The talk focused on "Nutritional Interventions in Autoimmune Diseases (AD)", the subject being hotly debated and fast progressions taking place. Established guidelines incorporate these findings increasingly as the topic gains prominence in disease prevention/ modification and are of interest to any healthcare professional.
The presentation includes:
- A brief overview of the prevalence and cost of AD,
- Problems with current treatment approaches,
- A short overview of the genesis of AD
- The role our environment (incl. our food) plays
- Finally a solution suggesting an oligoantigenic elimination diet
- A "Paleo Autoimmune Protocol" is proposed and some clinical practice insights are given.
Thanks very much to everybody who attended the talk. I am looking forward to receive your questions, concerns and feedback!
John Quackenbush, PhD, a professor of biostatistics and computational biology talks about genomics, the human genome and what the study of it means for our understanding of diseases and, specifically, cancer.
A Rare International Dialogue (Friday, May 10, 2019) Applying Digital Technologies to Rare Disease Diagnosis, Care, Treatment, and Cure - Michael Liebman, IPQ Analytics, LLC
Role of ayurveda in the management of cancerDr Joban
this pdf contains a compilation of various presentations and papers to get an idea how Ayurved -Panchakarma- Herbal treatment can be helpful to combat Cancer, chemotherapy, Radio therapy hazards, antitumor activities of plants, role of Ayurveda diet in prevention of cancer
Seminário Nacional do Benzeno (5 e 6 dez/12) - Derivação de Limites de Exposição Ocupacional para Substâncias Carcinogênicas e
Mutagênicas - Experiências Internacionais e Nacional
Gene therapy is a new tool used in combating different diseases. The majority of gene therapy clinical trials are focused on cancer and so it was no coincidence that the first commercial treatment in 2003 was for neoplasia. Currently there are a wide variety of gene therapy proposals involving a large number of anti tumour molecular mechanisms that will conceivably pave the way for highly effective a treatment options. Despite the significant advances that how been made in gene therapy in the fight against cancer, its efficacy,safety and commercial availability are still limited. Ms. Chetana D. Patil | Ms. Siddhi Chavan | Mr. Ritesh Kadam "Gene Therapy for Cancer Treatment" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-5 , August 2019, URL: https://www.ijtsrd.com/papers/ijtsrd26537.pdfPaper URL: https://www.ijtsrd.com/pharmacy/biotechnology-/26537/gene-therapy-for-cancer-treatment/ms-chetana-d-patil
Shaklee Vivix slows aging at the cellular level. Plug in and learn the story behind scenes. To hear the live presentation contact Cindy McAsey 888-272-6701/
John Quackenbush, PhD, a professor of biostatistics and computational biology talks about genomics, the human genome and what the study of it means for our understanding of diseases and, specifically, cancer.
A Rare International Dialogue (Friday, May 10, 2019) Applying Digital Technologies to Rare Disease Diagnosis, Care, Treatment, and Cure - Michael Liebman, IPQ Analytics, LLC
Role of ayurveda in the management of cancerDr Joban
this pdf contains a compilation of various presentations and papers to get an idea how Ayurved -Panchakarma- Herbal treatment can be helpful to combat Cancer, chemotherapy, Radio therapy hazards, antitumor activities of plants, role of Ayurveda diet in prevention of cancer
Seminário Nacional do Benzeno (5 e 6 dez/12) - Derivação de Limites de Exposição Ocupacional para Substâncias Carcinogênicas e
Mutagênicas - Experiências Internacionais e Nacional
Gene therapy is a new tool used in combating different diseases. The majority of gene therapy clinical trials are focused on cancer and so it was no coincidence that the first commercial treatment in 2003 was for neoplasia. Currently there are a wide variety of gene therapy proposals involving a large number of anti tumour molecular mechanisms that will conceivably pave the way for highly effective a treatment options. Despite the significant advances that how been made in gene therapy in the fight against cancer, its efficacy,safety and commercial availability are still limited. Ms. Chetana D. Patil | Ms. Siddhi Chavan | Mr. Ritesh Kadam "Gene Therapy for Cancer Treatment" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-5 , August 2019, URL: https://www.ijtsrd.com/papers/ijtsrd26537.pdfPaper URL: https://www.ijtsrd.com/pharmacy/biotechnology-/26537/gene-therapy-for-cancer-treatment/ms-chetana-d-patil
Shaklee Vivix slows aging at the cellular level. Plug in and learn the story behind scenes. To hear the live presentation contact Cindy McAsey 888-272-6701/
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Are There Any Natural Remedies To Treat Syphilis.pdf
Think food nutritional interventions in autoimmune diseases
1. Nutritional Interventions in
Autoimmune Diseases
Academic talk, Christiaan Barnard Memorial Hospital
24th January 2013
Thursday 24 January 2013 1
2. GOOD MORNING. Who’s talking
PAST PRESENT
Universities of Helping people to get
Düsseldorf and Cape off drugs rather than
Town supplying them
2nd pharmacist in Working independently
Europe’s biggest mail in own practice -
order pharmacy: No disclosures
Docmorris
Grey Healthcare/ Not favouring any
working for particular Supplement®
Big Food and Pharma
Pfizer Animal Health
EUAfME
Christoph Lenz
Pharmacist & nutritional coach
2
Thursday 24 January 2013 2
3. DEFINITION of Autoimmune Disease
The basic definition of an autoimmune disease is a disorder caused by an
autoimmune response, i.e., an immune response directed to something in
the body of the patient. Since autoimmunity can affect any organ in the body
(including brain, skin, kidney, lungs, liver, heart, and thyroid), the clinical
expression of the disease depends upon the site affected. In our system of highly
compartmentalized medicine, patients with autoimmune disease may be cared
for by physicians in virtually any medical specialty.
The presence of an autoimmune response is signaled by the appearance of
autoantibody in the circulation, and so the demonstration of a particular
autoantibody usually constitutes the path to recognize an autoimmune
disease.
Diagnosis done by specialists
Many patients are not or mis-diagnosed
Thursday 24 January 2013 3
4. PREVALENCE of Autoimmune Diseases
According to the American Autoimmune Related
Diseases Association (AARDA), it is estimated that
50 million Americans have an autoimmune
disease. (Cancer 9 million, CVD 22 million)
Autoimmune diseases affect women 75
percent more often than men. The cause of
this sex bias is not fully known.
Most autoimmune diseases are relatively rare, and
most are not fatal. They never appear on the
public "radar screen" as a serious health
problem requiring more attention and more
funding. Taken together, however, the autoimmune
diseases occupy the third or fourth place in
the list of prevalent diseases in the US.
Thursday 24 January 2013 4
5. PROGRESS in Health Care
$100M
$10M Moore’s Law
$1M
$100k
$10k
$1k
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012
Cost of 1GB memory in the 80s ~ $1 000 000
.
Analysis of 1 Megabase DNA costs <10 Cents in 2012
National Human Genome Research Institute
genome.gov/sequencingcosts
Thursday 24 January 2013 5
6. COSTS of Autoimmune Diseases
NIH estimates annual direct health care costs
Runner
Autoimmune diseases > $100 billionup
Cancer $57 billion
Best
price
Heart and stroke $200 billion
AARDA, NCAPG; The Cost Burden of Autoimmune Disease; 2011
Thursday 24 January 2013 6
7. REPERCUSSIONS of AD
“... patients face a lifetime
of illness and treatment.
They often endure
debilitating symptoms,
loss of organ function,
reduced productivity at
work, and high medical
expenses.”
NIH, Autoimmune Diseases Coordinating Committee, Progress in
Autoimmune Diseases Research, Report to Congress 2005
Thursday 24 January 2013 7
8. CAUSAL Factors of Autoimmune Disease
Genetic
Pollutants/ toxins
Infectious agents
Microbiome
Environmental triggers
Food
Polyautoimmunity and familial autoimmunity are common
What is the red thread?
Thursday 24 January 2013 8
9. Autoimmune diseases
>33% already linked to “Leaky gut”
Disease Organ/ tissue involved Source
Allergies various Liu et al. Acta Paediatrica 2005, 94, 386-93
Ankyllosing Spondylitis Skeletal system Vaile JH et al. J. Rheumatol. 1999, 26, 128-35
Aphthous stomatitis Mouth Veloso FT et al. Hepatogastroenterol. 1987, 34, 36-7
Asthma Lungs Benard A et al. J. Allergy Clin. Immun. 1996, 97, 1173-8
Autism Nerve/ brain White JF. Exp. Bio. Med. 2003, 228, 639-49
Autoimmun gastritis GIT Greenwood DL et al. Eur. J. Pediatr. 2008, 167, 917-25
Autoimmune hepatitis Liver Terjung B Clin. Rev. Allergy Immunol. 2009, 36, 40-51
Morbus Behçet Small blood vessels Fresko I et al. Ann. Rheum. Dis. 2001, 60, 65-6
Celiac disease Gut Schulzke JD et al. Pediatric. Res. 1998,43, 435-41
Chronic fatigue syndrome (CFS) Multiple Maes M et al. Neuroendol. Lett. 2007, 28, 739-44
Crohn’s disease Gut Caradonna L et al. J. Endotoxin. Res. 2000, 6, 205-14
Depression Brain, gut Maes M et al. Neuroendocrinol. Lett. 2008, 29, 117-24
Morbus Duhring (dermatitis herpet.) Skin (men > women) Kieffer M et al. Br J. Dermatol. 1983, 108, 673-8
Diabetes Typ I Pancreas Sapone A et al. Diabetes 2006, 55, 1443-49
Eczema Skin Hamilton et al. Q. J. Med. 1985, 56, 559-67
Gut migraine children Gut Amery WK et al. Cephalalgia 1989, 9, 227-9
“Dietary Mechanisms of Autoimmunity”, Loren Cordain, Ph. D
Thursday 24 January 2013 9
10. Autoimmune diseases
>33% already linked to “Leaky gut”
Disease Organ/ tissue involved Source
Hashimoto’s thyroiditis Thyroid Sasso FC et al. Gut 2004, 53, 1878-80
IgG Nephropathy Kidney Rostoker G et al. Nephron. 1993, 63, 286-290.
Intrahep. cholestasis of pregn. Liver/ gallbladder/ GIT Reyes H et al. Hepatology 2006, 43, 715-22
Juvenile Arthritis Collagen/ joints Picco P et al. Clin. Exp. Rheumatol. 2000, 18, 773-8
Lupus erythematosis Multiple Apperloo HZ et al. Epidemiol. Infect. 1994, 112, 367-73
Multiple sclerosis Nerve/ brain Yacyshyn B et al. Dig. Dis. Sci. 1996, 41, 2493-98
Pemphigus-diseases Skin Kieffer M et al. Br J. Dermatol. 1983, 108, 673-8
Primary biiary cirrhosis Liver/ gallbladder/ GIT Di Leo V et al. Eur. J. Gastro. Hepatol. 2003, 15, 967-73
Psoriasis Skin Hamilton et al. Q. J. Med. 1985, 56, 559-67
Rheumatoid arthritis Joints Smith MD et al. J. Rheumatol. 1985, 12, 299-305
Rosacea Skin Kendall SN. Exp. Dermatol. 2004, 29, 297-99
Schizophrenia Brain Wood NC et al. Br. J. Psychiatry 1987, 150, 853-6
Skleroderma Connective tissue Caserta L et al. Rheumatol. Int. 2003, 23, 226-30
Sclerosing Cholangitis Liver Terjung B Clin. Rev. Allergy Immunol. 2009, 36, 40-51
Spontanous abortion Uterus Friebe A Int. J. Biochem. Cell Biol. 2008, 40, 2348-52
Ulcerative colitis Gut Caradonna L et al. J. Endotoxin Res. 2000, 6, 205-14
Urticaria Skin Buhner S et al. Allergy 2004, 59, 1118-23
Uveitis Eye Benitez JM et al. Eye 2000, 14(pt 3A), 340-3
“Dietary Mechanisms of Autoimmunity”, Loren Cordain, Ph. D
Thursday 24 January 2013 10
11. Diet shapes gut microbial
community structure and function,
Diet shapes gut microbial community
and the microbiota adapts in
structure and function, and the microbiota
adapts in ways promote nutrient
ways that that promote nutrient
processing; the ability of the
processing; the ability of the microbiota to
process a given to process athe nutrient and
microbiota diet affects given diet
energetic value nutrient andThe microbiota
affects the of that diet. energetic
value of that diet. The
and immune systems co-evolve: malnutrition
microbiota and immune
affects the innate and adaptive immune
systems as well co-evolve:
systems as the microbiota.
malnutrition affects the innate and
adaptive immune systems as well
as the microbiota.
Kau etal; Nature; 474(7351): 327–336, 2011
Thursday 24 January 2013 11
12. A disrupted microbiome has been
associated with a lengthening list of problems:
obesity and its opposite, malnutrition;
diabetes (both type-1 and type-2);
atherosclerosis and heart disease;
multiple sclerosis; asthma and eczema;
liver disease; numerous diseases of
the intestines, including bowel cancer; and
autism.
Thursday 24 January 2013 12
13. SIDE EFFECTIVE Treatments for AD
Resulting in bad compliance
Patients are often referred to as “psycho somatic”
Thursday 24 January 2013 13
14. EFFECTIVENESS of DM Drugs in MS
“The outcomes so far obtained in the prespecified primary
analysis suggest a lack of delay in disease progression for
all disease modifying treatments” Boggild M, Palace J, Barton P, Ben-Shlomo Y, Bregenzer T,
Dobson C, Gray R., Multiple sclerosis risk sharing scheme:
“Disease progression was worse than that in the untreated two year results of clinical cohort study with historical
control group” comparator. BMJ. 2009, 9 pages.
“... it took untreated persons 14.4 years with a 95%
Veugelers PJ, Fisk JD, Brown MG, Stadnyk K, Sketris IS,
Murray TJ, Bhan V., Disease progression among multiple confidence interval of 12-17.4 years whereas the treated
sclerosis patients before and during a disease-modifying patients were estimated to reach EDSS 6 at 18.6 years with
drug program: a longitudinal population-based evaluation.
Mult Scler. 2009 Nov;15(11):1286-94. a 95% confidence interval of 15.9-21.9 years.”
“... 38.6% of untreated patients (those on betaseron
for less than 10% of the time) reached EDSS 6 within
the past 16 years. This compares with 35.7% of Ebers, G, Traboulsee A, Li D, et al., Analysis of
treated patients (those on betaseron for over 80% of clinical outcomes according to original treatment
groups 16 years after the pivotal IFNB-1b trial. J
the time) reaching EDSS 6 in the same time interval.” Neurol Neurosurg Psychiatry, in press, 6 pages.
$25.000 = Disease Modifying drug therapy/a
Not taking adverse drug events into consideration
Thursday 24 January 2013 14
15. MTX Actions and REACTIONS
Mode of Action
Methotrexate is an antimetabolite that interferes with DNA synthesis,
repair, and cellular replication by inhibiting DHF reductase.
Tissues with high proliferation rate are affected: neoplasms, bone
marrow, fetal cells, buccal and intestinal mucosa, urinary bladder
Common ADE
Rash, nausea, vomiting, thrombocytopenia, dizziness
Severe ADE
Pericardial effusion, thromboembolic disorder, epidermal necrolysis, GI
hemorrhage, stomatitis, aplastic anemia, malignant lymphoma,
myelosuppression, liver cirrhosis/ fibrosis, hepatitis, liver failure,
encephalopathy, neurotoxicity, seizure, nephrotoxicity, interstitial
pneumonia, infectious diseases
Complimentary drugs are prescribed to counteract ADE
Are we really surprised if the liver fails?
Thursday 24 January 2013 15
16. Treat the PATIENT, not a Disease
- Many chronic diseases are very responsive to dietary and
lifestyle interventions
- Agents of the industry teach about drugs to persuade
doctors to use the newest and most expensive
medications - even in the absence of scientific evidence
that they are any better than older, less costly ones.
- In fact, many significantly less expensive.therapeutically
effective and
non-drug interventions are
Relman As. Your doctor’s drug problem. The New York Times, November 18, 2003
How much can we change a patients environment?
Healthcare spendings need to invest in prevention an patient education
Thursday 24 January 2013 16
17. INFLUENCE the Factors You Can
Genetics and epigenetics
Most AD “run in families”
Infections and Microbiota
i.e. Epstein Barr Virus, chlamydia
pneumoniae, measals, rubella
Geography
Risk increases with distance from the equator
Sunlight, UV, vitamin D
Dr. Terry Wahls Trauma
Operations, psychological stress,
environmental toxins, heavy metals, smoking
Vaccinations
Which adjuvants were used?
Food
Certain triggers compromise gut
integrity.
Poser C. M. Clin. Neurol. Neurosurg. 2006, 108, 227-33
Hafler D.A. et al. Nat. Rev. Immunol. 2005, 5, 83-91
Willer C. et al. Proc. natl. Acad. Sci. 2003, 100, 12877-12882
Thursday 24 January 2013 17
18. PATHOGENESIS of Autoimmune Disease
Epithelial cells are targeted
Leaky gut
One of the hottest research topics currently
Thursday 24 January 2013 18
20. 1. Miscommunication between innate and adaptive
immunity
2. Molecular mimicry or bystander effects alone don’t
entirely explain the complex events involved.
Continuous stimulation by environmental triggers is
necessary to perpetuate the process. ... the
autoimmune response can theoretically be stopped
and perhaps reversed if the interplay between genes
predisposing individuals to the development of
autoimmunity and environmental triggers is prevented
or eliminated.
3. In addition to genetic predisposition and exposure to
triggering nonself-antigens, the loss of the protective
function of mucosal barriers that interact with the
environment (mainly the gastrointestinal and lung
mucosa) is necessary for autoimmunity to develop.
Thursday 24 January 2013 20
21. Are Autoimmune Diseases HEREDITARY?
MYTH Autoimmune diseases are hereditary and a patients genetic and
metabolic makeup far outweighs the role of environmental
factors in disease
TRUTH One major environmental factor that modifies gene expression is the
individual’s nutritional status. Both macro- and micronutrients can
influence the expression of genes, the translation of the genetic message
into active protein, and that protein’s ultimate influence in controlling
metabolic function.
Desiere F. Towards a systems biology understanding of human health: interplay between genotype,
environment and nutrition. Biotechnol Annu Rev. 2004; 10:51-84
Masson LF, McNeill G, Avenell A. Genetic variations and the lipid response to dietary intervention: a
systematic review. Am J Clin Nutr. 2003;77:1098-111.
Thursday 24 January 2013 21
22. PRIMAL body
"we are the heirs of inherited characteristics accrued over
millions of years; the vast majority of our biochemistry and
physiology is tuned to life conditions that existed before the
advent of agriculture some 10,000 years ago.
Genetically our bodies are virtually the same as they were at
the end of the Paleolithic era some 20,000 years ago."
Today’s environment
Food, stress, toxins, allergens, pollution
Eaton SB, Eaton SB 3rd, Konner MJ (1997). "Paleolithic nutrition revisited: a twelve-year retrospective on its nature and implications"
European Journal of Clinical Nutrition 51 (4): 207–16
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24. FUNCTIONAL Roles of the GUT
Digestion/ absorption
Intestinal permeability
Gut microbiota
Immune Regulation
Nervous System
“Gut Feelings “
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25. Rx. 5R FRAMEWORK
Targeted, individualised intervention
aiming to normalise critical gut functions
–Remove
–Replace
–ReInoculate
–Repair
–Re-Balance
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26. REMOVE...
... refers to the elimination of factors such as:
-Pathogenic microflora (e.g., bacteria, fungi, parasites)
-Foods to which an individual is sensitive, intolerant, or allergic
-Environmental stressors such as pollutants
-Stress
Clinical approaches may include:
-Oligoantigenic elimination diet - Paleo Autoimmune Protocol
-Botanical antimicrobials or bacteriostatic/bacteriocidal phytonutrients
-Antibiotics/Antifungals
-Stress management
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27. REPLACE...
... refers to the replacement of factors that may be inadequate or lacking.
Clinical approaches may include:
-Digestive enzymes (HCL, pancreatic enzymes, ox bile)
-Intrinsic secretions
-Soluble fiber to support transit and general GI function
-Vit D, B vitamins, selenium, magnesium, zinc, antioxidants, ...
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28. REINOCULATE...
... refers to the reintroduction of desirable GI microflora (prebiotics,
probiotics, FMT) to obtain a more desirable balance to the intestinal milieu
Clinical approaches may include:
-Bifidobacteria strains
-Lactobacillus strains
-Saccharomyces Boulardii
-Inulin or fructooligosaccharides (FOS)
-Soluble fibers
-Arabinogalactans
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29. REPAIR...
... refers to providing nutritional support for healing of the GI mucosa
Clinical approaches may include:
-zinc, phosphatidylcholine repair: Glutamine, arginine, vitamins A D C,
Nutrients important for GI
-polysaccharides protectants: phosphatidylcholine, plantain,
Mucosal secretion
-lactoferrin, lactoperoxidase, whey immunoglobulins) function (e.g.,
Support for GALT (Gut-Associated Lymphoid Tissue)
-Antioxidants known to function in the GI (e.g. catechins)
-E, carotenoids, ...) to support healing (e.g., pantothenic acid, vitamin
Micronutrients shown
-Nutritional anti-inflammatories (e.g., curcumin, EPA and DHA)
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30. REBALANCE...
... refers to providing support for restorative processes in a patients life
Clinical approaches may include:
-‘Scheduling’ and relaxation
-Mindful eating and better choices for ‘difficult’ situations
-Heart Rate Variability, BioFeedback
-Yoga, meditation, Tai Chi, prayer, breathing or other centering practices
-Psychotherapy, life counceling
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31. Olive oil. Virgin coco. Unleaded. Diesel. Super.
Which type are you?
Nutrition should meat your needs ;)
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32. ALTERNATIVE Treatments
Ozone therapy Acupuncture
Bioresonance therapy Walking
Tai Chi/ Qi Gong Low dose naltrexone
sub blabla
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33. Further Reading
http://www.ncbi.nlm.nih.gov/pubmed/ The Autoimmune Epidemic,
by D. Jackson Nakazawa
http://www.functionalmedicine.org
Minding My Mitochondria, Terry Wahls
http://www.thepaleomom.com The Paleo Solution, by Robb Wolf
http://robbwolf.com/ Good Calories, Bad Calories, by Gary Taubes
http://whole9life.com/ Why we got fat, by Gary Taubes
Food Rules: An Eater’s Manual,
http://www.westonaprice.org by Michael Pollan
http://thinkfood.co.za/ Food, Inc. (documentary film)
The Future of Food (documentary film)
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34. Thank you for your attention.
Any QUESTIONS?
... feedback is welcome!
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