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Technical review of the data
collection, scoring and analysis
process
14th National Microbiology Focal Points meeting
Katrin Leitmeyer, Senior Expert, Office of the Chief Scientist
European Centre for Disease Prevention and Control
14th NMFP, Stockholm, 12-13 May 2016
1
EULabCap data sources
1. Information on file at ECDC
− 20 indicators
− TESSy data by country
− EU disease network activity reports
2. NMFPs
− 40 indicators
− data available at the national level
− Self-assessment by competent body
2
EULabCap scores and indices
Score Interpretation Level
0 No or limited capability/capacity Low
1 Partial capability/capacity (e.g. below the EU target,
or partial compliance)
Intermediate
2 Complete capability/capacity (e.g. EU target
reached, or high compliance)
High
NA Capability/capacity not known or indicator not
applicable to country
Not scored
Capability indices
- per target, dimension and overall (for each country and the EU/EEA)
- aggregated scores, normalised to 10.
Indicator scores
3
Indicators modifications made between
data call 2013 and 2014
For the data call 2014 the same indicators were used as in the
2013 data call with the following modifications:
Indicator 3.23 “IBD-LabNet participation” (ECDC)
Country was an active participant in the Invasive bacterial diseases in the
EU Laboratory Network (IBD-LabNet).
• Indicator was not applicable / not scored in 2014 as participation
to the workshop was not available to all the Member States.
4
Indicators modifications made between
data call 2013 and 2014 (2)
NMFP Self-scoring ECDC scoring
Indicator 1.33 “C. difficile test rates” (NMFP; EU quartiles)
Total number of C. difficile diagnostic tests performed/ 1000
hospital inpatient days, based on national estimate.
Indicator 2.13 “NRL core functions” (NMFP)
The majority of NRLs delivered the following functions: (ECDC
will use the answers provided for each function (indicators
2.13a to 2.13e) to calculate the indicator score).
Indicator 2.35 “HIV ARV genotyped” (NMFP)
Total number of HIV isolates genotyped by ARV target sequence analysis
divided by the total number of new HIV cases reported.
5
Indicators modifications made between
data call 2013 and 2014 (3)
Score calculation method was slightly changed for:
Indicator 1.32 “Blood culture test rate” (ECDC; quartiles)
Average number of blood culture sets tested/1 000 hospital
inpatient days reported by EARS-Net participating hospitals
from your country.
• “Non available/ non applicable” option was removed; in 2014, no
data reporting was scored 0.
Indicator 2.24 “Serogroup STEC” (ECDC)
Total number of O-serogrouped Shiga toxin-producing/ verotoxin
producing Escherichia coli (STEC/VTEC) isolates, divided by the total
number of TESSy notified STEC/VTEC cases in accordance with EU
case definition/ECDC FWD network guidance.
• Non-typeable strains were included in the numerator in 2014.
6
Indicators modifications made between
data call 2013 and 2014 (4)
Indicator 2.34 “N. meningitidis typed” (ECDC)
Total number of invasive Neisseria meningitidis isolates typed
by serogroup:MLST:porA:fetA method reported to TESSy
divided by the total of number of invasive cases reported to
TESSy”.
• Partial typing results obtained by either MLST or porA:fetA
sequence analysis were included in the numerator in 2014.
Indicator 3.34 “L. monocytogenes genotyped” (NMFP)
Ratio of the total number of Listeria isolates genotyped by pulsed-field gel
electrophoresis (PFGE), or by whole genome sequencing (WGS), by the total
number of notified cases (in percentage)”.
• Higher resolution typing method (WGS) were added in 2014 as
some countries are performing solely this one.
7
Analysis and reporting – country report
NEW in 2014
• Executive summary
– How well was your country performing in 2014?
– How did your country progress compared to 2013?
8
Reflection on 2014 EULabCap process
• Feasible 30 EU/EEA countries responded 
• Complete 95% complete*
No obvious learning curve effect
• Laborious Number of emails exchanged 408
- Emails received 154
- Emails sent 254
• Belated not following the timeline for data
submission and validation
* One indicator was not applicable/not scored
9
Timeline 2014 EULabCap data collection
2016
10
EULabCap@ecdc.europa.eu

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Technical review of the data collection, scoring and analysis process

  • 1. Technical review of the data collection, scoring and analysis process 14th National Microbiology Focal Points meeting Katrin Leitmeyer, Senior Expert, Office of the Chief Scientist European Centre for Disease Prevention and Control 14th NMFP, Stockholm, 12-13 May 2016
  • 2. 1 EULabCap data sources 1. Information on file at ECDC − 20 indicators − TESSy data by country − EU disease network activity reports 2. NMFPs − 40 indicators − data available at the national level − Self-assessment by competent body
  • 3. 2 EULabCap scores and indices Score Interpretation Level 0 No or limited capability/capacity Low 1 Partial capability/capacity (e.g. below the EU target, or partial compliance) Intermediate 2 Complete capability/capacity (e.g. EU target reached, or high compliance) High NA Capability/capacity not known or indicator not applicable to country Not scored Capability indices - per target, dimension and overall (for each country and the EU/EEA) - aggregated scores, normalised to 10. Indicator scores
  • 4. 3 Indicators modifications made between data call 2013 and 2014 For the data call 2014 the same indicators were used as in the 2013 data call with the following modifications: Indicator 3.23 “IBD-LabNet participation” (ECDC) Country was an active participant in the Invasive bacterial diseases in the EU Laboratory Network (IBD-LabNet). • Indicator was not applicable / not scored in 2014 as participation to the workshop was not available to all the Member States.
  • 5. 4 Indicators modifications made between data call 2013 and 2014 (2) NMFP Self-scoring ECDC scoring Indicator 1.33 “C. difficile test rates” (NMFP; EU quartiles) Total number of C. difficile diagnostic tests performed/ 1000 hospital inpatient days, based on national estimate. Indicator 2.13 “NRL core functions” (NMFP) The majority of NRLs delivered the following functions: (ECDC will use the answers provided for each function (indicators 2.13a to 2.13e) to calculate the indicator score). Indicator 2.35 “HIV ARV genotyped” (NMFP) Total number of HIV isolates genotyped by ARV target sequence analysis divided by the total number of new HIV cases reported.
  • 6. 5 Indicators modifications made between data call 2013 and 2014 (3) Score calculation method was slightly changed for: Indicator 1.32 “Blood culture test rate” (ECDC; quartiles) Average number of blood culture sets tested/1 000 hospital inpatient days reported by EARS-Net participating hospitals from your country. • “Non available/ non applicable” option was removed; in 2014, no data reporting was scored 0. Indicator 2.24 “Serogroup STEC” (ECDC) Total number of O-serogrouped Shiga toxin-producing/ verotoxin producing Escherichia coli (STEC/VTEC) isolates, divided by the total number of TESSy notified STEC/VTEC cases in accordance with EU case definition/ECDC FWD network guidance. • Non-typeable strains were included in the numerator in 2014.
  • 7. 6 Indicators modifications made between data call 2013 and 2014 (4) Indicator 2.34 “N. meningitidis typed” (ECDC) Total number of invasive Neisseria meningitidis isolates typed by serogroup:MLST:porA:fetA method reported to TESSy divided by the total of number of invasive cases reported to TESSy”. • Partial typing results obtained by either MLST or porA:fetA sequence analysis were included in the numerator in 2014. Indicator 3.34 “L. monocytogenes genotyped” (NMFP) Ratio of the total number of Listeria isolates genotyped by pulsed-field gel electrophoresis (PFGE), or by whole genome sequencing (WGS), by the total number of notified cases (in percentage)”. • Higher resolution typing method (WGS) were added in 2014 as some countries are performing solely this one.
  • 8. 7 Analysis and reporting – country report NEW in 2014 • Executive summary – How well was your country performing in 2014? – How did your country progress compared to 2013?
  • 9. 8 Reflection on 2014 EULabCap process • Feasible 30 EU/EEA countries responded  • Complete 95% complete* No obvious learning curve effect • Laborious Number of emails exchanged 408 - Emails received 154 - Emails sent 254 • Belated not following the timeline for data submission and validation * One indicator was not applicable/not scored
  • 10. 9 Timeline 2014 EULabCap data collection 2016