Jeanne Safer grew up with a difficult brother named Steven who had developmental issues and struggled in school. This led Jeanne to experience premature maturity, survivor's guilt, a compulsion to achieve, and a fear of contagion from her brother's conditions. As an adult, Jeanne became a psychotherapist and wrote books about living with a damaged sibling and the "Caliban syndrome" she experienced as a result of having Steven as her brother.