1. CURRICULUM VITAE
Dr (Lt Col) PAWAN KUMAR GUPTA.
& Former
Dean
Manipal Institute of Regenerative Medicine
GKVK post, Bellary Road.
Allalsandra, Yelahanka.
Bangalore 560065. Phone number: 080 28460671.
Associate Professor
Dept of Transfusion Medicine & Haematopathology
Armed Forces Medical College, Pune, India
Contact Address:
Dr Pawan Kumar Gupta, Flat No: RFB-408, Purva Riviera, Varthur Main Road, Marathahalli,
Bangalore – 560037
I am working as Vice President, Medical Affairs, in Manipal Group for last 6 years. Before that,
for a period of 2 ½ years, I worked as Dean, Manipal Institute of Regenerative Medicine
(MIRM), Bangalore. My role in Stempeutics is to look after the Clinical Development, pre-
clinical research and basic research involving stem cells including Mesenchymal Stromal cells.
Earlier during my tenure with the Armed Forces (for 24 years), I also worked in both
professional and administrative appointments in zonal hospitals (bed strength of > 200) and
tertiary care hospitals. Professionally I am a trained Haematopathologist, from All India Institute
of Medical Sciences (AIIMS), New Delhi, and have done my PhD in Hematology from the same
Institute. During these 14 years as specialist in the Armed Forces, I have held varying
appointments, both as a clinician, teacher and researcher giving me vast experience in
Haematopathology, Transfusion Medicine, Pathology and Stem Cells. I have also worked for
many years in a premier Institution of the Armed Forces like Armed Forces Medical College,
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Vice President, Medical Affairs
Stempeutics Research, Akshay Tech Park, #72 & 73,
2nd
Floor, EPIP Zone, Phase – 1 Area, Whitefield,
Bangalore – 560066. Phone: 09611101633 (Mobile)
E mail: colonelpkg@yahoo.com
2. Pune, Army Hospital (Research & Referral), Delhi and Command Hospital, Kolkata. I have total
of 72 research publications of which 48 are in International indexed peer reviewed journals.
1. Personal Particulars
a. Name: Pawan Kumar Gupta
b. Address: RFB – 408, Purva Riviera, Varthur Main Road,
Marathahalli, Bangalore – 560037, India
c. Date of birth: 26 Aug 1960
d. Marital status: Married
2. Educational qualifications:
a. M.B.B.S. (Calcutta University)
b. M.D. (Pathology) (Armed Forces Medical College, Pune, Pune University)
c. Diplomate of National Board of Examination (Pathology), New Delhi.
d. Ph.D. (Haematology) (All India Institute of Medical Sciences (AIIMS), New
Delhi)
e. M.N.A.M.S. (Member of National Academy of Medical Sciences, New Delhi)
f. Professional Diploma in Clinical Research
3. Recognized Teacher for
a) Undergraduate (M.B.B.S.) and Post graduate (M.D.)
courses by University of Pune and Maharashtra University Health Sciences, Nashik in :-
i) Pathology & ii) Transfusion Medicine
b) PhD guide recognized by Manipal University.
c) Total teaching experience: 22 years
d) Industry member in National Apex Committee of Stem Cell Research & Therapy –
appointed by Ministry of Health, New Delhi
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3. 4. Dean, Manipal Institute of Regenerative Medicine Manipal
University, Bangalore (01 Oct to 31 Mar 2011) & Senior Director,
Medical Services, Stempeutics Research Ltd, Bangalore – from 01 Oct
08 till date
In charge of basic research component and education on stem cell, recruitment of talented
scientists for conducting basic research, Lead efforts to obtain extra-mural funding,
Running post-graduate program and doctoral program in stem cells and regenerative
medicine.
Has extensive industry experience, including leading the design and execution of clinical
strategies for product approvals and competitive positioning of cell therapies products in
India. Has expertise in clinical trial design and his ability to drive clinical development
programs towards regulatory approvals has earned recognition among peers and
regulators. My work includes all aspects and stages of clinical development, successful
collaboration with key opinion leaders and extensive interactions with regulators.
Key Accomplishment:
• Initiated post-graduate program in Regenerative Medicine
• Initiated doctoral program
• Established research groups
• Conducting clinical trials using allogeneic mesenchymal stem cells for different
disease like Acute Myocardial Infarction, Critical Limb Ischemia, Liver cirrhosis,
Osteoarthritis of knee joint, Diabetes Mellitus type 2 and Diabetic Foot Ulcer.
• Experience in presentation in front of Indian Regulatory authorities for getting
approval of stem cells clinical trials and finding for different research projects.
• Audit of clinical trials both at the clinical trial site and at CRO.
• Experience in maintaining GCP & GMP compliant documentation
• Extensive experience in presentation in Scientific conferences & facing Indian
FDA audit
• Conduct of pre-clinical studies using stem cells – both safety and efficacy models.
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4. 5. As Associate Professor & Haematopathologist - Dept of Haematopathology &
Transfusion Medicine, Armed Forces Medical College, Pune, was Officer in charge of
the following facilities:
a. Specialized Hematological Laboratory which includes
morphological diagnosis and coagulation parameters of
the disease.
b. Molecular diagnosis laboratory for different
hematological disorders.
c. Stem Cell Laboratory at AFMC, Pune.
d. Blood Bank, Component Laboratory and Infectious
disease screening laboratory of the Armed Forces in
Pune.
e. Flow Cytometry laboratory (Haematology).
6. Posting profile as a Specialist Officer in Indian Army:
Period Unit Appointment
Mar 1995 to Mar 1998 Department of Pathology,
Military Hospital, Saugor,
MP
Graded Specialist
(Pathology)
Mar 1998 to Feb 2001 Department of Pathology,
Command Hospital,
Kolkata
Classified Specalist
(Pathology)
Feb 2001 to Feb 2003 Dept of Haematology,
AIIMS, New Delhi
Under going training in
Haematapathology & PhD
in Haematology
Feb 2003 to Aug 2004 Army Hospital (R & R),
New Delhi
Classified Spl (Pathology &
Haematology)
Aug 2004 till 30 Sep 08 Armed Forces Medical
College, Pune
Associate Professor
(Pathology, Haematology &
Transfusion Medicine)
6. Advanced Specialized Training
(a) International
(i) Molecular diagnosis of different hematological disorders (Trained at University
Hospital, Hamburg, Germany).
(ii) Advanced laboratory diagnosis of bleeding disorders (Trained at University Hospital,
Hamburg, Germany).
(iii) Stem Cells – its isolation, differentiation and research on stem cells (Trained at Stem
Cell Institute, University of Minnesota, Minneapolis, Minnesota, USA).
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5. (b) National
(i) Hematological diagnosis of disease including morphological diagnosis. (Trained at
AIIMS, New Delhi)
(ii) Coagulation parameters of the disease and investigation of all the coagulation
parameters. (Trained at AIIMS, New Delhi).
(iii) Trained in Histopathology, FNAC, Cytology & running a Pathology laboratory.
(Received basic training in Pathology while doing M.D, & D.N.B. (Pathology) at AFMC,
Pune).
(iv) Advanced Haematology Training at Institute of Immunohaematology, Indian Council
of Medical Research, KEM Hospital, Parel, Mumbai.
(v) Trained in Hematopoietic stem cells – isolation, characterization and use of the cells
from Armed Forces Medical College, Pune.
7. Research projects completed / ongoing:
(i) Study of hypopigmented skin lesions for an early diagnosis of leprosy in intermediate
form.
(ii) Characterization of von Willebrand disease into its variants (Project sanctioned by
Dept of Science & Technology, Govt of India)
(iii) Molecular genetics of thrombophilia.
(iv) Use of autologous mononuclear stem cells in spinal cord injuries (Investigator Led
Trial conducted at Armed Forces Medical College, Pune)
(v) Role of Protein Z and its association with F V Leiden mutation in arterial and venous
thrombosis (Project funded by Armed Forces Medical Research Committee, New Delhi).
(vi) Assessment of Haemostatic risk factors including Fibrinogen β - 448 Arg / Lys
polymorphism in predicting myocardial infarction of the young (Project funded by
Armed Forces Medical Research Committee, New Delhi)..
(vii) Molecular characterization of von Willebrand disease.
(viii) To study the incidence of anti HBc IgM amongst blood donors and to evaluate its
utility as a screening procedure for hepatitis B in donated blood in the current scenario.
(ix) Principal Co – Investigator in Stem Cells project on: Efficacy of stem cell in
improvement of left ventricular function in patients with acute myocardial infarction.
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6. (Project sanctioned by Dept of Biotechnology, Ministry of Science & Technology, New
Delhi).
(x) Principal Co – investigator in Stem cells project on: Intravenous autologous bone
marrow derived stem cell therapy for patients with acute ischemic stroke: a multi
institutional project (Project sanctioned by Dept of Biotechnology, Ministry of Science &
Technology, New Delhi).
(xi) Project Coordinator for the BIPP sponsored clinical trial titled “A parallel group
randomized open blinded end point evaluation, multicentric, dose escalation, phase –II
study assessing the safety and efficacy of intra-arterial (hepatic) ex-vivo cultured adult
allogenicmesenchymal stem cells in patients with alcoholic liver cirrhosis” (Project
sanctioned by Dept of Biotechnology, BIPP, Ministry of Science & Technology, New
Delhi).
(xii) Principal Co – Investigator in different clinical trials on use of bone marrow derived
allogeneic mesenchymal stem cells:
a) A randomized double blind, multicentric, placebo controlled, single dose,
phase – I/II study assessing the safety and efficacy of intravenous ex vivo
cultured adult allogeneic mesenchymal stem cells in patients with ST
elevated acute myocardial infarction (STEMI) – study completed
b) A randomized double blind, multicentric, placebo controlled, single dose,
phase – I/II study assessing the safety and efficacy of intramuscular ex
vivo cultured adult allogeneic mesenchymal stem cells in patients with
critical limb ischemia – study completed.
c) A non-randomized, open label, multicentric, dose ranging, phase II study
assessing the efficacy and safety of intramuscular administration of
stempeucel – CLI TM
(ex vivo cultured adult bone marrow derived
allogeneic mesenchymal stem cells) in patients with critical limb
ischaemia due to Buerger’s disease – study completed.
d) A randomized double blind, multicentric, placebo controlled, phase – II
study assessing the safety and efficacy of intraarticular ex vivo cultured
adult allogeneic mesenchymal stem cells in patients with Osteoarthritis of
knee – study completed.
e) A parallel group randomized, open blinded end point evaluation,
multicentric, dose escalation, phase II study assessing the safety and
efficacy of intraarterial (Hepatic) ex vivo cultured adult allogeneic
mesenchymal stem cells in patients with Alcoholic Liver Cirrhosis – study
completed.
(xiii) Generation and analysis of the reprogramming efficiency of human induced pluripotent
stem cells from different adult cells – Project approved and funded by CSIR, New Delhi
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7. (xiv) Isolation and characterization of dental pulp mesenchymal stem cells isolated from
deciduous and adult humans and its differentiation into dopaminergic neurons and islet cells –
Project approved and funded by Indian Council of Medical Research, New Delhi.
8. Organization of Conferences & CMEs:
Has organized the following conferences / CMEs:
(i) International CME on Stem Cells, at Armed Forces Medical College, Pune, on 23rd
and 24th
December 2006.
(ii) Recent Advances in Management of Haemorrhagic disorders, at Armed Forces
Medical College, Pune, on 28th
and 29th
July 2007.
(iii) CME in Hemato - Oncology at MDTC, Command Hospital (SC), Pune on 30th
April
06.
(iv) Haematology Update 2007, at Command Hospital, (SC), Pune on 17th
June 2007.
(v) Organized the Workshop on “Use of flow cytometry and molecular biology
techniques in stem cells” at Manipal Institute of Regenerative Medicine, Bangalore from
26th
Dec 08 to 04th
Jan 09.
9. Awards: (From Indian Army)
a. Chief of Army Staff Commendation Card – 1995
b. Chief of Army Staff Commendation Card – 1996
c. General – Officer - in - Commanding – in – Chief - Commendation Card –
1993
10. Memberships in Societies:
a. Life member of Indian Society of Haematology and Transfusion Medicine.
b. Life member of Indian Society of Pathologists and Microbiologists.
c. Life member of Delhi Society of Haematology.
d. Life member of West Bengal Society of Pathologists & Microbiologists.
e. Member of International Society of Thrombosis & Haemostasis
f. Member of International Society of Stem Cell Research.
g. Member of International Society of Cellular Therapy
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8. 11. Special Interest:
a. Coagulation disorders including von Willebrand disease
b. Molecular diagnosis in leukaemia.
c. Bone marrow transplant chimerism study.
d. Stem cell isolation and its differentiation.
e. Clinical application of mesenchymal and hematopoietic stem cells.
f. Basic research in different sources of mesenchymal stem cells.
12. Papers published
International Publications- 48
(i) Gupta P.K., Ahmed R., Kannan M., Dwidvedi S.N., Choudhry V.P., Saxena R.
Pro CR
Global: An Effective Screening Test for Thrombophilia. American Journal of
Hematology. 2003 Nov;74(3):208-10.
(ii) Ahmed R.P.H., Gupta P.K., Kannan M., Choudhry V.P., Saxena R. Factor V
Leiden – the commonest molecular defect in arterial and venous thrombophilia in India.
Thrombosis Research . 2003 Apr 15;110(1):19-21
(iii) Saxena R., Gupta M., Gupta P.K., Kashyap R., Choudhry V.P., Bhargava M.
Inherited bleeding disorders in Indian women with menorrhagia. Haemophilia. 2003
Mar;9(2):193-6.
(iv) Gupta P.K., Ahmed R., Kannan M., Chatterjee T., Saxena R. – Platelet Factor 3
Availability defect: an effective screening test for types 1 & 2 Von Willebrand disease. –
Ann Hematol. 2004 Jul;83(7):489-90.
(v) Chatterjee T., Dixit A., Mohaptra S., Tyagi S., Gupta P.K., Mishra M., et al.
Clinical Haematological and Histomorphological Profile of Adult Myelodysplastic
Syndrome. Study of Ninety Six cases in Single Institute. Paper accepted for publication
in European Journal of Haematology. 2004 Aug;73(2):93-7.
(vi) Ahmed RPH, Gupta P.K., Kannan M, Suresh K, Kashyap R, Choudhry VP,
Saxena R. Haemophilia A: Role of FVIIIC / Ag in assisting linkage analysis for carrier
detection – Clin Appl Thrombosis/Hemostasis. 2004 Apr;10(2):127-31
(vii) Gupta P.K., Ahmed RPH, Kannan M, Kalra M, Saxena R. Protein C system
defects in Indian Children with Thrombosis: Ann Hematol. 2005 Feb;84(2):85-8.
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9. (viii) Bhattacharyya M, Makharia G, Kannan M, Ahmed RP, Gupta PK, Saxena R.
Inherited prothrombotic defects in Budd-Chiari syndrome and portal vein thrombosis: a
study from North India. Am J Clin Pathol. 2004 Jun; 121(6):844-7.
(ix) Gupta P.K., Ahmed RPH, Sazawal S., et al. Relatively high frequency of VWD
types 3 and 2 in a Cohort of Indian patients: the role of multimeric analysis. J Thromb
Haemost. 2005 Jun;3(6):1321-3.
(x) Gupta P.K., Kannan M., Saxena R. Carrier detection in severe von Willebrand's
disease. Ann Hematol. 2004 Oct;83(10):625-7.
(xi) Gupta P.K., E. Adamtziki, U. Budde, M. Jaiprakash, H. Kumar, A. Harbeck-
Seu, M. Kannan, F. Oyen, T.Obser, I. Wedekind, R. Saxena, R. Schneppenheim. Gene
conversions are a common cause of von Willebrand Disease. Br J Haemat. 2005 130: 752
– 758.
(xii) Gupta P.K., M. Kannan, T. Chatterjee,A. Dixit, M. Mahapatra, V. P. Choudhry,
R. Saxena . Acquired von Willebrand Disease Associated with Gastrointestinal
-Angiodysplasia – A case report. Haemophilia.(2006), 12, 452–455.
(xiii) Gupta PK, Charan VD, Saxena R. Spectrum of von Willebrand disease and
platelet function disorders amongst Indian bleeders. Ann Hematol (2007) 86:403–407.
(xiv) Gupta PK, Budde U, Saxena R, Schineppenheim R. Spectrum of genetic defects
in severe von Willebrand disease type 3 in Indians. Int J Lab Hematol (2007) 20
(Supplement 1) 71 Abst 206.
(xv) Gupta PK, R. Saxena, E. Adamtziki, U. Budde, F. Oyen, T.Obser , R.
Schneppenheim. Genetic defects in von Willebrand disease type 3 in Indian and Greek
patients. Blood Cells Mol Dis. 2008 Sep-Oct;41(2):219-22
(xvi) Gambhir R, Gupta PK, Chaudhry RK. Prothrombotic work up in vascular
thrombosis – are we guilty of under assessment? British Journal of Surgery. 2008;
95(S3): 1–84 (Abst 0907)
(xvii) Gambhir R, Malhotra M, Gupta PK. Therapeutic angiogenesis in non-
reconstructable critical limb Ischemia: a ray of hope. British Journal of Surgery. 2008;
95(S3): 1–84 (Abst 0899)
(xviii) Gupta PK, Ahuja A, Kumar H, Sarkar r, Mehta A. Role of Protein Z and its
association with factor V Ledien mutation in ;thrombophilia amongst Indians. Int Jnl Lab
Hem. 2008; 30: (Sl) 58 – 147 (Abst 410)
(xix) Neelam K Venkataramana, V Satishkumar K, Sudheer Balaraju, C.R.Radhika,
Abhilash Bansal, Ashish Dixit, Deepthi K.R., Madhulita Das, Majahar Jan, Pawan
Kumar Gupta, Satish Totey . An Open labeled study of unilateral autologous bone
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10. marrow derived mesenchymal stem cells transplantation in Parkinson’s disease.
Translational Research. 2010 Feb: 155 (2), 62-70.
(xx) Gupta PK, Venkataramana NK, Rao S, Murogod U, Totey S. Use of Human
Mesenchymal Stem Cells in Neurological and other disorders. Regenerative Medicine.
Nov 2009. Vol 4, No. 6 (Suppl 2) S – 93.
(xxi) Mamidi MK, Pal R, Mori NA, Arumugam G, Thrichelvam ST, Noor PJ, Abdullah
HM, Gupta PK, Das AK, Zakaria Z, Bhonde R. Co-culture of mesenchymal-like stromal
cells derived from human foreskin permits long term propagation and differentiation of
human embryonic stem cells. J Cell Biochem. 2011 May;112(5):1353-63. Erratum in: J
Cell Biochem. 2014 Aug;115(8):1467.
(xxii) Pal R, Mamidi MK, Das AK, Gupta PK, Bhonde R. A simple and economical
way to generate functional hepatocyte – like cells from hESCs and their application in
evaluating alcohol induced liver damage. J Cell Biochem. 2012 Jan;113(1):19-30.
(xxiii) Mathews S, Gupta PK, Bhonde R, Totey S Chitosan enhances mineralization
during osteoblast differentiation of human bone marrow derived mesenchymal stem cells
by up regulating the associated genes. Cell Proliferation. 2011; 44, 537 – 549.
(xxiv) Mathews S, Bhonde R, Gupta PK, Totey S. A novel tripolymer coating
demonstrating the synergistic effect of chitosan, collagen type 1 and hyaluronic acid on
osteogenic differentiation of human bone marrow derived mesenchymal stem cells.
Biochem Biophys Res Commun. 2011 Oct 14;414(1):270-6.
(xxv) Gupta PK, Das AK, CH Anoop, Majumdar AS. Mesenchymal Stem Cells for
Cartilage Repair in Osteoarthritis. Stem Cell Res Ther. 2012 Jul 9;3(4):25
(xxvi) Mathews S, Bhonde R, Gupta PK, Totey S. Extracellular matrix protein
mediated regulation of the osteoblast differentiation of bone marrow derived human
mesenchymal stem cells. Differentiation. 2012 Sep;84(2):185-92.
(xxvii) Mathews S, Mathew SA, Gupta PK, Bhonde R, Totey S. Glycosaminoglycans
enhance osteoblast differentiation of bone marrow derived human mesenchymal stem
cells. J Tissue Eng Regen Med. 2014 Feb;8(2):143-52.
(xxviii) Kanafi Mohammad, Pal Rajarshi, Gupta PK. Phenotypic and functional
comparison of optimum culture conditions for upscaling of dental pulp stem cells. Cell
Biol Int. 2013 Feb;37(2):126-36.
(xxix) Kanafi Mohammad, Gupta PK, Bhonde R Influence of Hypoxia, High Glucose,
and Low Serum on the Growth Kinetics of Mesenchymal Stem Cells from Deciduous and
Permanent Teeth. Cells Tissues Organs. Cells Tissues Organs. 2013;198(3):198-208.
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12. (xl) P.K. Gupta, A. Chullikana, M. Rajkumar, M. Krishna, S. Dutta, U. Sarkar, S.
Desai, R. Radhakrishnan, A. Dhar, S. Balasubramanian, U. Kumar, U. Baikunje, K.
Prasanth, N. Anthony, A. Majumdar. Role of bone marrow derived allogeneic
mesenchymal stromal cells (stempeucel ®) in critical limb ischemia due to Buerger's
disease – efficacy and safety results of non-randomized, open label, multicentric, dose
ranging, phase II study in India. April 2014Volume 16, Issue 4, Supplement, Pages S80–
S81.
(xli) AS Majumdar, S Balasubramanian, C Thej, M Rajkumar, M Krishna,S Dutta, U
Sarkar, S Desai, R Radhakrishnan, A Dhar, R Mathiazhagan, UK Kolkundkar, U
Baikunje, KV Prasanth, N Nutan, S Sundarraj, CH Anoop, PK Gupta. A First Of Its
Kind Phase II Clinical Trial In Critical Limb Ischemia Patients Using Bone Marrow
Derived, Pooled, Allogeneic Mesenchymal Stromal Cells (Stempeucel®). Cytotherapy
06/2015; 17(6):S84.
(xlii) Gupta PK, Chullikana A, Desai S, Rajkumar M, Krishna M, Dutta S, Sarkar U,
Radhakrishnan R, Dhar A, Rajiv Parakh, Lakshmanan Jeyaseelan, Pachaiyappan. V,
Prasanth KV, Seetharam RN, Thej C, Balasubramanian S, Majumdar AS. Administration
of Adult Human Bone Marrow-Derived, Cultured, Pooled, Allogeneic Mesenchymal
Stromal Cells in Critical Limb Ischemia Due to Buerger’s Disease: Phase II Study Report
Suggests Clinical Efficacy. Stem Cell Translational Medicine. 2016;5:1–11
(xliii) Kanafi MM, Majumdar D, Bhonde R, Gupta PK, Datta I. Differential neuronal
plasticity of dental pulp stem cells from exfoliated deciduous and permanent teeth
towards dopaminergic neurons. J Cell Physiol. 2016 Sep;231(9):2048-63.
(xliv) Gupta PK, Chullikana, A, Rengasamy M, Shetty N, Pandey V, Agarwal V,
Wagh SY, Vellotare PK, Damodaran D, Viswanathan P, Thej C, Balasubramanian S,
Majumdar AS. Efficacy and safety of stempeucel® (adult human bone marrow derived,
cultured pooled, allogeneic mesenchymal stromal cells) in both pre-clinical and clinical
trial in Osteoarthritis of knee joint. Submitted to Arthritis Research & Therapy.
(xlv) S. Balasubramanian, M. R, C. Thej, B. R, A.Walvekar, P. Swamynathan, S.
SundarRaj, P.K. Gupta, A. Majumdar. Evaluation of Potency and Efficacy of
Stempeucel®—Allogeneic Pooled Human MSCs in a Preclinical Model of Limb
Ischemia. Cytotherapy 18(6):S114 · June 2016.
(xlvi) Gupta PK, Anoop Chullikana, Sudha Balasubramanian, Mathiazhagan R, Swathi
Sundar Raj, Anish Sen Majumdar. The role of mesenchymal stem cells in the
management of critical limb ischemia. In, The Biology and Therapeutic Application of
Mesenchymal Cells. Ed K. Atkinson. John Wiley and Sons Inc. Hoboken, New Jersey,
USA. 2016. In press
(xlvii) Mathiyazhagan Rengaswamy, Gurbind Singh, Siddikuzzaman, Sudha
Balasubramanian, Priyanka Swamynathan, Charan Thej, Gopinath Sasidharan, Pawan
Kumar Gupta, Anjan Kumar Das, Noor Atiqah Fakharuzi, Ahmad Zuhairi Abdul
Rahman, Kamal S Fakiruddin, Lim Moon Nian2
, Zubaidah Zakaria, Anish S Majumdar.
Transplantation of human bone marrow derived mesenchymal stromal cells reduces rat
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13. liver fibrosis more effectively than Wharton’s Jelly derived cells. Submitted for
publication to Liver International.
(xlviii) Balasubramanian S, Mathiyazhagan R, Thej C, Gupta PK, Majumdar AS.
Mesenchymal stromal cells: Emerging treatment option for diabetic wounds. In,
Regenerative Medicine: Laboratory to Clinic, Ed A. Mukhopadhyay.Springer, Singapore.
(Revised version submitted and accepted for publication).
National Publications - 24
(i) Gupta P. K., Kumar Harsh, Diwan R.N. Blood Ordering Strategies in the Armed
Forces – A Proposal. Medical Journal Armed Forces India. 2003; 59: 302 – 305.
(ii) Gupta P. K., Saxena R., Karan A.S., Choudhry V.P. Red cell indices for
distinguishing macrocytosis of aplastic anaemia and megaloblastic anaemia. Indian J
Pathology & Microbiology. 2003 Jul;46(3):375-7.
(iii) Saxena R., Gupta P. K., Ahmed R., Batra V., Kumar S. D – dimer test:
diagnostic role in clinical and sub – clinical DIC. Indian J Pathology & Microbiology.
2003 Jul; 46(3): 425-6.
(iv) Saxena R., Gupta P.K., Choudhry V.P. von Willebrand Disease. Recent
Advances in Pediatrics – 13. Edited by Suraj Gupte. 2003; Jaypee Brothers, New Delhi.
385 – 398.
(v) Saxena R., Gupta P.K. Anaemia of Chronic Disease. Medicine Update. The
Association of Physicians of India (Assam State Chapter). Vol. VII. 2003; 471 – 475.
(vi) Saxena R., Gupta P.K., Mahapatra M., Choudhry V.P. von Willebrand disease:
Diagnosis and Management. Indian Journal of Haematology & Blood Transfusion. 2003;
XXI NO 2. 61 – 66.
(vii) Gupta P.K., Mahapatra M., Saxena R. – Sudan black B positive Acute
Lymphoblastic Leukaemia. MJAFI. 2004; 60: 297 – 298.
(viii) Saxena R., Gupta P.K. Newer Anticoagulants. Indian Journal of Haematology &
Transfusion Medicine. 2003; 4 : 120 –123.
(ix) Chopra G.S., Gupta P.K., Anand A.C., Varma P.P., Nair V., Rai R. Real Time
PCR : HBV – DNA analysis : Significance & First Experience in Armed Forces. Medical
Journal Armed Forces of India. 2005; 61: 234 – 237.
(x) Chopra G.S., Gupta P.K. Health Care Medical Wastes – A Hotbed of Infection. J
Ind Soc Hosp Waste Management. 2004; 3 (1): 41 – 45.
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14. (xi) Saxena R., Kannan M., Ahmed RPH., Gupta P.K. Carrier detection in
haemophilia A and VWD. Haematology Today. X th National CME in Haematology,
2004. Published by Prof. M.B.Aggarwal, Mumbai. 215 – 226.
(xii) Gupta P.K., Gupta M., Chatterjee T., Saxena R. Comparative evaluation of
whole blood D-dimer test to plasma D-dimer test for diagnosis of disseminated
intravascular coagulation. Indian J Exp Biol. 2005 Apr;43(4):382-4.
(xiii) Gupta P.K., Charan V.D., Kumar H. Cancer Related Thrombophilia: Clinical
Importance and Management . JAPI, 2005; 53: 877 – 882.
(xiv) Kumar H, Gupta PK, Mishra DK, Sarkar RS, Jaiprakash M. Leucodepletion and
Blood Products. MJAFI. 2006; 62: 174 – 177.
(xv) Chopra GS, Gupta PK. Evaluation of Monoclonal Gammopathy. MJAFI. 2005;
Vol 62, page 134-137.
(xvi) Jaiprakash M, Gupta PK, Kumar H. Role Of Gel Based Technique For Coombs
Test. Indian J Path & Micro. 2006; 49(3): 370 – 372.
(xvii) Gupta PK, Kumar H, Basannar DR, Jaiprakash M. Transfusion transmitted
infection in Armed Forces : Prevalence & Trends. MJAFI. 2006; 62: 348 – 350.
(xviii) Gupta PK, Kumar H, Saxena R. Multimeric analysis in diagnosis of VWD
variants in Indians. Indian J Pathol & Microbiol 2007; 50 (3): 636 – 639.
(xix) Kumar H, Gupta PK. Is Seroprevalence of HTLV – I/II among blood donors in
India relevant ? Indian J of Pathology & Microbiology. 2006; 49 (4), 532 – 534.
(xx) Kumar H, Gupta PK., Jaiprakash M. The role of anti – HBc IgM in screening of
blood donors. MJAFI 2007; 63 : 350 – 352.
(xxi) Gupta PK, Kumar H, Kumar S. Hereditary factor X (Stuart – Prower factor)
deficiency – a rare disorder. MJAFI, 2008, Vol. 64, Issue 3, Pages 286-287.
(xxii) Gupta PK, Charan VD, Kumar H. PNH Revisited – Clinical Profile, Laboratory
Diagnosis and Follow – up. Indian J Pathol Microbiol. 2009 Jan-Mar;52(1):38-41.
(xxiii) Kumar H, Gupta PK, Kumar S, Sarkar RS Is seroprevalence of anti-IGM CMV
among blood donors relevant in India?, Indian J Pathol Microbiol. 2008 Jul-
Sep;51(3):351-2.
(xxiv) Mathiyazhagan Rengasamy, Pawan Kumar Gupta, Udaykumar Kolkundkar,
Gurbind Singh, Sudha Balasubramanian, Swathi SundarRaj, Anoop Chullikana & Anish
S Majumdar. Preclinical safety and toxicity evaluation of a pooled, allogeneic human
14
15. bone marrow derived mesenchymal stromal cell product (Stempeucel®). Accepted for
publication in Indian Journal of Medical Research
13. Patents:
(i) US Patent no: 8956862. Methods Of Preparing Mesenchymal Stem Cells,
Compositions And Kit Thereof
14. Papers presented in conference / Guest Lectures delivered:
(i) Gupta P. K. , Bhangui G. Study of hypopigmented skin lesions for an early
diagnosis of intermediate leprsoy – Paper presented in Annual conference of
Indian Society of Pathologists & Microbiologists – 1998.
(ii) Gupta P. K., Gupta M. L., Chopra G. S.; Acute Leukemia – Our Experience in
Calcutta – Paper presented in Annual Conference of West Bengal Chapter of
Indian Society of Pathologists & Microbiologists- 1998
(iii) Gupta P.K. , Kumar H, Prasad R. S; Incidence of Hepatitis Markers In Healthy
Blood donors – Paper presented in Annual Conference of West Bengal Chapter
of Indian Society of Pathologists & Microbiologists – 1999.
(iv) Gupta P.K., Kumar H; Rational use of blood by objective transfusion
guidelines – Paper presented in Annual conferences of Indian Society of
Haematology & Transfusion guidelines – 2000
(v) Elhence P., Dixit A., Chatterjee T., Gupta P.K., Pati H.P., Saxena R., Choudhry
V.P. – Neutrophilic CML – A case report. Paper presented in Annual conference
of Indian Society of Haematology and Transfusion Medicine – 2002.
(vi) Chatterjee T., Gupta P.K., Dixit A., Saxena R., Choudhry V.P. – Clinical,
Haematological and Histomorphological profile of Adult Myelodysplastic
syndrome: Study of Ninety six cases at AIIMS. - Paper presented in Annual
conference of Indian Society of Haematology and Transfusion Medicine – 2002.
(vii) Chatterjee T., Gupta P.K., Mahapatra M., Dixit A., Saxena R., Choudhry V.P. –
Clinical, Haematological and Histomorphological profile of Paediatric
Myelodysplastic syndrome. – Paper presented in 2 nd
SIOP – Asia conference & 6
th
National Conference of Paediatric Haematology Oncology – 2002.
(viii) Gupta P.K., Ahmed R.P.H., Kannan M., Choudhry V.P., Saxena R. –
Characterization of Von Willebrand disease variants in Paediatric Indian
population. - Paper presented in 2 nd
SIOP – Asia conference & 6 th
National
Conference of Paediatric Haematology Oncology – 2002.
(ix) Ahmed R.P.H., Gupta P.K., Kannan M., Kalra V., Choudhry V.P., Saxena R. –
Molecular factors underlying Pediatric Indian thrombophilics - Paper presented in
15
16. 2 nd
SIOP – Asia conference & 6 th
National Conference of Pediatric Haematology
Oncology – 2002.
(x) Gupta P.K., Kannan M., Mahapatra M., Choudhry V.P., Saxena R. Acquired
VWD associated with Gastrointestinal Angiodysplasis – A case report. Paper
presented in Annual Conference of Delhi Society of Haematology. 2003.
(xi) Gupta P.K., Sazawal S., Ahmed RPH., Kannan M., Choudhry VP., Saxena R.
Multimeric Analysis for sub characterization of von Willebrand disease in
Indians. Presented in 44 th Annual Conference of ISHTM. 2003. (Abst. I – 1/75).
Indian J Hemat & Blood Transf. 2003; Vol. XXI: Conf. Suppl –1: 17. Awarded
the Best Poster presentation in the Conference.
(xii) Kotwal J., Noatay M., Gupta P.K., Dutta V., Nema S.K., Chopra G.S., Nair V.,
Rao r., Rai R. A study of Non Hodgkin’s Lymphoma with discordant bone
marrow morphology. Presented in 44 th Annual Conference of ISHTM. 2003.
(Abst. N – 6/153). Indian J Hemat & Blood Transf. 2003; Vol. XXI: Conf. Suppl
–1: 29.
(xiii) Gupta P.K., Ahmed RPH, Kannan M., Chatterjee T., Choudhry VP., Saxena R.
Pro CR
Global: An Effective Screening Test for Thrombophilia. Presented in 44 th
Annual Conference of ISHTM. 2003. (Abst. PH – 21/109). Indian J Hemat &
Blood Transf. 2003; Vol. XXI: Conf. Suppl –1: 52.
(xiv) Nair V., Kotwal J., Gupta P.K., Dixit A., Nema S.K., Mohan C. Deep Venous
Thrombosis : An Unusual presentation of AML. Presented in 44 th Annual
Conference of ISHTM. 2003. (Abst. PH – 29/152). Indian J Hemat & Blood
Transf. 2003; Vol. XXI: Conf. Suppl –1: 54.
(xv) Pathak N., Kotwal J., Chopra G.S., Gupta P.K., Bhardwaj J.R. A study of
Cryglobulinemia with varied presentations. Paper presented in XIX Annual
Meeting – Delhi Chapter of Indian Association of Pathologists & Microbiologists.
2004. (P – HCP – 7) (Abst – 24).
(xvi) Gupta P.K., Chopra G.S. Diagnosis of von Willebrand Disease and its
subcharacterization by Multimeric Analysis. Paper presented at Sixth Annual
Medical Update, 2004, at IMTRAT, Bhutan.
(xvii) Gupta P.K., E. Adamtziki, U. Budde, M. Jaiprakash, H. Kumar, A. Harbeck-
Seu, M. Kannan, F. Oyen, T.Obser, I. Wedekind, R. Saxena, R. Schneppenheim.
Gene conversions are a common cause of von Willebrand
Disease. Presented at XX th Congress of International Society of Thrombosis
and Haemastasis at Sydney in 2005.
(xviii) Gorthi SP, Gupta PK, Sahoo PK, Sinha PK, Kumar H, Singh HP. Autologous
bone marrow mononuclear cell therapy for patients with Amyotrophic lateral
sclerosis, spinal cord trauma and muscular dystrophy (A pilot study). Presented at
16
17. 56th
Annual Conference of Neurological Society of India on 4th
to 17th
December
2007.
(xix) Gupta PK, Mishra S, Kumar H, Prasad BAK. Protein Z levels in normal
pregnancy and in pregnancy complications amongst Indians. Paper presented at
48th
Annual Conference of Indian Society of Hematology & Transfusion Medicine
on 15th
– 17th
November at Lucknow.
(xx) Kumar H, Gupta PK., Jaiprakash M. The role of anti – HBc (IgM) in screening
of blood donors. Paper presented at 48th
Annual Conference of Indian Society of
Hematology & Transfusion Medicine on 15th
– 17th
November at Lucknow.
(xxi) Gupta P.K., Kumar H, Saxena R. von Willebrand Disease: Indian Scenario.
Presented at 46th
Annual Conference of Indian Society of Haematology &
Transfusion Medicine (ISHTM) at Imphal, Manipur on 15 Jan 2006, and also
presented at 54th
AFMRC, AFMC, Pune on 9th
Feb 2006.
(xxii) Kumar H, Gupta P K. Is Seroprevalence of HTLV – I/II among blood donors in
India relevant? Presented at 46th
Annual Conference of Indian Society of
Haematology & Transfusion Medicine (ISHTM) at Imphal, Manipur on 15th
January 2006.
(xxiii) Gupta PK. Cytogenetics & flow cytometry in leukemias. Guest Lecture delivered
at CME in Oncology on 30th
April 06 organized by MDTC, Command Hospital
(SC) & AFMC, Pune.
(xxiv) Gupta PK, Harsh Kumar. Haemotherapy in management of leukemias. Guest
Lecture delivered at CME in Oncology on 30th
April 06 organized by MDTC,
Command Hospital (SC) & AFMC, Pune.
(xxv) Gupta PK, Harsh Kumar, Satish Kumar, Jaiprakash M. Role of Transfusion
Serives in Nuclear, Biological & Chemical Emergencies. Presented at conference
on Physical protection and medical management for NBC emergencies at DRDE,
Gwalior on 20 – 21 Jan 2006.
(xxvi) Gupta PK. Investigation of Hypercoagulability. Guest Lecture delivered on
XXIV CME and Post Graduate Course in Pathology at Dept of Pathology,
Jawaharlal Nehru Medical College, Belgaum on 8th
Jun 2006.
(xxvii) Gupta P K. Newer Haematological markers for Coronary Artery Disease. Guest
lecture delivered at Live Interventional Cardiology workshop at Military Hospital
(Cardio Thoracic Center), Pune on 02 July 2006.
(xxviii) Gupta PK. Inherited bleeding disorder including von Willebrand disease.
Guest lecture delivered at CME in Recent Advances in Haemorrhagic Disorders
at AFMC, Pune on 30 July 2006.
17
18. (xxix) Gupta PK. Practice of Blood Component Therapy. Guest Lecture delivered at
Haematology Update 2007, at CH (SC), Pune on 17th
June 2007.
(xxx) Gupta PK, Mishra S, Kumar H, Prasad BAK. Protein Z levels in normal
pregnancy and in pregnancy complications amongst Indians. Paper presented at
48th
Annual Conference of Indian Society of Hematology & Transfusion Medicine
on 15th
– 17th
November at Lucknow.
(xxxi) Gene Mutational studies in haematology. Guest lecture delivered at Workshop
in Molecular Techniques in Pathology at AFMC, Pune on 17th
November 07.
(xxxii) Carrier detection in Haemophilia. Guest lecture delivered at Workshop in
Molecular Techniques in Pathology at AFMC, Pune on 17th
November 07.
(xxxiii) Gorthi SP, Gupta PK, Sahoo PK, Sinha PK, Kumar H, Singh HP.
Autologous bone marrow mononuclear cell therapy for patients with
Amyotrophic lateral sclerosis, spinal cord trauma and muscular dystrophy (A pilot
study). Presented at 56th
Annual Conference of Neurological Society of India on
4th
to 17th
December 2007.
(xxxiv)Delivered Guest lecture at CME in Pathology, Kasturba Medical College,
Mangalore on “von Willebrand Disease – Indian Scenario” on 08th
Dec 2008.
(xxxv) Delivered Guest lecture at CME in Dept of Biotechnology, Baramati,
Maharashtra, for UCG teachers on “Basics of embryonic and adult stem cells” on
19 Dec 08.
(xxxvi)Delivered Invited Guest lecture during DERMACON 2009 (37th National
Conference of Indian Association of Dermatologists, Venerologists and
Leprologists) at Bangalore on 07th Jan 2009 on “Stem Cells in Dermatology
Practice”.
(xxxvii) Delivered Invited Guest lecture during 122nd Annual Scientific Sessions
of the Sri Lanka Medical Association at Colombo on 18th March on
“Mesenchymal stem cells and its clinical application”.
(xxxviii) Delivered Guest lecture at National Stem Cell Update of KMC, Manipal &
MLSC, Manipal University on 11th April 09 at Manipal on “Mesenchymal stem
cells”.
(xxxix)Gupta PK, Ghosh Debapriya, Radhika CR, Kumar K.V. Satish, Balaraju S,
Venkataramana NK, Rao Suja, Murugod U, Totey Satish. Use of Autologous
adult human mesenchymal stem cells in neurological disorder. Presented at 7th
Annual meeting of International Society for Stem Cell Research at Barcelona,
Spain from 08th
July to 11th
July 09.
18
19. (xl) Prasanna Jyothi S, S Shipa Rano, Vasandan Anoop B, Gopalakrishnan Divya,
Gupta Pawan Kumar. Distinct Mechanisms of immune modulation by human
bone marrow and wharton’s jelly derived mesenchymal stem cells on priming
with pro-inflammatory cytokines. 7th
Annual meeting of International Society for
Stem Cell Research at Barcelona, Spain from 08th
July to 11th
July 09.
(xli) Datta Indrani, Tattikotta Surendra Mohan, Mohanty Lipsa, Gupta Pawan
Kumar. Directed differentiation of HUES9 and HUES7 human embryonic stem
cells to dopaminergic cells. 7th
Annual meeting of International Society for Stem
Cell Research at Barcelona, Spain from 08th
July to 11th
July 09.
(xlii) Delivered Invited Guest Lecture titled “Advances in Mesenchymal Stem cell
Research in understanding CNS disorders” at CME on Trends in Neuroscience
Research An Eye Opener – 2009 at Dept of Physiology, Kasturba Medical
College, Manipal on 14th
Nov 09.
(xliii) Delivered Invited Guest lecture titled “ Haemovigilance – Practical issues” at 50th
Annual Conference on Indian Society of Haematology and Transfusion Medicine
at All India Institute of Medical Science, New Delhi on 19th
Nov 09.
(xliv) Delivered Guest Lecture titled “Mesenchymal stem cells – basic research &
clinical applications” at Berlin – Brandenburg Centre of Regenerative Medicine,
Berlin, Germany on 03rd
Nov 09.
(xlv) The 8th
Translational Research Educational Program Organized by The
Foundation for Biomedical Research and Innovation (FBRI), Tokyo on 06 Mar
2010. Topic: Use of Allogeneic Bone Marrow Derived Mesenchymal Stem cells
in Critical Limb Ischemia : Report on Phase I/II clinical trial in India
(xlvi) Delivered Invited Guest Lecture titled “ Research, Innovation &
Commercialization in Regenerative Medcine” at University of Colombo during
CME of Postgraduate students of Medicine on 28th
April 2011, Sri Lanka.
(xlvii) Delivered Guest Lecture titled “A Randomized, Double Blind, Placebo
Controlled, Single Dose, Phase I/II Study Using Adult Bone Marrow Derived
Allogeneic Mesenchymal Stem Cells In Patients With Critical Limb Ischemia” at
Wake Forest University, School of Medicine, Institute of Regenerative Medicine,
Winston – Salem, NC, USA on 26th
Aug 2011 and also presented the above paper
at MSC 2011 meeting at Cleveland, USA on 23rd
Aug 2011.
(xlviii) Delivered Guest Lecture titled “A Phase I/II study assessing the safety and
efficacy of intravenous ex vivo cultured adult allogeneic mesenchymal stem cells
in patients with ST Elevated Acute Myocardial Infarction (STEMI)” at 18th
Annual International Society of Cellular Therapy Meeting. On June 5-8, 2012. at
Seattle, WA USA.
19
20. (xlix) Delivered talk titled “A Randomized, Double Blind, Multicentric, Placebo
Controlled, Phase –II Study Assessing The Safety And Efficacy Of Intra-articular
Ex-vivo Cultured Adult Allogeneic Mesenchymal Stem Cells In Patients With
Osteoarthritis Of Knee” at the Mesenchymal stem cells 2013 meeting at
Cleveland, USA on 20 Aug 2013.
(l) Delivered talk titled “First Potential Stem Cell Drug in India for Patients with
Buerger’s Disease” at 6th World Congress on Preventive and Regenerative
Medicine conference"(WCPRM) 2013 on 16th
Nov 2013.
(li) Delivered talk titled “First Potential Stem Cell Drug in India for Patients with
Buerger’s Disease” at Indian Pharmacological society 46th annual conference on
16th Dec 2013.
(lii) Delivered talk titled “Pluripotent stem cells and its application” at 127th
Anniversary International Medical Congress of Sri Lanka Medical Association at
Colombo on 14th July 2014
(liii) Delivered talk titled “Hematopoietic stem cells and its application” at 127th
Anniversary International Medical Congress of Sri Lanka Medical Association at
Colombo on 15th July 2014
(liv) Delivered talk titled “Clinical Applications of stem cells” at 127th Anniversary
International Medical Congress of Sri Lanka Medical Association at Colombo on
16th July 2014.
(lv) Delivered talk titled “First Potential Stem Cell Drug in India for Patients with
Buerger’s Disease – A Case Study” at 127th Anniversary International Medical
Congress of Sri Lanka Medical Association at Colombo on 17th
July 2014.
(lvi) Delivered talk titled “Perspective on Clinical application of Stem Cells &
Therapeutic Potential of Stempeucel® for Patients with CLI due to Buerger’s
disease” at Indo – Danish Symposium, SCTIMST, Trivandrum on 08th
Feb 2015.
(lvii) Delivered talk titled “Clinical trials using stem cells” in the CME on “Stem Cells:
Hope and Scope” at Kasturba Medical College, Mangaluru, Manipal University
on 14th
Mar 2015.
(lviii) Delivered talk titled “Therapeutic potential of bone marrow derived allogenic
mesenchymal stem cells (stempeucel®) in Critical Limb Ischemia due to
Buerger’s disease” at Malaysia Association of Cell Therapy annual mini
symposium on 28th
Mar 2015 at Kula Lumpur, Malaysia.
(lix) Delivered talk titled “Therapeutic Potential of Bone Marrow-derived, Allogeneic
Mesenchymal Stromal Cells (Stempeucel®) for Patients with Critical Limb
Ischemia due to Buerger’s disease” at Mesenchymal Stem Cells meeting at
Cleveland, US on 17th
Aug 2015.
20
21. (lx) Delivered talk titled “Stem cells and its applications” at Oxford University,
Bangalore.
(lxi) Delivered talk titled “Overcoming challenges in treating Critical Limb Ischemia
with Mesenchymal Stromal Cells” at Bio Korea on 30th
Mar 2016.
(lxii) Delivered talk titled “A Randomized, Double Blind, Placebo Controlled, Phase 2
Study Assessing The Safety & Efficacy Of Stempeucel® (Bone Marrow-derived,
Allogeneic Mesenchymal Stromal Cells) In Patients With Osteoarthritis Of Knee
joint” at Malaysia Association of Cell Therapy Annual Symposium at Kuala
Lumpur, Malaysia on 02nd
April 2016 and also presented at STEM 2016 meeting
at MIRM, Bangalore on 16th
Feb 2016.
15. Awards received:
(i) Travel Scholarship Award at International Society of Laboratory Haematology,
2007 at Miami, Florida, USA on 8th
to 11th
May 2007 for the paper titled
“Spectrum of genetic defects in severe von Willebrand disease type 3 in
Indians”.
(ii) Travel fellowship award at International Society of Thrombosis & Haemostatis,
2005, Annual conference at Sydney, for the paper titled: “Gene conversions are
a common cause of von Willebrand Disease”.
(iii) Travel fellowship award at International Society of Stem Cell Research and
therapy, 2009. Annual conference at Barcelona, Spain for paper titled “Use of
Autologous mesenchymal stem cells for neurological disorders”.
(iv) Travel fellowship award at International Society of Stem Cell Research and
therapy, 2010. Annual conference at San Francisco, USA (from 15th
Jun to 19th
Jun 2010) for paper titled “An Open labelled pilot study using autologous stem
cell transplantation using human bone marrow derived mesenchymal stem
cells in Parkinson’s disease”.
16. Experience in Molecular work & Stem cells:
(i) Molecular diagnosis of von Willebrand Disease in Hamburg, Germany.
(ii) Molecular diagnosis in microbiological disease in Real time PCR.
(iii) Molecular diagnosis of Thrombophilia.
21
22. (iv) Molecular diagnosis of CML.
(v) Culture and expansion of Multi potent Adult Progenitor cells.
(vi) Isolation of Multi lineage progenitor cells from Umbilical cord blood.
(vii) Isolation and upscaling of mesenchymal stem cells from different sources
22
