This paper compares different local search algorithms within the three stage optimal memetic exploration (3SOME) sequential structure. 3SOME normally uses steepest descent local search (S) as the third stage, but this is replaced with Rosenbrock and Powell algorithms to test the importance of the structure. Results show the meme activation rates vary slightly but performance is generally similar, indicating the sequential structure is important alongside the specific local search methods. The paper concludes algorithm structure is as important as the individual components and future automatic design should consider both.