Two third of Nepal's population depends on agriculture but struggles to produce adequate food for its people and imports around NPR 200 billion worth of food products each year. Inefficient production practices mainly because of lack of technologies resulting into negative margin for majority of the producers. Many farmers, particularly the young farmers are interested to adapt new technologies to reduce drudgery and production cost, to enhance input-use-efficiency and to generate more profit. In addition, due to a higher rate of male out-migration, we should be focused on a series of technology focused programs and projects. Some already tested and proven technologies for examples use of genomic selection to enhance plant and livestock productivity, use of remote sensing data to uniform distribution of fertilizers and other farm chemicals, use of sexed semen to produce female calves for higher milk production, precision nutrient and water management technologies, use of scale-appropriate mechanization, disease resistance varieties of plant and animal species are common practices in developed world. As many of these technologies are already tested and proven elsewhere, a small investment and optimization to custom in Nepalese context can bring a big return to Nepalese agriculture. For export, Nepal has a huge potential to produce premium and organic agri-products along with some optimized indigenous technology to export in international markets. New technology, market and risk management need to go together for better results. Government led risk management programs in big sectors like cereals, poultry, dairy and other commercial enterprises would greatly help in increasing efficiency of the sector and encourage new investments. There is also substantial outreach and investment required to smallholder subsistence farms for certifying the premium and organic products. However, the adoption of technologies generated in other countries have potential social, economic, human, animal, and ecosystem health impacts and slow adoption. Nevertheless, through training, investments and mobilization in technology uptake and commercialization may overcome these shortcomings. In conclusion, Nepal can adopt technologies and best practices from around the world to reduce food import while it can also export premium agri-products in international markets.