No-regret learning is a collection of tools designed to give provable performance guarantees in the absence of any statistical or other assumptions on the data (!), and thus stands in stark contrast to most classical modeling approaches. With origins stretching back to the 1950s, the field has yielded a rich body of algorithms and analyses that covers problems ranging from forecasting from expert advice to online convex optimization. Dr. Kearns will survey the field, with special emphasis on applications to quantitative finance problems, including portfolio construction and inventory risk.