Targacept- neuronal nicotinic receptors
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Targacept is a biopharmaceutical company located in Winston-Salem, NC that was founded in 1997 and has 117 employees. They research disorders of the central nervous system by targeting the nicotinic subtype of acetylcholine neurons in the brain. During their first three years, they were a subsidiary of RJ Reynolds and published many articles on the molecular effects of nicotine and the potential of the neuronal nicotinic receptor as a therapeutic target. They currently have five drug candidates in development for conditions like depression, ADHD, and Alzheimer's, and are conducting a Phase II clinical trial of TC-5619 as an adjunct treatment for cognitive dysfunction in schizophrenia.
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Altered proliferation and networks in neural cells derived from idiopathic au...
Altered proliferation and networks in neural cells derived from idiopathic au...
Targacept- neuronal nicotinic receptors
- 2. Vital stats Located in Winston Salem, NC Founded in March 1997 117 Employees Indications targeted: disorders of the central nervous system Therapeutic target: Nicotinic subtype of acetylcholine neurons in the brain
- 3. Targacept’s History During Targacept’s first 3 years, functioned as subsidiary for RJ Reynolds Scientists published hundreds of articles exploring the molecular effects of nicotine Research suggests role of NNR (neuronal nicotinic receptor) as a good potential therapeutic target
- 4. Nicotine and Behavior Neurons which produce and utilize Acetylcholine are ubiquitous Has been linked to cognition (memory, attention and learning) and sensory processing Epidemiology of tobacco smoking indicates self-medication by schizophrenic patients Genomic studies indicate reduced expression of α7 nicotinic receptor
- 5. Funding and Pipeline All products are in development; funding comes from exclusive partnerships with GSK and AstraZeneca TC-5214 major depressive disorderTC-1734 ADHDTC-6683 Alzheimer’sTC-5685 depression/anxietyTC-5619 cognitive dysfunction in schizophrenia (open clinical trial)
- 6. Phase II trial with TC-5619 Double-blind, randomized, placebo-controlled, multi-center trial to assess safety, efficacy and tolerability Adjunctively administered with quetiapine (Seroquel) or risperidone –popular antipsychotic meds Enrollment 200; must be diagnosed with schizophrenia per DSM-IV 15 sites; US (GA, KA, NY-2, TX) India (10 sites) Oct 2009 – Dec 2010