The Science Council believes that every scientist has a responsibility to society, and themselves, to work with integrity, keep their skills and knowledge up to date and consider how their efforts affect the world around them. How can we encourage this among the science workforce?
Presented at SLS Lab Show and Conference, 25 May 2016.
What is Ethical Behaviour in Science Research? Dawn Bazely
In 2014, I returned to the Biology Department after being the director of a York University research institute for 7 years. Based on that experience, I expanded the topics discussed at my weekly lab meetings to include more of the so-called "soft-skills" that were not being explicitly covered in science courses . This included the topic of ethics in research.
I also introduced science communication training for my students. This included showing students how to make Pecha Kucha style presentations. Here is my 20 slide x 20 seconds talk on the topic of ethical behaviour in STEM (Science, Technology, Engineering and Mathematics).
My talk 5/19/2016 for the Massachusetts Medical Society's Residents Fellows Section (RFS) annual meeting in Boston. Many doctors want to know how to get involved online. I discuss why to get online and highlight MMS' recently updated guidelines.
Belief Based Safety Leadership™ addresses the human barriers to the achievement of a ‘true culture of safety’ that can exist at the corporate, team and individual level – namely beliefs, expectations, habits, attitudes, values and efficacy.
What is Ethical Behaviour in Science Research? Dawn Bazely
In 2014, I returned to the Biology Department after being the director of a York University research institute for 7 years. Based on that experience, I expanded the topics discussed at my weekly lab meetings to include more of the so-called "soft-skills" that were not being explicitly covered in science courses . This included the topic of ethics in research.
I also introduced science communication training for my students. This included showing students how to make Pecha Kucha style presentations. Here is my 20 slide x 20 seconds talk on the topic of ethical behaviour in STEM (Science, Technology, Engineering and Mathematics).
My talk 5/19/2016 for the Massachusetts Medical Society's Residents Fellows Section (RFS) annual meeting in Boston. Many doctors want to know how to get involved online. I discuss why to get online and highlight MMS' recently updated guidelines.
Belief Based Safety Leadership™ addresses the human barriers to the achievement of a ‘true culture of safety’ that can exist at the corporate, team and individual level – namely beliefs, expectations, habits, attitudes, values and efficacy.
Communicating Research to the Real World through News Media and MoreKara Gavin
A presentation about interacting with news media, institutional communicators and general audiences directly, created for the CHOP Fellows at the University of Michigan, October, 2020
How to cultivate a research culture in the emergency departmentkellyam18
Getting research going in emergency departments can be hard but it is vitally important for improving healthcare. This presentation gives tips and strategies for building a research culture. Taking the first step is often the hardest part!
Sudhir Srivastava, Founder, Chairman, and CEO of SS Innovations International Inc., graced the cover of World’s Leaders Magazine as one of the Worlds Most Pioneering Leaders in Healthcare, 2024
Healthcare Asia Pacific 2018 welcomes all the speakers and delegates from around the world to go to "10th Asia Pacific Global Summit on Healthcare" during March 12-14, 2018 in Singapore city, Singapore. This incorporates provoke keynote introductions, Oral talks, Poster introductions and Exhibitions
One of the best ways to develop yourself is through sharing your knowledge and skills with others. However, presenting well is a skill in itself! Join us for a whistle-stop tour through ways to improve how you present.
Presented at SLS Lab Show and Conference, 25 May 2016.
Communicating Research to the Real World through News Media and MoreKara Gavin
A presentation about interacting with news media, institutional communicators and general audiences directly, created for the CHOP Fellows at the University of Michigan, October, 2020
How to cultivate a research culture in the emergency departmentkellyam18
Getting research going in emergency departments can be hard but it is vitally important for improving healthcare. This presentation gives tips and strategies for building a research culture. Taking the first step is often the hardest part!
Sudhir Srivastava, Founder, Chairman, and CEO of SS Innovations International Inc., graced the cover of World’s Leaders Magazine as one of the Worlds Most Pioneering Leaders in Healthcare, 2024
Healthcare Asia Pacific 2018 welcomes all the speakers and delegates from around the world to go to "10th Asia Pacific Global Summit on Healthcare" during March 12-14, 2018 in Singapore city, Singapore. This incorporates provoke keynote introductions, Oral talks, Poster introductions and Exhibitions
One of the best ways to develop yourself is through sharing your knowledge and skills with others. However, presenting well is a skill in itself! Join us for a whistle-stop tour through ways to improve how you present.
Presented at SLS Lab Show and Conference, 25 May 2016.
Thinking outside the box for development opportunitiesScience Council
In this masterclass we will be introducing you to ways you can develop your skills, knowledge and experience that you may not have considered. We will also help you identify how different activities can contribute to your professional development.
Presented at SLS Lab Show and Conference, 25 May 2016.
Professional development for teachers and educatorsScience Council
Teaching is a demanding job. In between calls to parents and lesson-planning, when can you make time for your own development? Find out in this session.
Presented at SLS Lab Show and Conference, 25 May 2016.
Thinking of your next career move? Before you hit the job sites, come along to find out how to search smart.
Presented at SLS Lab Show and Conference, 25 May 2016.
Keeping your skills up to date during a career breakScience Council
Perhaps you have maternity or paternity leave on the horizon, or have been thinking about taking a sabbatical. Whatever your situation, it is possible to maintain your professional development and in this masterclass we will explore how.
Presented at SLS Lab Show and Conference, 25 May 2016.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
2. Profession
A paid occupation, especially one that involves prolonged training and a
Formal qualification:
• his/her chosen profession of teaching,
• a barrister by profession
Professional
Worthy of or appropriate to a professional person; competent, skilful, or assured:
• their professional expertise
• their music is both memorable and professional
What is a Professional?
3. Trust is a funny thing …
How do you gain it and keep it and how do others verify you are trustworthy?
4.
5. Trust of others affects
promotion, earning and
grants
Can you trust yourself?
Would an ethical code
and framework help? Because science can have consequences for
public health and safety, the public need a
means of assuring themselves that
scientists are, collectively and individually,
trustworthy.
The planet needs scientists to help make
life comfortable for all as well as
sustainable. The need is urgent and
science must be done well and ethically to
safeguard all our futures.
6. Doctors, Nurses and Midwives must be registered and regulated but not scientists, even those
working in the same hospitals?
7.
8. Failure of Skill,
Knowledge or
Diligence
Conflict of
Interest or
Loyalty
Lack of Ethical
consideration.
Creation of
unmitigated
Risk
Fraud
9. How long did scientists in
this company know of
the risk of ovarian
cancer?
16. The structure of Science Council registration
www.sciencecouncil.org
A: Application of knowledge and
understanding
E: Professionalism
D: Professional practice
B: Personal responsibility
C: Interpersonal skills
Commitment
to CPD
Professional
body code of
conduct
19. Independent recognition of your achieving and
maintaining the exacting standards required to join the
global community of professional scientists.
Registration with the Science Council
How much does science generate for UK economy?
How much is research grants
How much does trust affect you reputation and employability
Each of the register standards is divided into five main areas of competence A – E and these subdivide into further statements.
The CSci standards have recently been redrafted in the same format – which will help to enable progression through the registers.
Someone applying for registration will need to demonstrate how they meet each of the competences for registration at the appropriate level. They also sign up to a code of conduct and a CPD standard – which requires them to maintain an annual CPD record in order to remain registered.
The SC’s role in addressing trust and professionalism- linked to the Science Council’s professional standards etc. both in terms of practicing scientists (might be good to include 10 types of scientists to showcase diversity/breadth of science) and the training of new scientists (how we are embedding the standards into apprenticeships through the trailblazers etc.) and how we will embed them into future degree apprenticeships. (Could also include something about how can you trust that the salesperson from your company who is selling you an item of equipment etc. ha the relevant scientific expertise? Through RSci etc!)
Professional standards as an employability framework in HE – introducing students to standards at an early stage so that professionalism is integrated as early as possible. (Along with placement project etc.)
Working with our member bodies to on the accreditation of science degrees – ensuring education of science at appropriate standard etc etc.