section
on research methodology, which is then followed by a section
on results and discussion. The final section gives the
conclusion of the study.
II. LITERATURE REVIEW
A. Health Mapping
Health mapping can be described as the activities, tools,
and techniques that are utilized to link geographic location as
the common denominator which integrates community and
health data [12, 23]. Health maps are good at showing the
cartographic representation of the environmental setting, health
services, and spatial distribution of diseases at the same time.
Health mapping supports the core functions of public health
such as targeting, surveillance, and intervention. Similarly,
these functions are reinforced through public health practices
that include policy development, assessment, and assurance
[16]. The actual importance of health mapping arises when
maps are associated with disease prevention and control efforts
to prevent future infection [4, 11].
Health experts have historically considered both geographic
information systems (GIS) and conventional mapping, as
critical tools for combating and tracking infectious diseases.
The first disease map that shows the association between health
and geographic location was based on plague outbreaks at Bari,
Italy in 1694 [5]. Since then, the importance of a map as a
communication tool thrived up to today in the service of
tracking and surveillance of infectious diseases such as yellow
fever, cholera, and influenza pandemics [22]. However, the
disease mapping tasks encountered several challenges during
that time [19]. Firstly, the authors hardly documented some of
the evidence which was used to create maps. Secondly, before
the advancement of GIS, several errors arose in mapping tasks
which were expanded exceedingly at global scales. Thirdly,
there was a lack of reliable assessment of maps which resulted
in inaccurate precision. With the advent of computerized
geographic information systems in the 1960s, the possibilities
for visualizing, analyzing as well as spotting patterns of
infectious disease dramatically improved again [1]. According
to [3], the latest review of health GIS literature established that
28.7% of the reviewed papers focused on infectious disease
mapping.
Research on the distribution of infectious diseases across
geographic space can be categorized into three main classes
that are related to disease ecological analysis and clustering,
and mapping. GIS-based disease mapping is influenced by
several aspects such as the socio-economic data, environmental
risk factors, and location as well as spreading patterns of
disease [15]. Likewise, GIS-based disease clustering evaluates
the spatial clustering of diseases [13]. Furthermore, disease
clustering relies on the assessment of potential environmental
risk factors prevailing at a particular geographic location that
represents a possible hazard. Ecological analysis research is
related to epidemiological inquiry since the main focus is on
the analysis of the spatial distribution of diseases about
explanatory covariates which are aggregated at spatial levels
[24].
3. Norman Karimazondo et al. International Journal of Engineering and Applied Computer Science (IJEACS)
Volume: 04, Issue: 03, ISBN: 9780995707544, April 2022
DOI: 10.24032/IJEACS/0403/001 www.ijeacs.com 11
B. Modeling Diseases Clustering in GIS
A set of analytics can be performed by GIS software to
reveal COVID-19 clustering. These analytics can support
studies on the spread of COVID-19 by integrating as well as
modeling spatial data in a way that helps health experts to
locate cases and exposures and identify disease clusters [6].
Previous studies have observed that infectious diseases tend to
be clustered in certain geographic areas [7, 18]. Likewise, the
spatial heterogeneity of infectious diseases such as COVID-19
is mostly ascribed to changes in environmental risk factors
such as climate and land use [10]. As such, hot spots
distribution usually coincides with high population densities
hence those areas are at great risk of diseases [11].
There are three most important analytics for modeling
disease clustering within GIS software. Firstly, is the Kernel
Density Estimation Method, which is used to generate
geographical distribution maps for epidemics by way of
predictive modeling of disease risks [15]. Secondly, is the
Weighted Standard Deviational Ellipses Method, which can
match disease spatial distributions as well as identify the
possible spatial directions [20]. Thirdly, is the Hotspot Analysis
Method that calculates the Getis’Ord Gi* value to ascertain
where the particular disease is more concentrated [25].
In the intervening time, the rapid development in GIS itself
is showing unlimited potential as a way of sharing infectious
disease information [8]. Infectious disease like COVID-19
travels so rapidly and information has to move even quickly
hence the need for GIS become crucial [17]. Communication
through maps improves data transparency and offers reachable
information to the public [3]. According to [19] such disease
surveillance requires many statistical epidemiological methods
with geospatial features to investigate epidemics, if possible,
from localized areas. This study is particularly focused on the
city of Bulawayo in Zimbabwe, where the COVID-19 outbreak
seems to emerge in small areas and then spread widely.
III. MATERIAL AND METHODS
A. Study Area
The study was carried out in Bulawayo (20°09′00″ S,
28°34′59″ E) Province, Zimbabwe. It is located 444km
southwest of Harare and is the second-largest city in Zimbabwe
(Figure 1). The area of Bulawayo is approximately 1,706.8
km2 and has an elevation of about 1,358 m above sea level.
Figure 1. Bulawayo Map Showing Hotspot Areas
B. Materials
About two software packages were employed for data
processing, visualization, and analysis in this study. These
include ArcGIS 10.5 for editing geodata in the graphical front
end and Microsoft Excel for creating comma-separated value
(CSV) files on point data.
C. Methods
1. Sampling
In this study, a cross-sectional study design was used to
assess the prevalence of COVID-19 in Bulawayo. As a cross-
sectional study, the study was interested in COVID-19 cases
that occurred in Bulawayo during a given period. Based on the
study, the population consisted of 837 COVID-19 cases that
occurred in Bulawayo between 21 March 2020 and 1 August
2020. About 246 COVID-19 cases were randomly selected
from the list of cases that occurred in Bulawayo during that
time.
2. Data acquisition
This study used both primary and secondary data sources to
model the clustering of COVID-19 in Bulawayo. Secondary
data used in this study include shapefiles for rivers, roads,
suburbs, and provincial boundaries which were digitized from
the topographic map of Bulawayo and were obtained from the
Department of Surveyor General. The non-spatial data
associated with these shapefiles include the number of COVID-
19 patient cases for each suburb and contact addresses for
confirmed COVID-19 cases, which were collected from the
Ministry of Health and Child Care records
To suit the research needs for this study, the secondary data
obtained from the Ministry of Health and Child Care was
combined with primary data collected in the field. The contact
list for sampled COVID-19 cases was updated to show the
point location for each COVID-19 case. The points were
collected during a field measurement using a single GPS,
Garmin Etrex 20 with an average error of 3 m based on the
UTM grid system.
3. Data analysis in QGIS
Spatial analysis was used to map the clustering of the
COVID-19 to detect the trends of prevalence in Bulawayo.
Initially, Global Moran’s I, spatial autocorrelation statistic was
used to identifying the spatial pattern of COVID-19 in
Bulawayo. Global Moran’s I technique indicates that a
significant positive spatial autocorrelation of COVID-19 would
mean that the geographical distribution is more spatially
grouped than a random-based spatial process. Global Moran’s I
index stretches from −1 to +1, with the zero scores indicating
that there is no clustering. Whereas, a positive score would
indicate clustering of COVID-19 cases. Contrary, a negative
score showed that neighboring areas are characterized by
dissimilar C0VID-19 cases and indicate dispersal.
Finally, the Getis’Ord Gi* statistic was used to model the
spatial spread of COVID 19. The application of this model was
centered on the available COVID-19 datasets for each suburb
4. Norman Karimazondo et al. International Journal of Engineering and Applied Computer Science (IJEACS)
Volume: 04, Issue: 03, ISBN: 9780995707544, April 2022
DOI: 10.24032/IJEACS/0403/001 www.ijeacs.com 12
in Bulawayo. This study used a hotspot analysis tool for
calculating the Getis’Ord Gi* statistic for each particular
COVID-19 case in the dataset. The subsequent z-scores and p-
values from the results define where COVID-19 cases with
either low or high values are spatially clustered. For
statistically significant positive z-scores, the greater the z-score,
the higher intensity of clustering for high values and this
resembles the hot spot areas. For statistically significant
negative z-scores, the lesser the z-score, the higher intensity of
clustering for low values and this resembles cold spots. The
results of hotspot analysis determine where COVID-19 will be
highly concentrated which helps in the allocation of health
services as well as the promotion of well-being and good health
by scaling up COVID-19 interventions [14].
IV. RESULTS AND DISCUSSION
A. Results
Figure 2 illustrates the spatial autocorrelation results based
on sampled COVID-19 cases in Bulawayo. Given a z-score of
2.49908507644, there is a less than 5% likelihood that this
clustered pattern obtained could be a result of random chance.
The results demonstrate that there was a significant overall
spatial autocorrelation and clustering of COVID-19 in
Bulawayo.
Figure 2. Bulawayo COVID-19 Spatial Autocorrelation Report
In this study, the Getis’Ord Gi* statistic was applied to the
collected data to model the clustering of COVID-19. Figure 3
presents the hotspot analysis results. The hotspot analysis
revealed hotspot locations in the Western suburbs and cold spot
locations in the Northern, Eastern, and Southern suburbs. This
confirms that COVID-19 is more concentrated in the Western
part of Bulawayo (Figure 3).
Figure 3. The Clustering Effect of COVID-19 in Bulawayo
B. Discussion
The utilization of GIS in health care research is improving,
and its application is becoming more sophisticated. In this
study, GIS-based spatial statistical methods were successfully
used to model the clustering of COVID-19 in Bulawayo,
Zimbabwe. The study showed that COVID-19 is greatly
concentrated in the Western part of the city as compared to the
Eastern, Northern, and Southern parts of the city. This is
supported by the significant spatial autocorrelation of COVID-
19 cases, which demonstrates that the spatial distribution of
COVID-19 follows a clustered pattern. Therefore, the results
for this current study, confirms the findings from previous
studies which observed that infectious disease tend to be
clustered in certain geographic areas [7, 18]. Based on previous
studies, the spatial heterogeneity of infectious diseases such as
COVID-19 is mostly ascribed to changes in environmental risk
factors such as climate and land use [10].
Based on the observed pattern, variation in COVID-19
coincides with hotspot distribution. The hotspot analysis
showed hotspot locations in and around the Western suburbs
such as Nkulumane, Cowdry Park, and Luveve. These suburbs
are considered high-density areas, which confirms that patterns
of COVID-19 infections follow the population density pattern
in Bulawayo. These suburbs are often dominated by great
levels of low socio-economic status. This demonstrates that
COVID-19 clusters in Bulawayo are not occurring by chance
and this reflects the spatial distribution of the population which
is at great risk from the disease [9].
5. Norman Karimazondo et al. International Journal of Engineering and Applied Computer Science (IJEACS)
Volume: 04, Issue: 03, ISBN: 9780995707544, April 2022
DOI: 10.24032/IJEACS/0403/001 www.ijeacs.com 13
The GIS-based clustering methods used in this study are
exploratory tools that assist policymakers and researchers to
comprehend complex geospatial patterns. Indeed, GIS has
provided knowledge on the existence of COVID-19 clusters in
Bulawayo together with their respective locations which
provide significant grounds for both policy and research
formulation in the health sector. Therefore, as Zimbabwe gears
toward COVID-19 elimination, there is a greater need to
prioritize control efforts by focussing on high-risk areas since
there are potential reservoirs of COVID-19 infections.
Likewise, the discovery of statistically significant COVID-19
clusters is an important step toward spatial selection and
targeting these areas to prevent future infections [4, 11]. The
targeting of great risk areas for COVID-19 aligns with the
Ministry of Health and Child Care’s efforts which seek to
promote well-being and good health by scaling up COVID-19
interventions [14].
V. CONCLUSION
Because of GIS, this study was able to combine location-
specific and attribute information on the COVID-19 cases to
fully comprehend COVID-19 infection dynamics in Bulawayo.
Such insights were not possible had the study only opted to
purely investigate COVID-19 clustering without GIS-based
input. The results of the study can now be utilized to plan the
timing of COVID-19 control interventions by targeting areas
where clusters are prevalent. Furthermore, the hotspot areas
detected in this study can serve as important starting points for
future infectious disease surveillance where resources are
limited in cities such as Bulawayo. Therefore, the hotspot areas
could be prioritized in the course of resource allocation to
achieve real disease control in Zimbabwe. However, further
research should be focused on these hotspot areas to fully
appreciate local factors that cause elevated COVID-19
infections.
ACKNOWLEDGMENT
For conducting this study, mostly we have used records
from the Ministry of Health and Child Care and GPS data
collected from the field. We are grateful to the Ministry of
Health and Child Care officials and the research assistance
team for helping us to conduct this research work.
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AUTHORS PROFILE
Mr. Norman Karimazondo holds an
MSc in Education Degree in
Geography, MSc Human and Social
Science specialty- Research in
Education and Training, BSc-
Education in Geography, Postgraduate
Diploma in Teacher Training in
Science and Technology, Postgraduate Diploma in GIS
and Remote Sensing. He is a geography teacher and Head
of Department at Rakodzi High School, Marondera,
Zimbabwe. Currently, he is pursuing Ph.D. studies
(Environmental Management) from the Prince of Songkla
University, Thailand.
Mr. Lawrence Mango has completed
his Master’s Degree in Agroforestry,
BSc Environmental Science,
Executive Certificate in Project and
Programme Monitoring and
Evaluation, and Post Graduate
Diploma in Education. He is a lecturer
in the Department of Agricultural Management at
Zimbabwe Open University, Bindura, Zimbabwe, and has
published several research papers. Currently, he is
pursuing Ph.D. studies (Environmental Management)
from the Prince of Songkla University, Thailand.
Mr. Michael Make Montana is a
Managing Consultant at
Environmental Guardians Services,
Bulawayo, Zimbabwe. He has
completed his MSc Degree in
Ecotourism and Biodiversity
Conservation, BSc in Geography and
Environmental Studies, Post Graduate Diploma in GIS
and Remote Sensing, and Diploma in Environmental
Health. He is pursuing a Ph.D. (Environmental
Management) from Prince of Songkla University,
Thailand.
Dr. Gideon Walter Mutanda is a
lecturer in the Department of
Geography and Environmental
Science at Great Zimbabwe
University, Masvingo, Zimbabwe. He
has completed his Ph.D. in Geography
and Environmental Science, MSc in
Natural Resources Management and Environmental
Sustainability, BSc Hons in Geography and
Environmental Science, B.A. General (Geography and
Religious Education), Post Graduate Diploma in GIS and
Remote Sensing, Postgraduate Diploma in Education,
Diploma in Human Resources Management, Certificate
GIS and Remote Sensing.