Complete overview of the transitional oral appliance for sleep apnea the ApneaRx. This is an excellent device to 1. manage jaw position in order to decrease CPAP pressure 2 support the mandible to reduce cpap mask leaks 3 evaluate a patients response to jaw position relative to their Snoring or OSA

1. Introducing ApneaRx
Easy to Use Titratable Transition
Oral Appliance
Designed for Non Sleep Dentists

2. Important!!
ApneaRx = More Sleep Apnea Patients

3. How Does MAD Work?
Opens Airway!!
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3

4. 2006 AASM - Practice Guidelines
Oral appliances (OAs) are indicated for use in
patients
• with mild to moderate OSA who, prefer them to
continuous positive airway pressure (CPAP)
therapy,
• who do not respond to, are not appropriate
candidates for, who fail, treatment attempts with
CPAP.

5. Key Product Features
Advance Design – No screws, springs, rubber
bands to adjust and maintain jaw position.
Comfort-Fit Micro-Fit
Thermally molded to 1mm jaw advancement
patient’s mouth in 10 for more comfort and
minutes. clinical efficacy.
V-Flow Posi-Lock
Assures full air flow and Jaw position can be
device alignment set and relocked at
for stability & better fit. anytime.

6. Competition
Apnea Guard
MATRx
Somnoguard AP Snore Silencer

7. ApneaRx
Key Clinical Applications
• Reduce Snoring
• Predictor Device for Custom Oral Appliance
Therapy
• Combo Therapy T with CPAP
• Stand Alone Usage

8. Preliminary Study Results
• Dr. Patrick Wolcott – San Diego
• 18 patients with f/u sleep studies
• Results
• Average base line AHI = 17
• Average AHI after using ApneaRx = 9.5
T
• Average reduction in AHI is 44%
• 4 of 10 patients > 50% reduction in AHI.
• ApneaRx is too big for about 40% of patients -
especially women.

9. Reimbursement
• Prefabricated Oral Appliance - HCPCS E0485
A prefabricated device is defined as one that may be trimmed,
bent, molded (with or without heat), or otherwise modified for use by
a specific patient i.e., custom fitted. An OAOSA that is assembled
from prefabricated components is considered prefabricated. Any
device that does not meet the definition of a custom-fabricated item
is considered prefabricated.
• Custom Fabricated Oral Appliance – HCPCS E0486
A custom-fabricated OAOSA is defined as one that is individually
made for a specific patient (no other patient would be able to use
this item) starting with basic materials. It involves substantial work
to produce, usually by a specialized lab. It may involve the
incorporation of some prefabricated components. It involves more
than trimming, bending, or making other modifications to a
substantially prefabricated item.

10. Who Reimburses for E0485
• Payers:
• Aetna
• Anthem
• BCBS
• Cigna
• United Health
• Amount = $300+
• Patient needs to confirm
policy guidelines for
each plan and each
insurer.

11. Why ApneaRx for Sleep Apnea
Sleep MDs DMEs Sleep Dentists
• Predictor • New Revenue • Repairs
• Alternative Treatment • Combo with CPAP • Trial for Custom OA
Other Applications
• Non Compliant CPAP Patients
• Frequent Travelers
• Patients without Insurance or with High Deductible Plans.
• Snorers
Remember
• No Risk Guarantee – 30 day refund & 90 days replacement

12. Sleep Apnea - New Clinical
Algorithm with ApneaRx
Sleep Test
Mild to Moderate OSA < 30 Severe OSA > 30
ApneaRx (as Predictor)
Sleep Study
CPAP
OSA < 30 OSA >30
Custom Oral Appliance Compliant Non-compliant
• ApneaRx for Travel • Combo Therapy
• ApneaRx
Sleep Study • Custom OA

13. Why ApneaRx for Snoring
• More Patients for Sleep Centers – Feeder
Program
• Targets - General Dentists/PCPs
• New Revenue
• Existing Patients
• Helps Solve Huge Sleep Problem
• For General Dentists – Feeds Custom OA
Program (if Sleep Center has one)

14. Snorer - Clinical Algorithm
Snorer
OSA Screen
Negative Positive
• ApneaRx • Sleep Test
OSA < 30 OSA > 30
• CPAP • CPAP
• ApneaRx
• Custom OA
Non-compliant
Compliant • Combo Therapy
• ApneaRx for Travel • ApneaRx
• Custom OA

15. General Dentists – Potential $’s
# Patients New
Adult per Profit $’s
Patients Week
Patients Visits 3,000 60
Patients (50%) 1,500 30
Snorers (30%) 500 10 *$57,300
Snorers with 165 3.3 **$60,500
Sleep Apnea (33%)
* 60% of patients = 300 @ $191 = $57,300
** 70% of custom OA candidates with mild to moderate OSA - 120 @ $500= $60,000

16. Sleep Tests Add Up !!
Each Sleep & Wellness
Rep 50
(Sleep Tests) (Sleep Tests)
100% of Potential
1 conversion 165 8,250
10 conversions 1,650 82,500
25% of Potential
1 conversion 41 2,050
10 conversions 412 20,600

17. Summary - Target Customers
Key to Success – Mutual Benefit
• General Dentists and PCPs – Start with
snoring application More $$
• Partner DMEs - More referrals & f/u sleep
studies More $$
• Sleep Clinicians - As predictor device -
more f/u sleep studies More $$

18. Need to Know
• ApneaRx should be used on large jawed
patients
• If not adjusted properly EVA insert will
dislodge
• New ApneaRx by Summer
• Smaller standard size
• Easier to adjust
• Bonded – will not dislodge
• Better Retention

19. Need to Know
• Words - Use “transition” or “predictor” OA
vs OA
• Personally in-service 1st use of the device
• Keep ApneaRx in your hands until
customer can adjust it.
• Do not leave ApneaRx with customer until
they can demonstrate how to adjust it.
• Remember - No Risk Guarantee

20. Sales Support

21. General Sales Sheet

22. Patient Sales Sheet

23. Sleep Diagnostic & Therapy Article

24. Practice Builder

25. Table Top Display

26. Mailer - eBlast

27. ApneaRx.com Website
• www.apnearx.com
• Fitting Video
• Testimonials
• Sales Sheets
• OA Clinical Studies
• FAQS

28. Questions

29. Pat Maley Randy Clare
Apnea Sciences CareFusion
617 835 3757 949 466 6574
pmaley@apneasciences.com randy.clare@carefusion.com