The document discusses how emerging technologies will disrupt philanthropy over the next 25 years. It outlines several disruptive technologies like artificial intelligence, blockchain, and the internet of things that will change the way organizations operate and create new social problems to address. It also discusses challenges like algorithmic bias, filter bubbles dividing public discourse, challenges to civil society from closing civic spaces, and implications of trends like automation threatening jobs, urbanization shifting power to cities, and an aging population. The document advocates for grantmakers and charities to start preparing for these changes by exploring new opportunities to achieve their missions, understanding the impacts on their organizations, and helping shape debates around future challenges.