Fencing has been used in South Africa to address conflicts between wildlife conservation and livestock grazing, but has often harmed wildlife. Fences were erected to protect non-native cattle from disease and predators, but eliminated large wildlife populations and failed to prevent disease spread. This containment caused additional biodiversity loss and alienated locals. Fencing can control disease and conflict if carefully planned and monitored, but also impedes wildlife migration and fragmentation. The impacts of fencing require consideration of wildlife needs, climate change, and community involvement to most effectively protect wildlife, livestock, and humans.