This randomized controlled clinical trial investigated the effects of photodynamic therapy (PDT) as an adjunct to scaling and root planing (SRP) for the treatment of class II furcation defects. 37 subjects with class II furcation defects were randomly assigned to receive either PDT plus SRP (test group, n=16) or non-activated laser plus SRP (control group, n=21). Clinical parameters, microbiological samples, and cytokine levels were evaluated at baseline and 3 and 6 months. While both groups showed improvements in clinical parameters from baseline to 6 months, there were no significant differences between groups. However, PDT resulted in greater reductions in specific periodontal pathogens and lower cytokine levels associated with inflammation
application of nanoparticles in the early diagnosis and treatment of tumors: ...LucyPi1
Abstract
Objective: Malignant tumors pose a serious threat to human life and health. Despite recent developments in
modern medical techniques, the early diagnosis and treatment of tumors remain difficult due to their asymptomatic
nature in the early stages of disease and the limitations in current clinical diagnostic methods. Advancements in
nanotechnology, particularly in the area of multi-functional diagnostic nanomaterials, can help effectively resolve
present inadequacies via concurrently achieving early diagnosis, image-guided intervention, and real-time
monitoring and treatment of tumors. The development of nanomaterials and nanotechnology may also aid in the
area of anti-cancer drug development by improving the safety and side-effect profile, as well as by enhancing the
targeted specificity of the drugs, which are two of the long-standing challenges in Western medicine. The progress
in the field of nanomaterials has also uncovered novel approaches for the clinical application of traditional Chinese
medicine because the combination of traditional Chinese medicine components with nanoparticles overcomes
various drawbacks, including poor water solubility, low bioavailability, and short half-life, of the former. Moreover,
nanoparticles also enhance the biological effectiveness and targeted specificity of these medicines. In this review,
we discuss the application of nanoparticles in the early diagnosis and treatment of tumors, through modern and
traditional medicine.
Personalized Therapies for OA: Can Biomarkers Get Us There?OARSI
This document discusses the potential for using biomarkers to enable personalized therapies for osteoarthritis (OA). It defines key terms like personalized therapies, biomarkers, phenotypes, and endotypes. The presenter argues that biomarkers could help identify the right treatment for individual OA patients by enabling prognostic and predictive enrichment in clinical trials. However, moving biomarkers from discovery to clinical validation and use involves a long process including assay development, testing biological links and hypotheses, and conducting randomized controlled trials. Several studies are highlighted that have discovered potential new biomarkers and are beginning to test biological links and hypotheses regarding how biomarkers may reflect disease processes and response to treatments.
1. The document analyzes changes in treatment strategies for metastatic colorectal cancer in Germany between 2005-2007 based on data from large population surveys. It finds that results from clinical trials showing increased effectiveness of new drugs like oxaliplatin and irinotecan were quickly implemented in clinical practice.
2. The treatment objective of achieving secondary resection of metastases after chemotherapy increased significantly from 18% to 27% during this period, as clinical trials showed biologicals improving resectability rates. Biologicals were used more often when secondary resection was the goal compared to other objectives.
3. A multivariate analysis found that while many factors influenced treatment choices, the objective of secondary resection and patient age had the most significant impact
This document discusses chronic prostatitis and the potential role of clinical pharmacists in improving treatment. It notes that current drug therapies for conditions like chronic prostatitis often have high relapse rates. The document suggests that clinical pharmacists could help develop new drug delivery systems to better target treatment to the prostate and improve outcomes. It argues pharmaceutical companies may underestimate the need for innovative delivery methods to more effectively treat chronic prostatitis and other conditions with current therapies.
The document describes a retrospective analysis of interventions made by a clinical pharmacist (CP) during their participation in the medical intensive care unit (ICU) team of a university hospital over a period of 9 months. The CP reviewed medications for 321 patients and made a total of 307 interventions in 95 patients. The interventions were categorized as: pharmacotherapy adjustments for kidney function (147 interventions), therapeutic drug monitoring (57), administration through a nasogastric tube (30), drug-drug interactions (22), and unspecified (51). The majority of interventions (203) were related to antimicrobial drugs. ICU physicians completely accepted 80.2% of the CP's suggestions. The analysis found that inclusion of a CP contributed to more individualized pharmacological
Gabapentin reduced acute pain after mastectomy and decreased the incidence of chronic pain in two studies. A single dose of gabapentin was ineffective for reducing thoracotomy pain when an epidural was also used. Regional anesthesia and intravenous lidocaine reduced chronic pain incidence after mastectomy or thoracotomy in several studies. Ketamine and intercostal cryoanalgesia did not reduce chronic pain. Total intravenous anesthesia may reduce post-thoracotomy pain in one study.
Ginger compress therapy was studied to understand its effects on people with osteoarthritis. 10 participants received daily ginger compresses for a week. The compresses created:
1) A meditative state of relaxation and stillness of thoughts, allowing positive reconsideration of life's challenges.
2) A feeling of constant, penetrating warmth that spread throughout the body and increased relaxation.
3) A positive change in outlook, with past memories viewed with fresh insight and acceptance, renewing interest in the world.
application of nanoparticles in the early diagnosis and treatment of tumors: ...LucyPi1
Abstract
Objective: Malignant tumors pose a serious threat to human life and health. Despite recent developments in
modern medical techniques, the early diagnosis and treatment of tumors remain difficult due to their asymptomatic
nature in the early stages of disease and the limitations in current clinical diagnostic methods. Advancements in
nanotechnology, particularly in the area of multi-functional diagnostic nanomaterials, can help effectively resolve
present inadequacies via concurrently achieving early diagnosis, image-guided intervention, and real-time
monitoring and treatment of tumors. The development of nanomaterials and nanotechnology may also aid in the
area of anti-cancer drug development by improving the safety and side-effect profile, as well as by enhancing the
targeted specificity of the drugs, which are two of the long-standing challenges in Western medicine. The progress
in the field of nanomaterials has also uncovered novel approaches for the clinical application of traditional Chinese
medicine because the combination of traditional Chinese medicine components with nanoparticles overcomes
various drawbacks, including poor water solubility, low bioavailability, and short half-life, of the former. Moreover,
nanoparticles also enhance the biological effectiveness and targeted specificity of these medicines. In this review,
we discuss the application of nanoparticles in the early diagnosis and treatment of tumors, through modern and
traditional medicine.
Personalized Therapies for OA: Can Biomarkers Get Us There?OARSI
This document discusses the potential for using biomarkers to enable personalized therapies for osteoarthritis (OA). It defines key terms like personalized therapies, biomarkers, phenotypes, and endotypes. The presenter argues that biomarkers could help identify the right treatment for individual OA patients by enabling prognostic and predictive enrichment in clinical trials. However, moving biomarkers from discovery to clinical validation and use involves a long process including assay development, testing biological links and hypotheses, and conducting randomized controlled trials. Several studies are highlighted that have discovered potential new biomarkers and are beginning to test biological links and hypotheses regarding how biomarkers may reflect disease processes and response to treatments.
1. The document analyzes changes in treatment strategies for metastatic colorectal cancer in Germany between 2005-2007 based on data from large population surveys. It finds that results from clinical trials showing increased effectiveness of new drugs like oxaliplatin and irinotecan were quickly implemented in clinical practice.
2. The treatment objective of achieving secondary resection of metastases after chemotherapy increased significantly from 18% to 27% during this period, as clinical trials showed biologicals improving resectability rates. Biologicals were used more often when secondary resection was the goal compared to other objectives.
3. A multivariate analysis found that while many factors influenced treatment choices, the objective of secondary resection and patient age had the most significant impact
This document discusses chronic prostatitis and the potential role of clinical pharmacists in improving treatment. It notes that current drug therapies for conditions like chronic prostatitis often have high relapse rates. The document suggests that clinical pharmacists could help develop new drug delivery systems to better target treatment to the prostate and improve outcomes. It argues pharmaceutical companies may underestimate the need for innovative delivery methods to more effectively treat chronic prostatitis and other conditions with current therapies.
The document describes a retrospective analysis of interventions made by a clinical pharmacist (CP) during their participation in the medical intensive care unit (ICU) team of a university hospital over a period of 9 months. The CP reviewed medications for 321 patients and made a total of 307 interventions in 95 patients. The interventions were categorized as: pharmacotherapy adjustments for kidney function (147 interventions), therapeutic drug monitoring (57), administration through a nasogastric tube (30), drug-drug interactions (22), and unspecified (51). The majority of interventions (203) were related to antimicrobial drugs. ICU physicians completely accepted 80.2% of the CP's suggestions. The analysis found that inclusion of a CP contributed to more individualized pharmacological
Gabapentin reduced acute pain after mastectomy and decreased the incidence of chronic pain in two studies. A single dose of gabapentin was ineffective for reducing thoracotomy pain when an epidural was also used. Regional anesthesia and intravenous lidocaine reduced chronic pain incidence after mastectomy or thoracotomy in several studies. Ketamine and intercostal cryoanalgesia did not reduce chronic pain. Total intravenous anesthesia may reduce post-thoracotomy pain in one study.
Ginger compress therapy was studied to understand its effects on people with osteoarthritis. 10 participants received daily ginger compresses for a week. The compresses created:
1) A meditative state of relaxation and stillness of thoughts, allowing positive reconsideration of life's challenges.
2) A feeling of constant, penetrating warmth that spread throughout the body and increased relaxation.
3) A positive change in outlook, with past memories viewed with fresh insight and acceptance, renewing interest in the world.
1) The document describes a study on the effects of low level laser therapy (LLLT) on human appendicular bone fracture healing.
2) A total of 40 patients with fractures were divided into a laser group (20 patients) who received LLLT, and a control group (20 patients) who did not.
3) Results showed the laser group had better clinical outcomes like less pain and earlier movement, and radiological outcomes like faster/greater callus formation and bone density increases.
4) The study concluded LLLT can accelerate bone union and enhance healing when used as an adjunct to standard fracture treatment.
The emergence of multidrug-resistant TB (MDR-TB) against first-line drugs and extensively drug resistant TB (XDRTB)
due to misuse of second-line anti tubercular drugs (ATDs) is a further concern. Recommended treatment involves
long term and multiple drug therapy with severe side effects. Due to this concern nanoparticle-based systems
have significant potential for treatment and prevention of tuberculosis (TB) to overcome the need to administer
ATDs at high and frequent doses, would assist in improving patient compliance and circumvent hepatotoxic ity
and/or nephrotoxicity/ocular toxicity/ototoxicity associated with the prevalent first-line chemotherapy.
Nanostructured delivery systems constitute a wide range of systems varying from liposomes, micelles, micro- and
nanoemulsions, to polymeric nanoparticles (PNPs ) and solid lipid nanoparticles (SLNs). Pulmonary administration
of inhaled nanoparticles in the form of dry powder inhalers offer particular advantages for pulmonary administration
of anti tubercular drugs (ATDs). Present review comprehensively about different approaches of nanobased
drug delivery, devises and techniques for pulmonary delivery of nanoparticle encapsulated ATD.
1) A double-blind randomized controlled study evaluated a wearable pulsed radiofrequency electromagnetic field (PRFE) device for treating plantar fasciitis.
2) 70 subjects with plantar fasciitis were randomly assigned either an active or placebo PRFE device to wear overnight for 7 days.
3) The active PRFE device showed a progressive 40% decline in morning heel pain over 7 days, significantly greater than the 7% decline in the control group, demonstrating PRFE's potential as a drug-free noninvasive treatment for reducing plantar fasciitis pain.
EFFICACY OF TRANSDERMAL PATCHES IN THE MANAGEMENT OF POSTOPERATIVE PAIN: AN O...DrHeena tiwari
This study compared the efficacy of a single 100mg transdermal diclofenac patch to a single 75mg intramuscular diclofenac injection for managing postoperative pain in 30 patients who underwent maxillofacial surgery. Patients were randomly assigned to receive either the patch or injection. Pain levels were assessed at various timepoints using a visual analogue scale. The results found that the patch provided longer lasting analgesia (15 hours on average) compared to the injection (9 hours), and fewer patients in the patch group required rescue pain medication. No local complications occurred with the patch. The study concluded that a single diclofenac patch was more effective than intramuscular diclofenac for managing immediate postoperative pain
Postoperative pain is a major concern for patients and doctors. This preliminary study investigated the use of a wearable pulsed radiofrequency energy (PRFE) device to control postoperative pain in 18 women undergoing breast augmentation surgery. Patients were randomly assigned to receive either an active or placebo PRFE device. Those receiving the active device experienced significantly lower pain scores over 7 days as measured by a visual analog scale. They also took fewer narcotic pain medications than those receiving the placebo. The findings suggest PRFE therapy is an effective non-drug method for controlling postoperative pain.
Au Psy492 M6 A3 Ssal Smith Marcanne Research Skillsmarcanne
The document summarizes a student's self-appraisal of their learning related to research skills. It describes a quasi-experimental study the student designed to examine the effects of patient-controlled analgesia versus conventional pain management after surgery. The study has threats to validity due to the non-random assignment of patients to treatment groups and lack of control for factors like pain tolerance and medical history. The student recommends adding pretesting and placebo treatments to help control for these threats.
Abstract— Occupational exposure to formaldehyde (FA) has been related to adverse outcomes. However, a short period of exposure has never been assessed in terms of evaluating DNA. This study conducted on 39 medical students exposed to FA in a university laboratory of human anatomy and aimed to analyze the relationship between FA exposure and DNA damage. The buccal micronucleus cytome assay (BMCyt) was used to evaluate the students at four time points: before FA exposure, after four months of FA exposure, after eight months of FA exposure and after three months without FA exposure (remission period). Pyknotic cells, karyolitic cells, karyorrhetic cells, condensed chromatin, binucleated cells, basal cells differentiated cells, micronucleated cells and nuclear bridges were enumerated. This study shows that FA exposure caused genomic instability in all periods and the remission period was not sufficient to reverse all damage. Thus, prolonged occupational exposure to FA not only causes DNA damage but a shorter exposure period can have the same effect.
Medical Conferences, Pharma Conferences, Engineering Conferences, Science Conferences, Manufacturing Conferences, Social Science Conferences, Business Conferences, Scientific Conferences Malaysia, Thailand, Singapore, Hong Kong, Dubai, Turkey 2014 2015 2016
Global Research & Development Services (GRDS) is a leading academic event organizer, publishing Open Access Journals and conducting several professionally organized international conferences all over the globe annually. GRDS aims to disseminate knowledge and innovation with the help of its International Conferences and open access publications. GRDS International conferences are world-class events which provide a meaningful platform for researchers, students, academicians, institutions, entrepreneurs, industries and practitioners to create, share and disseminate knowledge and innovation and to develop long-lasting network and collaboration.
GRDS is a blend of Open Access Publications and world-wide International Conferences and Academic events. The prime mission of GRDS is to make continuous efforts in transforming the lives of people around the world through education, application of research and innovative ideas.
Global Research & Development Services (GRDS) is also active in the field of Research Funding, Research Consultancy, Training and Workshops along with International Conferences and Open Access Publications.
International Conferences 2014 – 2015
Malaysia Conferences, Thailand Conferences, Singapore Conferences, Hong Kong Conferences, Dubai Conferences, Turkey Conferences, Conference Listing, Conference Alerts
This study evaluated the effectiveness of a regenerating matrix therapy (RGTA/CACIPLIQ20) for treating chronic wounds. 16 patients with 22 chronic wounds received twice weekly applications of CACIPLIQ20 for up to 4 weeks. Wound size and pain were measured before, during, and after treatment. The results showed that CACIPLIQ20 significantly reduced wound size by 15-18% and pain levels by 60-70% within 4 weeks. Patient and clinician satisfaction with the treatment also remained high. The therapy may help facilitate wound healing and alleviate wound-related pain.
This study investigated the efficacy of pulsed electromagnetic field therapy (PEMF) in reducing delayed onset muscle soreness (DOMS) in marathon runners. A double-blind randomized controlled trial assigned 133 marathon runners to either an active PEMF device or placebo device to use for 20 minutes, 4 times per day for 5 days after a marathon. The primary outcome was thigh pain assessed using a visual analog scale during squats. Subjects using the active PEMF device had significantly lower pain scores compared to the placebo group, indicating PEMF reduced DOMS in marathon runners.
This randomized, double-blind pilot study examined the effects of pulsed electromagnetic field (PEMF) therapy on pain in patients with early knee osteoarthritis. 34 patients were randomly assigned to either an active PEMF device group (n=15) or a sham device group (n=19). The PEMF signal was designed to modulate the calcium/calmodulin dependent nitric oxide signaling pathway. Results showed a 50% reduction in pain scores from baseline in the active group starting on day 1 and persisting to day 42, while no significant reduction was seen in the sham group. The overall decrease in pain was nearly threefold greater in the active group. The rapid and sustained pain relief seen with PEMF therapy suggests it may reduce inflammation
An overview of drug regulatory system in South AfricaSriramNagarajan17
This study compared the use of opioid and non-opioid analgesics for cancer pain treatment in 100 patients over 8 months. The study found that opioids were the most commonly prescribed drug for cancer pain (89% of patients), followed by non-opioids (11% of patients). The minor side effects of opioids occurred in 85% of patients, while major side effects occurred in 15% of patients. Therefore, the study concluded that opioids were effective for treating severe cancer pain with relatively few adverse effects.
This study evaluated the impact of new graphic health warnings on cigarette packs in Malaysia compared to the existing text-only warnings. 140 adult male smokers viewed either mockups of the graphic warnings or packs with the text warnings and completed surveys before and after. Exposure to the graphic warnings resulted in increased awareness of smoking risks, stronger responses to the warnings, and greater interest in quitting smoking compared to the text warnings. The findings suggest the graphic warnings will enhance smokers' knowledge of health effects and positively impact quit intentions when implemented in Malaysia.
1. This study analyzed direct and indirect costs of ankle sprain patients based on their Foot and Ankle Outcome Scores (FAOS) at 1 month post-injury. 2. Patients were categorized into low, moderate, and good recovery groups based on their FAOS scores. 3. Results found no significant differences in direct healthcare costs between groups. However, indirect costs from missed work, assistance, etc. were highest for the low recovery group and lowest for the good recovery group.
(1) A systematic literature review identified strategies to reduce delays in diagnosis and management of inflammatory arthritis.
(2) Community screening strategies and education of primary care providers aimed to improve early identification and referral of at-risk patients.
(3) Standardized referral forms and early arthritis clinics helped prioritize rheumatology assessments.
Full Mouth Disinfection Versus Scaling and Root Planing per Quadrant in Agg...DR. ZERAIBI N
This document summarizes a systematic review comparing the effectiveness of full-mouth disinfection (FMD) versus scaling and root planing by quadrant (SRP-Q) for treating aggressive periodontitis. The review included two studies that found:
1) FMD resulted in slightly greater reductions in probing depth and clinical attachment loss compared to SRP-Q in some cases, but differences were minor.
2) One study found a statistically significant difference in bleeding on probing favoring FMD, while the other found no significant differences between the treatments.
3) Due to limitations and heterogeneity between studies, the review could not draw clear conclusions about the comparative effectiveness of FMD versus SRP-Q for treating aggressive periodontitis
1) The document describes a study on the effects of low level laser therapy (LLLT) on human appendicular bone fracture healing.
2) A total of 40 patients with fractures were divided into a laser group (20 patients) who received LLLT, and a control group (20 patients) who did not.
3) Results showed the laser group had better clinical outcomes like less pain and earlier movement, and radiological outcomes like faster/greater callus formation and bone density increases.
4) The study concluded LLLT can accelerate bone union and enhance healing when used as an adjunct to standard fracture treatment.
The emergence of multidrug-resistant TB (MDR-TB) against first-line drugs and extensively drug resistant TB (XDRTB)
due to misuse of second-line anti tubercular drugs (ATDs) is a further concern. Recommended treatment involves
long term and multiple drug therapy with severe side effects. Due to this concern nanoparticle-based systems
have significant potential for treatment and prevention of tuberculosis (TB) to overcome the need to administer
ATDs at high and frequent doses, would assist in improving patient compliance and circumvent hepatotoxic ity
and/or nephrotoxicity/ocular toxicity/ototoxicity associated with the prevalent first-line chemotherapy.
Nanostructured delivery systems constitute a wide range of systems varying from liposomes, micelles, micro- and
nanoemulsions, to polymeric nanoparticles (PNPs ) and solid lipid nanoparticles (SLNs). Pulmonary administration
of inhaled nanoparticles in the form of dry powder inhalers offer particular advantages for pulmonary administration
of anti tubercular drugs (ATDs). Present review comprehensively about different approaches of nanobased
drug delivery, devises and techniques for pulmonary delivery of nanoparticle encapsulated ATD.
1) A double-blind randomized controlled study evaluated a wearable pulsed radiofrequency electromagnetic field (PRFE) device for treating plantar fasciitis.
2) 70 subjects with plantar fasciitis were randomly assigned either an active or placebo PRFE device to wear overnight for 7 days.
3) The active PRFE device showed a progressive 40% decline in morning heel pain over 7 days, significantly greater than the 7% decline in the control group, demonstrating PRFE's potential as a drug-free noninvasive treatment for reducing plantar fasciitis pain.
EFFICACY OF TRANSDERMAL PATCHES IN THE MANAGEMENT OF POSTOPERATIVE PAIN: AN O...DrHeena tiwari
This study compared the efficacy of a single 100mg transdermal diclofenac patch to a single 75mg intramuscular diclofenac injection for managing postoperative pain in 30 patients who underwent maxillofacial surgery. Patients were randomly assigned to receive either the patch or injection. Pain levels were assessed at various timepoints using a visual analogue scale. The results found that the patch provided longer lasting analgesia (15 hours on average) compared to the injection (9 hours), and fewer patients in the patch group required rescue pain medication. No local complications occurred with the patch. The study concluded that a single diclofenac patch was more effective than intramuscular diclofenac for managing immediate postoperative pain
Postoperative pain is a major concern for patients and doctors. This preliminary study investigated the use of a wearable pulsed radiofrequency energy (PRFE) device to control postoperative pain in 18 women undergoing breast augmentation surgery. Patients were randomly assigned to receive either an active or placebo PRFE device. Those receiving the active device experienced significantly lower pain scores over 7 days as measured by a visual analog scale. They also took fewer narcotic pain medications than those receiving the placebo. The findings suggest PRFE therapy is an effective non-drug method for controlling postoperative pain.
Au Psy492 M6 A3 Ssal Smith Marcanne Research Skillsmarcanne
The document summarizes a student's self-appraisal of their learning related to research skills. It describes a quasi-experimental study the student designed to examine the effects of patient-controlled analgesia versus conventional pain management after surgery. The study has threats to validity due to the non-random assignment of patients to treatment groups and lack of control for factors like pain tolerance and medical history. The student recommends adding pretesting and placebo treatments to help control for these threats.
Abstract— Occupational exposure to formaldehyde (FA) has been related to adverse outcomes. However, a short period of exposure has never been assessed in terms of evaluating DNA. This study conducted on 39 medical students exposed to FA in a university laboratory of human anatomy and aimed to analyze the relationship between FA exposure and DNA damage. The buccal micronucleus cytome assay (BMCyt) was used to evaluate the students at four time points: before FA exposure, after four months of FA exposure, after eight months of FA exposure and after three months without FA exposure (remission period). Pyknotic cells, karyolitic cells, karyorrhetic cells, condensed chromatin, binucleated cells, basal cells differentiated cells, micronucleated cells and nuclear bridges were enumerated. This study shows that FA exposure caused genomic instability in all periods and the remission period was not sufficient to reverse all damage. Thus, prolonged occupational exposure to FA not only causes DNA damage but a shorter exposure period can have the same effect.
Medical Conferences, Pharma Conferences, Engineering Conferences, Science Conferences, Manufacturing Conferences, Social Science Conferences, Business Conferences, Scientific Conferences Malaysia, Thailand, Singapore, Hong Kong, Dubai, Turkey 2014 2015 2016
Global Research & Development Services (GRDS) is a leading academic event organizer, publishing Open Access Journals and conducting several professionally organized international conferences all over the globe annually. GRDS aims to disseminate knowledge and innovation with the help of its International Conferences and open access publications. GRDS International conferences are world-class events which provide a meaningful platform for researchers, students, academicians, institutions, entrepreneurs, industries and practitioners to create, share and disseminate knowledge and innovation and to develop long-lasting network and collaboration.
GRDS is a blend of Open Access Publications and world-wide International Conferences and Academic events. The prime mission of GRDS is to make continuous efforts in transforming the lives of people around the world through education, application of research and innovative ideas.
Global Research & Development Services (GRDS) is also active in the field of Research Funding, Research Consultancy, Training and Workshops along with International Conferences and Open Access Publications.
International Conferences 2014 – 2015
Malaysia Conferences, Thailand Conferences, Singapore Conferences, Hong Kong Conferences, Dubai Conferences, Turkey Conferences, Conference Listing, Conference Alerts
This study evaluated the effectiveness of a regenerating matrix therapy (RGTA/CACIPLIQ20) for treating chronic wounds. 16 patients with 22 chronic wounds received twice weekly applications of CACIPLIQ20 for up to 4 weeks. Wound size and pain were measured before, during, and after treatment. The results showed that CACIPLIQ20 significantly reduced wound size by 15-18% and pain levels by 60-70% within 4 weeks. Patient and clinician satisfaction with the treatment also remained high. The therapy may help facilitate wound healing and alleviate wound-related pain.
This study investigated the efficacy of pulsed electromagnetic field therapy (PEMF) in reducing delayed onset muscle soreness (DOMS) in marathon runners. A double-blind randomized controlled trial assigned 133 marathon runners to either an active PEMF device or placebo device to use for 20 minutes, 4 times per day for 5 days after a marathon. The primary outcome was thigh pain assessed using a visual analog scale during squats. Subjects using the active PEMF device had significantly lower pain scores compared to the placebo group, indicating PEMF reduced DOMS in marathon runners.
This randomized, double-blind pilot study examined the effects of pulsed electromagnetic field (PEMF) therapy on pain in patients with early knee osteoarthritis. 34 patients were randomly assigned to either an active PEMF device group (n=15) or a sham device group (n=19). The PEMF signal was designed to modulate the calcium/calmodulin dependent nitric oxide signaling pathway. Results showed a 50% reduction in pain scores from baseline in the active group starting on day 1 and persisting to day 42, while no significant reduction was seen in the sham group. The overall decrease in pain was nearly threefold greater in the active group. The rapid and sustained pain relief seen with PEMF therapy suggests it may reduce inflammation
An overview of drug regulatory system in South AfricaSriramNagarajan17
This study compared the use of opioid and non-opioid analgesics for cancer pain treatment in 100 patients over 8 months. The study found that opioids were the most commonly prescribed drug for cancer pain (89% of patients), followed by non-opioids (11% of patients). The minor side effects of opioids occurred in 85% of patients, while major side effects occurred in 15% of patients. Therefore, the study concluded that opioids were effective for treating severe cancer pain with relatively few adverse effects.
This study evaluated the impact of new graphic health warnings on cigarette packs in Malaysia compared to the existing text-only warnings. 140 adult male smokers viewed either mockups of the graphic warnings or packs with the text warnings and completed surveys before and after. Exposure to the graphic warnings resulted in increased awareness of smoking risks, stronger responses to the warnings, and greater interest in quitting smoking compared to the text warnings. The findings suggest the graphic warnings will enhance smokers' knowledge of health effects and positively impact quit intentions when implemented in Malaysia.
1. This study analyzed direct and indirect costs of ankle sprain patients based on their Foot and Ankle Outcome Scores (FAOS) at 1 month post-injury. 2. Patients were categorized into low, moderate, and good recovery groups based on their FAOS scores. 3. Results found no significant differences in direct healthcare costs between groups. However, indirect costs from missed work, assistance, etc. were highest for the low recovery group and lowest for the good recovery group.
(1) A systematic literature review identified strategies to reduce delays in diagnosis and management of inflammatory arthritis.
(2) Community screening strategies and education of primary care providers aimed to improve early identification and referral of at-risk patients.
(3) Standardized referral forms and early arthritis clinics helped prioritize rheumatology assessments.
Full Mouth Disinfection Versus Scaling and Root Planing per Quadrant in Agg...DR. ZERAIBI N
This document summarizes a systematic review comparing the effectiveness of full-mouth disinfection (FMD) versus scaling and root planing by quadrant (SRP-Q) for treating aggressive periodontitis. The review included two studies that found:
1) FMD resulted in slightly greater reductions in probing depth and clinical attachment loss compared to SRP-Q in some cases, but differences were minor.
2) One study found a statistically significant difference in bleeding on probing favoring FMD, while the other found no significant differences between the treatments.
3) Due to limitations and heterogeneity between studies, the review could not draw clear conclusions about the comparative effectiveness of FMD versus SRP-Q for treating aggressive periodontitis
The use of low level laser in periodontal diseaseJan Tunér
This study investigated the effects of low-level laser therapy (LLLT) as an adjunct to scaling and root planing (SRP) for the treatment of chronic periodontitis. 16 patients received SRP on one side of their mouth and SRP plus 10 sessions of LLLT on the other side. Sites treated with SRP plus LLLT showed greater reductions in pocket depth at 5 weeks and 3 months compared to SRP alone. SRP plus LLLT sites also had a statistically significant increase in mean radiographic bone density from baseline to 12 months. However, LLLT did not significantly affect gingival index, plaque index, or levels of the inflammatory marker IL-1β in gingival crevicular fluid
This study evaluated the effects of nonsurgical periodontal therapy alone or in combination with diode laser therapy on clinical parameters and tumor necrosis factor-alpha (TNF-α) levels in patients with chronic periodontitis. 22 patients received scaling and root planing either with or without subsequent laser pocket decontamination. Clinical measurements and TNF-α levels from gingival crevicular fluid were assessed at baseline and 1 week, 1 month, and 3 months post-treatment. Both treatments significantly improved clinical parameters from baseline to 3 months. Laser therapy further reduced TNF-α levels at 1 month compared to nonsurgical therapy alone, but this effect was not sustained at 3 months. The study concluded that laser therapy provides additional short-term
The FMD protocol has evolved over the past 20 years with several modifications proposed:
1. Removal of CHX from the original protocol, creating the full-mouth scaling approach (FMS).
2. Extension of hygiene methods and increasing the duration of post-treatment CHX use.
3. Replacement of CHX with other antiseptics like amine fluoride/stannous fluoride or povidone-iodine.
4. Supplementation with antibiotics like azithromycin or amoxicillin/metronidazole.
5. Addition of probiotics like Lactobacillus reuteri tablets.
Studies have found some modifications provide additional
This document discusses apical periodontitis (AP), an inflammatory disease caused by polymicrobial infection of the root canal. It provides context on the historical use of intracanal medicaments and discusses the present status and future directions of intracanal medicaments. Specifically, it notes that intracanal medicaments are still useful for confirming initial signs of healing or symptom resolution before completing treatment, but that their efficacy is unpredictable in the presence of debris. The document also discusses limitations of classifying AP as a binary disease and the need for a more thorough classification that considers characteristics of bone loss severity.
This document summarizes several scientific studies that have evaluated the use of antimicrobial photodynamic therapy (aPDT) as an adjunct to non-surgical periodontal and peri-implant treatment over the past 15+ years. The studies demonstrated the following:
1) A randomized controlled clinical trial found that non-surgical treatment of mild-moderate peri-implantitis with aPDT or local drug delivery were both effective in reducing inflammation over 12 months.
2) Another randomized trial found that repeated aPDT treatments over 2 weeks as an adjunct to cleaning led to greater reductions in pocket depth and bleeding compared to cleaning alone when measured at 6 months.
3) A third study
Photodynamic therapy in treatment of oral lichen planus: Dr AparnaAparna Srivastava
PHOTODYNAMIC THERAPY is also known as Photoradiation therapy,
Phototherapy,
Photochemotherapy.
Photodynamic therapy (PDT) is a treatment that uses a drug, called a photosensitizer or photosensitizing agent.
Photosensitizers are exposed to a specific wavelength of light, photoactivation causes the formation of singlet oxygen, which produces peroxidative reactions that can cause cell damage and death.
Extracorporeal shockwave therapy (ESWT) has analgesic and anti-inflammatory effects. With the evolu- tion and comprehension of its biological and physical mechanisms, the application of ESWT on other pathologies has also been studied, especially in musculoskeletal diseases. Recently, studies on animal models have shown its angiogenic capacity and a higher rate of local re-epithelization. These small stud- ies led to few trials using low-energy, radial ESWT to treat problematic chronic skin ulcers. Skin ulcers have diverse etiologies, ranging from pressure ulcers, burns, venous or arterial ulcers, and even diabetic ulcers. Their treatment is usually a challenge, due to the long-term treatment and high costs.
Short-term improvement of clinical parameters and microbial diversity in peri...M ALTAMIMI
Indocyanine green-based antimicrobial photodynamic therapy as an adjunct to scaling and root planing resulted in significantly greater reductions in periodontal pocket depth and clinical attachment loss compared to scaling and root planing alone. Microbiome analysis showed a reduction in key periodontal pathogens like Porphyromonas gingivalis and favorable shifts in the subgingival microbiome with the addition of photodynamic therapy. The combination treatment led to significantly greater short-term clinical improvements and microbial changes associated with periodontal healing.
This document describes a study that used Six Sigma methodology to compare two antibiotic therapies - Ceftriaxone and a combination of Cefazolin and Clindamycin - for patients undergoing surgery for bone cancer at a university hospital in Naples, Italy. The study used the Six Sigma DMAIC process to analyze length of hospital stay and infection rates for patients receiving each antibiotic. The results showed that patients receiving Ceftriaxone had a lower length of hospital stay (over 40% lower) and fewer complications and infections compared to those receiving the antibiotic combination. Therefore, using Ceftriaxone allows for better patient outcomes with reduced hospitalization costs. The study demonstrates the value of using Six Sigma as a tool for health
Local Treatment in Periodontal pocket Journal PresentationDr. B.V.Parvathy
It was a systematic review and network meta-analysis aimed to evaluate the efficacy of adjunctive locally delivered antimicrobials, compared to sub gingival instrumentation alone or plus a placebo, on changes in probing pocket depth (PPD) and clinical attachment level (CAL), in patients with residual pockets during supportive periodontal care.
This document describes a study examining the clinical results of bilateral pallidothalamic tractotomy (PTT) using MR-guided focused ultrasound for 10 patients with Parkinson's disease followed for 1 year after the second PTT procedure. The main findings were:
1) Total UPDRS scores off medication were reduced by 52% compared to baseline on medication scores. Significant reductions were seen in tremor, distal rigidity, and distal hypobradykinesia.
2) Dyskinesias, dystonia, and sleep disorders improved in most patients. Pain was reduced by 89% on average.
3) Mean daily levodopa intake reduced from 690 mg to 110 mg.
4) L
The 2016 World Health Organization classification of tumors of the central nervous system broadly employs genetic alterations for diagnostic criteria including isocitrate dehydrogenase-1 (IDH1) mutation or IDH2 mutation, and 1p/19q codeletion,[1] with the goal of creating more homogeneous disease categories with greater prognostic value.[2-5] Molecular diagnostics is becoming an increasingly important aspect of clinical oncologic neuropathology practice.
This document provides an overview of local drug delivery (LDD) systems for treating periodontitis. It discusses the history and rationale for LDD, including how it can achieve higher drug concentrations in periodontal pockets than systemic treatments. Ideal requirements for LDD like reaching the target site and maintaining adequate concentration for sufficient time are explained. Various types of LDD systems are classified and described, such as fibers, strips, gels, microparticles and nanoparticles. Specific examples of products using different agents are provided. The document concludes that LDD can augment mechanical debridement for managing periodontitis.
The document summarizes an evidence based project presentation on negative pressure wound therapy (NPWT) for diabetic foot ulcers (DFU). It includes objectives of the presentation, background information on evidence based nursing practice and DFUs. It also outlines the research question comparing NPWT to standard moist wound therapy for healing diabetic foot ulcers over 60 days. A literature review was conducted and findings from 5 systematic reviews showing NPWT increases healing rates for DFUs are summarized. National guidelines also support the use of NPWT for DFUs.
This document describes a proposed study protocol for a randomised controlled trial comparing different treatments for toenail fungus: 1) Photodynamic therapy using a PACTMED laser system, 2) Treatment with the Clearanail nail drilling device followed by topical antifungal, and 3) A combined treatment of Clearanail and PACTMED photodynamic therapy. The study aims to evaluate the efficacy of these treatments and determine if a combined approach provides enhanced results. It provides background on toenail fungus, photodynamic therapy, and discusses previous related studies.
Antibiotics in the management of chronic periodontitis.pptmalti19
This document summarizes evidence on the use of adjunctive antibiotics for chronic periodontitis. A systematic review of 25 studies found some additional benefits of antibiotics in deep pockets, including 0.2-0.6 mm more attachment gain and 0.2-0.8 mm more probing depth reduction. However, the clinical relevance is uncertain given limitations in defining chronic periodontitis and its microbiota. Overall, current studies have not conclusively established benefits of adjunctive antibiotics, so they cannot be routinely indicated as adjuncts for chronic periodontitis.
Similar to Terapia fotodinamica en el tto furcas (20)
(June 12, 2024) Webinar: Development of PET theranostics targeting the molecu...Scintica Instrumentation
Targeting Hsp90 and its pathogen Orthologs with Tethered Inhibitors as a Diagnostic and Therapeutic Strategy for cancer and infectious diseases with Dr. Timothy Haystead.
Evidence of Jet Activity from the Secondary Black Hole in the OJ 287 Binary S...Sérgio Sacani
Wereport the study of a huge optical intraday flare on 2021 November 12 at 2 a.m. UT in the blazar OJ287. In the binary black hole model, it is associated with an impact of the secondary black hole on the accretion disk of the primary. Our multifrequency observing campaign was set up to search for such a signature of the impact based on a prediction made 8 yr earlier. The first I-band results of the flare have already been reported by Kishore et al. (2024). Here we combine these data with our monitoring in the R-band. There is a big change in the R–I spectral index by 1.0 ±0.1 between the normal background and the flare, suggesting a new component of radiation. The polarization variation during the rise of the flare suggests the same. The limits on the source size place it most reasonably in the jet of the secondary BH. We then ask why we have not seen this phenomenon before. We show that OJ287 was never before observed with sufficient sensitivity on the night when the flare should have happened according to the binary model. We also study the probability that this flare is just an oversized example of intraday variability using the Krakow data set of intense monitoring between 2015 and 2023. We find that the occurrence of a flare of this size and rapidity is unlikely. In machine-readable Tables 1 and 2, we give the full orbit-linked historical light curve of OJ287 as well as the dense monitoring sample of Krakow.
Discovery of An Apparent Red, High-Velocity Type Ia Supernova at 𝐳 = 2.9 wi...Sérgio Sacani
We present the JWST discovery of SN 2023adsy, a transient object located in a host galaxy JADES-GS
+
53.13485
−
27.82088
with a host spectroscopic redshift of
2.903
±
0.007
. The transient was identified in deep James Webb Space Telescope (JWST)/NIRCam imaging from the JWST Advanced Deep Extragalactic Survey (JADES) program. Photometric and spectroscopic followup with NIRCam and NIRSpec, respectively, confirm the redshift and yield UV-NIR light-curve, NIR color, and spectroscopic information all consistent with a Type Ia classification. Despite its classification as a likely SN Ia, SN 2023adsy is both fairly red (
�
(
�
−
�
)
∼
0.9
) despite a host galaxy with low-extinction and has a high Ca II velocity (
19
,
000
±
2
,
000
km/s) compared to the general population of SNe Ia. While these characteristics are consistent with some Ca-rich SNe Ia, particularly SN 2016hnk, SN 2023adsy is intrinsically brighter than the low-
�
Ca-rich population. Although such an object is too red for any low-
�
cosmological sample, we apply a fiducial standardization approach to SN 2023adsy and find that the SN 2023adsy luminosity distance measurement is in excellent agreement (
≲
1
�
) with
Λ
CDM. Therefore unlike low-
�
Ca-rich SNe Ia, SN 2023adsy is standardizable and gives no indication that SN Ia standardized luminosities change significantly with redshift. A larger sample of distant SNe Ia is required to determine if SN Ia population characteristics at high-
�
truly diverge from their low-
�
counterparts, and to confirm that standardized luminosities nevertheless remain constant with redshift.
Compositions of iron-meteorite parent bodies constrainthe structure of the pr...Sérgio Sacani
Magmatic iron-meteorite parent bodies are the earliest planetesimals in the Solar System,and they preserve information about conditions and planet-forming processes in thesolar nebula. In this study, we include comprehensive elemental compositions andfractional-crystallization modeling for iron meteorites from the cores of five differenti-ated asteroids from the inner Solar System. Together with previous results of metalliccores from the outer Solar System, we conclude that asteroidal cores from the outerSolar System have smaller sizes, elevated siderophile-element abundances, and simplercrystallization processes than those from the inner Solar System. These differences arerelated to the formation locations of the parent asteroids because the solar protoplane-tary disk varied in redox conditions, elemental distributions, and dynamics at differentheliocentric distances. Using highly siderophile-element data from iron meteorites, wereconstruct the distribution of calcium-aluminum-rich inclusions (CAIs) across theprotoplanetary disk within the first million years of Solar-System history. CAIs, the firstsolids to condense in the Solar System, formed close to the Sun. They were, however,concentrated within the outer disk and depleted within the inner disk. Future modelsof the structure and evolution of the protoplanetary disk should account for this dis-tribution pattern of CAIs.
PPT on Sustainable Land Management presented at the three-day 'Training and Validation Workshop on Modules of Climate Smart Agriculture (CSA) Technologies in South Asia' workshop on April 22, 2024.
Signatures of wave erosion in Titan’s coastsSérgio Sacani
The shorelines of Titan’s hydrocarbon seas trace flooded erosional landforms such as river valleys; however, it isunclear whether coastal erosion has subsequently altered these shorelines. Spacecraft observations and theo-retical models suggest that wind may cause waves to form on Titan’s seas, potentially driving coastal erosion,but the observational evidence of waves is indirect, and the processes affecting shoreline evolution on Titanremain unknown. No widely accepted framework exists for using shoreline morphology to quantitatively dis-cern coastal erosion mechanisms, even on Earth, where the dominant mechanisms are known. We combinelandscape evolution models with measurements of shoreline shape on Earth to characterize how differentcoastal erosion mechanisms affect shoreline morphology. Applying this framework to Titan, we find that theshorelines of Titan’s seas are most consistent with flooded landscapes that subsequently have been eroded bywaves, rather than a uniform erosional process or no coastal erosion, particularly if wave growth saturates atfetch lengths of tens of kilometers.
Candidate young stellar objects in the S-cluster: Kinematic analysis of a sub...Sérgio Sacani
Context. The observation of several L-band emission sources in the S cluster has led to a rich discussion of their nature. However, a definitive answer to the classification of the dusty objects requires an explanation for the detection of compact Doppler-shifted Brγ emission. The ionized hydrogen in combination with the observation of mid-infrared L-band continuum emission suggests that most of these sources are embedded in a dusty envelope. These embedded sources are part of the S-cluster, and their relationship to the S-stars is still under debate. To date, the question of the origin of these two populations has been vague, although all explanations favor migration processes for the individual cluster members. Aims. This work revisits the S-cluster and its dusty members orbiting the supermassive black hole SgrA* on bound Keplerian orbits from a kinematic perspective. The aim is to explore the Keplerian parameters for patterns that might imply a nonrandom distribution of the sample. Additionally, various analytical aspects are considered to address the nature of the dusty sources. Methods. Based on the photometric analysis, we estimated the individual H−K and K−L colors for the source sample and compared the results to known cluster members. The classification revealed a noticeable contrast between the S-stars and the dusty sources. To fit the flux-density distribution, we utilized the radiative transfer code HYPERION and implemented a young stellar object Class I model. We obtained the position angle from the Keplerian fit results; additionally, we analyzed the distribution of the inclinations and the longitudes of the ascending node. Results. The colors of the dusty sources suggest a stellar nature consistent with the spectral energy distribution in the near and midinfrared domains. Furthermore, the evaporation timescales of dusty and gaseous clumps in the vicinity of SgrA* are much shorter ( 2yr) than the epochs covered by the observations (≈15yr). In addition to the strong evidence for the stellar classification of the D-sources, we also find a clear disk-like pattern following the arrangements of S-stars proposed in the literature. Furthermore, we find a global intrinsic inclination for all dusty sources of 60 ± 20◦, implying a common formation process. Conclusions. The pattern of the dusty sources manifested in the distribution of the position angles, inclinations, and longitudes of the ascending node strongly suggests two different scenarios: the main-sequence stars and the dusty stellar S-cluster sources share a common formation history or migrated with a similar formation channel in the vicinity of SgrA*. Alternatively, the gravitational influence of SgrA* in combination with a massive perturber, such as a putative intermediate mass black hole in the IRS 13 cluster, forces the dusty objects and S-stars to follow a particular orbital arrangement. Key words. stars: black holes– stars: formation– Galaxy: center– galaxies: star formation