The document discusses 5 major problems faced by Oracle E-Business Suite administrators: 1) Ignoring security risks like using default passwords and not enabling features like hashing and auditing; 2) Failing to reduce the EBS data footprint by periodic purging; 3) Dependency on browsers supporting NPAPI plug-ins which are being phased out; 4) Failing to regularly install security updates and patches which can lead to issues; 5) Common missteps like manually editing auto-config files and using the 'hotpatch' option incorrectly.