Microneedling, A brief review by Dr. Mohammad Baghaei Mohammad Baghaei
Microneedling is a physical method that induces modification in the SC mechanically and produces micron-sized channels or pores in the skin. This characteristic of the microneedling technique provides delivery of various molecules or therapeutic substances, including proteins, which would usually not penetrate ...
A brief introduction to chemical peeling as a cosmetic procedure performed in the outpatient setting of dermatology clinics. It describes the concept of chemical peeling, materials used, indications, side effects, contraindications, how to perform it step by step at the clinic as well as post peeling precautions.
THE ART OF NON SURGICAL SKIN REJUVENATION. MULTIPLE APPROACHESOsama Moawad
The sudden explosion in recent years of nonsurgical
rejuvenative techniques is patient-driven. The modern
patient, man or woman, desires quick, safe and pre-
dictable nonsurgical techniques that will confer some
form of facial rejuvenation and at the same time allow
them to get back to work or their social lives with a
minimum of downtime. By that is meant a modicum
of bruising and swelling for 2–3 days (i.e., over a week-
end) and not the 2–4 weeks of downtime and scars
that often accompany open surgical techniques.
Whilst nonsurgical techniques are not a substitute
for traditional rejuvenative surgery, the combination
of several nonsurgical tools and procedures has be-
come a powerful adjunct to or a temporizing substi-
tute for open surgery.
facelift without surgery can be done by
Botox
ultherapy
laser
threadlifts
LED
laser skin resurfacing
fillers
All these are age defying non surgical facelift alternatives
No risk of surgery is involved.These treatments encourages increased collagen production or remodelling of existing collagen.Supportive underlying tissues of the skin contract,resulting in tighter,more uplifted appearance of the skin.
Dr Sachdeva's Dental clinic and Facial aesthetic centre is one of the leading clinics performing facelift without surgery in Delhi. So hurry up and come book an appointment with us at Dr.Sachdeva’s Dental Institute, Ashok Vihar, Delhi which has state of the art clinic and all the latest and advanced equipments.
To book an appointment contact:
Dr. Rajat Sachdeva
Director & Mentor
Dr Sachdeva’s Dental Aesthetic And Implant Institute
I 101, Ashok Vihar Phase 1, Delhi- 110052
Contact us at
Phone : +919818894041,01142464041
Our Websites:
www.sachdevadentalcare.com
www.dentalimplantindia.co.in
www.dentalclinicindelhi.com
www.dentalcoursesdelhi.com
Facebook- dentalcoursesdelhi
Youtube- drrajatsachdeva
Linkedin- drrajatsachdeva
Slideshare- Dr Rajat Sachdeva
Twitter Page- drrajatsachdeva
Instagram page- surgicalmasterrajat
Microneedling, A brief review by Dr. Mohammad Baghaei Mohammad Baghaei
Microneedling is a physical method that induces modification in the SC mechanically and produces micron-sized channels or pores in the skin. This characteristic of the microneedling technique provides delivery of various molecules or therapeutic substances, including proteins, which would usually not penetrate ...
A brief introduction to chemical peeling as a cosmetic procedure performed in the outpatient setting of dermatology clinics. It describes the concept of chemical peeling, materials used, indications, side effects, contraindications, how to perform it step by step at the clinic as well as post peeling precautions.
THE ART OF NON SURGICAL SKIN REJUVENATION. MULTIPLE APPROACHESOsama Moawad
The sudden explosion in recent years of nonsurgical
rejuvenative techniques is patient-driven. The modern
patient, man or woman, desires quick, safe and pre-
dictable nonsurgical techniques that will confer some
form of facial rejuvenation and at the same time allow
them to get back to work or their social lives with a
minimum of downtime. By that is meant a modicum
of bruising and swelling for 2–3 days (i.e., over a week-
end) and not the 2–4 weeks of downtime and scars
that often accompany open surgical techniques.
Whilst nonsurgical techniques are not a substitute
for traditional rejuvenative surgery, the combination
of several nonsurgical tools and procedures has be-
come a powerful adjunct to or a temporizing substi-
tute for open surgery.
facelift without surgery can be done by
Botox
ultherapy
laser
threadlifts
LED
laser skin resurfacing
fillers
All these are age defying non surgical facelift alternatives
No risk of surgery is involved.These treatments encourages increased collagen production or remodelling of existing collagen.Supportive underlying tissues of the skin contract,resulting in tighter,more uplifted appearance of the skin.
Dr Sachdeva's Dental clinic and Facial aesthetic centre is one of the leading clinics performing facelift without surgery in Delhi. So hurry up and come book an appointment with us at Dr.Sachdeva’s Dental Institute, Ashok Vihar, Delhi which has state of the art clinic and all the latest and advanced equipments.
To book an appointment contact:
Dr. Rajat Sachdeva
Director & Mentor
Dr Sachdeva’s Dental Aesthetic And Implant Institute
I 101, Ashok Vihar Phase 1, Delhi- 110052
Contact us at
Phone : +919818894041,01142464041
Our Websites:
www.sachdevadentalcare.com
www.dentalimplantindia.co.in
www.dentalclinicindelhi.com
www.dentalcoursesdelhi.com
Facebook- dentalcoursesdelhi
Youtube- drrajatsachdeva
Linkedin- drrajatsachdeva
Slideshare- Dr Rajat Sachdeva
Twitter Page- drrajatsachdeva
Instagram page- surgicalmasterrajat
Pdo thread lift
PDO Thread Lift is a popular non-surgical skin lifting treatment carried out by many doctors
Thread lifting is a procedure that works to tackle sags and folds. The procedure is becoming more popular than ever before as demand grows for skin care where less is more.
Cutis PDO thread lift is a procedure that involves the insertion of a blunt-tip cannula with a very fine absorbable polydioxanone threads into the skin or the subcutaneous fat of the specific areas to be treated.For more information, you can book an appointment at
Dr Sachdeva's Dental Aesthetic And Implant Institute,
I 101, Ashok Vihar Phase 1, Delhi- 110052
Contact us at
• Phone : +919818894041,01142464041
• Our Websites:
• www.sachdevadentalcare.com
• www.dentalclinicindelhi.com
• www.dentalimplantindia.co.in
• www.dentalcoursesdelhi.com
• www.facialaestheticsdelhi.com
• Google+ link: https://goo.gl/vqAmvr
• Facebook link: https://goo.gl/tui98A
• Youtube link: https://goo.gl/mk7jfm
• Linkedin link: https://goo.gl/PrPgpB
• Slideshare link : http://goo.gl/0HY6ep
• Twitter Page : https://goo.gl/tohkcI
• Instagram page : https://goo.gl/OOGVig
Micro needling is a procedure that uses small needles to prick the skin which helps in generation of new collagen and makes the skin smoother,firmer and toned.It is also known as collagen induction therapy.It is used for the treatment of acne,wrinkles,scars, stretch marks,fine lines and other signs of ageing.As we age collagen content in our skin reduces and we lose our radiance. Micro needling is not a quick fix it might take weeks to months to show the desired results as it takes some time for the new skin to be formed.
Dr Sachdeva's Dental clinic and Facial aesthetic center is one of the leading clinics performing micro needling for anti ageing in Delhi. So hurry up and come book an appointment with us at Dr.Sachdeva’s Dental Institute, Ashok Vihar, Delhi which has state of the art clinic and all the latest and advanced equipments.
To book an appointment contact:
Dr. Rajat Sachdeva
Director & Mentor
Dr Sachdeva’s Dental Aesthetic And Implant Institute
I 101, Ashok Vihar Phase 1, Delhi- 110052
Contact us at
Phone : +919818894041,01142464041
Our Websites:
www.sachdevadentalcare.com
www.dentalimplantindia.co.in
www.dentalclinicindelhi.com
www.dentalcoursesdelhi.com
Facebook- dentalcoursesdelhi
Youtube- drrajatsachdeva
Linkedin- drrajatsachdeva
Slideshare- Dr Rajat Sachdeva
Twitter Page- drrajatsachdeva
Instagram page- surgicalmasterrajat
Micro Needling is a minimally invasive procedure that has little downtime, is safe on all skin types and will leave skin looking smoother and younger.
Micro Needling stimulates the bodies natural healing and will rejuvenate the skin and can reduce:
Lines & Wrinkles
Sun Damage
Skin Laxity
Acne Scars
Stretch Marks
Hair Loss and more
www.MDNeedlePen.com
Dermal fillers are an excellent choice for minimizing wrinkles and restoring youthful fullness to the face. However, with all the different options available, choosing the right dermal filler can be overwhelming. To help you find the right dermal filler for you Images Med Spa has created a guide to help you through your decision.
cosderma chemical peels
we have wide range of chemical peels , glycolic, lactic, salicylic, TCA, jessner's, mandelic peel, yellow peel & many more combos are available
Hyperpigmentation on the face slide sharevanita rattan
Hyperpigmentation on the face. How to recognise the distribution of hyperpigmentation on the face and how to treat it. The classic causes of Hyperpigmentation.
Minimally Invasive Techniques In Facial RejuvenationSummit Health
In this presentation Naheed R. Abbasi, MD, MPH, FAAD, Summit Medical Group Department of Dermatology, shares how an understanding of the skin helps to identify technologies most likely to be effective in improving pigment, lines, volume loss and skin laxity. Dr. Abbasi explains numerous minimally invasive technologies available that pose minimal risk and produce little downtime and how surgery can be avoided or postponed through less invasive techniques.
Laser Hair Removal
Also known as light based hair removal and laser hair reduction
Laser hair removal is a convenient, noninvasive method for permanently reducing or removing unwanted facial or body hair. It leaves the skin looking smoother and silkier than waxing, electrolysis or razors and is a gentle technique that can treat larger areas effectively with minimal discomfort and with no downtime. Today, laser hair removal is one of the most common aesthetic procedures performed in the United States.
Pdo thread lift
PDO Thread Lift is a popular non-surgical skin lifting treatment carried out by many doctors
Thread lifting is a procedure that works to tackle sags and folds. The procedure is becoming more popular than ever before as demand grows for skin care where less is more.
Cutis PDO thread lift is a procedure that involves the insertion of a blunt-tip cannula with a very fine absorbable polydioxanone threads into the skin or the subcutaneous fat of the specific areas to be treated.For more information, you can book an appointment at
Dr Sachdeva's Dental Aesthetic And Implant Institute,
I 101, Ashok Vihar Phase 1, Delhi- 110052
Contact us at
• Phone : +919818894041,01142464041
• Our Websites:
• www.sachdevadentalcare.com
• www.dentalclinicindelhi.com
• www.dentalimplantindia.co.in
• www.dentalcoursesdelhi.com
• www.facialaestheticsdelhi.com
• Google+ link: https://goo.gl/vqAmvr
• Facebook link: https://goo.gl/tui98A
• Youtube link: https://goo.gl/mk7jfm
• Linkedin link: https://goo.gl/PrPgpB
• Slideshare link : http://goo.gl/0HY6ep
• Twitter Page : https://goo.gl/tohkcI
• Instagram page : https://goo.gl/OOGVig
Micro needling is a procedure that uses small needles to prick the skin which helps in generation of new collagen and makes the skin smoother,firmer and toned.It is also known as collagen induction therapy.It is used for the treatment of acne,wrinkles,scars, stretch marks,fine lines and other signs of ageing.As we age collagen content in our skin reduces and we lose our radiance. Micro needling is not a quick fix it might take weeks to months to show the desired results as it takes some time for the new skin to be formed.
Dr Sachdeva's Dental clinic and Facial aesthetic center is one of the leading clinics performing micro needling for anti ageing in Delhi. So hurry up and come book an appointment with us at Dr.Sachdeva’s Dental Institute, Ashok Vihar, Delhi which has state of the art clinic and all the latest and advanced equipments.
To book an appointment contact:
Dr. Rajat Sachdeva
Director & Mentor
Dr Sachdeva’s Dental Aesthetic And Implant Institute
I 101, Ashok Vihar Phase 1, Delhi- 110052
Contact us at
Phone : +919818894041,01142464041
Our Websites:
www.sachdevadentalcare.com
www.dentalimplantindia.co.in
www.dentalclinicindelhi.com
www.dentalcoursesdelhi.com
Facebook- dentalcoursesdelhi
Youtube- drrajatsachdeva
Linkedin- drrajatsachdeva
Slideshare- Dr Rajat Sachdeva
Twitter Page- drrajatsachdeva
Instagram page- surgicalmasterrajat
Micro Needling is a minimally invasive procedure that has little downtime, is safe on all skin types and will leave skin looking smoother and younger.
Micro Needling stimulates the bodies natural healing and will rejuvenate the skin and can reduce:
Lines & Wrinkles
Sun Damage
Skin Laxity
Acne Scars
Stretch Marks
Hair Loss and more
www.MDNeedlePen.com
Dermal fillers are an excellent choice for minimizing wrinkles and restoring youthful fullness to the face. However, with all the different options available, choosing the right dermal filler can be overwhelming. To help you find the right dermal filler for you Images Med Spa has created a guide to help you through your decision.
cosderma chemical peels
we have wide range of chemical peels , glycolic, lactic, salicylic, TCA, jessner's, mandelic peel, yellow peel & many more combos are available
Hyperpigmentation on the face slide sharevanita rattan
Hyperpigmentation on the face. How to recognise the distribution of hyperpigmentation on the face and how to treat it. The classic causes of Hyperpigmentation.
Minimally Invasive Techniques In Facial RejuvenationSummit Health
In this presentation Naheed R. Abbasi, MD, MPH, FAAD, Summit Medical Group Department of Dermatology, shares how an understanding of the skin helps to identify technologies most likely to be effective in improving pigment, lines, volume loss and skin laxity. Dr. Abbasi explains numerous minimally invasive technologies available that pose minimal risk and produce little downtime and how surgery can be avoided or postponed through less invasive techniques.
Laser Hair Removal
Also known as light based hair removal and laser hair reduction
Laser hair removal is a convenient, noninvasive method for permanently reducing or removing unwanted facial or body hair. It leaves the skin looking smoother and silkier than waxing, electrolysis or razors and is a gentle technique that can treat larger areas effectively with minimal discomfort and with no downtime. Today, laser hair removal is one of the most common aesthetic procedures performed in the United States.
New modalities in antiaging by Dr. Juliana Ghaben Specialist Dermatologist . ...Spectronix Group
DR Juliana Ghaben http://www.drjulianaghaben.com spoke on new modalities on antiaging at CME for KAYA skin CLinics . She is Board certified in Aesthetic Medicine and a trainer with SPECTRONIX . She spoke on Carboxytherapy , SECRET MICROFRACTIONAL RF AND Q SWITCH ND YAG , ALL MACHINES COURTSEY ; SPECTRONIX . http://spectronixglobal.com/
Scar Revision in oral and Maxillofacial SurgeryPunam Nagargoje
A scar can be defined as a fault or blemish resulting from some former condition, wound, sore or burn. Scar formation is an inevitable consequence of wound healing in which the normal skin is replaced by a fibrous tissue.
• Mechanism
– Trauma
– Surgical
• Location & orientation
– Cosmesis
– Function.
Ideal Scar
• Flat
• Narrow
• Good color match
• Parallel to or within skin crease, folds and RSTLs
The ideal scar is level with the surrounding tissues, has a favorable color match, is narrow, parallel to or lying within a RSTL, and sinuous without long straight unbroken lines. Not all scars are able to be improved by revision techniques and those that are already optimal may be made much worse if a poorly thought out attempt at revision is undertaken. Patients should be carefully counseled to assure that their expectations are realistic – if they expect the scar to be completely gone - I.e invisible – they need education or they are likely to be displeased
Strategies
• Prevention
– Incision planning
• Relaxed skin tension lines
• Facial subunits
– Careful surgical technique
Postop Wound care
• Steroid injection
• Antitension taping
• Excision
– Irregularization
– Reorientation
• Camouflage
– Cosmetics
– Dermabrasion
Timing
• Traditionally 6 to 12 months
• Perhaps earlier for those perpendicular to tension lines
• Dermabrasion 6 to 9 weeks
– High fibroblast activity
The timing of scar revision has traditionally been after the scar has had a period of maturation of 6 to 12 months.
This allows time for scar maturation and better defines what needs to be accomplished in the revision.
Many would argue that scars lying outside RSTLs and especially those perpendicular to RSTLs are likely to have a poor cosmetic outcome and early revision and reorientation can be considered.
Dermabrasion is frequently performed at 6-9 weeks post injury utilizing the high fibroblastic activity in the wound at that time to aid in favorable wound healing.
Wound Healing
• Inflammatory phase – hours
• Proliferative phase – days
• Remodeling phase – months
Cellular Activity in Wound
Healing
Wound Healing.
TYPES OF SCARS
Mature scar
Imature scar
Contractures
Linear hypertrophic scar
Widespread hypertrophic scar
Minor keloid
Major keloid
Ice pick scar
Rolling scars
Boxcar scars
Hypertrophic scar
Can regress
Oriented collagen
Confined to wound
Scant mucin No myofibroblasts
Scars to consider revision
Longer than 20 mm
• Wider than 1-2 mm
• Disturbing function
• Poor match to surrounding tissue
– Colour
– Depth
• Against RSTLs
Timing of Scar Revision
Generally, every scar will show improvement without revision for up to 1 – 3 years
Traditionally we wait 6 to 12 months
Allows time for the scar to mature
Perhaps earlier for those poorly positioned (perpendicular to tension lines) or those that are markedly uneven
Relevant anatomy
Hide i
MACS-Facelift (Minimal Access Cranial Suspension) is a procedure that leaves you looking fresher and youthful. People may not notice that you have had surgery, just that you look refreshed. The MACS-Lift helps to remove excessive jowling around the chin, deep creases that appear between your nose and mouth, and restores the outline of the jaw. The MACS-Lift is less invasive than other facelift procedures and leaves a shorter scar. This type of facelift will lift and hold up sagging tissues in the neck, cheeks, chin, or near the nose with suspension sutures in the deeper tissues. This operation is done on an outpatient basis while you are under local anesthesia.MACS FaceLift provides natural rejuvenation with shorter operative time, quicker recovery, and less potential for complications compared with traditional face lifts. Fat grafting and Blepharoplasty can enhance the final result.
Acne is one of the most common diseases with a point prevalence of up to 100% among adolescents and often persists into adulthood, with detrimental effects on self-esteem. Sixty percent of all acne cases are so-called ‘physiologic acne’, the other 40% are those that need continuous help by a specialist to prevent physical or psychological scarring
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
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Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
13. PREOPERATIVE ASSESSMENT
HISTORY
HSV infection
Recent use of Isotretinoin
Keloidal tendency
Current medication
Previous surgery
Degree of sunexpusre
Immunocompromising condition
15. Antiviral therapy 2 days prior and for 7-10 days after
procedure
Sun screen, HQ, Glycolic acid
Consent form
Photograph- mandatory for resurfacing with laser,
dermabrasion, chemical peels
18. CONTRAINDICATION
Active herpes labialis
Keloidal tendency
Isotretinoin therapy in the preceeding 6 months
Bleeding disorders
19. DERMAROLLER
Drum shaped roller
192 microneedles of 0.1 mm dia.
Needle length 0.5 – 2 mm
Motorised Dermastamps &
Home care dermastamps
20. PROCEDURE
Topical anaesthesia
Stretch the skin perpendicular to direction of
movement of derma roller
Roll the tool 4 times in 4 different directions
250-300 Pricks/cm sq.
Needle penetrates at an angle, then goes deeper, and
extracted at a converse angle
End point- uniform bleeding points over scarred area
21. POST PROCEDURE
Clean with NS
Oral analgesic
No need of phtoprotection
3-4 sessions at 4-8 wks intervals
24. PRINCIPLE
Releasing fibrotic strands underlying scars
Organization of blood in the induced dermal
pockets
Connective tissue formation in the area
26. Insert the needle at periphery of scarred area
Move back and forth, fanlike motion
Firm pressure for 5 mts.
Avoid preauricular, temporal and mandibular
areas
29. PUNCH EXCISION AND CLOSURE
Ind- Ice pick and Boxcar scars
PROCEDURE
Local anaesthesia
Select appropriate size punch
Traction at right angles to RSTL
Descend upto s/c fat and excise scar plug
Undermine the wound edges
Suture
30.
31. PUNCH INCISION AND ELEVATION [Punch floatation]
Depressed scars with normal surface texture
Boxcar scar>3mm
32. PROCEDURE
Punch that match to inner dia. of crateriform scar
Rotating motion release bound down scar
Elevate the plug and free from underlying tissue
Elevate the plug and position to lie slightly higher than
surrounding skin
Secure in position by cyanoacrylate tissue adhesive
33. PUNCH REPLACEMENT AND GRAFTING
INDICATION
Deep irregular pits
Tethered boxcar scars with altered skin
texture
34. PROCEDURE
Scar plug is removed and graft is transferred to
the plug site
Donor site- post auricular area and inner arm
Donor punch graft size> 0.5mm larger
35.
36. CROSS
Technique using high strength TCA focally on atrophic
acne scars to induce collagenisation and cosmetic
improvement
PRINCIPLE
Precipitation of proteins
Coagulative necrosis of epidermal cells and collagen
Dermal remodelling
37. INDICATION
Ice pick scars
PROCEDURE
Mark the scar
Clean with spirit and degrease with acetone
Patient in sitting position
Stretch the skin and apply 100% TCA focally
38. Avoid spillage
Keep the skin stretched until frosted
Wash the face
Photo protection
3 sessions , 4 wkly intervals
41. DERMAL GRAFTING
Placing dermal grafts into precise pockets under skin
ADVANTAGES
Not susceptible to infection
Can be tailored accurately
Creates a permanent space
Readily available
Easy to perform
43. CONVENTIONAL
Local anaesthesia
Subcsion 10- 14 days before
Donor tissue from post auricular area or from
dermabraded site
Defective area is tunnelled
Trim the grafts according to shape
Insert the graft and suture slit
44. ENZYMATIC TECHNIQUE
Graft in 0.25% trypsin in EDTA solution
Incubate at 37⁰ C for 75 mts.
Transfer to phosphate buffered saline and
remove epidermis
Insert the graft by conventional technique
or inject using a wide bore needle
46. CHEMICAL PEELING
Salicylic acid 20-30%- active acne and
superficial scars
TCA 10%, 15%, 25%
Glycolic acid 25-35%
Jessener’s peel
47. Medium depth & deep phenol peels –
effective but not recommended
48. ABLATIVE
DERMABRASION
Ind- superficial acne scars
Spot dermabrasion can be done in office setting
Full face dermabrasion needs an operation theatre facility
Topical or infiltrative anaesthesia
49. Mark scars and stretch the skin
Dermabrade till the base of scars
Maximum level- Jn of upper and mid reticular dermis
Manual dermabrader to feather the edges
53. MICRODERMABRASION
Superficial minimally invasive technique of mechanical
abrasion of skin using a pressurised stream of abrasive
particles
Aluminium oxide crystals
Disposble diamond tip
Ind- Superficial scars
CI- Active infection
Concurrent dermatoses on face
Eye protection
54. Set machine parameters with pr. level 10-30 mm of Hg
Stretch the skin under tension
Move the hand piece in a sweeping, outward motion
2nd pass in a direction perpendicular to first pass
except in neck
End point- erythema
Topical antibiotic
Repeated weekly
58. SOFT TISSUE AUGMENTATION
Ind- soft atrophic scars with loss of dermal tissue
Dermal filers are placed under scars
Elevate and bring the surface of scar in level with
surrounding skin
Subcsion or microneedling can be done prior
65. FRACTIONAL PHOTOTHERMOLYSIS
Non injured part of skin is the source of
keratinocytes
Migration begins within 24 hrs
Keratinocytes facilitate removal of MENDs
66. NON ABLATIVE
1550nm erbium doped fibre laser
ABLATIVE
Fractional CO2laser
Direct vaporizing effect on epidermis and some part
of dermis
67. Free of any active acne lesions
No history of keloidal tendency
PROCEDURE
Clean the skin with 70% alcohol
LA cream for 1 hr
No. of passes and fluence depending on skin
type & severity of scarring
Cool the skin with ice packs after procedure
Non comedogenic Abs for 3-5 days +sunscreen
68. COMPLICATIONS
Erythema and crusting
PIH
Dryness of skin
Pruritus
Bronzing of skin
Aggravation of acne