The NIH spends a lot of its research funding abroad, amongst which a significant portion in Europe. This presentation provides guidance for non-US entities to attract NIH funding.

1. • Webinar
• Opportunities for orphan drug
development in Horizon 2020
© ttopstart BV
www.ttopstart.com
info@ttopstart.com
How to get NIH funding as a
non-US entity
ttopstart academy
January 2016
Ferdinand Los, PhD – consultant @ ttopstart

2. For every € 100 from Horizon 2020 for life sciences
the NIH spends another $ 15 in Europe
$$
This is a guide to NIH grants for non-US entities

3. Empowering biomedical researchers and
entrepreneurs to establish breakthroughs

4. The National Institutes of Health (NIH) is the primary U.S. agency
responsible for biomedical and health-related research. The NIH provides
major research funding to non-NIH research facilities, including foreign
institutions and international organisations.
The NIH research budget in 2014 was $24B, approximately $1.3B is spent
outside the US and of that, $175M in Europe.
This presentation aims to guide non-US entities to NIH funding:
• How to determine whether you meet the requirements for eligibility
• How to identify which type of NIH grant fits you best
• Where to search for Funding Opportunity Announcements (FOAs) and
specific topics that match your envisioned project
Introduction
NIH

5. In general,
• eligible institutions can be higher education, government, non-profit
and for-profit organisations and institutions.
The NIH usually accepts applications both by individual researchers and
by research consortia, for all types of programs and calls.
General criteria on eligibility are provided in sections III.1.A and III.1.B of
each FOA, describing the suitable type of institutions or individuals
General requirements for applicants
NIH

6. For non-US applicants the following will be assessed:
• Does the project employ unusual talents, resources, populations, or
environmental conditions that are not readily available in the U.S.
that either facilitate further research or augment existing resources?
• Is the proposed project specifically relevant to the mission and
objectives of the NIH and does it have the potential to significantly
advance health sciences in the U.S?
Additional information on the requirements for non-US applicants may
be found here.
Specific requirements for non-US applicants
NIH

7. Types of NIH programs
NIH
R01 specified research project 3-5 years No set budget, typically
$250k a year
R03 limited funding for a short period 2 years $50k a year
R21 early stage research 2 years $275k total
R34 phase III clinical trials 1 year $100k
U01 specified research project, by
investigator(s) in their specific area of
interest and competencies
No set budget
P01 multi-project research projects No set budget
The NIH accepts both unsolicited grant applications as well as responses
to specific calls. Unsolicited programs are investigator-initiated and
bottom-up, open to any kind of project. For both types of applications,
the NIH has a number of grant programs or instruments. Non-US entities
are eligible to apply for a subset of these:

8. • R01 - discrete, specified, circumscribed research projects
• R03 - limited funding for a short period, including: pilot or feasibility
studies, collection of preliminary data, secondary analysis of existing
data, small, self-contained research projects, development of new
research technology, etc.
• R21 - exploratory and developmental research projects
• R34 - phase III clinical trials
• U01 - discrete and specified research projects, to be performed by
investigator(s) in their specific area of interest and competencies
• P01 - integrated, multi-project research projects involving different
independent investigators. Open to non-US applicants under specific
conditions, mentioned in FOAs
Types of NIH programs
NIH

9. NIH is made up of 27 Institutes and Centers, each with a specific
research agenda, often focusing on particular diseases or body systems.
Based on the research topic, the grant application is send to one of these
institutes. For instance the:
• National Cancer Institute (NCI)
• National Institute on Aging (NIA)
• National Institute of Allergy and
Infectious Diseases (NIAID)
NIH institutions
NIH

10. Open calls can be found through different means:
• For unsolicited grant applications there are so-called parent FOAs.
• All U.S. grants are published through this website.
• Relevant NIH-calls can also be found in the ttopstart database, listed
by topic.
Certain FOAs describe specific objectives and expected outcomes. In
other cases, there are no specific program requirements, but the
proposed research plan must be related to the stated program interests
of one or more of the 27 NIH Institutes and Centers.
Specifics and exceptions are found in the FOA descriptions.
Funding Opportunity Announcements and specific topics
NIH

11. Generally, NIH grants cycle through three annual deadlines, details of
which may be found here. For the relevant programs, the deadlines are
outlined below.
Submission deadlines
NIH
R01, U01 February 5 June 5 October 5
R03, R21, R34 February 16 June 16 October 16
P01 January 25 May 25 September 25

12. Interested?
info@ttopstart.com
or check our dedicated NIH page

13. The ttopstart team
NIH

14. ttopstart is a science and business consulting company that
serves leading researchers and innovative companies in the
fields of life sciences and medical technology.
Our excellent track-record is attributable to:
• Our broad technological and scientific knowledge
• Our business development background
• Our in-depth knowledge of subsidy programmes
• Our structured approach
• Our writing skills
About ttopstart
NIH

15. ttopstart offers a balanced set of funding and business
development services, all dedicated to biomedical
researchers and entrepreneurs.
ttopstart services
NIH
Prepare
Funding strategy
Develop
Proposal writing
PRO-ACTIV
• Analysis
• Customised strategy
• Training & Implementation
• Valuation
FFWD
• Fit
• Framework
• Write
• Develop
Empower your team to excel Reach a 50% success rate
Execute
Project management
• Management
• Dissemination
• Exploitation
Focus on the science
Exploit
Business development

16. Check our funding database:
www.ttopstart.com/subsidies/database

17. ttopstart BV
www.ttopstart.com
info@ttopstart.com
P.C. Staalweg 30
3721 TJ Bilthoven
The Netherlands
+31 (0)30 73 70 779
Our services
• Subsidies
• Business development
• Project management
For life sciences and medical technology
The ttopstart team:
Patrick de Boer, MSc
Jochem Bossenbroek, MSc
ir. Jasper Levink
Sanne Kuijper, PhD
Marije aan den Toorn, PhD
Ferdinand Los, PhD
Jean-Pierre Sommeijer, PhD
Michelle van Wijk, MSc
Andrée Schram, PhD
Georgia Xouri, PhD
Antoin de Weijer, PhD
Karlijn Bastiaansen, PhD
Karin Bosch-Elberse, PhD
Jelle Zijlstra, MSc
Anouk IJlst, MA