Sir Isaac Newton (1642-1727) was a seminal English scientist and mathematician known for his groundbreaking contributions to physics, mathematics, and optics, including the laws of motion and universal gravitation. His works, particularly 'Principia Mathematica' and 'Opticks,' laid the foundations for modern science, including the creation of calculus. Newton is often regarded as the greatest scientist of all time, with a legacy that significantly advanced our understanding of the natural world.