The document summarizes the development and use of a microfluidic capillary gel electrophoresis (CGE) platform method for the release and stability testing of monoclonal antibodies. The method was developed to improve on sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) analysis. The platform method involved designing experimental conditions through design of experiments, validating the method using multiple examples, and then efficiently implementing the method for new products through a sample verification procedure. The method has been transferred to multiple Good Manufacturing Practice laboratories, though a primary challenge has been a high invalid rate. A case study demonstrated how applying a "go and see" approach through identifying gaps helped reduce the invalid rate over time.