Translational medicine is about reserach which links both preclinical and clinical trials

1. TRANSLATIONAL
MEDICINE
: Dr Aswathy Menon

2. Overview
CONCEPT OF TRANSLATIONAL MEDICINE,
PHASES , NEEDS AND IMPORTANCE OF
TRANSLATIONAL MEDICINE ,
OBJECTIVES, STEPS,TYPES , EXAMPLES AND
CHALLENGES OF TRANSLATIONAL MEDICINE

3. HISTORY

4. RESEARCH
HEALTH
RESEARCH
OR MEDICAL
RESEACH
BASIC OR PRECLINICAL
RESEARCH
CLINICAL RESEARCH
EXPERIMENTAL MEDICINE OR
BIOMEDICAL RESEARCH

5. TRANSLATING FINDINGS
1
KNOWLEDGE AND
UNDERSATNDING
2
ACTION AND
INTERVENTION
<

6. CLINICAL
RESEARCH
TRANSLATIONAL
RESEARCH
BASIC
RESEARCH

7. BASIC RESEARCH
In vitro
In vivo
In silico
We ask question ?
how

8. TYPES OF
STUDIES
IN-VITRO IN -VIVO IN -SILICO

9. CLINICAL RESEARCH Does it have effect ?
Does it improve
symptoms ?
Does an intervention
prevent disease ?

10. BENCH TO BED SIDE

11. TRANSLATIONAL RESEARCH
How can we use our knowledge
to cure disease and connect
basic research and clinical
research
We use – HUMAN SAMPLES
PATIENTS
HEALTHY
VOULENTIEERS

12. ■ TO DISCOVER - ORIGIN
PATHWAY & MECHANISM OF DISEASE AND BIOMARKERS
■ TO DEVELOP - NEW DIAGNOSTIC & THERAPEUTIC MEASURES
■ TO DISCOVER – NEW DRUG WITH IN SHORT DURATION
■ TO DESIGN - PHARMACOKINETIC AND TOXICOKINETIC STUDIES
OBJECTIVES

13. NEED ?
COST -EFFECTIVE TIME
RESEARCH IDEAS
INCORPORATED
IN TO CLINICS
BRIDGING THE
GAP
NEW
DIAGNOSTIC AND
THERAPEUTIC
TOOLS

14. CONCEPT
■ PREVENTIVE
■ DIAGNOSTIC
■ THERAPEUTIC

15. PHASES

16. STEPS
BASIC
RESEARCH
T1 -PHASE
1 TRIAL
T2-PHASE 2 &3
T3-PHASE 4
DISSEMINATION OF RESEARCH
IMPLEMENTATION OF RESEARCH
T4- OUTCOME
RESEARCH

17. EXAMPLES

18. ANTIMICROBIAL
RESISTANCE
THEME
CANCER THEME
CARDIOVASCULAR
THEME

19. DEMENTIA AND
NEURODEGENERATIVE
THEME
COGNITIVE
AND
GENOMICS
GASTRO
INTESTINAL
THEME

20. MENTAL
HEALTH
ENDOCRINOLOGY
AND
METABOLISUM
NEUROSCIENCE
THEME
NUTRITION
DIET AND
LIFE STYLE

21. POPULATION
SCIENCE
TRANSPLANT
AND
REGENERATIVE
MEDICINE
WOMEN HEALTH
AND PAEDIATRICS

25. CHALLENGES/TRANSLATIONAL BLOCKS
■ PRE CLINICAL STUDY IS MUST
■ DATA VARIABILITY & BIAS
■ MISSING DATA & INCLUSION AND EXCLUSION CRITERIA
■ ANIMAL DEATHS
■ AVAILABILITY OF FUNDING , CONFLICT OF INTEREST, REGULATORY BURDEN,
RIGHT TO PRIVACY
■ FRAGMENTED INFRA STRUCTURE, SHORTAGE OF QUALIFIED INVESTIGATORS &
WILLING PARTICIPANTS
■ LACK OF PUBLIC SUPPORT

26. REFERENCE
■ The continuum of translation research in genomic medicine: how can we
accelerate the appropriate integration of human genome discoveries into
health care and disease prevention? Muin J. Khoury, MD, PhD, Marta Gwinn,
MD, MPH, Paula W. Yoon, PhD, MPH, Nicole Dowling, PhD, Cynthia A. Moore,
MD, PhD, and Linda Bradley, PhD
■ POST GRADUATE PHARMACOLOGY
■ Bruce H. LITTMAN∗, Linda DI MARIO†, Mario PLEBANI‡ and Francesco M.
MARINCOLA§ ∗Global Translational Medicine, Pfizer Global Research and
Development, Pfizer Inc, New London, CT 23240, U.S.A., †Clinical Strategies,
BioAdvance, Philadelphia, PA 19104, U.S.A., ‡Laboratory Medicine
Department, University Hospital of Padova, Padova, Italy, and §Immunogenet

27. THANK YOU