Tay-Sachs disease is a rare, fatal genetic disorder that is caused by the lack of an enzyme called hexosaminidase A. It primarily affects Ashkenazi Jewish populations and people of French-Canadian or Cajun heritage. The disease causes harmful ganglioside buildup in neurons which leads to progressive damage to the nervous system and loss of physical and mental abilities over time, ultimately resulting in death in childhood. There is currently no treatment or way to prevent the progression of Tay-Sachs disease.