This document describes the steps taken to search the PubMed database on the topic of home care services for patients with schizophrenia or bipolar disorder. Key terms were identified and translated to MeSH headings. A search strategy was developed and run in PubMed, retrieving 26 results. These results were saved to Mendeley and the references were exported in Vancouver format. One reference is then located and its full text PDF retrieved from the journal's website. The document provides guidance on searching bibliographic databases for literature on a health topic.
Faculty of Arts and Social Sciences, University of Technology, Sydney.
Presentation given at "Health Literacy Network: Crossing Disciplines, Bridging Gaps", November 26, 2013. The University of Sydney.
Faculty of Arts and Social Sciences, University of Technology, Sydney.
Presentation given at "Health Literacy Network: Crossing Disciplines, Bridging Gaps", November 26, 2013. The University of Sydney.
Presentatie autisme escap 2015m4 madrid how_malleable_is_autism_escap_postUtrecht
KEYNOTE abstract by professor Sally Rogers (UC Davis MIND Institute, Sacramento) titled 'How malleable is autism? Outcome studies from the youngest children with ASD', held at the ESCAP 2015 Congress in Madrid, Monday June 22nd 2015
Caring for all in the last year of life: making a difference.Bruce Mason
Inaugural presentation by Prof. Scott A. Murray, St Columba's Hospice Chair of Primary Palliative Care, Primary Palliative Care Research Group, Centre for Population Health Sciences: General Practice Section, University of Edinburgh. April 21, 2009
Presentatie autisme escap 2015m4 madrid how_malleable_is_autism_escap_postUtrecht
KEYNOTE abstract by professor Sally Rogers (UC Davis MIND Institute, Sacramento) titled 'How malleable is autism? Outcome studies from the youngest children with ASD', held at the ESCAP 2015 Congress in Madrid, Monday June 22nd 2015
Caring for all in the last year of life: making a difference.Bruce Mason
Inaugural presentation by Prof. Scott A. Murray, St Columba's Hospice Chair of Primary Palliative Care, Primary Palliative Care Research Group, Centre for Population Health Sciences: General Practice Section, University of Edinburgh. April 21, 2009
· Describe the research problem.· Conduct a literature review, a.docxLynellBull52
· Describe the research problem.
· Conduct a literature review, and locate two articles that relate to the research problem.
· Use the articles to assist in describing the problem.
· Formulate the null hypothesis and the alternative hypothesis.
· Determine if the null hypothesis should be rejected or retained, based on the results.
· Support the decision with 3-5 references from the text.
Write a 700- to 1,050-word summary paper with your results.
Format your paper consistent with APA guidelines.Research Data Critique Scenario One
The CEO of ABC manufacturing commissioned a study to look at the differences between the current salaries of her employees by employee job title. There were three job categories: clerical, custodial, and managerial. The study collected current salary data of the three groups and the researcher conducted a statistic and the results are presented below. Using the five steps of hypothesis testing, explain what the researcher might have done, including the appropriate analysis, and interpret the results. Are there any problems with this study? If so, explain what they are.
Average Salary
Clerical (n = 363) $27,838.54
Custodial (n = 27) $30,938.89
Manager (n = 84) $63,977.80
Test statistic = 434.48, p< .05
References:
Agrawal, A., Madden, P. A. F., Buchholz, K. K., Heath, A. C., & Lynskey, M. T. (2008). Transitions to regular smoking and to nicotine dependence in women using cannabis. Drug and Alcohol Dependence, 95, 107–114.
Aillaud, M., & Piolat, A. (2012). Influence of gender on judgment of dark and nondark humor. Individual Differences Research, 10, 211–222.
Albert, U., Salvi, V., Saracco, P., Bogetto, P., & Maina, G. (2007). Health-related quality of life among first-degree relatives of patients with obsessive-compulsive disorder in Italy. Psychiatric Services, 58(7), 970–976.
Altamura, A. C., Dell’Osso, B., Vismara, S., & Mundo, E. (2008). May duration of untreated illness influence the long-term course of major depressive disorder? European Psychiatry, 23, 92–96.
American Psychological Association. (2009). Publication manual of the American Psychological Association (6th ed.). Washington, DC: Author.
Andrade, A. M., Kresge, D. L., Teixeira, P. J., Baptista, F., & Melanson, K. J. (2012). Does eating slowly influence appetite and energy intake when water intake is controlled? International Journal of Behavioral Nutrition and Physical Activity, 9, 135. doi:10.1186/1479-5868-9-135
Apatu, E., Alperin, M., Miner, K. R., & Wiljer, D. (2013). A drive through web 2.0: An exploration of driving safety promotion on FacebookTM. Health Promotion Practice, 14, 88–95. doi:10.1177/1524839911405845
Azrin, N. H., Brooks, J., Kellen, M. J., Ehle, C., & Vinas, V. (2008). Speed of eating as a determinant of the bulimic desire to vomit. Child & Family Behavior Therapy, 30, 263–270. doi:10.1080/07317100802275728
Bachner, J., Raffetseder, P., Walz, B., & Schredl, M. (2012). The effects of dream socialization in childhood on d.
1ReferencesAmerican College of Obstetricians and Gynecolog.docxfelicidaddinwoodie
1
References
American College of Obstetricians and Gynecologists. (2010). ACOG Committee
Opinion No. 343: Psychosocial risk factors: Perinatal screening and intervention.Obstetrics and Gynecology Committee, 108(2), 469–477.
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.), Arlington, VA: American Psychiatric Publishing.
Almond, P. (2009). Postnatal depression: a global public health perspective; Perspectives in public health: 129(5): 221–7.
Ashworth, P., & Greasley (2009). The phenomenology of approach to studying: The idiographic
turn. Studies in Higher Education, 34(5), 561-576.
Baker, L., & Oswalt, K. (2008). Screening for postpartum depression in a rural community. Community Ment Health J 44:171–180.
Babbie, E. (2014). The practice of social research, (13th ed.). Belmont, CA: Wadsworth.
Beck, C.T. (2012). Postpartum depression: It isn’t just the blues. American Journal of
Nursing, 106(5), 40–50.
Borra, C., Lacovou, M. & Sevilla, A. (2015).New Evidence on Breastfeeding and Postpartum Depression: The Importance of Understanding Women’s Intentions. Maternal and Child Health Journal, 19(4), 897-907.
Beck, C.T. (2006). Postpartum depression: It isn’t just the blues. American Journal of
Nursing, 106(5), 40–50.
Brockington, I. F., McDonald, E., & Wainscott, G. (2006). Anxiety, obsession, and
morbid preoccupation in pregnancy. Archives of Women’s Mental Health, 9, 253-
263.
Berglund, S. (2008). Competing Everyday Discourses: The Construction of Heterosexual Risk-Taking Behavior among Adolescents in Nicaragua. Malmö: Malmö högskola, Hälsa och samhälle, 250.
Bernard. H.R. & Ryan, G. (2010). Qualitative data analysis. Systematic approaches. Thousand Oaks:29-35.
Braunack-Mayer, A. and Louise, J. (2008). The Ethics of Community Empowerment: tensions in health promotion theory and practice. IUHPE – Promotion & Education, 15(3), 5-8.
Buchanan, D. R. (2008). Autonomy, paternalism, and justice: Ethical priorities in public
health. American Journal of Public Health, 98(1), 15–21.
Buetow, S. A. (2005). To care is to coprovide. Annals of Family Medicine, 3(6), 553–
555.
Buist, A. (2006). Perinatal depression: Assessment and management. Australian Family
107 Physician, 35(9), 670–673.
Buetow, S. (2011). Person-Centered Care: bridging current models of the clinician patient relationship; International Journal of Person Centered Medicine1 (1), 196-203.
Chaudron, L. H., Kitzman, H. J., Szilagyi, P. G., Sidora-Arcoleo, K., & Anson, E. (2006).
Changes in maternal depressive symptoms across the postpartum year at well
child care visits. Ambulatory Pediatrics, 6, 221–224.
Corwin, E.J. & Arbour, M. (2007). Postpartum fatigue and evidence-based interventions: The American journal of maternal child nursing; 32(4): 215–20; quiz 21–2.
Centers for Disease Control and Prevention. (2012). Prevalence of self-reported
postpartum depressive symptoms—17 states, 2004-2005. Morbidity and Mortality ...
Discussion 1 Mood Disorders and the ClientAlthough you may have e.docxowenhall46084
Discussion 1: Mood Disorders and the Client
Although you may have experienced intense sadness or overt happiness within a given situation, chances are these emotions were not long-lasting. Research has shown diagnoses of mood disorders highlight two specific, factors: severity and consistency. Clients suffering from mood disorders may also present a variety of chronic, maladaptive thoughts, such as suicidal ideation, and behaviors, such as suicide attempts. Although suicidal ideation and suicide attempts may be associated with particular disorders, they are not specific to one disorder or another.
For this Discussion, you apply your knowledge of the DSM to the client case study located in the Learning Resources. Think about your rationale for this diagnosis. Also, consider client risk factors for suicide.
With these thoughts in mind:
Post by Day 3
a diagnosis of the client in the case study. Then explain your rationale for assigning on the basis of the DSM. Finally, explain whether this person is
at risk
for suicide and how you might specifically assess them for suicide. Justify your response with client data and the current literature.
Be sure to support your postings and responses with specific references to the Learning Resources and current literature.
·
American Psychiatric Association. (2013).
Diagnostic and statistical manual of mental disorders
(5th ed.). Arlington, VA: American Psychiatric Publishing.
o
Depressive Disorders
o
Bipolar and Related Disorders
o
Considerations of Medical Conditions
Paris, J. (2015
). The intelligent clinician’s guide to the DSM-5
(2nd ed.).
New York, NY: Oxford University Press.
·
Chapter 9, Bipolar and Related Disorders
·
Chapter 10, Depressive Disorders
Bondi, M. W. (1992). Distinguishing psychological disorders from neurological disorders: Taking Axis III seriously.
Professional Psychology: Research and Practice, 23
(4), 306–309. Retrieved from the Walden Library databases.
Neblett, E. W., Jr., Hammond, W. P., Seaton, E. K., & Townsend, T. G. (2010). Underlying mechanisms in the relationship between Africentric worldview and depressive symptoms.
Journal of Counseling Psychology, 57
(1), 105–113. Retrieved from the Walden Library databases.
Wang, J., Keown, L., Patten, S., Williams, J., Currie, S., Beck, C., & ... El-Guebaly, N. (2009). A population-based study on ways of dealing with daily stress: Comparisons among individuals with mental disorders, with long-term general medical conditions and healthy people.
Social Psychiatry & Psychiatric Epidemiology
,
44
(8), 666–674. Retrieved from the Walden Library databases.
Baskin, T. W., Wampold, B. E., Quintana, S. M., & Enright, R. D. (2010). Belongingness as a protective factor against loneliness and potential depression in a multicultural middle school.
The Counseling Psychologist, 38
(5), 626–651. Retrieved from the Walden Library databases.
Good, G. E., Schopp, L. H., Thomson, D., Hathaway, S., Sanford-Martens, T., Mazurek, M. O.
Resource List The Biological PerspectiveAmerican Psychological .docxdebishakespeare
Resource List: The Biological Perspective
American Psychological Association. (2014). Ethical principles of psychologists and code of conduct. Retrieved from http://www.apa.org/ethics/code/index.aspx
Genetics: Heredity, twin, and adoption studies
· Demirkan, A. A., Penninx, B., Hek, K. K., Wray, N. R., Amin, N. N., Aulchenko, Y. S., Middeldorp, C. M. (2011). Genetic risk profiles for depression and anxiety in adult and elderly cohorts. Molecular Psychiatry, 16(7), 773–783.
· Shyn, S. I., & Hamilton, S. P. (2010). The genetics of major depression: Moving beyond the monoamine hypothesis. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824618/
· Kendler, K. S., & Myers, J. (2010). The genetic and environmental relationship between major depression and the five-factor model of personality. Psychological Medicine, 40(5), 801–806.
· Elder, B. L., & Mosack, V. (2011). Genetics of depression: An overview of the current science. Issues in Mental Health Nursing, 32(4), 192–202.
· Schnittker, J. (2010). Gene-environment correlations in the stress-depression relationship.Journal of Health and Social Behavior, 51(3), 229–243.
· Silberg, J. L., Maes, H., & Eaves, L. J. (2010). Genetic and environmental influences on the transmission of parental depression to children's depression and conduct disturbance: An extended children of twins study. Journal of Child Psychology and Psychiatry, 51(6), 734–744.
Biochemical Studies
· France, C. M., Lysaker, P. H., & Robinson, R. P. (2007). The "chemical imbalance" explanation for depression: Origins, lay endorsement, and clinical implications. Professional Psychology: Research and Practice, 38(4), 411– 420.
· JAMA and Archives Journals. (2009, February 8). Hormone level during pregnancy may identify women at risk for postpartum depression.Science Daily. Retrieved from http://www.sciencedaily.com/releases/2009/02/090202174820.htm
· The Endocrine Society. (2009, June 29). Symptoms of depression in obese children linked to elevated cortisol. Obesity & Diabetes Week, 151.
· Howland, R. H. (2010). Use of endocrine hormones for treating depression. Journal of Psychosocial Nursing and Mental Health Services, 48(12), 13–16.
· Krishnan, V., & Nestler, E. J. (2010). Linking molecules to mood: New insight into the biology of depression. The American Journal of Psychiatry, 167(11), 1305–1320.
· Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: Evidence of genetic moderation. Archives of General Psychiatry, 68(5), 444–454.
· Munafò, M. R. (2012). The serotonin transporter gene and depression. Depression and Anxiety, 29(11), 915–917.
· Naninck, E. F. G., Lucassen, P. J., & Baker, J. (2011). Sex differences in adolescent depression: Do sex hormones determine vulnerability?Journal of Neuroendocrinology, 23(5), 383–392.
· Young, E., & Korszun, A. (2010). Sex, trauma, stress hormones and depression. Molecular Psychi ...
Perceived Stress, Ways of Coping and Care Giving Burden among Family Caregive...iosrjce
Addressing perceived stress, ways of coping and care giving burden among family caregivers are
highly relevant in the current scenario in terms of prevention of mental illness and promotion of mental health of
people engaged in the care of their family member with schizophrenia. A community prevalence study
conducted by the IMHANS, Kerala estimated that 3.2 lakh people in the State suffer from schizophrenia (THE
HINDU, May 25, 2006).
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Astronomy Update- Curiosity’s exploration of Mars _ Local Briefs _ leadertele...
Tarea 5
1. Tarea 5: Búsqueda en la
base de datos: PubMed
Asignatura Competencias Informacionales en Ciencias de la Salud
Máster Oficial Nuevas Tendencias Asistenciales en Ciencias de la Salud
Priscila Távara Vidalón
2. Tema: Atención domiciliaria en
pacientes con esquizofrenia o psicosis
maniaco-depresiva.
1. Identificación de conceptos que vamos a
buscar:
▫ Atención domiciliaria
▫ Esquizofrenia
▫ Psicosis maniaco-depresiva
3. 2. Buscamos los términos en DeCs para su
traducción al inglés:
4. 3. Buscamos los 3 conceptos:
Elegimos “Home Care
Services” porque se refiere a
servicios de enfermería, y
descartamos “Home Nursing”
porque se refiere al cuidado
NO profesional, por familia o
amigos.
5.
6. 4. Planificamos la estrategia de búsqueda
mediante descriptores MeSH:
▫ Home care services
▫ Schizophrenia
▫ Bipolar Disorder
5. Entramos en PubMed:
7. 6. Cambiamos “PubMed” por “MeSH”, buscamos
los términos y pinchamos en “Add to search
builder”:
8. 7. Debemos añadir paréntesis entre
“Schizophrenia” y “Bipolar Disorder”debido a
que estamos usando un conector OR.
Quedaría de la siguiente forma:
▫ ("Home Care Services"[Mesh]) AND
(("Schizophrenia"[Mesh]) OR "Bipolar
Disorder"[Mesh]))
15. 14. La bibliografía debe aparecer en formato
Vancouver. Para esto, pinchamos en “View”,
luego en “Citation Style” y en “Vancouver”:
16. 15. Para exportar la bibliografía, seleccionamos los
artículos y hacemos click derecho y pinchamos
en “Copy As” y luego en “Formatted Citation”:
17. 1. Andrade C. Once- to twice-daily, 3-year domiciliary maintenance transcranial direct
current stimulation for severe, disabling, clozapine-refractory continuous auditory
hallucinations in schizophrenia. J ECT. 2013 Sep;29(3):239–42.
2. Carson VB, Yambor SL. Managing patients with bipolar disorder at home: a family affair
and a psychiatric challenge in home healthcare. Home Healthc Nurse. 2012
May;30(5):280–91; quiz 291–3.
3. Chadda RK, Singh TB, Ganguly KK. Caregiver burden and coping: a prospective study of
relationship between burden and coping in caregivers of patients with schizophrenia
and bipolar affective disorder. Soc Psychiatry Psychiatr Epidemiol. 2007
Nov;42(11):923–30.
4. Bechdolf A, Skutta M, Horn A. [Clinical effectiveness of home treatment as compared to
inpatient treatment at the Alexianer Hospital Krefeld, Germany]. Fortschr Neurol
Psychiatr. 2011 Jan;79(1):26–31.
5. Munz I, Ott M, Jahn H, Rauscher A, Jäger M, Kilian R, et al. [Comparison of “home
treatment” with traditional inpatient treatment in a mental hospital in rural southern
Germany]. Psychiatr Prax. 2011 Apr;38(3):123–8.
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Asignatura Competencias Informacionales en Ciencias de la Salud
Máster Oficial Nuevas Tendencias Asistenciales en Ciencias de la Salud
Priscila Távara Vidalón