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Ms. DEVKI SONAL SINGH
(18BMIN001)
 Outermost / Cell membrane.
 Thickness is about 5-8 nm.
 Selectively permeable.
 Serves as outer boundary.
 Made up of Phospholipids, Proteins, and
conjugated molecules.
 Separate and protect cell from external
environment.
 Proposed in 1972, by Singer and Nicolson.
 “Cell membrane is lipid bilayer in which
proteins are partially embedded like floating
icebergs in sea.”
 It describes the plasma membrane as a
flexible boundary of a cell. The phospholipids
move within the membrane.
 The plasma membrane is composed of two
layers of phospholipids back-to-back.
 It consists of some components:-
i. Phospholipids
ii. Peripheral (extrinsic) protein
iii. Integral (Intrinsic) protein
iv. Cholesterol
v. Glycoprotein
vi. Glycolipid
 Phospholipids are lipids with a phosphate
attached to them. They have fatty acid tails
(hydrophobic) and phosphate group head
(hydrophilic) arranged as a bilayer.
 Phospholipids, glycolipids, cholesterol are
amphipathic lipids containing hydrophobic
and hydrophilic ends.
 Also called as
Peripheral Protein.
 Proteins loosely
associated with
membrane surface.
 Located entirely
outside of the lipid
bilayer.
 Either on the
extracellular or
cytoplasmic surface.
 Also called as
Integral Protein.
 Tightly bound to
lipid layer.
 Provides channel for
the water-soluble
substances
 Transport proteins allow needed substances
or waste materials to move through the
plasma membrane.
ACTIVE TRANSPORT PASSIVE TRANSPORT
 Diffusion against
concentration
gradient.
 Low  High
 Uses a protein
pump.
 Requires ATP.
 SIMPLE diffusion
i. Diffusion of non-
polar, hydrophobic
molecules (lipids)
ii. High  Low
 FACILIATED
diffusion
i. Diffusion of polar,
hydrophilic
molecules.
ii. Through a protein
channel.
iii. High  Low
Ultra Structure of Plasma Membrane
Ultra Structure of Plasma Membrane

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Ultra Structure of Plasma Membrane

  • 1. Submitted To:- Submitted By:- Ms. DEVKI SONAL SINGH (18BMIN001)
  • 2.  Outermost / Cell membrane.  Thickness is about 5-8 nm.  Selectively permeable.  Serves as outer boundary.  Made up of Phospholipids, Proteins, and conjugated molecules.  Separate and protect cell from external environment.
  • 3.  Proposed in 1972, by Singer and Nicolson.  “Cell membrane is lipid bilayer in which proteins are partially embedded like floating icebergs in sea.”  It describes the plasma membrane as a flexible boundary of a cell. The phospholipids move within the membrane.
  • 4.
  • 5.  The plasma membrane is composed of two layers of phospholipids back-to-back.  It consists of some components:- i. Phospholipids ii. Peripheral (extrinsic) protein iii. Integral (Intrinsic) protein iv. Cholesterol v. Glycoprotein vi. Glycolipid
  • 6.
  • 7.  Phospholipids are lipids with a phosphate attached to them. They have fatty acid tails (hydrophobic) and phosphate group head (hydrophilic) arranged as a bilayer.  Phospholipids, glycolipids, cholesterol are amphipathic lipids containing hydrophobic and hydrophilic ends.
  • 8.  Also called as Peripheral Protein.  Proteins loosely associated with membrane surface.  Located entirely outside of the lipid bilayer.  Either on the extracellular or cytoplasmic surface.  Also called as Integral Protein.  Tightly bound to lipid layer.  Provides channel for the water-soluble substances
  • 9.  Transport proteins allow needed substances or waste materials to move through the plasma membrane.
  • 10. ACTIVE TRANSPORT PASSIVE TRANSPORT  Diffusion against concentration gradient.  Low  High  Uses a protein pump.  Requires ATP.  SIMPLE diffusion i. Diffusion of non- polar, hydrophobic molecules (lipids) ii. High  Low  FACILIATED diffusion i. Diffusion of polar, hydrophilic molecules. ii. Through a protein channel. iii. High  Low