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Understanding the
Endo-Cannabinoid
System
And Usage of
Medicinal Cannabis in
Massachusetts
Created by
Tracey Gregory, RN
We are not making recommendations for
or against legal recreational use of
Cannabis
Any name brand cannabis products or
services are for example only, we are not
endorsing any specific products, brand
or businesses
This Presentation Focuses
on the use of Cannabis for
Medicinal Purposes Only
OBJECTIVE
S
1. History and politics of
cannabis
2. How the Endo Cannabinoid
System works
3. The healing properties and
side effects of cannabis
4. Process of obtaining
medical cannabis in MA
5. Legalized cannabis laws in
Massachusetts
“Stoner” Stereotype
What’s in a name ?
"There are 100,000 total marijuana smokers in the US, and
most are Negroes, Hispanics, Filipinos, and entertainers.
Their satanic music, jazz, and swing, result from marijuana
use. This marijuana causes white women to seek sexual
relations with Negroes, entertainers, and any others.“
Harry Anslinger, head of Federal Bureau of Narcotics
Illustration by Adam Simpson
Therapeutic
Ratio
Effective dose/
Lethal Dose
No cases of death
by cannabis
overdose
ever recorded
Drug Dependence Withdrawal Tolerance Intoxication
Nicotine 6 4 3 2
Heroin 5 5 6 5
Cocaine 4 3 3 4
Alcohol 3 6 4 6
Caffeine 2 2 2 1
Cannabis 1 1 1 3
Cannabinoid
Receptors
found on the
surface of
cells
Metabolic
enzymes
break down
endocannabinoids
after they are used
Endocannabinoids
small molecules
that activate
cannabinoid
receptors
Key Pieces of the Endo
Cannabinoid System
Cannabinoid Receptors
Effect on CB1 receptors
(Brain)
“In-da- “sat-vive-a”
There
are
over 85
Cannabinoids
Whole plant
works together
for a more
therapeutic
effect
Marinol & Cesamet
These are part of a class of
medications called
cannabinoids.
The active ingredient of
MARINOL Capsules is
man-made dronabinol also
chemically known as
tetrahydrocannabinol, or
THC”
http://www.marinol.com
Synthetic Medications-THC
only
Possible medication
interactions
Birth Control Pills:may be less effective
Anti-coagulants:may increase risk of
bleeding
SSRI:may increase serotonin levels
May cause over sedation with sedatives,
anti-psychotics, opiates and
benzodiazepines
Top 4
side effects
of cannabis
Severe paranoia
Fear and anxiety
Lack of energy
and enthusiasm
Heavy limbs
Lack of mobility
Extreme dry
mouth
Burning eyes
Shortness of
breath
Tachycardia
Shaking
trembling
Chills / sweats
Disorientation
Upset stomach
Chapter 369 of acts of 2012
AN ACT FOR THE
HUMANITARIAN
MEDICAL USE OF
MARIJUANA.
The citizens of Massachusetts intend
that there should be no punishment
under state law for qualifying patients,
physicians and health care
professionals, personal caregivers for
patients, or medical marijuana treatment
center agents for the medical use of
marijuana, as defined herein.
105 CMR 725.00 May 24, 0213-DPH
implements the Act
 Scientific review of marijuana’s status as a federal Schedule I
controlled substance and relisting marijuana as a federal Schedule II
controlled substance for purposes of facilitating research.
 Development of prescribing standards that includes indications for
use, specific dose, route, expected effect and possible side effects, as
well as indications for stopping a medication.
 Establishing evidence-based standards for the use of marijuana and
related cannabinoids.
 Protection from criminal or civil penalties for patients using
therapeutic marijuana and related cannabinoids as permitted under
state laws.
 Exemption from criminal prosecution, civil liability, or professional
sanctioning, such as loss of licensure or credentialing, for health care
practitioners who discuss treatment alternatives concerning marijuana
or who prescribe, dispense or administer marijuana in accordance with
professional standards and state laws.
 Confirmation of the therapeutic efficacy of medical marijuana
Prescription Drug Use Falls in
Medical Cannabis States
Researchers at the
University of Georgia
found that the use of
prescription drugs is
significantly less in
states with legal medical
marijuana.
The drop was especially
pronounced for patients
with chronic pain, a
condition often treated
with opioids.
Massachusetts Qualifying
Conditions of “Debilitating
Medical Condition”
Cancer or malignant tumors
Glaucoma
AIDS
Hepatitis C
ALS
Crohn's disease
Parkinson's disease
Multiple Sclerosis
“Other conditions as determined
in writing by a qualifying patient's
physician
Such as (but not limited to):”
Chronic back pain
Rheumatoid Arthritis
Insomnia
Anorexia
Anxiety
Depression
Massachusetts Qualifying Conditions of
“Debilitating medical condition”
Weakness
Cachexia
Wasting Syndrome
Intractable Pain
Nausea
Impairing Strength or
Ability
The symptom(s) need
to be progressing to
such an extent that
one or more of a
patient’s major life
activities is
substantially limited.
“Debilitating Medical Condition that has
caused one or more of the following
symptoms”:
So.. Your hospice patient wants to try
medical Cannabis…
Finding a Marijuana
DoctorInitial Fees range from $125-$250 and are not
covered by Insurance
All are required to have hardship discounts,
most all have Veteran discounts
Annual renewal fees run from $75 to $250
https://www.marijuanadoctors.com/medical-marijuana-doctors/ma/
4. Make an appointment
5. Bring:
a. Medical documentation such
as doctor’s office notes, a referral from
the physician/clinician stating the
condition(s), MRI or Radiography
reports, Laboratory reports (for certain
conditions),and in some cases
prescription records from the
pharmacy.
b. Proof of MA residency**
c. Fee for the visit ($150-$225) Is
usually not covered by any insurance
although there is usually a small
discount for veterans-must provide
proof of military experience such as a
DD-214 or military/veterans ID.
6. If the MD finds them qualified,
s/he will register them with the
Department of Health-Medical Use
of Marijuana Program at the end of
the visit and give them a
registration number
7. The medical marijuana law
requires that there is a bona-fide
relationship with the qualifying
physician so they will schedule a
follow up appointment per their
office policy. (Cost usually $125-
200)
More time consuming
(may take 3-4 weeks)
Ability to pay by check
or money order
Will still need all documentation
Call 617-660-5370
Mon-Fri 9am -4:30 pm
unable to go
to the Dispensary ?
May designate/register up to
2 caregivers
Cannot be currently designated
by another patient, unless that
caregiver is an immediate family
member.
Pt and caregivers MUST carry
registration card at all times when
have medical cannabis on person
How Much Medical Cannabis in
MA?
what does that look like?
10 Ozs
Bring the paper ID until the plastic card arrives
Find a Massachusetts Dispensary here
Each dispensary will set the limit on how much can
be purchased at a given time
ONLY approved patients and caregivers can
enter the dispensaries
Go Shopping…
Average prices at
MA Dispensaries
subject to change daily
¼ oz flower $100
Pre-rolled “joint” $15 each
Tincture $50-70
Edibles $5-30
Topicals $20-55
(6) 105 cmr 725.100 A (6):
RMD must have a program to provide reduced
cost or free marijuana to patients with
documented verified financial hardship.
RIGHT TO YOUR
DOORUsually a minimum delivery price
from $60-175
Onset 5-15 minutes
Duration 1-4 hours
Rolled
AKA ”joints”
Rolling Papers $3-
5
Rolling Machine
$7-15
Pipes
$5-200+ Water Pipes
AKA “Bongs”
$25-200+
Will need a
grinder
$12-100
Use of precise heat to vaporize flower or
concentrates instead of combustion
ConcentratesKief the tiny, sticky crystals that
cover the cannabis flower
contains terpenes and cannabinoids
Cannabis
Infused
Alcohol
Onset 30-60 mins
Duration 2-6 hours
Grow Your Own
Allowed up to a dozen plants
$100 annual cultivation fee
$8-25 per seed
May not cultivate cannabis plants in places where
plants are "visible from a public place without the
use of binoculars, aircraft or other optical aids."
1.
Date/Tim
e:
2.
Amount:
3.
Strain:
7. Therapeutic
Effects:
8. Negative
Side Effects:
9. Response
Time:
10.
StrainPri
nt
Releaf
UPDATED MMJ REGULATIONS
1. Certified nurse practitioners can apply for
permission to issue marijuana
recommendations
2. Allows employees of nursing homes, hospice
centers, and other medical facilities to
administer cannabis to patients
(Facility/agency must resister)
3. Medical dispensaries are allowed to post
their prices online
4. Medical dispensaries can grow from
clippings instead of seeds, boosting yields,
So now what?
Massachusetts and Cannabis
1911
• MA Becomes First State to Outlaw Cannabis
2008
• Possession of small amounts of cannabis
decriminalized
2012
• Became the eighteenth state to legalize medical
cannabis
2013
• Eliminated criminal and civil penalties for the possessions
and use of up to a 60-day supply of marijuana for patients
possessing a state issued registration card
2016
• Recreational use legalized with parameters
FACTO
R
MEDICAL RECREATIONAL
FINANCIA
L
YEARLY DR FEE ( $125-250)
YEARLY MA FEE ($50)
COST OF PRODUCTS AT LIST
PRICE
NO YEARLY FEES
COST IS LIST PRICE PLUS 17%
TAX
ADDITIONAL 3% TAX IN MOST
TOWNS
EDIBLES NO RESTRICTIONS ON THC
LEVELS
LIMIT OF 5MG THC PER PORTION
ID STATE ISSUED CARD
GOVERNMENT ID PROVING
AGE 21 OR OLDER
GOVERNMENT ID PROVING AGE
21 OR OLDER
AMOUNT
S
10 OZ IN 60 DAYS
STATE TRACKS
1 OZ FLOWER OR 5MG
CONCENTRATE PER
TRANSACTION
STATE DOES NOT TRACK
TESTING CURRENT LAB TESTING LABS HAVE NOT YET BEEN SET
UP
PAYMEN DEBIT AND CASH MOST LIKELY CASH ONLY FOR
Legal
Grey Area
Cannabis remains illegal under federal law
It’s legal to purchase but
Retail stores selling cannabis won’t open before
Summer of 2018
Towns and cities have the right to vote to block
recreational marijuana shops
Selling will remain a crime punishable by up to two
years of incarceration and up to a $5,000 fine.
You can “gift” but may not sell
Internet shipping not allowed
Medical cannabis patients transferring products to
other people remains illegal
Medical cannabis patients are not protected if
crossing state lines with cannabis, even to another
state that has medical cannabis laws
Questions?
Sources
http://medicalmarijuana.procon.org/view.timeline.php?timelineID=000026
https://www.leafly.com/news/cannabis-101/where-did-the-word-marijuana-come-
from-anyway-01fb
https://en.wikipedia.org/wiki/Cannabis_in_Massachusetts
https://www.bostonglobe.com/metro/2016/12/13/with-legal-marijuana-
massachusetts-state-enters-hazy-legal-gray-
zone/jLjYVpIvgevl28jidQQWtO/story.html
http://www.rxlist.com/marijuana-page3/supplements.htm
http://herb.co/2016/07/28/endocannabinoid-system-dummies/
http://greenito.com/news/how-much-is-a-gram-ounce-of-weed/
https://www.coloradopotguide.com/images/blog/Health-Effects-of-Marijuana-
Reduced.png
http://www.narconon.org/drug-information/marijuana-faq.html
http://www.lung.org/stop-smoking/smoking-facts/marijuana-and-lung-
health.html?referrer=https://www.google.com/
http://netacare.org/wp-content/uploads/2016/06/Patient-Handbook.pdf
http://www.huffingtonpost.com/inverse/what-is-shatter-weed-and_b_8924396.html
https://s-media-cache-
ak0.pinimg.com/736x/13/35/46/13354616df24336310fd93d57a4bbfbb.jpg
https://gooeyrabinski.com/2015/04/21/how-cannabis-became-illegal-book-excerpt/
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