The document provides an overview of tablets, defining them as solid dosage forms containing medicaments, with distinct types and advantages such as low cost and ease of packaging. It outlines the formulation process involving components like diluents, binders, and disintegrants, along with manufacturing methods like direct compression and wet granulation. Additionally, it discusses both the benefits and disadvantages of tablets, including challenges in administering to certain patients and difficulty in formulating drugs with specific properties.

1. Tablets
By Priyanka .N
19AB1T0017
Vignan pharmacy college
vadlamudi

2. Introduction
Definition:
Tablet is defined as compresse unit solid dosage form containing medicament with or without
excipient.
According to indin pharmacopiea
Pharmaceutical tablets are solid , flat or biconvex dishes , unit dosage form , prepared by compressing
a drug or mixture of drugs with or without diluents
They vary in shape and differ greatly In size depending upon amount of medicament and intended
mode of administration.

3. Advantages
1. Greatest dose prescription and the least content variability
2. Cost is lowest of all oral dosage form
3. Light and compact
4. Easiest to package and strip
5. Easy to swallow
6. Sustaine release is possible by various techniques
7. Bad odour can be masked by various techniques
8. Suitable for large scale production
9. Greatest chemical and microbial stability over all oral dosage forms

4. Dis Advantages
1. Difficult to swallow in case of children and unconscious patients
2. Some drugs resist compression into dense compacts owing amorphous in nature ,low density in
charechter
3. Drugs with poor wetting and slow dissolution properties are difficult to formulate
4. Bitter tasting of drugs with an objectional odour and taste that are sensitive to oxygen may require
encapsulation

5. Types of tablets
 A) tablets ingested orally
1. Compressed tablet – paracetamol
2. Multiple compressed tablet-
3. Repeat action tablet
4. delayed release tablet – enteric coated tablet
5. Film coated tablet – metronidazole tablet
6. Chewable tablet – antacid tablet
 B) Tablets used in oral activity
1.Buccal tablet- vitamin c tablet
2.sub lingual tablet- Vicks menthol tablet
3.troches or lozenges
4.Dental cones

6. Types of tablets
Tablets administered by other route
1. Implantation tablet
2. Vaginal tablet
Tablets used to prepare solutions
1. Effervescent tablets- Disprin tablet
2. Dispensing tablet- Enzyme tablet
3.Hypodermic tablet
4.tablet triturates

7. Formulation of tablets
 It includes the following steps In addition to active ingredients tablet contains number of inert
subsatances
1. Diluent
2. Binder and adhesive
3. Disintegrants
4. Lubricants and glidants
5. Colouring agents
6. Flavouring agents
7. Sweetning agents

8. Diluents
Used to increase bulk quantity of medicament
Ex. Lactose sucrose , sodium chloride, dextrose and starch

9. Disintegrants
 To break the tablets into smaller particles when swalloed .It can act by three ways swelling, by
producing effervesence, and by melting at body temperature
 Disentegrate agent divided into 2 parts one part is mixed other excipients before granulation and
the other part is mixed with dry granules before compression
 Ex: potato, maize, starch.

10. Granulating agents
 This provides moisture to convert fine powder into damp masses which after sieve passes granules
 Starch paste , isopropyl alcohol,

11. Glidant
 To improve flow properties of granules
 Ex: magnesium sterate and talc

12. Binding agents
 These provides strength to the granules to keep the tablet intact
 Ex: gum tragacanth methyl cellulose

13. Lubricants
 To reduce inter particular friction during compression between tablet and due wall during ejection
of tablet
 Ex: talcand mg sterate

14. Adsorbing agents
 Used to absorb volatile oil , liquid extracts and tincture etc
 Prevents sticking
 Magnesium sterate and steric acid

15. Colours , Flavouring and Sweetning agents
 Must be approved and certified by FDA
 Two forms of colour s are used FD&c D&c types
 Dyes are applied in the form of granulating agent or lake form of these
dyes

16. Tablet manufacturing methods
 1. Direct compression
 2.wet granulation
 3.dry granulation

17. Dry granulation

18. Direct compression

19. Wet granulation

20. Rotary compression

21. Single process punching machine

22. 🌷 Thank you🌷